ASF1B (anti-silencing function 1B histone chaperone)

Gene

• Entrez ID: 55723
• Gene name: Anti-silencing function 1B histone chaperone
• Gene symbol: ASF1B
• Synonyms (NCBI Gene): CIA-II
• Chromosome: 19
• Chromosome location: 19p13.12
• Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may pla

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016454	hsa-miR-193b-3p	Microarray	20304954
MIRT029781	hsa-miR-26b-5p	Microarray	19088304
MIRT035546	hsa-miR-214-3p	Luciferase reporter assay	23100276
MIRT043037	hsa-miR-324-5p	CLASH	23622248
MIRT040934	hsa-miR-18a-3p	CLASH	23622248
MIRT040666	hsa-miR-92b-3p	CLASH	23622248
MIRT038280	hsa-miR-130b-5p	CLASH	23622248
MIRT559422	hsa-miR-3133	PAR-CLIP	21572407
MIRT559421	hsa-miR-3677-5p	PAR-CLIP	21572407
MIRT559422	hsa-miR-3133	PAR-CLIP	21572407
MIRT559421	hsa-miR-3677-5p	PAR-CLIP	21572407
MIRT802752	hsa-miR-1245b-3p	CLIP-seq
MIRT802753	hsa-miR-1286	CLIP-seq
MIRT802754	hsa-miR-1287	CLIP-seq
MIRT802755	hsa-miR-1301	CLIP-seq
MIRT802756	hsa-miR-1321	CLIP-seq
MIRT802757	hsa-miR-1343	CLIP-seq
MIRT802758	hsa-miR-2116	CLIP-seq
MIRT802759	hsa-miR-214	CLIP-seq
MIRT802760	hsa-miR-24	CLIP-seq
MIRT802761	hsa-miR-300	CLIP-seq
MIRT802762	hsa-miR-3120-3p	CLIP-seq
MIRT802763	hsa-miR-3124-3p	CLIP-seq
MIRT802764	hsa-miR-3126-5p	CLIP-seq
MIRT802765	hsa-miR-3135b	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802767	hsa-miR-3150a-3p	CLIP-seq
MIRT802768	hsa-miR-3153	CLIP-seq
MIRT802769	hsa-miR-3169	CLIP-seq
MIRT802770	hsa-miR-3175	CLIP-seq
MIRT802771	hsa-miR-3184	CLIP-seq
MIRT802772	hsa-miR-3192	CLIP-seq
MIRT802773	hsa-miR-3619-5p	CLIP-seq
MIRT802774	hsa-miR-3661	CLIP-seq
MIRT802775	hsa-miR-3685	CLIP-seq
MIRT802776	hsa-miR-3689a-3p	CLIP-seq
MIRT802777	hsa-miR-3689c	CLIP-seq
MIRT802778	hsa-miR-381	CLIP-seq
MIRT802779	hsa-miR-384	CLIP-seq
MIRT802780	hsa-miR-423-5p	CLIP-seq
MIRT802781	hsa-miR-4266	CLIP-seq
MIRT802782	hsa-miR-4270	CLIP-seq
MIRT802783	hsa-miR-4284	CLIP-seq
MIRT802784	hsa-miR-4291	CLIP-seq
MIRT802785	hsa-miR-4300	CLIP-seq
MIRT802786	hsa-miR-4314	CLIP-seq
MIRT802787	hsa-miR-4328	CLIP-seq
MIRT802788	hsa-miR-4330	CLIP-seq
MIRT802789	hsa-miR-4436a	CLIP-seq
MIRT802790	hsa-miR-4441	CLIP-seq
MIRT802791	hsa-miR-4476	CLIP-seq
MIRT802792	hsa-miR-4492	CLIP-seq
MIRT802793	hsa-miR-4498	CLIP-seq
MIRT802794	hsa-miR-4505	CLIP-seq
MIRT802795	hsa-miR-4514	CLIP-seq
MIRT802796	hsa-miR-4515	CLIP-seq
MIRT802797	hsa-miR-4640-5p	CLIP-seq
MIRT802798	hsa-miR-4645-5p	CLIP-seq
MIRT802799	hsa-miR-4646-5p	CLIP-seq
MIRT802800	hsa-miR-4648	CLIP-seq
MIRT802801	hsa-miR-4654	CLIP-seq
MIRT802802	hsa-miR-4656	CLIP-seq
MIRT802803	hsa-miR-4660	CLIP-seq
MIRT802804	hsa-miR-4666-3p	CLIP-seq
MIRT802805	hsa-miR-4667-5p	CLIP-seq
MIRT802806	hsa-miR-4668-5p	CLIP-seq
MIRT802807	hsa-miR-4673	CLIP-seq
MIRT802808	hsa-miR-4677-5p	CLIP-seq
MIRT802809	hsa-miR-4679	CLIP-seq
MIRT802810	hsa-miR-4682	CLIP-seq
MIRT802811	hsa-miR-4685-5p	CLIP-seq
MIRT802812	hsa-miR-4687-3p	CLIP-seq
MIRT802813	hsa-miR-4688	CLIP-seq
MIRT802814	hsa-miR-4692	CLIP-seq
MIRT802815	hsa-miR-4700-3p	CLIP-seq
MIRT802816	hsa-miR-4700-5p	CLIP-seq
MIRT802817	hsa-miR-4705	CLIP-seq
MIRT802818	hsa-miR-4709-3p	CLIP-seq
MIRT802819	hsa-miR-4716-3p	CLIP-seq
MIRT802820	hsa-miR-4717-3p	CLIP-seq
MIRT802821	hsa-miR-4723-5p	CLIP-seq
MIRT802822	hsa-miR-4726-5p	CLIP-seq
MIRT802823	hsa-miR-4728-5p	CLIP-seq
MIRT802824	hsa-miR-4731-3p	CLIP-seq
MIRT802825	hsa-miR-4731-5p	CLIP-seq
MIRT802826	hsa-miR-4739	CLIP-seq
MIRT802827	hsa-miR-4751	CLIP-seq
MIRT802828	hsa-miR-4756-5p	CLIP-seq
MIRT802829	hsa-miR-4769-5p	CLIP-seq
MIRT802830	hsa-miR-4801	CLIP-seq
MIRT802831	hsa-miR-5047	CLIP-seq
MIRT802832	hsa-miR-514	CLIP-seq
MIRT802833	hsa-miR-514b-3p	CLIP-seq
MIRT802834	hsa-miR-541	CLIP-seq
MIRT802835	hsa-miR-619	CLIP-seq
MIRT802836	hsa-miR-631	CLIP-seq
MIRT802837	hsa-miR-651	CLIP-seq
MIRT802838	hsa-miR-654-5p	CLIP-seq
MIRT802839	hsa-miR-665	CLIP-seq
MIRT802840	hsa-miR-761	CLIP-seq
MIRT802841	hsa-miR-762	CLIP-seq
MIRT802842	hsa-miR-767-3p	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT802844	hsa-miR-920	CLIP-seq
MIRT802845	hsa-miR-922	CLIP-seq
MIRT802846	hsa-miR-939	CLIP-seq
MIRT802847	hsa-miR-940	CLIP-seq
MIRT1937038	hsa-miR-122	CLIP-seq
MIRT802752	hsa-miR-1245b-3p	CLIP-seq
MIRT1937039	hsa-miR-1245b-5p	CLIP-seq
MIRT1937040	hsa-miR-128	CLIP-seq
MIRT802753	hsa-miR-1286	CLIP-seq
MIRT802756	hsa-miR-1321	CLIP-seq
MIRT802757	hsa-miR-1343	CLIP-seq
MIRT1937041	hsa-miR-193a-5p	CLIP-seq
MIRT1937042	hsa-miR-203	CLIP-seq
MIRT1937043	hsa-miR-2115	CLIP-seq
MIRT802758	hsa-miR-2116	CLIP-seq
MIRT802763	hsa-miR-3124-3p	CLIP-seq
MIRT802764	hsa-miR-3126-5p	CLIP-seq
MIRT1937044	hsa-miR-3127-5p	CLIP-seq
MIRT802765	hsa-miR-3135b	CLIP-seq
MIRT1937045	hsa-miR-3142	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802767	hsa-miR-3150a-3p	CLIP-seq
MIRT802768	hsa-miR-3153	CLIP-seq
MIRT802770	hsa-miR-3175	CLIP-seq
MIRT802772	hsa-miR-3192	CLIP-seq
MIRT1937046	hsa-miR-320a	CLIP-seq
MIRT1937047	hsa-miR-320b	CLIP-seq
MIRT1937048	hsa-miR-320c	CLIP-seq
MIRT1937049	hsa-miR-320d	CLIP-seq
MIRT1937050	hsa-miR-320e	CLIP-seq
MIRT802775	hsa-miR-3685	CLIP-seq
MIRT802779	hsa-miR-384	CLIP-seq
MIRT1937051	hsa-miR-3922-5p	CLIP-seq
MIRT1937052	hsa-miR-3977	CLIP-seq
MIRT802782	hsa-miR-4270	CLIP-seq
MIRT1937053	hsa-miR-4292	CLIP-seq
MIRT802785	hsa-miR-4300	CLIP-seq
MIRT1937054	hsa-miR-4308	CLIP-seq
MIRT802787	hsa-miR-4328	CLIP-seq
MIRT802788	hsa-miR-4330	CLIP-seq
MIRT1937055	hsa-miR-4429	CLIP-seq
MIRT802789	hsa-miR-4436a	CLIP-seq
MIRT802790	hsa-miR-4441	CLIP-seq
MIRT1937056	hsa-miR-4481	CLIP-seq
MIRT802792	hsa-miR-4492	CLIP-seq
MIRT802793	hsa-miR-4498	CLIP-seq
MIRT802794	hsa-miR-4505	CLIP-seq
MIRT1937057	hsa-miR-4527	CLIP-seq
MIRT802797	hsa-miR-4640-5p	CLIP-seq
MIRT802800	hsa-miR-4648	CLIP-seq
MIRT802801	hsa-miR-4654	CLIP-seq
MIRT802805	hsa-miR-4667-5p	CLIP-seq
MIRT802806	hsa-miR-4668-5p	CLIP-seq
MIRT802808	hsa-miR-4677-5p	CLIP-seq
MIRT802810	hsa-miR-4682	CLIP-seq
MIRT802811	hsa-miR-4685-5p	CLIP-seq
MIRT802813	hsa-miR-4688	CLIP-seq
MIRT802816	hsa-miR-4700-5p	CLIP-seq
MIRT802819	hsa-miR-4716-3p	CLIP-seq
MIRT802821	hsa-miR-4723-5p	CLIP-seq
MIRT802822	hsa-miR-4726-5p	CLIP-seq
MIRT802823	hsa-miR-4728-5p	CLIP-seq
MIRT802824	hsa-miR-4731-3p	CLIP-seq
MIRT802825	hsa-miR-4731-5p	CLIP-seq
MIRT802826	hsa-miR-4739	CLIP-seq
MIRT1937058	hsa-miR-4745-5p	CLIP-seq
MIRT802828	hsa-miR-4756-5p	CLIP-seq
MIRT1937059	hsa-miR-4759	CLIP-seq
MIRT802829	hsa-miR-4769-5p	CLIP-seq
MIRT802830	hsa-miR-4801	CLIP-seq
MIRT1937060	hsa-miR-516a-3p	CLIP-seq
MIRT802834	hsa-miR-541	CLIP-seq
MIRT802838	hsa-miR-654-5p	CLIP-seq
MIRT1937061	hsa-miR-670	CLIP-seq
MIRT802841	hsa-miR-762	CLIP-seq
MIRT802842	hsa-miR-767-3p	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT1937062	hsa-miR-888	CLIP-seq
MIRT802844	hsa-miR-920	CLIP-seq
MIRT802846	hsa-miR-939	CLIP-seq
MIRT1937038	hsa-miR-122	CLIP-seq
MIRT802752	hsa-miR-1245b-3p	CLIP-seq
MIRT802753	hsa-miR-1286	CLIP-seq
MIRT802757	hsa-miR-1343	CLIP-seq
MIRT1937041	hsa-miR-193a-5p	CLIP-seq
MIRT802758	hsa-miR-2116	CLIP-seq
MIRT802761	hsa-miR-300	CLIP-seq
MIRT802762	hsa-miR-3120-3p	CLIP-seq
MIRT802763	hsa-miR-3124-3p	CLIP-seq
MIRT802764	hsa-miR-3126-5p	CLIP-seq
MIRT1937044	hsa-miR-3127-5p	CLIP-seq
MIRT802765	hsa-miR-3135b	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802767	hsa-miR-3150a-3p	CLIP-seq
MIRT2176833	hsa-miR-3161	CLIP-seq
MIRT802770	hsa-miR-3175	CLIP-seq
MIRT802772	hsa-miR-3192	CLIP-seq
MIRT1937046	hsa-miR-320a	CLIP-seq
MIRT1937047	hsa-miR-320b	CLIP-seq
MIRT1937048	hsa-miR-320c	CLIP-seq
MIRT1937049	hsa-miR-320d	CLIP-seq
MIRT1937050	hsa-miR-320e	CLIP-seq
MIRT802775	hsa-miR-3685	CLIP-seq
MIRT802778	hsa-miR-381	CLIP-seq
MIRT802779	hsa-miR-384	CLIP-seq
MIRT1937051	hsa-miR-3922-5p	CLIP-seq
MIRT802785	hsa-miR-4300	CLIP-seq
MIRT802787	hsa-miR-4328	CLIP-seq
MIRT802788	hsa-miR-4330	CLIP-seq
MIRT1937055	hsa-miR-4429	CLIP-seq
MIRT802789	hsa-miR-4436a	CLIP-seq
MIRT1937056	hsa-miR-4481	CLIP-seq
MIRT802792	hsa-miR-4492	CLIP-seq
MIRT802793	hsa-miR-4498	CLIP-seq
MIRT802794	hsa-miR-4505	CLIP-seq
MIRT1937057	hsa-miR-4527	CLIP-seq
MIRT802802	hsa-miR-4656	CLIP-seq
MIRT802804	hsa-miR-4666-3p	CLIP-seq
MIRT802805	hsa-miR-4667-5p	CLIP-seq
MIRT802808	hsa-miR-4677-5p	CLIP-seq
MIRT802810	hsa-miR-4682	CLIP-seq
MIRT802811	hsa-miR-4685-5p	CLIP-seq
MIRT802813	hsa-miR-4688	CLIP-seq
MIRT802816	hsa-miR-4700-5p	CLIP-seq
MIRT802817	hsa-miR-4705	CLIP-seq
MIRT802819	hsa-miR-4716-3p	CLIP-seq
MIRT802820	hsa-miR-4717-3p	CLIP-seq
MIRT802821	hsa-miR-4723-5p	CLIP-seq
MIRT802823	hsa-miR-4728-5p	CLIP-seq
MIRT802825	hsa-miR-4731-5p	CLIP-seq
MIRT1937058	hsa-miR-4745-5p	CLIP-seq
MIRT1937059	hsa-miR-4759	CLIP-seq
MIRT802841	hsa-miR-762	CLIP-seq
MIRT802842	hsa-miR-767-3p	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT802844	hsa-miR-920	CLIP-seq
MIRT802846	hsa-miR-939	CLIP-seq
MIRT802762	hsa-miR-3120-3p	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802817	hsa-miR-4705	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT2464864	hsa-miR-302a	CLIP-seq
MIRT2464865	hsa-miR-302b	CLIP-seq
MIRT2464866	hsa-miR-302c	CLIP-seq
MIRT2464867	hsa-miR-302d	CLIP-seq
MIRT2464868	hsa-miR-302e	CLIP-seq
MIRT2464869	hsa-miR-3140-3p	CLIP-seq
MIRT2464870	hsa-miR-3616-5p	CLIP-seq
MIRT2464871	hsa-miR-3646	CLIP-seq
MIRT2464872	hsa-miR-3647-5p	CLIP-seq
MIRT2464873	hsa-miR-372	CLIP-seq
MIRT2464874	hsa-miR-373	CLIP-seq
MIRT2464875	hsa-miR-4795-5p	CLIP-seq
MIRT2464876	hsa-miR-4799-5p	CLIP-seq
MIRT2464877	hsa-miR-520a-3p	CLIP-seq
MIRT2464878	hsa-miR-520b	CLIP-seq
MIRT2464879	hsa-miR-520c-3p	CLIP-seq
MIRT2464880	hsa-miR-520d-3p	CLIP-seq
MIRT2464881	hsa-miR-520e	CLIP-seq
MIRT2464882	hsa-miR-520f	CLIP-seq
MIRT2464883	hsa-miR-573	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Activation	17328667

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IBA
GO:0000785	Component	Chromatin	IDA	14718166
GO:0000785	Component	Chromatin	IEA
GO:0001835	Process	Blastocyst hatching	IEA
GO:0005515	Function	Protein binding	IPI	16980972, 22407294, 23075851, 24981860, 26167883, 27705803, 28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006334	Process	Nucleosome assembly	IDA	14718166
GO:0006334	Process	Nucleosome assembly	IEA
GO:0006334	Process	Nucleosome assembly	IEA
GO:0006335	Process	DNA replication-dependent chromatin assembly	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IEA
GO:0140713	Function	Histone chaperone activity	IDA	12842904, 26527279
GO:0140713	Function	Histone chaperone activity	IEA

Other IDs

• MIM: 609190
• HGNC: 20996
• e!Ensembl: ENSG00000105011

Protein

• UniProt ID: Q9NVP2
• Protein name: Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)
• Protein function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates
• PDB: 5BNX, 5BO0, 7V1M, 7VCQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04729	ASF1_hist_chap	1 → 154	ASF1 like histone chaperone	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in testis and at lower levels in colon, small intestine and thymus. {ECO:0000269|PubMed:12842904}.
• Sequence:

  MAKVSVLNVAVLENPSPFHSPFRFEISFECSEALADDLEWKIIYVGSAESEEFDQILDSV
  LVGPVPAGRHMFVFQADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNP
  ELRENPPMKPDFSQLQRNILASNPRVTRFHINWDNNMDRLEAIETQDPSLGCGLPLNCTP
  IKGLGLPGCIPGLLPENSMDCI

• Sequence length: 202