Gene Gene information from NCBI Gene database.
Entrez ID 55676
Gene name Solute carrier family 30 member 6
Gene symbol SLC30A6
Synonyms (NCBI Gene)
MST103MSTP103ZNT6
Chromosome 2
Chromosome location 2p22.3
Summary This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer`s disease brain plaques. [provided b
miRNA miRNA information provided by mirtarbase database.
663
miRTarBase ID miRNA Experiments Reference
MIRT026066 hsa-miR-196a-5p Sequencing 20371350
MIRT032161 hsa-let-7d-5p Sequencing 20371350
MIRT042568 hsa-miR-423-3p CLASH 23622248
MIRT026066 hsa-miR-196a-5p HITS-CLIP 23313552
MIRT206422 hsa-miR-196b-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0005385 Function Zinc ion transmembrane transporter activity IDA 15994300
GO:0005385 Function Zinc ion transmembrane transporter activity IEA
GO:0005515 Function Protein binding IPI 15994300, 19759014, 25657003, 32296183, 35271311
GO:0005794 Component Golgi apparatus IBA
GO:0005794 Component Golgi apparatus IDA 17349999
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611148 19305 ENSG00000152683
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6NXT4
Protein name Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6)
Protein function Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695,
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01545 Cation_efflux 34 255 Cation efflux family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kid
Sequence
MGTIHLFRKPQRSFFGKLLREFRLVAADRRSWKILLFGVINLICTGFLLMWCSSTNSIAL
TAYTYLTIFDLFSLMTCLISYWVTLRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILK
ESAERFLEQPEIHTGRLLVGTFVALCFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLS
RSLCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTF
GTMYPMSVYSGKVLL
QTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVH
VRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIP
MPLLKGTDDLNPVTSTPAKPSSPPPEFSFNTPGKNVNPVILLNTQTRPYGFGLNHGHTPY
SSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP
Sequence length 461
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Insulin processing
Zinc efflux and compartmentalization by the SLC30 family
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMERS DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Alzheimer Disease Associate 21659953, 25065914
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Associate 40282424
★☆☆☆☆
Found in Text Mining only
Dementia Associate 21659953, 25065914
★☆☆☆☆
Found in Text Mining only
Glioma Associate 23595627
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Neurodegenerative Diseases Associate 30623748
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Associate 27833104
★☆☆☆☆
Found in Text Mining only