Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55676
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 30 member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC30A6
Synonyms (NCBI Gene) Gene synonyms aliases
MST103, MSTP103, ZNT6
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer`s disease brain plaques. [provided b
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026066 hsa-miR-196a-5p Sequencing 20371350
MIRT032161 hsa-let-7d-5p Sequencing 20371350
MIRT042568 hsa-miR-423-3p CLASH 23622248
MIRT026066 hsa-miR-196a-5p HITS-CLIP 23313552
MIRT206422 hsa-miR-196b-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005385 Function Zinc ion transmembrane transporter activity IDA 15994300
GO:0005385 Function Zinc ion transmembrane transporter activity IEA
GO:0005515 Function Protein binding IPI 15994300, 19759014, 25657003, 32296183, 35271311
GO:0005794 Component Golgi apparatus IBA
GO:0005794 Component Golgi apparatus IDA 17349999
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611148 19305 ENSG00000152683
Protein
UniProt ID Q6NXT4
Protein name Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6)
Protein function Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695,
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01545 Cation_efflux 34 255 Cation efflux family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kid
Sequence
MGTIHLFRKPQRSFFGKLLREFRLVAADRRSWKILLFGVINLICTGFLLMWCSSTNSIAL
TAYTYLTIFDLFSLMTCLISYWVTLRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILK
ESAERFLEQPEIHTGRLLVGTFVALCFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLS
RSLCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTF
GTMYPMSVYSGKVLL
QTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVH
VRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIP
MPLLKGTDDLNPVTSTPAKPSSPPPEFSFNTPGKNVNPVILLNTQTRPYGFGLNHGHTPY
SSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP
Sequence length 461
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Insulin processing
Zinc efflux and compartmentalization by the SLC30 family
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glioblastoma Glioblastoma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 21659953, 25065914
Carcinoma Pancreatic Ductal Associate 40282424
Dementia Associate 21659953, 25065914
Glioma Associate 23595627
Neurodegenerative Diseases Associate 30623748
Prostatic Neoplasms Associate 27833104