CDC37L1 (cell division cycle 37 like 1, HSP90 cochaperone)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55664
Gene name Gene Name - the full gene name approved by the HGNC.
Cell division cycle 37 like 1, HSP90 cochaperone
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDC37L1
Synonyms (NCBI Gene) Gene synonyms aliases
CDC37B, HARC
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p24.1
Summary Summary of gene provided in NCBI Entrez Gene.
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(555)
miRTarBase ID miRNA Experiments Reference
MIRT020478 hsa-miR-106b-5p Microarray 17242205
MIRT027214 hsa-miR-103a-3p Sequencing 20371350
MIRT028177 hsa-miR-93-5p Sequencing 20371350
MIRT032005 hsa-miR-16-5p Sequencing 20371350
MIRT042137 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0002576 Process Platelet degranulation TAS
GO:0005515 Function Protein binding IPI 21988832, 25036637, 25416956, 32814053
GO:0005576 Component Extracellular region TAS
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610346 17179 ENSG00000106993
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q7L3B6
Protein name Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37)
Protein function Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08565 CDC37_M 168 → 278 Cdc37 Hsp90 binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, heart, kidney, liver, placenta and skeletal muscle. {ECO:0000269|PubMed:11413142}.
Sequence 
MEQPWPPPGPWSLPRAEGEAEEESDFDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEF
VKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQR
EKMCLWSTDAISKDVFNKSFINQDKRKDTEDEDKSESFMQKYEQKIRHFGMLSRWDDSQR
FLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGC
FRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLE
SLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV
Sequence length 337
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Platelet degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Show/Hide Text Mining Associations (2)
Associations from Text Mining
Disease Name Relationship Type References
Cardiomyopathy Dilated Associate 30368515
Heart Failure Associate 30368515