Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55577
Gene name Gene Name - the full gene name approved by the HGNC.
N-acetylglucosamine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NAGK
Synonyms (NCBI Gene) Gene synonyms aliases
GNK, HSA242910
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by R
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028866 hsa-miR-26b-5p Microarray 19088304
MIRT050916 hsa-miR-17-5p CLASH 23622248
MIRT527037 hsa-miR-6790-3p HITS-CLIP 23824327
MIRT527034 hsa-miR-6499-3p HITS-CLIP 23824327
MIRT674284 hsa-miR-3135b HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 21516116, 25416956, 29892012, 31515488
GO:0005524 Function ATP binding IEA
GO:0005829 Component Cytosol TAS
GO:0006044 Process N-acetylglucosamine metabolic process TAS 10824116
GO:0006048 Process UDP-N-acetylglucosamine biosynthetic process TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606828 17174 ENSG00000124357
Protein
UniProt ID Q9UJ70
Protein name N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60)
Protein function Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). Involved in the N-glycolylneuraminic acid (Neu5Gc) degrada
PDB 2CH5 , 2CH6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01869 BcrAD_BadFG 7 284 BadF/BadG/BcrA/BcrD ATPase family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10824116}.
Sequence
Sequence length 344
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Biosynthesis of nucleotide sugars
  Synthesis of UDP-N-acetyl-glucosamine
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Associations from Text Mining
Disease Name Relationship Type References
Bacterial Infections Associate 34423323
Neoplasms Associate 32896084
Neuroblastoma Associate 32896084
Neurodegenerative Diseases Associate 37511433
Prader Willi Syndrome Associate 37511433
Virus Diseases Associate 34423323