PRG2 (proteoglycan 2, pro eosinophil major basic protein)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5553
Gene name Gene Name - the full gene name approved by the HGNC.
Proteoglycan 2, pro eosinophil major basic protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRG2
Synonyms (NCBI Gene) Gene synonyms aliases
BMPG, MBP, MBP1, proMBP
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q12.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
miRTarBase ID miRNA Experiments Reference
MIRT1261261 hsa-miR-1827 CLIP-seq
MIRT1261262 hsa-miR-22 CLIP-seq
MIRT1261263 hsa-miR-3612 CLIP-seq
MIRT1261264 hsa-miR-4768-3p CLIP-seq
MIRT1261265 hsa-miR-4779 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
CEBPE Repression 12202480
GATA1 Activation 10438731;12202480
GATA2 Repression 10438731;9558404
SPI1 Activation 12202480
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 7685339, 12421832
GO:0005576 Component Extracellular region TAS
GO:0008201 Function Heparin binding IEA
GO:0030021 Function Extracellular matrix structural constituent conferring compression resistance HDA 28344315
GO:0030021 Function Extracellular matrix structural constituent conferring compression resistance RCA 25037231
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605601 9362 ENSG00000186652
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P13727
Protein name Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Protein function Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activit
PDB 1H8U , 2BRS , 4QXX , 7Y5N , 8HGG , 9DKZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00059 Lectin_C 114 → 222 Lectin C-type domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in plasma and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected in placenta (at protein level) (PubMed:32337544). High levels of the proform in placenta and pregnancy serum; in placenta, lo
Sequence 
MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEW
GSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQ
AWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRW
NFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
Sequence length 222
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Asthma   Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
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Show/Hide Text Mining Associations (14)
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 29692868, 30876376
Crohn Disease Associate 22412388
Diabetes Gestational Associate 33188009
Disease Associate 28347715
Fetal Diseases Associate 33188009
Ige Responsiveness Atopic Associate 26292806
Inflammation Associate 7531438
Leukemia Myelogenous Chronic BCR ABL Positive Associate 29936783
Neoplasms Inhibit 18852884
Neoplasms Associate 29936783