Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55388
Gene name	Minichromosome maintenance 10 replication initiation factor
Gene symbol	MCM10
Synonyms (NCBI Gene)	CNA43DNA43IMD80PRO2249
Chromosome	10
Chromosome location	10p13
Summary	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004854	hsa-miR-192-5p	Luciferase reporter assayqRT-PCR	19074876
MIRT016315	hsa-miR-193b-3p	Microarray	20304954
MIRT019273	hsa-miR-148b-3p	Microarray	17612493
MIRT024276	hsa-miR-215-5p	Microarray	19074876
MIRT004854	hsa-miR-192-5p	Reporter assay;Microarray;Other	19074876
MIRT030381	hsa-miR-24-3p	qRT-PCR;Microarray	19748357
MIRT047354	hsa-miR-34a-5p	CLASH	23622248
MIRT016315	hsa-miR-193b-3p	CLASH	23622248
MIRT039760	hsa-miR-615-3p	CLASH	23622248
MIRT038395	hsa-miR-296-3p	CLASH	23622248
MIRT437480	hsa-miR-185-5p	Luciferase reporter assayqRT-PCRWestern blot	24014023
MIRT684117	hsa-miR-4432	HITS-CLIP	23313552
MIRT684116	hsa-miR-3664-5p	HITS-CLIP	23313552
MIRT684115	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT684114	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT684113	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT684112	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT684111	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT684110	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT684109	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT684108	hsa-miR-4522	HITS-CLIP	23313552
MIRT684107	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT684106	hsa-miR-6510-3p	HITS-CLIP	23313552
MIRT684117	hsa-miR-4432	HITS-CLIP	23313552
MIRT684116	hsa-miR-3664-5p	HITS-CLIP	23313552
MIRT684115	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT684114	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT684113	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT684112	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT684111	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT684110	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT684109	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT684108	hsa-miR-4522	HITS-CLIP	23313552
MIRT684107	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT684106	hsa-miR-6510-3p	HITS-CLIP	23313552
MIRT1137527	hsa-miR-1267	CLIP-seq
MIRT1137528	hsa-miR-1297	CLIP-seq
MIRT1137529	hsa-miR-149	CLIP-seq
MIRT1137530	hsa-miR-200b	CLIP-seq
MIRT1137531	hsa-miR-200c	CLIP-seq
MIRT1137532	hsa-miR-21	CLIP-seq
MIRT1137533	hsa-miR-2116	CLIP-seq
MIRT1137534	hsa-miR-2278	CLIP-seq
MIRT1137535	hsa-miR-26a	CLIP-seq
MIRT1137536	hsa-miR-26b	CLIP-seq
MIRT1137537	hsa-miR-300	CLIP-seq
MIRT1137538	hsa-miR-302a	CLIP-seq
MIRT1137539	hsa-miR-302b	CLIP-seq
MIRT1137540	hsa-miR-302c	CLIP-seq
MIRT1137541	hsa-miR-302d	CLIP-seq
MIRT1137542	hsa-miR-302e	CLIP-seq
MIRT1137543	hsa-miR-3064-5p	CLIP-seq
MIRT1137544	hsa-miR-3065-3p	CLIP-seq
MIRT1137545	hsa-miR-3115	CLIP-seq
MIRT1137546	hsa-miR-3119	CLIP-seq
MIRT1137547	hsa-miR-3120-3p	CLIP-seq
MIRT1137548	hsa-miR-3121-5p	CLIP-seq
MIRT1137549	hsa-miR-3126-3p	CLIP-seq
MIRT1137550	hsa-miR-3160-5p	CLIP-seq
MIRT1137551	hsa-miR-3180-5p	CLIP-seq
MIRT1137552	hsa-miR-338-5p	CLIP-seq
MIRT1137553	hsa-miR-3678-5p	CLIP-seq
MIRT1137554	hsa-miR-372	CLIP-seq
MIRT1137555	hsa-miR-373	CLIP-seq
MIRT1137556	hsa-miR-381	CLIP-seq
MIRT1137557	hsa-miR-410	CLIP-seq
MIRT1137558	hsa-miR-429	CLIP-seq
MIRT1137559	hsa-miR-4328	CLIP-seq
MIRT1137560	hsa-miR-4446-5p	CLIP-seq
MIRT1137561	hsa-miR-4459	CLIP-seq
MIRT1137562	hsa-miR-4465	CLIP-seq
MIRT1137563	hsa-miR-4468	CLIP-seq
MIRT1137564	hsa-miR-4477a	CLIP-seq
MIRT1137565	hsa-miR-4501	CLIP-seq
MIRT1137566	hsa-miR-4652-3p	CLIP-seq
MIRT1137567	hsa-miR-4666-3p	CLIP-seq
MIRT1137568	hsa-miR-4672	CLIP-seq
MIRT1137569	hsa-miR-4690-5p	CLIP-seq
MIRT1137570	hsa-miR-4694-5p	CLIP-seq
MIRT1137571	hsa-miR-4695-5p	CLIP-seq
MIRT1137572	hsa-miR-4742-5p	CLIP-seq
MIRT1137573	hsa-miR-4789-5p	CLIP-seq
MIRT1137574	hsa-miR-4794	CLIP-seq
MIRT1137575	hsa-miR-4804-3p	CLIP-seq
MIRT1137576	hsa-miR-490-3p	CLIP-seq
MIRT1137577	hsa-miR-498	CLIP-seq
MIRT1137578	hsa-miR-499-3p	CLIP-seq
MIRT1137579	hsa-miR-499a-3p	CLIP-seq
MIRT1137580	hsa-miR-500a	CLIP-seq
MIRT1137581	hsa-miR-501-5p	CLIP-seq
MIRT1137582	hsa-miR-513a-5p	CLIP-seq
MIRT1137583	hsa-miR-520a-3p	CLIP-seq
MIRT1137584	hsa-miR-520a-5p	CLIP-seq
MIRT1137585	hsa-miR-520b	CLIP-seq
MIRT1137586	hsa-miR-520c-3p	CLIP-seq
MIRT1137587	hsa-miR-520d-3p	CLIP-seq
MIRT1137588	hsa-miR-520e	CLIP-seq
MIRT1137589	hsa-miR-520f	CLIP-seq
MIRT1137590	hsa-miR-525-5p	CLIP-seq
MIRT1137591	hsa-miR-548a-5p	CLIP-seq
MIRT1137592	hsa-miR-548ab	CLIP-seq
MIRT1137593	hsa-miR-548ak	CLIP-seq
MIRT1137594	hsa-miR-548b-5p	CLIP-seq
MIRT1137595	hsa-miR-548c-5p	CLIP-seq
MIRT1137596	hsa-miR-548d-5p	CLIP-seq
MIRT1137597	hsa-miR-548h	CLIP-seq
MIRT1137598	hsa-miR-548i	CLIP-seq
MIRT1137599	hsa-miR-548j	CLIP-seq
MIRT1137600	hsa-miR-548w	CLIP-seq
MIRT1137601	hsa-miR-548y	CLIP-seq
MIRT1137602	hsa-miR-559	CLIP-seq
MIRT1137603	hsa-miR-590-3p	CLIP-seq
MIRT1137604	hsa-miR-590-5p	CLIP-seq
MIRT1137605	hsa-miR-758	CLIP-seq
MIRT1137606	hsa-miR-1225-3p	CLIP-seq
MIRT1137607	hsa-miR-1233	CLIP-seq
MIRT1137527	hsa-miR-1267	CLIP-seq
MIRT1137608	hsa-miR-1273e	CLIP-seq
MIRT1137609	hsa-miR-1288	CLIP-seq
MIRT1137528	hsa-miR-1297	CLIP-seq
MIRT1137610	hsa-miR-1915	CLIP-seq
MIRT1137611	hsa-miR-217	CLIP-seq
MIRT1137535	hsa-miR-26a	CLIP-seq
MIRT1137536	hsa-miR-26b	CLIP-seq
MIRT1137612	hsa-miR-3169	CLIP-seq
MIRT1137613	hsa-miR-3646	CLIP-seq
MIRT1137614	hsa-miR-3648	CLIP-seq
MIRT1137615	hsa-miR-3689a-3p	CLIP-seq
MIRT1137616	hsa-miR-3689c	CLIP-seq
MIRT1137617	hsa-miR-3692	CLIP-seq
MIRT1137618	hsa-miR-4302	CLIP-seq
MIRT1137619	hsa-miR-4418	CLIP-seq
MIRT1137620	hsa-miR-4436b-5p	CLIP-seq
MIRT1137562	hsa-miR-4465	CLIP-seq
MIRT1137566	hsa-miR-4652-3p	CLIP-seq
MIRT1137570	hsa-miR-4694-5p	CLIP-seq
MIRT1137621	hsa-miR-4728-5p	CLIP-seq
MIRT1137622	hsa-miR-4786-3p	CLIP-seq
MIRT1137623	hsa-miR-4793-3p	CLIP-seq
MIRT1137624	hsa-miR-508-5p	CLIP-seq
MIRT1137625	hsa-miR-509-3-5p	CLIP-seq
MIRT1137626	hsa-miR-509-5p	CLIP-seq
MIRT1137627	hsa-miR-548ac	CLIP-seq
MIRT1137628	hsa-miR-548ae	CLIP-seq
MIRT1137629	hsa-miR-548aj	CLIP-seq
MIRT1137630	hsa-miR-548am	CLIP-seq
MIRT1137631	hsa-miR-548d-3p	CLIP-seq
MIRT1137632	hsa-miR-548v	CLIP-seq
MIRT1137633	hsa-miR-548x	CLIP-seq
MIRT1137634	hsa-miR-548z	CLIP-seq
MIRT1137635	hsa-miR-607	CLIP-seq
MIRT1137636	hsa-miR-648	CLIP-seq
MIRT1137637	hsa-miR-671-5p	CLIP-seq
MIRT1137605	hsa-miR-758	CLIP-seq
MIRT1137638	hsa-miR-766	CLIP-seq
MIRT1137606	hsa-miR-1225-3p	CLIP-seq
MIRT1137607	hsa-miR-1233	CLIP-seq
MIRT1137608	hsa-miR-1273e	CLIP-seq
MIRT1137610	hsa-miR-1915	CLIP-seq
MIRT2039102	hsa-miR-192	CLIP-seq
MIRT1137532	hsa-miR-21	CLIP-seq
MIRT2039103	hsa-miR-215	CLIP-seq
MIRT1137615	hsa-miR-3689a-3p	CLIP-seq
MIRT1137616	hsa-miR-3689c	CLIP-seq
MIRT1137569	hsa-miR-4690-5p	CLIP-seq
MIRT1137621	hsa-miR-4728-5p	CLIP-seq
MIRT1137622	hsa-miR-4786-3p	CLIP-seq
MIRT1137591	hsa-miR-548a-5p	CLIP-seq
MIRT1137592	hsa-miR-548ab	CLIP-seq
MIRT1137593	hsa-miR-548ak	CLIP-seq
MIRT1137594	hsa-miR-548b-5p	CLIP-seq
MIRT1137595	hsa-miR-548c-5p	CLIP-seq
MIRT1137596	hsa-miR-548d-5p	CLIP-seq
MIRT1137597	hsa-miR-548h	CLIP-seq
MIRT1137598	hsa-miR-548i	CLIP-seq
MIRT1137599	hsa-miR-548j	CLIP-seq
MIRT1137600	hsa-miR-548w	CLIP-seq
MIRT1137601	hsa-miR-548y	CLIP-seq
MIRT1137602	hsa-miR-559	CLIP-seq
MIRT1137604	hsa-miR-590-5p	CLIP-seq
MIRT1137637	hsa-miR-671-5p	CLIP-seq
MIRT1137537	hsa-miR-300	CLIP-seq
MIRT1137550	hsa-miR-3160-5p	CLIP-seq
MIRT1137551	hsa-miR-3180-5p	CLIP-seq
MIRT2269083	hsa-miR-3620	CLIP-seq
MIRT1137615	hsa-miR-3689a-3p	CLIP-seq
MIRT1137616	hsa-miR-3689c	CLIP-seq
MIRT1137556	hsa-miR-381	CLIP-seq
MIRT1137557	hsa-miR-410	CLIP-seq
MIRT1137567	hsa-miR-4666-3p	CLIP-seq
MIRT1137621	hsa-miR-4728-5p	CLIP-seq
MIRT1137573	hsa-miR-4789-5p	CLIP-seq
MIRT1137582	hsa-miR-513a-5p	CLIP-seq
MIRT1137584	hsa-miR-520a-5p	CLIP-seq
MIRT1137590	hsa-miR-525-5p	CLIP-seq
MIRT2269084	hsa-miR-656	CLIP-seq
MIRT2453830	hsa-miR-1283	CLIP-seq
MIRT2453831	hsa-miR-3675-3p	CLIP-seq
MIRT2453832	hsa-miR-378g	CLIP-seq
MIRT2453833	hsa-miR-4684-5p	CLIP-seq
MIRT2453830	hsa-miR-1283	CLIP-seq
MIRT2453831	hsa-miR-3675-3p	CLIP-seq
MIRT2568370	hsa-miR-4293	CLIP-seq
MIRT2568371	hsa-miR-4470	CLIP-seq
MIRT2453833	hsa-miR-4684-5p	CLIP-seq
MIRT2568372	hsa-miR-4786-5p	CLIP-seq
MIRT2568373	hsa-miR-769-5p	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
E2F4	Repression	15195143
MYCN	Activation	17826980

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003688	Function	DNA replication origin binding	IBA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0003697	Function	Single-stranded DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11095689, 15232106, 16189514, 25416956, 28514442, 32296183, 35271311
GO:0005634	Component	Nucleus	IDA	11095689
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	32865517
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0006260	Process	DNA replication	IEA
GO:0006270	Process	DNA replication initiation	IBA
GO:0006270	Process	DNA replication initiation	IEA
GO:0006270	Process	DNA replication initiation	IMP	32865517
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	24726359
GO:0008270	Function	Zinc ion binding	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0042802	Function	Identical protein binding	IPI	17823614
GO:0043596	Component	Nuclear replication fork	IBA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
609357	18043	ENSG00000065328

Q7L590

Protein name

Protein MCM10 homolog (HsMCM10)

Protein function

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effec

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09329	zf-primase	382 → 427	Primase zinc finger	Domain
PF09332	Mcm10	524 → 873	Mcm10 replication factor	Domain

Sequence

MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEAD
DGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELR
NLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDV
PALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGE
TTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVI
LKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMK
PKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQY
KKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPK
KKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKA
TASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSS
RQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKL
AAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRR
EQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRV
VTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYK
WERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK

Sequence length

875

Interactions

View interactions

	Reactome
			Activation of ATR in response to replication stress Activation of the pre-replicative complex

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Fetal Cardiomyopathy	Pathogenic	rs2131558198, rs781204418	RCV003325996 RCV003325997
Immunodeficiency 80 with or without congenital cardiomyopathy	Pathogenic	rs746874909, rs2131579842, rs2131558198, rs781204418	RCV001391306 RCV001391307 RCV001391308 RCV001391309

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Uterine carcinosarcoma	Benign	rs116353713	RCV005903607
Uterine corpus endometrial carcinoma	Benign	rs116353713	RCV005903608

Show/Hide Text Mining Associations (35)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Aortic Syndrome	Associate	31721906
Adenocarcinoma of Lung	Associate	31323040
Adenocarcinoma of Lung	Stimulate	31545501
Aortic Dissection	Associate	31721906
Breast Neoplasms	Stimulate	31280346
Breast Neoplasms	Associate	31311202, 33340428, 35813483, 37592220
Carcinogenesis	Associate	24376576, 36233194, 37848534
Carcinoma Hepatocellular	Associate	29962817, 40255404
Carcinoma Squamous Cell	Stimulate	36445337
Carcinoma Squamous Cell	Associate	37746664
Cardiomyopathies	Associate	33712616
Cardiomyopathy Restrictive	Associate	33712616
Cell Transformation Neoplastic	Stimulate	35813483
Colonic Neoplasms	Associate	35392038
Cytomegalovirus Infections	Associate	32865517
Endometrial Neoplasms	Associate	37246638
Esophageal Squamous Cell Carcinoma	Associate	24551190
GATA2 Deficiency	Associate	32865517, 33712616
Glioblastoma	Associate	39528802
Immune System Diseases	Associate	33712616
Leiomyoma	Associate	36948524
Leukemia Large Granular Lymphocytic	Associate	32865517
Leukemia Myeloid Acute	Associate	30480765
Lung Neoplasms	Associate	35360518
Neoplasm Metastasis	Stimulate	27780919
Neoplasms	Associate	22838965, 23874974, 25046975, 27780919, 30095171, 31280346, 33340428, 36948524, 37880798, 38305604
Neoplasms	Stimulate	35813483, 37848534
Pancreatic Neoplasms	Associate	27695057
Polycystic Ovary Syndrome	Associate	37132453
Prostatic Neoplasms	Stimulate	30095171
Splenic Neoplasms	Associate	33712616
Stomach Neoplasms	Associate	37860833
Tertiary Lymphoid Structures	Associate	31280346
Urethral Neoplasms	Stimulate	27780919
Uterine Cervical Neoplasms	Associate	23874974, 37746664

MCM10 (minichromosome maintenance 10 replication initiation factor)