Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55359
Gene name	Serine/threonine/tyrosine kinase 1
Gene symbol	STYK1
Synonyms (NCBI Gene)	NOKSuRTK106
Chromosome	12
Chromosome location	12p13.2
Summary	Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]

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Show/Hide all (303)

miRTarBase ID	miRNA	Experiments	Reference
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT532798	hsa-miR-548u	PAR-CLIP	22012620
MIRT532797	hsa-miR-7161-5p	PAR-CLIP	22012620
MIRT532796	hsa-miR-7109-3p	PAR-CLIP	22012620
MIRT532795	hsa-miR-4499	PAR-CLIP	22012620
MIRT532794	hsa-miR-3614-3p	PAR-CLIP	22012620
MIRT532793	hsa-miR-1248	PAR-CLIP	22012620
MIRT532792	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT532791	hsa-miR-610	PAR-CLIP	22012620
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT712045	hsa-miR-2116-5p	HITS-CLIP	19536157
MIRT712044	hsa-miR-22-5p	HITS-CLIP	19536157
MIRT712043	hsa-miR-4666a-5p	HITS-CLIP	19536157
MIRT712042	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT270128	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT627120	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT621492	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT621491	hsa-miR-1208	HITS-CLIP	23824327
MIRT621490	hsa-miR-8064	HITS-CLIP	23824327
MIRT621489	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT621488	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT621487	hsa-miR-4420	HITS-CLIP	23824327
MIRT621486	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT621485	hsa-miR-5096	HITS-CLIP	23824327
MIRT614651	hsa-miR-8485	HITS-CLIP	23824327
MIRT532798	hsa-miR-548u	PAR-CLIP	22012620
MIRT532797	hsa-miR-7161-5p	PAR-CLIP	22012620
MIRT532796	hsa-miR-7109-3p	PAR-CLIP	22012620
MIRT532795	hsa-miR-4499	PAR-CLIP	22012620
MIRT532794	hsa-miR-3614-3p	PAR-CLIP	22012620
MIRT532793	hsa-miR-1248	PAR-CLIP	22012620
MIRT532792	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT532791	hsa-miR-610	PAR-CLIP	22012620
MIRT1401826	hsa-miR-128	CLIP-seq
MIRT1401827	hsa-miR-144	CLIP-seq
MIRT1401828	hsa-miR-27a	CLIP-seq
MIRT1401829	hsa-miR-27b	CLIP-seq
MIRT1401830	hsa-miR-3074-3p	CLIP-seq
MIRT1401831	hsa-miR-338-3p	CLIP-seq
MIRT1401832	hsa-miR-3942-3p	CLIP-seq
MIRT1401833	hsa-miR-421	CLIP-seq
MIRT1401834	hsa-miR-4422	CLIP-seq
MIRT1401835	hsa-miR-4530	CLIP-seq
MIRT1401836	hsa-miR-4709-5p	CLIP-seq
MIRT1401837	hsa-miR-4716-5p	CLIP-seq
MIRT1401838	hsa-miR-4740-3p	CLIP-seq
MIRT1401839	hsa-miR-513a-5p	CLIP-seq
MIRT1401840	hsa-miR-587	CLIP-seq
MIRT2342594	hsa-miR-1245b-3p	CLIP-seq
MIRT1401830	hsa-miR-3074-3p	CLIP-seq
MIRT2342595	hsa-miR-340	CLIP-seq
MIRT2342596	hsa-miR-362-5p	CLIP-seq
MIRT2342597	hsa-miR-3667-3p	CLIP-seq
MIRT2342598	hsa-miR-500b	CLIP-seq
MIRT2342599	hsa-miR-501-5p	CLIP-seq
MIRT1401840	hsa-miR-587	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 23010592, 32707033, 35384245
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA

MIM	HGNC	e!Ensembl
611433	18889	ENSG00000060140

Q6J9G0

Protein name

Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)

Protein function

Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase an

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07714	PK_Tyr_Ser-Thr	114 → 380	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in o

Sequence

MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG
PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI
CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL
EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE
FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL
RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK
SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS
ML

Sequence length

422

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Autism Spectrum Disorder	Associate	26398136	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Associate	22688887	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	39684488	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	24894011, 35840561	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Associate	24894011	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Hemorrhage	Associate	28487959	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Associate	28487959	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	25169509, 25884558	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Associate	19409952	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	22688887	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	19409952	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	19409952	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Associate	24894011	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	25884558	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Associate	28720063	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	25884558	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	24894011, 25169509, 35840561	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	19664042	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms Castration Resistant	Associate	19664042	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	32572882	★★★★★ ★☆☆☆☆ Found in Text Mining only
Subarachnoid Hemorrhage	Associate	28487959	★★★★★ ★☆☆☆☆ Found in Text Mining only

STYK1 (serine/threonine/tyrosine kinase 1)