Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55300
Gene name Gene Name - the full gene name approved by the HGNC.
Phosphatidylinositol 4-kinase type 2 beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PI4K2B
Synonyms (NCBI Gene) Gene synonyms aliases
PI4KIIB, PIK42B
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p15.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022232 hsa-miR-124-3p Microarray 18668037
MIRT031512 hsa-miR-16-5p Sequencing 20371350
MIRT685544 hsa-miR-548l HITS-CLIP 23313552
MIRT685543 hsa-miR-3973 HITS-CLIP 23313552
MIRT685542 hsa-miR-186-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004430 Function 1-phosphatidylinositol 4-kinase activity IBA 21873635
GO:0005524 Function ATP binding IEA
GO:0005768 Component Endosome IBA 21873635
GO:0005802 Component Trans-Golgi network IBA 21873635
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612101 18215 ENSG00000038210
Protein
UniProt ID Q8TCG2
Protein name Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)
Protein function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and G
PDB 4WTV , 8A5X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00454 PI3_PI4_kinase 129 429 Phosphatidylinositol 3- and 4-kinase Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11923287}.
Sequence
Sequence length 481
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of PIPs at the ER membrane
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Attention deficit hyperactivity disorder Attention deficit hyperactivity disorder rs786205019 30563984
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
19539307
Unknown
Disease term Disease name Evidence References Source
Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Graft vs Host Disease Associate 18316730
Neoplasms Associate 27798239
Small Cell Lung Carcinoma Associate 37189142