Gene Gene information from NCBI Gene database.
Entrez ID 55300
Gene name Phosphatidylinositol 4-kinase type 2 beta
Gene symbol PI4K2B
Synonyms (NCBI Gene)
PI4KIIBPIK42B
Chromosome 4
Chromosome location 4p15.2
Summary This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [p
miRNA miRNA information provided by mirtarbase database.
415
miRTarBase ID miRNA Experiments Reference
MIRT022232 hsa-miR-124-3p Microarray 18668037
MIRT031512 hsa-miR-16-5p Sequencing 20371350
MIRT685544 hsa-miR-548l HITS-CLIP 23313552
MIRT685543 hsa-miR-3973 HITS-CLIP 23313552
MIRT685542 hsa-miR-186-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 11923287, 12324459
GO:0000139 Component Golgi membrane IEA
GO:0000166 Function Nucleotide binding IEA
GO:0004430 Function 1-phosphatidylinositol 4-kinase activity IBA
GO:0004430 Function 1-phosphatidylinositol 4-kinase activity IDA 11923287, 12324459
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612101 18215 ENSG00000038210
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TCG2
Protein name Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)
Protein function Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and G
PDB 4WTV , 8A5X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00454 PI3_PI4_kinase 129 429 Phosphatidylinositol 3- and 4-kinase Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11923287}.
Sequence
Sequence length 481
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of PIPs at the ER membrane
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Abnormality of neuronal migration Benign rs863223383, rs143048917 RCV000201382
RCV000201422
Autism Uncertain significance rs1716360124 RCV003454378
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Graft vs Host Disease Associate 18316730
Neoplasms Associate 27798239
Small Cell Lung Carcinoma Associate 37189142