FGGY (FGGY carbohydrate kinase domain containing)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 55277
Gene name FGGY carbohydrate kinase domain containing
Gene symbol FGGY
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1p32.1
Summary This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sc
miRNA miRNA information provided by mirtarbase database.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
miRTarBase ID miRNA Experiments Reference
MIRT029931 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IBA
GO:0005975 Process Carbohydrate metabolic process IEA
GO:0016301 Function Kinase activity IEA
GO:0016740 Function Transferase activity IEA
GO:0016773 Function Phosphotransferase activity, alcohol group as acceptor IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
611370 25610 ENSG00000172456
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96C11
Protein name FGGY carbohydrate kinase domain-containing protein (D-ribulokinase FGGY) (EC 2.7.1.47)
Protein function Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to form D-ribulose 5-phosphate. Postulated to function in a metabolite repair mechanism by preventing toxic accumulation of free D-ribulose formed by non-specific phosphatase activitie
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00370 FGGY_N 11 → 267 FGGY family of carbohydrate kinases, N-terminal domain Domain
PF02782 FGGY_C 289 → 497 FGGY family of carbohydrate kinases, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level). {ECO:0000269|PubMed:17671248}.
Sequence
Sequence length 551
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Pentose and glucuronate interconversions
Metabolic pathways 		 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (7)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Uncertain significance rs41287704 RCV005932864
Cervical cancer Uncertain significance rs191411790 RCV005937483
Clear cell carcinoma of kidney Uncertain significance rs754065271 RCV005931186
Gastric cancer Uncertain significance rs41287704 RCV005932865
Show/Hide Text Mining Associations (4)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Aneuploidy Associate 35347416
Carcinoma Renal Cell Associate 33510822
COVID 19 Associate 35866388
Neoplasms Inhibit 36089125