PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6)

Gene

• Entrez ID: 55200
• Gene name: Pleckstrin homology and RhoGEF domain containing G6
• Gene symbol: PLEKHG6
• Synonyms (NCBI Gene): ARHGEF46, MyoGEF
• Chromosome: 12
• Chromosome location: 12p13.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1242059	hsa-miR-185	CLIP-seq
MIRT1242060	hsa-miR-3150a-3p	CLIP-seq
MIRT1242061	hsa-miR-3175	CLIP-seq
MIRT1242062	hsa-miR-3192	CLIP-seq
MIRT1242063	hsa-miR-326	CLIP-seq
MIRT1242064	hsa-miR-330-5p	CLIP-seq
MIRT1242065	hsa-miR-3927	CLIP-seq
MIRT1242066	hsa-miR-4279	CLIP-seq
MIRT1242067	hsa-miR-4306	CLIP-seq
MIRT1242068	hsa-miR-4314	CLIP-seq
MIRT1242069	hsa-miR-4451	CLIP-seq
MIRT1242070	hsa-miR-4644	CLIP-seq
MIRT1242071	hsa-miR-4646-5p	CLIP-seq
MIRT1242072	hsa-miR-4667-5p	CLIP-seq
MIRT1242073	hsa-miR-4700-5p	CLIP-seq
MIRT1242074	hsa-miR-634	CLIP-seq
MIRT1242075	hsa-miR-939	CLIP-seq
MIRT2298551	hsa-let-7a	CLIP-seq
MIRT2298552	hsa-let-7b	CLIP-seq
MIRT2298553	hsa-let-7c	CLIP-seq
MIRT2298554	hsa-let-7d	CLIP-seq
MIRT2298555	hsa-let-7e	CLIP-seq
MIRT2298556	hsa-let-7f	CLIP-seq
MIRT2298557	hsa-let-7g	CLIP-seq
MIRT2298558	hsa-let-7i	CLIP-seq
MIRT2298559	hsa-miR-106a	CLIP-seq
MIRT2298560	hsa-miR-106b	CLIP-seq
MIRT2298561	hsa-miR-1224-3p	CLIP-seq
MIRT2298562	hsa-miR-1260	CLIP-seq
MIRT2298563	hsa-miR-1260b	CLIP-seq
MIRT2298564	hsa-miR-1280	CLIP-seq
MIRT2298565	hsa-miR-1299	CLIP-seq
MIRT2298566	hsa-miR-1343	CLIP-seq
MIRT2298567	hsa-miR-150	CLIP-seq
MIRT2298568	hsa-miR-17	CLIP-seq
MIRT1242059	hsa-miR-185	CLIP-seq
MIRT2298569	hsa-miR-202	CLIP-seq
MIRT2298570	hsa-miR-20a	CLIP-seq
MIRT2298571	hsa-miR-20b	CLIP-seq
MIRT2298572	hsa-miR-302a	CLIP-seq
MIRT2298573	hsa-miR-302b	CLIP-seq
MIRT2298574	hsa-miR-302c	CLIP-seq
MIRT2298575	hsa-miR-302d	CLIP-seq
MIRT2298576	hsa-miR-302e	CLIP-seq
MIRT1242060	hsa-miR-3150a-3p	CLIP-seq
MIRT2298577	hsa-miR-3153	CLIP-seq
MIRT1242061	hsa-miR-3175	CLIP-seq
MIRT1242062	hsa-miR-3192	CLIP-seq
MIRT1242063	hsa-miR-326	CLIP-seq
MIRT1242064	hsa-miR-330-5p	CLIP-seq
MIRT2298578	hsa-miR-3663-5p	CLIP-seq
MIRT2298579	hsa-miR-372	CLIP-seq
MIRT2298580	hsa-miR-373	CLIP-seq
MIRT2298581	hsa-miR-378g	CLIP-seq
MIRT1242065	hsa-miR-3927	CLIP-seq
MIRT1242066	hsa-miR-4279	CLIP-seq
MIRT1242067	hsa-miR-4306	CLIP-seq
MIRT1242068	hsa-miR-4314	CLIP-seq
MIRT2298582	hsa-miR-4437	CLIP-seq
MIRT2298583	hsa-miR-4438	CLIP-seq
MIRT2298584	hsa-miR-4446-5p	CLIP-seq
MIRT1242069	hsa-miR-4451	CLIP-seq
MIRT2298585	hsa-miR-4458	CLIP-seq
MIRT2298586	hsa-miR-4500	CLIP-seq
MIRT2298587	hsa-miR-4514	CLIP-seq
MIRT2298588	hsa-miR-4527	CLIP-seq
MIRT1242070	hsa-miR-4644	CLIP-seq
MIRT1242071	hsa-miR-4646-5p	CLIP-seq
MIRT1242072	hsa-miR-4667-5p	CLIP-seq
MIRT2298589	hsa-miR-4668-5p	CLIP-seq
MIRT2298590	hsa-miR-4674	CLIP-seq
MIRT2298591	hsa-miR-4692	CLIP-seq
MIRT1242073	hsa-miR-4700-5p	CLIP-seq
MIRT2298592	hsa-miR-4708-5p	CLIP-seq
MIRT2298593	hsa-miR-4713-3p	CLIP-seq
MIRT2298594	hsa-miR-4731-5p	CLIP-seq
MIRT2298595	hsa-miR-4755-5p	CLIP-seq
MIRT2298596	hsa-miR-5095	CLIP-seq
MIRT2298597	hsa-miR-512-3p	CLIP-seq
MIRT2298598	hsa-miR-519d	CLIP-seq
MIRT2298599	hsa-miR-520a-3p	CLIP-seq
MIRT2298600	hsa-miR-520b	CLIP-seq
MIRT2298601	hsa-miR-520c-3p	CLIP-seq
MIRT2298602	hsa-miR-520d-3p	CLIP-seq
MIRT2298603	hsa-miR-520e	CLIP-seq
MIRT2298604	hsa-miR-520g	CLIP-seq
MIRT2298605	hsa-miR-520h	CLIP-seq
MIRT2298606	hsa-miR-532-3p	CLIP-seq
MIRT2298607	hsa-miR-548u	CLIP-seq
MIRT1242074	hsa-miR-634	CLIP-seq
MIRT2298608	hsa-miR-875-3p	CLIP-seq
MIRT2298609	hsa-miR-93	CLIP-seq
MIRT1242075	hsa-miR-939	CLIP-seq
MIRT2298610	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	19129481, 25416956, 31515488, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005902	Component	Microvillus	IEA
GO:0030054	Component	Cell junction	IDA
GO:0032154	Component	Cleavage furrow	IEA
GO:0042995	Component	Cell projection	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 611743
• HGNC: 25562
• e!Ensembl: ENSG00000008323

Protein

• UniProt ID: Q3KR16
• Protein name: Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
• Protein function: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involvi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	165 → 351	RhoGEF domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart.
• Sequence:

  MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA
  RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR
  LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL
  KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP
  LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ
  MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ
  ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE
  GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF
  QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST
  RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG
  SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP
  QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP
  LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ
  LDTPLSASEV

• Sequence length: 790

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
PLEKHG6-related disorder	Likely benign; Benign; Uncertain significance	rs71584817, rs540989527, rs1592024942	RCV003909548 RCV003921994 RCV003983599

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	25336641
Urinary Bladder Neoplasms	Associate	28388658