MTPAP (mitochondrial poly(A) polymerase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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55149 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Mitochondrial poly(A) polymerase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MTPAP |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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PAPD1, SPAX4, TENT6 |
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Chromosome
Chromosome number
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10 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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10p11.23 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3` poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 201 |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q9NVV4 | ||||||||||||||||||||
| Protein name | Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP) | ||||||||||||||||||||
| Protein function | Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the t | ||||||||||||||||||||
| PDB | 3PQ1 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle. {ECO:0000269|PubMed:15547249}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 582 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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