UBR7 (ubiquitin protein ligase E3 component n-recognin 7)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 55148 |
| Gene name | Ubiquitin protein ligase E3 component n-recognin 7 |
| Gene symbol | UBR7 |
| Synonyms (NCBI Gene) |
C14orf130LICAS
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| Chromosome | 14 |
| Chromosome location | 14q32.12 |
| Summary | This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residu |
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miRNA
miRNA information provided by mirtarbase database.
383
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8N806 | ||||||||||
| Protein name | Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) | ||||||||||
| Protein function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in sperm (at protein level). {ECO:0000269|PubMed:24664117}. | ||||||||||
| Sequence |
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| Sequence length | 425 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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