ACP3 (acid phosphatase 3)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55
Gene name Gene Name - the full gene name approved by the HGNC.
Acid phosphatase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ACP3
Synonyms (NCBI Gene) Gene synonyms aliases
5'-NT, ACP-3, ACPP, TM-PAP
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced trans
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(36)
GO ID Ontology Definition Evidence Reference
GO:0003993 Function Acid phosphatase activity IBA 21873635
GO:0003993 Function Acid phosphatase activity IDA 10506173
GO:0003993 Function Acid phosphatase activity IMP 8132635
GO:0004725 Function Protein tyrosine phosphatase activity IEA
GO:0005515 Function Protein binding IPI 9705354
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
171790 125 ENSG00000014257
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P15309
Protein name Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]
Protein function A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, Pu
PDB 1CVI , 1ND5 , 1ND6 , 2HPA , 2L3H , 2L77 , 2L79 , 2MG0 , 3PPD , 7ZZV , 8XJ4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00328 His_Phos_2 50 → 332 Histidine phosphatase superfamily (branch 2) Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithel
Sequence
Sequence length 386
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 19565504
Show/Hide Text Mining Associations (28)
Associations from Text Mining
Disease Name Relationship Type References
Acro Osteolysis Associate 24242705
Adenocarcinoma Associate 15859643
Alzheimer Disease Associate 27357282
Alzheimer Disease Stimulate 28060825
Anxiety Associate 27357282
Brain Diseases Associate 27357282
Carcinoma Adenoid Cystic Associate 33021555
Depressive Disorder Associate 27357282
Giant Cell Tumors Associate 15859643
Lung Neoplasms Inhibit 33728331