Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54962
Gene name Gene Name - the full gene name approved by the HGNC.	TIMELESS interacting protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TIPIN
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q22.31
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogene

Show/Hide all(169)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041905	hsa-miR-484	CLASH	23622248
MIRT696171	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT696170	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT696169	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696168	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT696167	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT696166	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696165	hsa-miR-6889-3p	HITS-CLIP	23313552
MIRT696164	hsa-miR-4252	HITS-CLIP	23313552
MIRT696163	hsa-miR-3926	HITS-CLIP	23313552
MIRT696162	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT696161	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT696160	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT696159	hsa-miR-7703	HITS-CLIP	23313552
MIRT696158	hsa-miR-548s	HITS-CLIP	23313552
MIRT461196	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT461221	hsa-miR-3714	PAR-CLIP	23592263
MIRT461220	hsa-miR-3910	PAR-CLIP	23592263
MIRT461219	hsa-miR-302f	PAR-CLIP	23592263
MIRT461218	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461217	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461216	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461215	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT461214	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT461213	hsa-miR-940	PAR-CLIP	23592263
MIRT461212	hsa-miR-4257	PAR-CLIP	23592263
MIRT461211	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT461210	hsa-miR-4459	PAR-CLIP	23592263
MIRT461209	hsa-miR-665	PAR-CLIP	23592263
MIRT461208	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461207	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT461206	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT461205	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT461204	hsa-miR-1827	PAR-CLIP	23592263
MIRT461203	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461202	hsa-miR-6086	PAR-CLIP	23592263
MIRT461201	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461200	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT461199	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461198	hsa-miR-3612	PAR-CLIP	23592263
MIRT461197	hsa-miR-650	PAR-CLIP	23592263
MIRT461196	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT461195	hsa-miR-506-3p	PAR-CLIP	23592263
MIRT461194	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT461193	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT250045	hsa-miR-1273e	PAR-CLIP	23592263
MIRT461192	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT461206	hsa-miR-1225-3p	PAR-CLIP	26701625
MIRT461205	hsa-miR-1233-3p	PAR-CLIP	26701625
MIRT461196	hsa-miR-124-3p	PAR-CLIP	26701625
MIRT250045	hsa-miR-1273e	PAR-CLIP	26701625
MIRT461204	hsa-miR-1827	PAR-CLIP	26701625
MIRT461217	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT461207	hsa-miR-219b-3p	PAR-CLIP	26701625
MIRT461201	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT461219	hsa-miR-302f	PAR-CLIP	26701625
MIRT461198	hsa-miR-3612	PAR-CLIP	26701625
MIRT461221	hsa-miR-3714	PAR-CLIP	26701625
MIRT461220	hsa-miR-3910	PAR-CLIP	26701625
MIRT461210	hsa-miR-4459	PAR-CLIP	26701625
MIRT461218	hsa-miR-4695-5p	PAR-CLIP	26701625
MIRT461200	hsa-miR-4722-5p	PAR-CLIP	26701625
MIRT461211	hsa-miR-4768-3p	PAR-CLIP	26701625
MIRT461195	hsa-miR-506-3p	PAR-CLIP	26701625
MIRT461197	hsa-miR-650	PAR-CLIP	26701625
MIRT461216	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT461209	hsa-miR-665	PAR-CLIP	26701625
MIRT461194	hsa-miR-6807-5p	PAR-CLIP	26701625
MIRT461215	hsa-miR-6808-5p	PAR-CLIP	26701625
MIRT461208	hsa-miR-6840-3p	PAR-CLIP	26701625
MIRT461214	hsa-miR-6893-5p	PAR-CLIP	26701625
MIRT461213	hsa-miR-940	PAR-CLIP	26701625
MIRT461206	hsa-miR-1225-3p	PAR-CLIP	27292025
MIRT696162	hsa-miR-1227-3p	PAR-CLIP	27292025
MIRT461205	hsa-miR-1233-3p	PAR-CLIP	27292025
MIRT461196	hsa-miR-124-3p	PAR-CLIP	27292025
MIRT250045	hsa-miR-1273e	PAR-CLIP	27292025
MIRT461204	hsa-miR-1827	PAR-CLIP	27292025
MIRT461217	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT461207	hsa-miR-219b-3p	PAR-CLIP	27292025
MIRT461201	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT461219	hsa-miR-302f	PAR-CLIP	27292025
MIRT461198	hsa-miR-3612	PAR-CLIP	27292025
MIRT461221	hsa-miR-3714	PAR-CLIP	27292025
MIRT461203	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT461220	hsa-miR-3910	PAR-CLIP	27292025
MIRT696164	hsa-miR-4252	PAR-CLIP	27292025
MIRT461212	hsa-miR-4257	PAR-CLIP	27292025
MIRT461210	hsa-miR-4459	PAR-CLIP	27292025
MIRT461193	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT461218	hsa-miR-4695-5p	PAR-CLIP	27292025
MIRT461200	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT461211	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT461195	hsa-miR-506-3p	PAR-CLIP	27292025
MIRT461202	hsa-miR-6086	PAR-CLIP	27292025
MIRT461199	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT461197	hsa-miR-650	PAR-CLIP	27292025
MIRT461216	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT461192	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT461209	hsa-miR-665	PAR-CLIP	27292025
MIRT461194	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT461215	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT461208	hsa-miR-6840-3p	PAR-CLIP	27292025
MIRT696165	hsa-miR-6889-3p	PAR-CLIP	27292025
MIRT461214	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT461213	hsa-miR-940	PAR-CLIP	27292025
MIRT696171	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT696170	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT696169	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT696168	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT696167	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT696166	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT696165	hsa-miR-6889-3p	HITS-CLIP	23313552
MIRT696164	hsa-miR-4252	HITS-CLIP	23313552
MIRT696163	hsa-miR-3926	HITS-CLIP	23313552
MIRT696162	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT696161	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT696160	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT696159	hsa-miR-7703	HITS-CLIP	23313552
MIRT696158	hsa-miR-548s	HITS-CLIP	23313552
MIRT461196	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT461221	hsa-miR-3714	PAR-CLIP	23592263
MIRT461220	hsa-miR-3910	PAR-CLIP	23592263
MIRT461219	hsa-miR-302f	PAR-CLIP	23592263
MIRT461218	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461217	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461216	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461215	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT461214	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT461213	hsa-miR-940	PAR-CLIP	23592263
MIRT461212	hsa-miR-4257	PAR-CLIP	23592263
MIRT461211	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT461210	hsa-miR-4459	PAR-CLIP	23592263
MIRT461209	hsa-miR-665	PAR-CLIP	23592263
MIRT461208	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461207	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT461206	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT461205	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT461204	hsa-miR-1827	PAR-CLIP	23592263
MIRT461203	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461202	hsa-miR-6086	PAR-CLIP	23592263
MIRT461201	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461200	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT461199	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461198	hsa-miR-3612	PAR-CLIP	23592263
MIRT461197	hsa-miR-650	PAR-CLIP	23592263
MIRT461196	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT461195	hsa-miR-506-3p	PAR-CLIP	23592263
MIRT461194	hsa-miR-6807-5p	PAR-CLIP	23592263
MIRT461193	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT250045	hsa-miR-1273e	PAR-CLIP	23592263
MIRT461192	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1425577	hsa-miR-106a	CLIP-seq
MIRT1425578	hsa-miR-106b	CLIP-seq
MIRT1425579	hsa-miR-1286	CLIP-seq
MIRT1425580	hsa-miR-17	CLIP-seq
MIRT1425581	hsa-miR-20a	CLIP-seq
MIRT1425582	hsa-miR-20b	CLIP-seq
MIRT1425583	hsa-miR-3121-3p	CLIP-seq
MIRT1425584	hsa-miR-3129-3p	CLIP-seq
MIRT1425585	hsa-miR-340	CLIP-seq
MIRT1425586	hsa-miR-3609	CLIP-seq
MIRT1425587	hsa-miR-4327	CLIP-seq
MIRT1425588	hsa-miR-4504	CLIP-seq
MIRT1425589	hsa-miR-4796-3p	CLIP-seq
MIRT1425590	hsa-miR-519d	CLIP-seq
MIRT1425591	hsa-miR-548ah	CLIP-seq
MIRT1425592	hsa-miR-93	CLIP-seq
MIRT1425593	hsa-miR-944	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000076	Process	DNA replication checkpoint signaling	IBA
GO:0000076	Process	DNA replication checkpoint signaling	IEA
GO:0000076	Process	DNA replication checkpoint signaling	IMP	17102137
GO:0000077	Process	DNA damage checkpoint signaling	IEA
GO:0000785	Component	Chromatin	IDA	17102137
GO:0003677	Function	DNA binding	IBA
GO:0005515	Function	Protein binding	IPI	17102137, 17116885, 24126761, 24910198, 25416956, 32296183, 32705708, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	17102137, 31429579
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	17102137
GO:0009411	Process	Response to UV	IEA
GO:0031297	Process	Replication fork processing	IEA
GO:0031298	Component	Replication fork protection complex	IBA
GO:0031573	Process	Mitotic intra-S DNA damage checkpoint signaling	IMP	17102137
GO:0033262	Process	Regulation of nuclear cell cycle DNA replication	TAS	17102137
GO:0043111	Process	Replication fork arrest	IBA
GO:0044770	Process	Cell cycle phase transition	IMP	17102137
GO:0051301	Process	Cell division	IEA

MIM	HGNC	e!Ensembl
610716	30750	ENSG00000075131

Protein

UniProt ID

Q9BVW5

Protein name

TIMELESS-interacting protein

Protein function

Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885)

PDB

7PFO , 7PLO , 8B9D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07962	Swi3	66 → 148	Replication Fork Protection Component Swi3	Family

Sequence

MLEPQENGVIDLPDYEHVEDETFPPFPPPASPERQDGEGTEPDEESGNGAPVRVPPKRTV
KRNIPKLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQF
EDFIDRVEYLGSKKEVQTCLKRIRLDLPILHEDFVSNNDEVAENNEHDVTSTELDPFLTN
LSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVE
EVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEA
R

Sequence length

301

Interactions

View interactions

	Reactome
			Processing of DNA double-strand break ends

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Testicular Germ Cell Tumor	Testicular germ cell tumor	N/A	N/A	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	32345670
Carcinoma Hepatocellular	Associate	35082931
Chromosome Aberrations	Associate	39955949
Neoplasms	Associate	32345670

TIPIN (TIMELESS interacting protein)