Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5496
Gene name Gene Name - the full gene name approved by the HGNC.	Protein phosphatase, Mg2+/Mn2+ dependent 1G
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PPM1G
Synonyms (NCBI Gene) Gene synonyms aliases	PP2CG, PP2CGAMMA, PPP2CG
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p23.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylatio

Show/Hide all(156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020613	hsa-miR-155-5p	Proteomics	18668040
MIRT032202	hsa-let-7b-5p	Proteomics	18668040
MIRT047658	hsa-miR-10a-5p	CLASH	23622248
MIRT041984	hsa-miR-484	CLASH	23622248
MIRT037135	hsa-miR-877-3p	CLASH	23622248
MIRT1254308	hsa-miR-1203	CLIP-seq
MIRT1254309	hsa-miR-1207-5p	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254312	hsa-miR-1266	CLIP-seq
MIRT1254313	hsa-miR-132	CLIP-seq
MIRT1254314	hsa-miR-1323	CLIP-seq
MIRT1254315	hsa-miR-142-5p	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT1254318	hsa-miR-1909	CLIP-seq
MIRT1254319	hsa-miR-1910	CLIP-seq
MIRT1254320	hsa-miR-212	CLIP-seq
MIRT1254321	hsa-miR-24	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT1254324	hsa-miR-27a	CLIP-seq
MIRT1254325	hsa-miR-27b	CLIP-seq
MIRT1254326	hsa-miR-3148	CLIP-seq
MIRT1254327	hsa-miR-3177-5p	CLIP-seq
MIRT1254328	hsa-miR-3656	CLIP-seq
MIRT1254329	hsa-miR-3664-3p	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT1254331	hsa-miR-4264	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT1254333	hsa-miR-4437	CLIP-seq
MIRT1254334	hsa-miR-4464	CLIP-seq
MIRT1254335	hsa-miR-4474-5p	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT1254337	hsa-miR-4518	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT1254340	hsa-miR-4721	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT1254342	hsa-miR-4748	CLIP-seq
MIRT1254343	hsa-miR-4763-3p	CLIP-seq
MIRT1254344	hsa-miR-4766-5p	CLIP-seq
MIRT1254345	hsa-miR-4797-5p	CLIP-seq
MIRT1254346	hsa-miR-488	CLIP-seq
MIRT1254347	hsa-miR-513a-5p	CLIP-seq
MIRT1254348	hsa-miR-541	CLIP-seq
MIRT1254349	hsa-miR-548aa	CLIP-seq
MIRT1254350	hsa-miR-548ac	CLIP-seq
MIRT1254351	hsa-miR-548ae	CLIP-seq
MIRT1254352	hsa-miR-548aj	CLIP-seq
MIRT1254353	hsa-miR-548am	CLIP-seq
MIRT1254354	hsa-miR-548d-3p	CLIP-seq
MIRT1254355	hsa-miR-548o	CLIP-seq
MIRT1254356	hsa-miR-548t	CLIP-seq
MIRT1254357	hsa-miR-548x	CLIP-seq
MIRT1254358	hsa-miR-548z	CLIP-seq
MIRT1254359	hsa-miR-561	CLIP-seq
MIRT1254360	hsa-miR-570	CLIP-seq
MIRT1254361	hsa-miR-622	CLIP-seq
MIRT1254362	hsa-miR-654-5p	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq
MIRT2074998	hsa-miR-1	CLIP-seq
MIRT1254308	hsa-miR-1203	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254312	hsa-miR-1266	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT2074999	hsa-miR-206	CLIP-seq
MIRT1254321	hsa-miR-24	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT1254328	hsa-miR-3656	CLIP-seq
MIRT1254329	hsa-miR-3664-3p	CLIP-seq
MIRT2075000	hsa-miR-3673	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT1254331	hsa-miR-4264	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT2075001	hsa-miR-4419a	CLIP-seq
MIRT1254333	hsa-miR-4437	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT2075002	hsa-miR-4510	CLIP-seq
MIRT1254337	hsa-miR-4518	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT2075003	hsa-miR-4687-5p	CLIP-seq
MIRT1254340	hsa-miR-4721	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT1254360	hsa-miR-570	CLIP-seq
MIRT2075004	hsa-miR-613	CLIP-seq
MIRT1254361	hsa-miR-622	CLIP-seq
MIRT2075005	hsa-miR-9	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq
MIRT1254327	hsa-miR-3177-5p	CLIP-seq
MIRT1254328	hsa-miR-3656	CLIP-seq
MIRT1254346	hsa-miR-488	CLIP-seq
MIRT1254308	hsa-miR-1203	CLIP-seq
MIRT1254312	hsa-miR-1266	CLIP-seq
MIRT1254313	hsa-miR-132	CLIP-seq
MIRT1254320	hsa-miR-212	CLIP-seq
MIRT1254321	hsa-miR-24	CLIP-seq
MIRT1254329	hsa-miR-3664-3p	CLIP-seq
MIRT1254331	hsa-miR-4264	CLIP-seq
MIRT1254333	hsa-miR-4437	CLIP-seq
MIRT1254337	hsa-miR-4518	CLIP-seq
MIRT1254340	hsa-miR-4721	CLIP-seq
MIRT1254360	hsa-miR-570	CLIP-seq
MIRT1254361	hsa-miR-622	CLIP-seq
MIRT2074998	hsa-miR-1	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT2074999	hsa-miR-206	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT2075000	hsa-miR-3673	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT2598387	hsa-miR-4267	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT2075001	hsa-miR-4419a	CLIP-seq
MIRT2598388	hsa-miR-4468	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT2075002	hsa-miR-4510	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT2075003	hsa-miR-4687-5p	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT2598389	hsa-miR-4786-3p	CLIP-seq
MIRT2075004	hsa-miR-613	CLIP-seq
MIRT2075005	hsa-miR-9	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq
MIRT2074998	hsa-miR-1	CLIP-seq
MIRT1254310	hsa-miR-1225-3p	CLIP-seq
MIRT1254311	hsa-miR-1233	CLIP-seq
MIRT1254316	hsa-miR-151-5p	CLIP-seq
MIRT1254317	hsa-miR-151b	CLIP-seq
MIRT2074999	hsa-miR-206	CLIP-seq
MIRT1254322	hsa-miR-2467-3p	CLIP-seq
MIRT1254323	hsa-miR-2467-5p	CLIP-seq
MIRT2075000	hsa-miR-3673	CLIP-seq
MIRT1254330	hsa-miR-3911	CLIP-seq
MIRT2598387	hsa-miR-4267	CLIP-seq
MIRT1254332	hsa-miR-4302	CLIP-seq
MIRT2075001	hsa-miR-4419a	CLIP-seq
MIRT2598388	hsa-miR-4468	CLIP-seq
MIRT1254336	hsa-miR-4505	CLIP-seq
MIRT2075002	hsa-miR-4510	CLIP-seq
MIRT1254338	hsa-miR-4533	CLIP-seq
MIRT1254339	hsa-miR-4646-5p	CLIP-seq
MIRT2075003	hsa-miR-4687-5p	CLIP-seq
MIRT1254341	hsa-miR-4747-5p	CLIP-seq
MIRT2598389	hsa-miR-4786-3p	CLIP-seq
MIRT2075004	hsa-miR-613	CLIP-seq
MIRT2075005	hsa-miR-9	CLIP-seq
MIRT1254363	hsa-miR-922	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004722	Function	Protein serine/threonine phosphatase activity	IDA	20801214
GO:0004724	Function	Magnesium-dependent protein serine/threonine phosphatase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	17572683, 21044950, 22190034, 28330616
GO:0005634	Component	Nucleus	TAS	9271424
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007050	Process	Cell cycle arrest	IEA
GO:0016020	Component	Membrane	IEA
GO:0035970	Process	Peptidyl-threonine dephosphorylation	IDA	20801214
GO:0046872	Function	Metal ion binding	IEA
GO:0106306	Function	Protein serine phosphatase activity	IEA
GO:0106307	Function	Protein threonine phosphatase activity	IEA

MIM	HGNC	e!Ensembl
605119	9278	ENSG00000115241

Protein

UniProt ID

O15355

Protein name

Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00481	PP2C	25 → 120	Protein phosphatase 2C	Family
PF00481	PP2C	262 → 492	Protein phosphatase 2C	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Most abundant in testis, skeletal muscle, and heart.

Sequence

MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYD
GHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGR
PTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEE
PGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPS
CSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEE
AEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKAL
DMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISA
LPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELL
DQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKK
KKAKRD

Sequence length

546

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Crohn Disease	Crohn Disease	GWAS
Takayasu Arteritis	Takayasu Arteritis	GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	37387407
Alcoholism	Associate	25982659
Carcinoma Hepatocellular	Associate	33771191
Carcinoma Hepatocellular	Stimulate	33952716, 34366322
Disruptive Impulse Control and Conduct Disorders	Associate	25982659
Glioma	Associate	27065332
Hepatitis B	Stimulate	34366322
Inflammation	Associate	33288725
Lung Neoplasms	Associate	37387407
Neoplasm Metastasis	Stimulate	34366322
Neoplasm Metastasis	Associate	37387407
Neoplasms	Associate	33288725, 33952716, 34366322, 37387407

PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)