Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54897
Gene name Gene Name - the full gene name approved by the HGNC.	Castor zinc finger 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CASZ1
Synonyms (NCBI Gene) Gene synonyms aliases	CAS11, CST, SRG, ZNF693, dJ734G22.1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.22
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT053612	hsa-miR-151a-5p	Luciferase reporter assay, qRT-PCR, Western blot	22928040
MIRT487889	hsa-miR-6784-5p	PAR-CLIP	20371350
MIRT487888	hsa-miR-1908-3p	PAR-CLIP	20371350
MIRT487887	hsa-miR-6777-5p	PAR-CLIP	20371350
MIRT487886	hsa-miR-6889-5p	PAR-CLIP	20371350
MIRT487885	hsa-miR-5090	PAR-CLIP	20371350
MIRT487884	hsa-miR-6775-5p	PAR-CLIP	20371350
MIRT487883	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT487882	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT487881	hsa-miR-3648	PAR-CLIP	20371350
MIRT487880	hsa-miR-3195	PAR-CLIP	20371350
MIRT487878	hsa-miR-4706	PAR-CLIP	20371350
MIRT487879	hsa-miR-4749-5p	PAR-CLIP	20371350
MIRT487877	hsa-miR-885-3p	PAR-CLIP	20371350
MIRT487876	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487875	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487874	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487873	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487872	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT487871	hsa-miR-486-3p	PAR-CLIP	20371350
MIRT487870	hsa-miR-4665-3p	PAR-CLIP	20371350
MIRT569207	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT569206	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569204	hsa-miR-8068	PAR-CLIP	20371350
MIRT569205	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT569203	hsa-miR-147a	PAR-CLIP	20371350
MIRT569202	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT569201	hsa-miR-4455	PAR-CLIP	20371350
MIRT569200	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT549040	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT549039	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT549038	hsa-miR-4517	PAR-CLIP	20371350
MIRT549036	hsa-miR-648	PAR-CLIP	20371350
MIRT549035	hsa-miR-4670-3p	PAR-CLIP	20371350
MIRT549034	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT549033	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT549031	hsa-miR-7975	PAR-CLIP	20371350
MIRT549040	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549039	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549038	hsa-miR-4517	PAR-CLIP	21572407
MIRT549037	hsa-miR-6838-3p	PAR-CLIP	21572407
MIRT549036	hsa-miR-648	PAR-CLIP	21572407
MIRT549035	hsa-miR-4670-3p	PAR-CLIP	21572407
MIRT549034	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT549033	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT549032	hsa-miR-4540	PAR-CLIP	21572407
MIRT549031	hsa-miR-7975	PAR-CLIP	21572407
MIRT487889	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT487888	hsa-miR-1908-3p	PAR-CLIP	23592263
MIRT487887	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT487886	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT487885	hsa-miR-5090	PAR-CLIP	23592263
MIRT487884	hsa-miR-6775-5p	PAR-CLIP	23592263
MIRT487883	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT487882	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT487881	hsa-miR-3648	PAR-CLIP	23592263
MIRT487880	hsa-miR-3195	PAR-CLIP	23592263
MIRT487878	hsa-miR-4706	PAR-CLIP	23592263
MIRT487879	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT487877	hsa-miR-885-3p	PAR-CLIP	23592263
MIRT487876	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487875	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487874	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487873	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487872	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT487871	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT487870	hsa-miR-4665-3p	PAR-CLIP	23592263
MIRT487889	hsa-miR-6784-5p	PAR-CLIP	20371350
MIRT487888	hsa-miR-1908-3p	PAR-CLIP	20371350
MIRT487887	hsa-miR-6777-5p	PAR-CLIP	20371350
MIRT487886	hsa-miR-6889-5p	PAR-CLIP	20371350
MIRT487885	hsa-miR-5090	PAR-CLIP	20371350
MIRT487884	hsa-miR-6775-5p	PAR-CLIP	20371350
MIRT487883	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT487882	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT487881	hsa-miR-3648	PAR-CLIP	20371350
MIRT487880	hsa-miR-3195	PAR-CLIP	20371350
MIRT487878	hsa-miR-4706	PAR-CLIP	20371350
MIRT487879	hsa-miR-4749-5p	PAR-CLIP	20371350
MIRT487877	hsa-miR-885-3p	PAR-CLIP	20371350
MIRT487876	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT487875	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT487874	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT487873	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT487872	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT487871	hsa-miR-486-3p	PAR-CLIP	20371350
MIRT487870	hsa-miR-4665-3p	PAR-CLIP	20371350
MIRT569207	hsa-miR-33a-3p	PAR-CLIP	20371350
MIRT569206	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569204	hsa-miR-8068	PAR-CLIP	20371350
MIRT569205	hsa-miR-6818-5p	PAR-CLIP	20371350
MIRT569203	hsa-miR-147a	PAR-CLIP	20371350
MIRT569202	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT569201	hsa-miR-4455	PAR-CLIP	20371350
MIRT569200	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT549040	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT549039	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT549038	hsa-miR-4517	PAR-CLIP	20371350
MIRT549036	hsa-miR-648	PAR-CLIP	20371350
MIRT549035	hsa-miR-4670-3p	PAR-CLIP	20371350
MIRT549034	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT549033	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT549031	hsa-miR-7975	PAR-CLIP	20371350
MIRT549040	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549039	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549038	hsa-miR-4517	PAR-CLIP	21572407
MIRT549037	hsa-miR-6838-3p	PAR-CLIP	21572407
MIRT549036	hsa-miR-648	PAR-CLIP	21572407
MIRT549035	hsa-miR-4670-3p	PAR-CLIP	21572407
MIRT549034	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT549033	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT549032	hsa-miR-4540	PAR-CLIP	21572407
MIRT549031	hsa-miR-7975	PAR-CLIP	21572407
MIRT487889	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT487888	hsa-miR-1908-3p	PAR-CLIP	23592263
MIRT487887	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT487886	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT487885	hsa-miR-5090	PAR-CLIP	23592263
MIRT487884	hsa-miR-6775-5p	PAR-CLIP	23592263
MIRT487883	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT487882	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT487881	hsa-miR-3648	PAR-CLIP	23592263
MIRT487880	hsa-miR-3195	PAR-CLIP	23592263
MIRT487878	hsa-miR-4706	PAR-CLIP	23592263
MIRT487879	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT487877	hsa-miR-885-3p	PAR-CLIP	23592263
MIRT487876	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487875	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487874	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487873	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487872	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT487871	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT487870	hsa-miR-4665-3p	PAR-CLIP	23592263
MIRT864326	hsa-miR-1226	CLIP-seq
MIRT864327	hsa-miR-1237	CLIP-seq
MIRT864328	hsa-miR-125a-5p	CLIP-seq
MIRT864329	hsa-miR-125b	CLIP-seq
MIRT864330	hsa-miR-1283	CLIP-seq
MIRT864331	hsa-miR-1297	CLIP-seq
MIRT864332	hsa-miR-1323	CLIP-seq
MIRT864333	hsa-miR-1324	CLIP-seq
MIRT864334	hsa-miR-135a	CLIP-seq
MIRT864335	hsa-miR-135b	CLIP-seq
MIRT864336	hsa-miR-145	CLIP-seq
MIRT864337	hsa-miR-1470	CLIP-seq
MIRT864338	hsa-miR-148a	CLIP-seq
MIRT864339	hsa-miR-148b	CLIP-seq
MIRT864340	hsa-miR-151-3p	CLIP-seq
MIRT864341	hsa-miR-151-5p	CLIP-seq
MIRT864342	hsa-miR-151b	CLIP-seq
MIRT864343	hsa-miR-152	CLIP-seq
MIRT864344	hsa-miR-198	CLIP-seq
MIRT864345	hsa-miR-19a	CLIP-seq
MIRT864346	hsa-miR-19b	CLIP-seq
MIRT864347	hsa-miR-2116	CLIP-seq
MIRT864348	hsa-miR-2355-5p	CLIP-seq
MIRT864349	hsa-miR-26a	CLIP-seq
MIRT864350	hsa-miR-26b	CLIP-seq
MIRT864351	hsa-miR-3130-3p	CLIP-seq
MIRT864352	hsa-miR-3132	CLIP-seq
MIRT864353	hsa-miR-3148	CLIP-seq
MIRT864354	hsa-miR-3150b-3p	CLIP-seq
MIRT864355	hsa-miR-3160-5p	CLIP-seq
MIRT864356	hsa-miR-3182	CLIP-seq
MIRT864357	hsa-miR-3185	CLIP-seq
MIRT864358	hsa-miR-324-5p	CLIP-seq
MIRT864359	hsa-miR-335	CLIP-seq
MIRT864360	hsa-miR-339-5p	CLIP-seq
MIRT864361	hsa-miR-3529	CLIP-seq
MIRT864362	hsa-miR-3611	CLIP-seq
MIRT864363	hsa-miR-361-3p	CLIP-seq
MIRT864364	hsa-miR-3655	CLIP-seq
MIRT864365	hsa-miR-3663-3p	CLIP-seq
MIRT864366	hsa-miR-3667-3p	CLIP-seq
MIRT864367	hsa-miR-3668	CLIP-seq
MIRT864368	hsa-miR-3671	CLIP-seq
MIRT864369	hsa-miR-3673	CLIP-seq
MIRT864370	hsa-miR-3679-3p	CLIP-seq
MIRT864371	hsa-miR-3690	CLIP-seq
MIRT864372	hsa-miR-3692	CLIP-seq
MIRT864373	hsa-miR-375	CLIP-seq
MIRT864374	hsa-miR-379	CLIP-seq
MIRT864375	hsa-miR-3908	CLIP-seq
MIRT864376	hsa-miR-4254	CLIP-seq
MIRT864377	hsa-miR-4263	CLIP-seq
MIRT864378	hsa-miR-4273	CLIP-seq
MIRT864379	hsa-miR-4277	CLIP-seq
MIRT864380	hsa-miR-4286	CLIP-seq
MIRT864381	hsa-miR-4304	CLIP-seq
MIRT864382	hsa-miR-4319	CLIP-seq
MIRT864383	hsa-miR-4326	CLIP-seq
MIRT864384	hsa-miR-4446-5p	CLIP-seq
MIRT864385	hsa-miR-4463	CLIP-seq
MIRT864386	hsa-miR-4465	CLIP-seq
MIRT864387	hsa-miR-4469	CLIP-seq
MIRT864388	hsa-miR-4499	CLIP-seq
MIRT864389	hsa-miR-4652-3p	CLIP-seq
MIRT864390	hsa-miR-4659a-3p	CLIP-seq
MIRT864391	hsa-miR-4659b-3p	CLIP-seq
MIRT864392	hsa-miR-4660	CLIP-seq
MIRT864393	hsa-miR-4667-3p	CLIP-seq
MIRT864394	hsa-miR-4677-5p	CLIP-seq
MIRT864395	hsa-miR-4684-5p	CLIP-seq
MIRT864396	hsa-miR-4691-5p	CLIP-seq
MIRT864397	hsa-miR-4707-5p	CLIP-seq
MIRT864398	hsa-miR-4732-3p	CLIP-seq
MIRT864399	hsa-miR-4733-5p	CLIP-seq
MIRT864400	hsa-miR-4755-5p	CLIP-seq
MIRT864401	hsa-miR-4778-3p	CLIP-seq
MIRT864402	hsa-miR-4784	CLIP-seq
MIRT864403	hsa-miR-4786-5p	CLIP-seq
MIRT864404	hsa-miR-4789-3p	CLIP-seq
MIRT864405	hsa-miR-483-3p	CLIP-seq
MIRT864406	hsa-miR-513a-3p	CLIP-seq
MIRT864407	hsa-miR-548c-3p	CLIP-seq
MIRT864408	hsa-miR-548o	CLIP-seq
MIRT864409	hsa-miR-571	CLIP-seq
MIRT864410	hsa-miR-576-5p	CLIP-seq
MIRT864411	hsa-miR-578	CLIP-seq
MIRT864412	hsa-miR-593	CLIP-seq
MIRT864413	hsa-miR-656	CLIP-seq
MIRT864414	hsa-miR-670	CLIP-seq
MIRT864415	hsa-miR-764	CLIP-seq
MIRT864416	hsa-miR-767-5p	CLIP-seq
MIRT864417	hsa-miR-2276	CLIP-seq
MIRT864418	hsa-miR-4287	CLIP-seq
MIRT864387	hsa-miR-4469	CLIP-seq
MIRT864419	hsa-miR-4685-3p	CLIP-seq
MIRT864420	hsa-miR-4708-3p	CLIP-seq
MIRT864421	hsa-miR-4713-5p	CLIP-seq
MIRT1956189	hsa-miR-1178	CLIP-seq
MIRT1956190	hsa-miR-1247	CLIP-seq
MIRT864330	hsa-miR-1283	CLIP-seq
MIRT1956191	hsa-miR-1285	CLIP-seq
MIRT864331	hsa-miR-1297	CLIP-seq
MIRT864337	hsa-miR-1470	CLIP-seq
MIRT1956192	hsa-miR-15a	CLIP-seq
MIRT1956193	hsa-miR-15b	CLIP-seq
MIRT1956194	hsa-miR-16	CLIP-seq
MIRT1956195	hsa-miR-1910	CLIP-seq
MIRT1956196	hsa-miR-195	CLIP-seq
MIRT1956197	hsa-miR-1973	CLIP-seq
MIRT864349	hsa-miR-26a	CLIP-seq
MIRT864350	hsa-miR-26b	CLIP-seq
MIRT1956198	hsa-miR-3187-5p	CLIP-seq
MIRT1956199	hsa-miR-3605-3p	CLIP-seq
MIRT864363	hsa-miR-361-3p	CLIP-seq
MIRT1956200	hsa-miR-3657	CLIP-seq
MIRT1956201	hsa-miR-3686	CLIP-seq
MIRT1956202	hsa-miR-378g	CLIP-seq
MIRT1956203	hsa-miR-3918	CLIP-seq
MIRT1956204	hsa-miR-424	CLIP-seq
MIRT864386	hsa-miR-4465	CLIP-seq
MIRT864387	hsa-miR-4469	CLIP-seq
MIRT1956205	hsa-miR-4486	CLIP-seq
MIRT864393	hsa-miR-4667-3p	CLIP-seq
MIRT1956206	hsa-miR-4669	CLIP-seq
MIRT864397	hsa-miR-4707-5p	CLIP-seq
MIRT1956207	hsa-miR-4738-5p	CLIP-seq
MIRT1956208	hsa-miR-4742-3p	CLIP-seq
MIRT864405	hsa-miR-483-3p	CLIP-seq
MIRT1956209	hsa-miR-497	CLIP-seq
MIRT1956210	hsa-miR-612	CLIP-seq
MIRT1956211	hsa-miR-760	CLIP-seq
MIRT2193842	hsa-miR-1229	CLIP-seq
MIRT864330	hsa-miR-1283	CLIP-seq
MIRT864337	hsa-miR-1470	CLIP-seq
MIRT864338	hsa-miR-148a	CLIP-seq
MIRT864339	hsa-miR-148b	CLIP-seq
MIRT864341	hsa-miR-151-5p	CLIP-seq
MIRT864342	hsa-miR-151b	CLIP-seq
MIRT864343	hsa-miR-152	CLIP-seq
MIRT2193843	hsa-miR-1908	CLIP-seq
MIRT2193844	hsa-miR-197	CLIP-seq
MIRT864347	hsa-miR-2116	CLIP-seq
MIRT864351	hsa-miR-3130-3p	CLIP-seq
MIRT864354	hsa-miR-3150b-3p	CLIP-seq
MIRT864355	hsa-miR-3160-5p	CLIP-seq
MIRT864363	hsa-miR-361-3p	CLIP-seq
MIRT2193845	hsa-miR-3621	CLIP-seq
MIRT864369	hsa-miR-3673	CLIP-seq
MIRT1956201	hsa-miR-3686	CLIP-seq
MIRT2193846	hsa-miR-3937	CLIP-seq
MIRT864378	hsa-miR-4273	CLIP-seq
MIRT864379	hsa-miR-4277	CLIP-seq
MIRT2193847	hsa-miR-4527	CLIP-seq
MIRT2193848	hsa-miR-4639-3p	CLIP-seq
MIRT864390	hsa-miR-4659a-3p	CLIP-seq
MIRT864391	hsa-miR-4659b-3p	CLIP-seq
MIRT864392	hsa-miR-4660	CLIP-seq
MIRT864393	hsa-miR-4667-3p	CLIP-seq
MIRT864397	hsa-miR-4707-5p	CLIP-seq
MIRT1956208	hsa-miR-4742-3p	CLIP-seq
MIRT2193849	hsa-miR-4757-5p	CLIP-seq
MIRT864402	hsa-miR-4784	CLIP-seq
MIRT864403	hsa-miR-4786-5p	CLIP-seq
MIRT2193850	hsa-miR-4793-3p	CLIP-seq
MIRT2193851	hsa-miR-4797-5p	CLIP-seq
MIRT864409	hsa-miR-571	CLIP-seq
MIRT2193852	hsa-miR-663	CLIP-seq
MIRT864415	hsa-miR-764	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	27693370
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	27693370
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	27693370
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0007275	Process	Multicellular organism development	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045664	Process	Regulation of neuron differentiation	IBA	21873635
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	27693370
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	27693370
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
609895	26002	ENSG00000130940

Protein

UniProt ID

Q86V15

Protein name

Zinc finger protein castor homolog 1 (Castor-related protein) (Putative survival-related protein) (Zinc finger protein 693)

Protein function

Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441).

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain. {ECO:0000269|PubMed:16631614}.

Sequence

MDLGTAEGTRCTDPPAGKPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQ
PRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRIAREGLELPPEG
VYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAAS
TMTEFLGMFGYDDQNTRDELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYE
EYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKATILPLPSHSSV
QMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMG
GAIAFKTGKVGRPSKYDVRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASL
SFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHI
HCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYH
GCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADC
QFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCV
YSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEES
SNDDLVDFSALSSKNSSLSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGL
PGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSAASATPDTPTLV
ASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVT
PARFPPAQVKPEPGESTGAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNK
MSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVYLRRFGTKDFCD
GQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKP
PMAPSSPPVPPVTTATVSSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLP
ASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNCKYVCKTSGKAE
SHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLP
WHIKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSH
ARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESSTMDRSCSSTPV
GNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLY
EDCKDAACQFSLKVTHYHCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLS
CHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFCQFSSSADCAVP
DCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSL
SLGAEPGSLLFLQSAAAGLGLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEE
ELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAEAAGAGARTPAL
AALAALGAPGPAPTAASSP

Sequence length

1759

Interactions

View interactions

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	30061737, 29892015
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	29059683
Hypertension	Hypertensive disease	rs13306026	25249183, 30487518, 31545351
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29662167

Show/Hide Unknown Diseases (9)

Disease term	Disease name	Evidence	References	Source
Unknown
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		30940143	ClinVar
Ischemic stroke	Ischemic stroke		29531354	ClinVar
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation		30061737, 29892015	ClinVar
Uterine Fibroids	Uterine Fibroids			GWAS
Atrial Fibrillation	Atrial Fibrillation			GWAS
Ischemic Stroke	Ischemic Stroke			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Diabetes	Diabetes			GWAS
Heart Failure	Heart Failure			GWAS

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	33029490
Carcinoma Hepatocellular	Associate	34147074
Carcinoma Renal Cell	Associate	31481981
Carcinoma Squamous Cell	Inhibit	38458428
Cardiomyopathy Dilated	Associate	31268246, 36293425
Cardiomyopathy Dilated with Left Ventricular Noncompaction	Associate	31268246
Cardiovascular Diseases	Associate	34895303
Chronic Disease	Associate	31570750, 35218958
Colorectal Neoplasms	Associate	26474385
Dermatitis Atopic	Inhibit	38458428
Developmental Disabilities	Associate	33004838
Heart Defects Congenital	Associate	35737725
Heart Murmurs	Associate	34793544
Heart Septal Defects Ventricular	Associate	31268246
Hypertension	Associate	31545351, 34793544
Idiopathic Pulmonary Fibrosis	Associate	25333685
Inflammation	Associate	33205602
Lung Diseases Interstitial	Associate	38575158
Lung Neoplasms	Associate	38575158
Marfan Syndrome	Associate	34895303
Melanoma	Associate	38077400
Neoplasms	Inhibit	21252912, 22928040, 23892435, 27270431, 31481981, 36243768
Neoplasms	Associate	36518628
Neuroblastoma	Inhibit	21252912, 27270431, 31481981, 36243768
Neuroblastoma	Associate	23892435
Osteoarthritis	Associate	33205602
Pancreatic Neoplasms	Associate	36518628
Prostatic Neoplasms	Associate	37686409
Psoriasis	Inhibit	38458428
Skin Diseases	Associate	38458428
Stroke	Associate	28682427
Varicose Veins	Associate	31570750, 34358671, 35218958, 40108671
Vascular Diseases	Associate	28693373

CASZ1 (castor zinc finger 1)