RETSAT (retinol saturase)

Gene

• Entrez ID: 54884
• Gene name: Retinol saturase
• Gene symbol: RETSAT
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020592	hsa-miR-155-5p	Proteomics	18668040
MIRT028456	hsa-miR-30a-5p	Proteomics	18668040
MIRT711236	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT711235	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT711234	hsa-miR-4267	HITS-CLIP	19536157
MIRT711233	hsa-miR-585-3p	HITS-CLIP	19536157
MIRT711232	hsa-miR-1268a	HITS-CLIP	19536157
MIRT711231	hsa-miR-1268b	HITS-CLIP	19536157
MIRT711230	hsa-miR-665	HITS-CLIP	19536157
MIRT711229	hsa-miR-1470	HITS-CLIP	19536157
MIRT711228	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT711227	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711226	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT711225	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT711224	hsa-miR-4469	HITS-CLIP	19536157
MIRT711223	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT711221	hsa-miR-4287	HITS-CLIP	19536157
MIRT711222	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT711220	hsa-miR-1976	HITS-CLIP	19536157
MIRT711219	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711218	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT711217	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711216	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT711236	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT711235	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT711234	hsa-miR-4267	HITS-CLIP	19536157
MIRT711233	hsa-miR-585-3p	HITS-CLIP	19536157
MIRT711232	hsa-miR-1268a	HITS-CLIP	19536157
MIRT711231	hsa-miR-1268b	HITS-CLIP	19536157
MIRT711230	hsa-miR-665	HITS-CLIP	19536157
MIRT711229	hsa-miR-1470	HITS-CLIP	19536157
MIRT711228	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT711227	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711226	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT711225	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT711224	hsa-miR-4469	HITS-CLIP	19536157
MIRT711223	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT711221	hsa-miR-4287	HITS-CLIP	19536157
MIRT711222	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT711220	hsa-miR-1976	HITS-CLIP	19536157
MIRT711219	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711218	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT711217	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711216	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT711236	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT711235	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT711234	hsa-miR-4267	HITS-CLIP	19536157
MIRT711233	hsa-miR-585-3p	HITS-CLIP	19536157
MIRT711232	hsa-miR-1268a	HITS-CLIP	19536157
MIRT711231	hsa-miR-1268b	HITS-CLIP	19536157
MIRT711230	hsa-miR-665	HITS-CLIP	19536157
MIRT711229	hsa-miR-1470	HITS-CLIP	19536157
MIRT711228	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT711227	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711226	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT711225	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT711224	hsa-miR-4469	HITS-CLIP	19536157
MIRT711223	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT711221	hsa-miR-4287	HITS-CLIP	19536157
MIRT711222	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT711220	hsa-miR-1976	HITS-CLIP	19536157
MIRT711219	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711218	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT711217	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711216	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT711236	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT711235	hsa-miR-383-3p	HITS-CLIP	19536157
MIRT711234	hsa-miR-4267	HITS-CLIP	19536157
MIRT711233	hsa-miR-585-3p	HITS-CLIP	19536157
MIRT711232	hsa-miR-1268a	HITS-CLIP	19536157
MIRT711231	hsa-miR-1268b	HITS-CLIP	19536157
MIRT711230	hsa-miR-665	HITS-CLIP	19536157
MIRT711229	hsa-miR-1470	HITS-CLIP	19536157
MIRT711228	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT711227	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711226	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT711225	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT711224	hsa-miR-4469	HITS-CLIP	19536157
MIRT711223	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT711221	hsa-miR-4287	HITS-CLIP	19536157
MIRT711222	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT711220	hsa-miR-1976	HITS-CLIP	19536157
MIRT711219	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711218	hsa-miR-103a-2-5p	HITS-CLIP	19536157
MIRT711217	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT711216	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT1301088	hsa-miR-1207-3p	CLIP-seq
MIRT1301089	hsa-miR-1258	CLIP-seq
MIRT1301090	hsa-miR-1262	CLIP-seq
MIRT1301091	hsa-miR-1913	CLIP-seq
MIRT1301092	hsa-miR-219-2-3p	CLIP-seq
MIRT1301093	hsa-miR-3126-5p	CLIP-seq
MIRT1301094	hsa-miR-3189-5p	CLIP-seq
MIRT1301095	hsa-miR-324-3p	CLIP-seq
MIRT1301096	hsa-miR-3612	CLIP-seq
MIRT1301097	hsa-miR-3622a-3p	CLIP-seq
MIRT1301098	hsa-miR-3622b-3p	CLIP-seq
MIRT1301099	hsa-miR-3622b-5p	CLIP-seq
MIRT1301100	hsa-miR-3669	CLIP-seq
MIRT1301101	hsa-miR-4266	CLIP-seq
MIRT1301102	hsa-miR-4317	CLIP-seq
MIRT1301103	hsa-miR-4419a	CLIP-seq
MIRT1301104	hsa-miR-4424	CLIP-seq
MIRT1301105	hsa-miR-4510	CLIP-seq
MIRT1301106	hsa-miR-4519	CLIP-seq
MIRT1301107	hsa-miR-4695-5p	CLIP-seq
MIRT1301108	hsa-miR-4701-3p	CLIP-seq
MIRT1301109	hsa-miR-4710	CLIP-seq
MIRT1301110	hsa-miR-4758-3p	CLIP-seq
MIRT1301111	hsa-miR-4779	CLIP-seq
MIRT1301112	hsa-miR-650	CLIP-seq
MIRT1301113	hsa-miR-671-5p	CLIP-seq
MIRT1301094	hsa-miR-3189-5p	CLIP-seq
MIRT2089444	hsa-miR-4708-5p	CLIP-seq
MIRT1301110	hsa-miR-4758-3p	CLIP-seq
MIRT1301089	hsa-miR-1258	CLIP-seq
MIRT1301094	hsa-miR-3189-5p	CLIP-seq
MIRT1301101	hsa-miR-4266	CLIP-seq
MIRT2314314	hsa-miR-4315	CLIP-seq
MIRT2314315	hsa-miR-4420	CLIP-seq
MIRT1301104	hsa-miR-4424	CLIP-seq
MIRT2314316	hsa-miR-4682	CLIP-seq
MIRT1301110	hsa-miR-4758-3p	CLIP-seq
MIRT2314317	hsa-miR-4790-5p	CLIP-seq
MIRT2393629	hsa-miR-3173-5p	CLIP-seq
MIRT2393630	hsa-miR-345	CLIP-seq
MIRT2393631	hsa-miR-4732-3p	CLIP-seq
MIRT2610741	hsa-miR-1	CLIP-seq
MIRT2610742	hsa-miR-1229	CLIP-seq
MIRT1301089	hsa-miR-1258	CLIP-seq
MIRT2610743	hsa-miR-1261	CLIP-seq
MIRT1301090	hsa-miR-1262	CLIP-seq
MIRT2610744	hsa-miR-1304	CLIP-seq
MIRT2610745	hsa-miR-141	CLIP-seq
MIRT1301091	hsa-miR-1913	CLIP-seq
MIRT2610746	hsa-miR-200a	CLIP-seq
MIRT2610747	hsa-miR-206	CLIP-seq
MIRT2610748	hsa-miR-24	CLIP-seq
MIRT2610749	hsa-miR-2467-3p	CLIP-seq
MIRT2610750	hsa-miR-2467-5p	CLIP-seq
MIRT2610751	hsa-miR-2964a-5p	CLIP-seq
MIRT1301093	hsa-miR-3126-5p	CLIP-seq
MIRT2610752	hsa-miR-3134	CLIP-seq
MIRT2610753	hsa-miR-3156-5p	CLIP-seq
MIRT2610754	hsa-miR-3161	CLIP-seq
MIRT2610755	hsa-miR-3163	CLIP-seq
MIRT2610756	hsa-miR-3165	CLIP-seq
MIRT2610757	hsa-miR-3188	CLIP-seq
MIRT1301094	hsa-miR-3189-5p	CLIP-seq
MIRT1301095	hsa-miR-324-3p	CLIP-seq
MIRT2610758	hsa-miR-339-3p	CLIP-seq
MIRT2610759	hsa-miR-339-5p	CLIP-seq
MIRT2610760	hsa-miR-33a	CLIP-seq
MIRT2610761	hsa-miR-33b	CLIP-seq
MIRT2610762	hsa-miR-340	CLIP-seq
MIRT1301096	hsa-miR-3612	CLIP-seq
MIRT2610763	hsa-miR-3617	CLIP-seq
MIRT2610764	hsa-miR-3620	CLIP-seq
MIRT1301097	hsa-miR-3622a-3p	CLIP-seq
MIRT1301098	hsa-miR-3622b-3p	CLIP-seq
MIRT1301099	hsa-miR-3622b-5p	CLIP-seq
MIRT2610765	hsa-miR-3673	CLIP-seq
MIRT2610766	hsa-miR-3678-3p	CLIP-seq
MIRT2610767	hsa-miR-3682-3p	CLIP-seq
MIRT2610768	hsa-miR-3688-3p	CLIP-seq
MIRT2610769	hsa-miR-3691-3p	CLIP-seq
MIRT2610770	hsa-miR-370	CLIP-seq
MIRT2610771	hsa-miR-3913-3p	CLIP-seq
MIRT2610772	hsa-miR-3975	CLIP-seq
MIRT1301101	hsa-miR-4266	CLIP-seq
MIRT2314314	hsa-miR-4315	CLIP-seq
MIRT2610773	hsa-miR-4327	CLIP-seq
MIRT1301103	hsa-miR-4419a	CLIP-seq
MIRT2314315	hsa-miR-4420	CLIP-seq
MIRT2610774	hsa-miR-4421	CLIP-seq
MIRT1301104	hsa-miR-4424	CLIP-seq
MIRT1301105	hsa-miR-4510	CLIP-seq
MIRT2610775	hsa-miR-4534	CLIP-seq
MIRT2610776	hsa-miR-4637	CLIP-seq
MIRT2314316	hsa-miR-4682	CLIP-seq
MIRT2610777	hsa-miR-4695-3p	CLIP-seq
MIRT1301107	hsa-miR-4695-5p	CLIP-seq
MIRT1301108	hsa-miR-4701-3p	CLIP-seq
MIRT1301109	hsa-miR-4710	CLIP-seq
MIRT2610778	hsa-miR-4711-5p	CLIP-seq
MIRT2610779	hsa-miR-4715-3p	CLIP-seq
MIRT1301110	hsa-miR-4758-3p	CLIP-seq
MIRT1301111	hsa-miR-4779	CLIP-seq
MIRT2314317	hsa-miR-4790-5p	CLIP-seq
MIRT2610780	hsa-miR-485-5p	CLIP-seq
MIRT2610781	hsa-miR-501-3p	CLIP-seq
MIRT2610782	hsa-miR-502-3p	CLIP-seq
MIRT2610783	hsa-miR-548aa	CLIP-seq
MIRT2610784	hsa-miR-549	CLIP-seq
MIRT2610785	hsa-miR-613	CLIP-seq
MIRT2610786	hsa-miR-641	CLIP-seq
MIRT1301112	hsa-miR-650	CLIP-seq
MIRT2610787	hsa-miR-670	CLIP-seq
MIRT2610788	hsa-miR-7	CLIP-seq
MIRT2610741	hsa-miR-1	CLIP-seq
MIRT2689666	hsa-miR-105	CLIP-seq
MIRT1301088	hsa-miR-1207-3p	CLIP-seq
MIRT2610742	hsa-miR-1229	CLIP-seq
MIRT1301089	hsa-miR-1258	CLIP-seq
MIRT2610743	hsa-miR-1261	CLIP-seq
MIRT1301090	hsa-miR-1262	CLIP-seq
MIRT2610744	hsa-miR-1304	CLIP-seq
MIRT2610745	hsa-miR-141	CLIP-seq
MIRT1301091	hsa-miR-1913	CLIP-seq
MIRT2610746	hsa-miR-200a	CLIP-seq
MIRT2610747	hsa-miR-206	CLIP-seq
MIRT2689667	hsa-miR-2114	CLIP-seq
MIRT1301092	hsa-miR-219-2-3p	CLIP-seq
MIRT2610748	hsa-miR-24	CLIP-seq
MIRT2610749	hsa-miR-2467-3p	CLIP-seq
MIRT2610750	hsa-miR-2467-5p	CLIP-seq
MIRT2689668	hsa-miR-2964a-3p	CLIP-seq
MIRT2610751	hsa-miR-2964a-5p	CLIP-seq
MIRT1301093	hsa-miR-3126-5p	CLIP-seq
MIRT2610752	hsa-miR-3134	CLIP-seq
MIRT2610753	hsa-miR-3156-5p	CLIP-seq
MIRT2610755	hsa-miR-3163	CLIP-seq
MIRT2610756	hsa-miR-3165	CLIP-seq
MIRT2610757	hsa-miR-3188	CLIP-seq
MIRT1301094	hsa-miR-3189-5p	CLIP-seq
MIRT2689669	hsa-miR-3201	CLIP-seq
MIRT1301095	hsa-miR-324-3p	CLIP-seq
MIRT2610758	hsa-miR-339-3p	CLIP-seq
MIRT2610759	hsa-miR-339-5p	CLIP-seq
MIRT2610760	hsa-miR-33a	CLIP-seq
MIRT2610761	hsa-miR-33b	CLIP-seq
MIRT2610762	hsa-miR-340	CLIP-seq
MIRT1301096	hsa-miR-3612	CLIP-seq
MIRT2610763	hsa-miR-3617	CLIP-seq
MIRT2610764	hsa-miR-3620	CLIP-seq
MIRT1301097	hsa-miR-3622a-3p	CLIP-seq
MIRT1301098	hsa-miR-3622b-3p	CLIP-seq
MIRT1301099	hsa-miR-3622b-5p	CLIP-seq
MIRT2610765	hsa-miR-3673	CLIP-seq
MIRT2610766	hsa-miR-3678-3p	CLIP-seq
MIRT2610768	hsa-miR-3688-3p	CLIP-seq
MIRT2610769	hsa-miR-3691-3p	CLIP-seq
MIRT2610770	hsa-miR-370	CLIP-seq
MIRT2610771	hsa-miR-3913-3p	CLIP-seq
MIRT2610772	hsa-miR-3975	CLIP-seq
MIRT1301101	hsa-miR-4266	CLIP-seq
MIRT2314314	hsa-miR-4315	CLIP-seq
MIRT2610773	hsa-miR-4327	CLIP-seq
MIRT1301103	hsa-miR-4419a	CLIP-seq
MIRT2314315	hsa-miR-4420	CLIP-seq
MIRT2610774	hsa-miR-4421	CLIP-seq
MIRT1301104	hsa-miR-4424	CLIP-seq
MIRT1301105	hsa-miR-4510	CLIP-seq
MIRT2610775	hsa-miR-4534	CLIP-seq
MIRT2610776	hsa-miR-4637	CLIP-seq
MIRT2314316	hsa-miR-4682	CLIP-seq
MIRT2610777	hsa-miR-4695-3p	CLIP-seq
MIRT1301107	hsa-miR-4695-5p	CLIP-seq
MIRT1301108	hsa-miR-4701-3p	CLIP-seq
MIRT1301109	hsa-miR-4710	CLIP-seq
MIRT2610778	hsa-miR-4711-5p	CLIP-seq
MIRT2610779	hsa-miR-4715-3p	CLIP-seq
MIRT2689670	hsa-miR-4717-3p	CLIP-seq
MIRT1301110	hsa-miR-4758-3p	CLIP-seq
MIRT1301111	hsa-miR-4779	CLIP-seq
MIRT2314317	hsa-miR-4790-5p	CLIP-seq
MIRT2689671	hsa-miR-4791	CLIP-seq
MIRT2610780	hsa-miR-485-5p	CLIP-seq
MIRT2610781	hsa-miR-501-3p	CLIP-seq
MIRT2610782	hsa-miR-502-3p	CLIP-seq
MIRT2610783	hsa-miR-548aa	CLIP-seq
MIRT2610784	hsa-miR-549	CLIP-seq
MIRT2689672	hsa-miR-587	CLIP-seq
MIRT2610785	hsa-miR-613	CLIP-seq
MIRT2689673	hsa-miR-617	CLIP-seq
MIRT2610786	hsa-miR-641	CLIP-seq
MIRT1301112	hsa-miR-650	CLIP-seq
MIRT2610787	hsa-miR-670	CLIP-seq
MIRT1301113	hsa-miR-671-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IEA
GO:0005640	Component	Nuclear outer membrane	IEA
GO:0005640	Component	Nuclear outer membrane	ISS	15358783
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS	15358783
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0031965	Component	Nuclear membrane	IEA
GO:0031965	Component	Nuclear membrane	ISS	15358783
GO:0042572	Process	Retinol metabolic process	IBA
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042572	Process	Retinol metabolic process	ISS	15358783
GO:0051786	Function	All-trans-retinol 13,14-reductase activity	IBA
GO:0051786	Function	All-trans-retinol 13,14-reductase activity	IEA
GO:0051786	Function	All-trans-retinol 13,14-reductase activity	ISS	15358783

Other IDs

• MIM: 617597
• HGNC: 25991
• e!Ensembl: ENSG00000042445

Protein

• UniProt ID: Q6NUM9
• Protein name: All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)
• Protein function: Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independe
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13450	NAD_binding_8	72 → 135		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in liver; expression positively correlates with obesity and liver steatosis (PubMed:28855500). Expressed in adipose tissue; expression tends to be decreased in obese versus lean individuals (PubMed:19139408). {ECO:0000269|Pub
• Sequence:

  MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFS
  ANQVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGI
  HYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGL
  KEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQ
  SLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHALLVNHYMKGGFYPRGGSSEIA
  FHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVSNAGLFNTY
  EHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAM
  ERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKG
  KRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHD
  LGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLD
  SRIRAQKKKN

• Sequence length: 610

Pathways

KEGG:

Retinol metabolism

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Familial cancer of breast	Likely benign	rs142596961	RCV005939166
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs376151430	RCV005930881

Associations from Text Mining
Disease Name	Relationship Type	References
Insulin Resistance	Associate	19786482