DEF8 (differentially expressed in FDCP 8 homolog)

Gene

• Entrez ID: 54849
• Gene name: Differentially expressed in FDCP 8 homolog
• Gene symbol: DEF8
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043288	hsa-miR-331-3p	CLASH	23622248
MIRT043241	hsa-miR-324-5p	CLASH	23622248
MIRT035878	hsa-miR-1303	CLASH	23622248
MIRT250718	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT250719	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT931839	hsa-miR-1227	CLIP-seq
MIRT931840	hsa-miR-1236	CLIP-seq
MIRT931841	hsa-miR-3064-3p	CLIP-seq
MIRT931842	hsa-miR-3074-5p	CLIP-seq
MIRT931843	hsa-miR-3669	CLIP-seq
MIRT931844	hsa-miR-370	CLIP-seq
MIRT931845	hsa-miR-3941	CLIP-seq
MIRT931846	hsa-miR-466	CLIP-seq
MIRT931847	hsa-miR-4672	CLIP-seq
MIRT931848	hsa-miR-125a-3p	CLIP-seq
MIRT931849	hsa-miR-3613-5p	CLIP-seq
MIRT931850	hsa-miR-552	CLIP-seq
MIRT931851	hsa-miR-568	CLIP-seq
MIRT931852	hsa-miR-101	CLIP-seq
MIRT931853	hsa-miR-193a-3p	CLIP-seq
MIRT931854	hsa-miR-193b	CLIP-seq
MIRT931855	hsa-miR-3136-5p	CLIP-seq
MIRT931856	hsa-miR-3187-3p	CLIP-seq
MIRT931857	hsa-miR-3668	CLIP-seq
MIRT931858	hsa-miR-4439	CLIP-seq
MIRT931859	hsa-miR-448	CLIP-seq
MIRT931860	hsa-miR-4529-5p	CLIP-seq
MIRT931861	hsa-miR-4645-3p	CLIP-seq
MIRT931862	hsa-miR-4775	CLIP-seq
MIRT931863	hsa-miR-943	CLIP-seq
MIRT931864	hsa-miR-103a	CLIP-seq
MIRT931865	hsa-miR-106a	CLIP-seq
MIRT931866	hsa-miR-106b	CLIP-seq
MIRT931867	hsa-miR-107	CLIP-seq
MIRT931839	hsa-miR-1227	CLIP-seq
MIRT931840	hsa-miR-1236	CLIP-seq
MIRT931868	hsa-miR-1285	CLIP-seq
MIRT931869	hsa-miR-130a	CLIP-seq
MIRT931870	hsa-miR-130b	CLIP-seq
MIRT931871	hsa-miR-1343	CLIP-seq
MIRT931872	hsa-miR-15a	CLIP-seq
MIRT931873	hsa-miR-15b	CLIP-seq
MIRT931874	hsa-miR-16	CLIP-seq
MIRT931875	hsa-miR-17	CLIP-seq
MIRT931876	hsa-miR-195	CLIP-seq
MIRT931877	hsa-miR-19a	CLIP-seq
MIRT931878	hsa-miR-19b	CLIP-seq
MIRT931879	hsa-miR-20a	CLIP-seq
MIRT931880	hsa-miR-20b	CLIP-seq
MIRT931881	hsa-miR-2277-3p	CLIP-seq
MIRT931882	hsa-miR-301a	CLIP-seq
MIRT931883	hsa-miR-301b	CLIP-seq
MIRT931841	hsa-miR-3064-3p	CLIP-seq
MIRT931842	hsa-miR-3074-5p	CLIP-seq
MIRT931884	hsa-miR-3144-5p	CLIP-seq
MIRT931885	hsa-miR-3187-5p	CLIP-seq
MIRT931886	hsa-miR-3591-3p	CLIP-seq
MIRT931887	hsa-miR-3607-3p	CLIP-seq
MIRT931888	hsa-miR-3609	CLIP-seq
MIRT931889	hsa-miR-3666	CLIP-seq
MIRT931890	hsa-miR-3686	CLIP-seq
MIRT931844	hsa-miR-370	CLIP-seq
MIRT931891	hsa-miR-3940-5p	CLIP-seq
MIRT931892	hsa-miR-424	CLIP-seq
MIRT931893	hsa-miR-4279	CLIP-seq
MIRT931894	hsa-miR-4295	CLIP-seq
MIRT931895	hsa-miR-4310	CLIP-seq
MIRT931896	hsa-miR-4507	CLIP-seq
MIRT931897	hsa-miR-454	CLIP-seq
MIRT931898	hsa-miR-4796-3p	CLIP-seq
MIRT931899	hsa-miR-4800-5p	CLIP-seq
MIRT931900	hsa-miR-497	CLIP-seq
MIRT931901	hsa-miR-519a	CLIP-seq
MIRT931902	hsa-miR-519b-3p	CLIP-seq
MIRT931903	hsa-miR-519c-3p	CLIP-seq
MIRT931904	hsa-miR-519d	CLIP-seq
MIRT931905	hsa-miR-542-3p	CLIP-seq
MIRT931906	hsa-miR-548ah	CLIP-seq
MIRT931907	hsa-miR-612	CLIP-seq
MIRT931908	hsa-miR-629	CLIP-seq
MIRT931909	hsa-miR-635	CLIP-seq
MIRT931910	hsa-miR-93	CLIP-seq
MIRT1975849	hsa-miR-128	CLIP-seq
MIRT1975850	hsa-miR-1200	CLIP-seq
MIRT931839	hsa-miR-1227	CLIP-seq
MIRT931840	hsa-miR-1236	CLIP-seq
MIRT1975851	hsa-miR-1238	CLIP-seq
MIRT931848	hsa-miR-125a-3p	CLIP-seq
MIRT1975852	hsa-miR-1273f	CLIP-seq
MIRT1975853	hsa-miR-1275	CLIP-seq
MIRT1975854	hsa-miR-143	CLIP-seq
MIRT931872	hsa-miR-15a	CLIP-seq
MIRT931873	hsa-miR-15b	CLIP-seq
MIRT931874	hsa-miR-16	CLIP-seq
MIRT1975855	hsa-miR-1912	CLIP-seq
MIRT1975856	hsa-miR-1915	CLIP-seq
MIRT931876	hsa-miR-195	CLIP-seq
MIRT1975857	hsa-miR-1972	CLIP-seq
MIRT1975858	hsa-miR-1976	CLIP-seq
MIRT931881	hsa-miR-2277-3p	CLIP-seq
MIRT931841	hsa-miR-3064-3p	CLIP-seq
MIRT931842	hsa-miR-3074-5p	CLIP-seq
MIRT1975859	hsa-miR-3154	CLIP-seq
MIRT1975860	hsa-miR-3175	CLIP-seq
MIRT1975861	hsa-miR-3179	CLIP-seq
MIRT1975862	hsa-miR-3183	CLIP-seq
MIRT1975863	hsa-miR-33a	CLIP-seq
MIRT1975864	hsa-miR-33b	CLIP-seq
MIRT1975865	hsa-miR-361-3p	CLIP-seq
MIRT1975866	hsa-miR-3663-3p	CLIP-seq
MIRT1975867	hsa-miR-3665	CLIP-seq
MIRT931844	hsa-miR-370	CLIP-seq
MIRT1975868	hsa-miR-3909	CLIP-seq
MIRT1975869	hsa-miR-3944-5p	CLIP-seq
MIRT931892	hsa-miR-424	CLIP-seq
MIRT1975870	hsa-miR-4271	CLIP-seq
MIRT1975871	hsa-miR-4324	CLIP-seq
MIRT1975872	hsa-miR-4447	CLIP-seq
MIRT1975873	hsa-miR-4449	CLIP-seq
MIRT1975874	hsa-miR-4462	CLIP-seq
MIRT1975875	hsa-miR-4464	CLIP-seq
MIRT1975876	hsa-miR-4472	CLIP-seq
MIRT1975877	hsa-miR-4525	CLIP-seq
MIRT1975878	hsa-miR-4649-3p	CLIP-seq
MIRT1975879	hsa-miR-4650-5p	CLIP-seq
MIRT1975880	hsa-miR-4655-3p	CLIP-seq
MIRT1975881	hsa-miR-4665-5p	CLIP-seq
MIRT1975882	hsa-miR-4668-5p	CLIP-seq
MIRT1975883	hsa-miR-4688	CLIP-seq
MIRT1975884	hsa-miR-4723-3p	CLIP-seq
MIRT1975885	hsa-miR-4723-5p	CLIP-seq
MIRT1975886	hsa-miR-4725-3p	CLIP-seq
MIRT1975887	hsa-miR-4726-3p	CLIP-seq
MIRT1975888	hsa-miR-4736	CLIP-seq
MIRT1975889	hsa-miR-4748	CLIP-seq
MIRT1975890	hsa-miR-4749-3p	CLIP-seq
MIRT1975891	hsa-miR-4757-5p	CLIP-seq
MIRT1975892	hsa-miR-4770	CLIP-seq
MIRT1975893	hsa-miR-486-3p	CLIP-seq
MIRT931900	hsa-miR-497	CLIP-seq
MIRT931905	hsa-miR-542-3p	CLIP-seq
MIRT1975894	hsa-miR-544b	CLIP-seq
MIRT1975895	hsa-miR-625	CLIP-seq
MIRT2211293	hsa-miR-3126-3p	CLIP-seq
MIRT2211294	hsa-miR-516b	CLIP-seq
MIRT931839	hsa-miR-1227	CLIP-seq
MIRT931840	hsa-miR-1236	CLIP-seq
MIRT2211295	hsa-miR-192	CLIP-seq
MIRT1975857	hsa-miR-1972	CLIP-seq
MIRT2211296	hsa-miR-215	CLIP-seq
MIRT931841	hsa-miR-3064-3p	CLIP-seq
MIRT931842	hsa-miR-3074-5p	CLIP-seq
MIRT931844	hsa-miR-370	CLIP-seq
MIRT1975879	hsa-miR-4650-5p	CLIP-seq
MIRT931865	hsa-miR-106a	CLIP-seq
MIRT931866	hsa-miR-106b	CLIP-seq
MIRT1975850	hsa-miR-1200	CLIP-seq
MIRT2515168	hsa-miR-122	CLIP-seq
MIRT1975851	hsa-miR-1238	CLIP-seq
MIRT931869	hsa-miR-130a	CLIP-seq
MIRT931870	hsa-miR-130b	CLIP-seq
MIRT931875	hsa-miR-17	CLIP-seq
MIRT1975855	hsa-miR-1912	CLIP-seq
MIRT1975856	hsa-miR-1915	CLIP-seq
MIRT1975858	hsa-miR-1976	CLIP-seq
MIRT931877	hsa-miR-19a	CLIP-seq
MIRT931878	hsa-miR-19b	CLIP-seq
MIRT931879	hsa-miR-20a	CLIP-seq
MIRT931880	hsa-miR-20b	CLIP-seq
MIRT931882	hsa-miR-301a	CLIP-seq
MIRT931883	hsa-miR-301b	CLIP-seq
MIRT1975862	hsa-miR-3183	CLIP-seq
MIRT931886	hsa-miR-3591-3p	CLIP-seq
MIRT931887	hsa-miR-3607-3p	CLIP-seq
MIRT931888	hsa-miR-3609	CLIP-seq
MIRT2515169	hsa-miR-3657	CLIP-seq
MIRT931889	hsa-miR-3666	CLIP-seq
MIRT931890	hsa-miR-3686	CLIP-seq
MIRT1975868	hsa-miR-3909	CLIP-seq
MIRT931894	hsa-miR-4295	CLIP-seq
MIRT931895	hsa-miR-4310	CLIP-seq
MIRT1975871	hsa-miR-4324	CLIP-seq
MIRT1975873	hsa-miR-4449	CLIP-seq
MIRT1975874	hsa-miR-4462	CLIP-seq
MIRT1975875	hsa-miR-4464	CLIP-seq
MIRT2515170	hsa-miR-4480	CLIP-seq
MIRT931897	hsa-miR-454	CLIP-seq
MIRT1975878	hsa-miR-4649-3p	CLIP-seq
MIRT1975880	hsa-miR-4655-3p	CLIP-seq
MIRT1975884	hsa-miR-4723-3p	CLIP-seq
MIRT1975889	hsa-miR-4748	CLIP-seq
MIRT1975890	hsa-miR-4749-3p	CLIP-seq
MIRT1975891	hsa-miR-4757-5p	CLIP-seq
MIRT931898	hsa-miR-4796-3p	CLIP-seq
MIRT931899	hsa-miR-4800-5p	CLIP-seq
MIRT931901	hsa-miR-519a	CLIP-seq
MIRT931902	hsa-miR-519b-3p	CLIP-seq
MIRT931903	hsa-miR-519c-3p	CLIP-seq
MIRT931904	hsa-miR-519d	CLIP-seq
MIRT1975894	hsa-miR-544b	CLIP-seq
MIRT931906	hsa-miR-548ah	CLIP-seq
MIRT931910	hsa-miR-93	CLIP-seq
MIRT931865	hsa-miR-106a	CLIP-seq
MIRT931866	hsa-miR-106b	CLIP-seq
MIRT1975850	hsa-miR-1200	CLIP-seq
MIRT931869	hsa-miR-130a	CLIP-seq
MIRT931870	hsa-miR-130b	CLIP-seq
MIRT931875	hsa-miR-17	CLIP-seq
MIRT1975858	hsa-miR-1976	CLIP-seq
MIRT931877	hsa-miR-19a	CLIP-seq
MIRT931878	hsa-miR-19b	CLIP-seq
MIRT931879	hsa-miR-20a	CLIP-seq
MIRT931880	hsa-miR-20b	CLIP-seq
MIRT931882	hsa-miR-301a	CLIP-seq
MIRT931883	hsa-miR-301b	CLIP-seq
MIRT1975862	hsa-miR-3183	CLIP-seq
MIRT931886	hsa-miR-3591-3p	CLIP-seq
MIRT931887	hsa-miR-3607-3p	CLIP-seq
MIRT931888	hsa-miR-3609	CLIP-seq
MIRT931889	hsa-miR-3666	CLIP-seq
MIRT931890	hsa-miR-3686	CLIP-seq
MIRT1975868	hsa-miR-3909	CLIP-seq
MIRT931894	hsa-miR-4295	CLIP-seq
MIRT1975871	hsa-miR-4324	CLIP-seq
MIRT1975874	hsa-miR-4462	CLIP-seq
MIRT2515170	hsa-miR-4480	CLIP-seq
MIRT931897	hsa-miR-454	CLIP-seq
MIRT1975878	hsa-miR-4649-3p	CLIP-seq
MIRT1975880	hsa-miR-4655-3p	CLIP-seq
MIRT1975884	hsa-miR-4723-3p	CLIP-seq
MIRT1975890	hsa-miR-4749-3p	CLIP-seq
MIRT931898	hsa-miR-4796-3p	CLIP-seq
MIRT931899	hsa-miR-4800-5p	CLIP-seq
MIRT931901	hsa-miR-519a	CLIP-seq
MIRT931902	hsa-miR-519b-3p	CLIP-seq
MIRT931903	hsa-miR-519c-3p	CLIP-seq
MIRT931904	hsa-miR-519d	CLIP-seq
MIRT1975894	hsa-miR-544b	CLIP-seq
MIRT931906	hsa-miR-548ah	CLIP-seq
MIRT931910	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0008270	Function	Zinc ion binding	IEA
GO:0032418	Process	Lysosome localization	IEA
GO:0032418	Process	Lysosome localization	ISS
GO:0045780	Process	Positive regulation of bone resorption	IEA
GO:0045780	Process	Positive regulation of bone resorption	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:1900029	Process	Positive regulation of ruffle assembly	IEA
GO:1900029	Process	Positive regulation of ruffle assembly	ISS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6ZN54
• Protein name: Differentially expressed in FDCP 8 homolog (DEF-8)
• Protein function: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00130	C1_1	200 → 253	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF13901	zf-RING_9	295 → 497	Putative zinc-RING and/or ribbon	Domain

• Sequence:

  MAILSLRAPGPWQAMQVWADRTLLTPHTGVTSQVLGVAAAVMTPLPGGHAAGRTREARWD
  AMEYDEKLARFRQAHLNPFNKQSGPRQHEQGPGEEVPDVTPEEALPELPPGEPEFRCPER
  VMDLGLSEDHFSRPVGLFLASDVQQLRQAIEECKQVILELPEQSEKQKDAVVRLIHLRLK
  LQELKDPNEDEPNIRVLLEHRFYKEKSKSVKQTCDKCNTIIWGLIQTWYTCTGCYYRCHS
  KCLNLISKPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRGVPSEARQCDYT
  GQYYCSHCHWNDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPVLRLREINPLLFSY
  VEELVEIRKLRQDILLMKPYFITCREAMEARLLLQLQDRQHFVENDEMYSVQDLLDVHAG
  RLGCSLTEIHTLFAKHIKLDCERCQAKGFVCELCREGDVLFPFDSHTSVCADCSAVFHRD
  CYYDNSTTCPKCARLSLRKQSLFQEPGPDVEA

• Sequence length: 512