FBLIM1 (filamin binding LIM protein 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 54751 |
| Gene name | Filamin binding LIM protein 1 |
| Gene symbol | FBLIM1 |
| Synonyms (NCBI Gene) |
CALFBLP-1FBLP1
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| Chromosome | 1 |
| Chromosome location | 1p36.21 |
| Summary | This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This prot |
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miRNA
miRNA information provided by mirtarbase database.
398
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8WUP2 | ||||||||||||||||||||
| Protein name | Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) | ||||||||||||||||||||
| Protein function | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabiliza | ||||||||||||||||||||
| PDB | 2K9U , 2W0P , 4P3W | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. {ECO:0000269|PubMed:12496242}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 373 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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