PPBP (pro-platelet basic protein)

Gene

• Entrez ID: 5473
• Gene name: Pro-platelet basic protein
• Gene symbol: PPBP
• Synonyms (NCBI Gene): B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
• Chromosome: 4
• Chromosome location: 4q13.3
• Summary: The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018016	hsa-miR-335-5p	Microarray	18185580
MIRT1252237	hsa-miR-101	CLIP-seq
MIRT1252238	hsa-miR-1257	CLIP-seq
MIRT1252239	hsa-miR-144	CLIP-seq
MIRT1252240	hsa-miR-331-5p	CLIP-seq
MIRT1252241	hsa-miR-3607-5p	CLIP-seq
MIRT1252242	hsa-miR-374c	CLIP-seq
MIRT1252243	hsa-miR-4678	CLIP-seq
MIRT1252244	hsa-miR-590-3p	CLIP-seq
MIRT1252245	hsa-miR-655	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
TBP	Unknown	7958954

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	28381538, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006952	Process	Defense response	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008009	Function	Chemokine activity	IBA
GO:0008009	Function	Chemokine activity	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0030593	Process	Neutrophil chemotaxis	IBA
GO:0031091	Component	Platelet alpha granule	IDA	10877842
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0031640	Process	Killing of cells of another organism	IDA	10877842
GO:0042742	Process	Defense response to bacterium	IEA
GO:0045236	Function	CXCR chemokine receptor binding	IBA
GO:0051781	Process	Positive regulation of cell division	IEA
GO:0055056	Function	D-glucose transmembrane transporter activity	TAS	4005226
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	10877842
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA
GO:1904659	Process	D-glucose transmembrane transport	TAS	4005226
GO:1904724	Component	Tertiary granule lumen	TAS

Other IDs

• MIM: 121010
• HGNC: 9240
• e!Ensembl: ENSG00000163736

Protein

• UniProt ID: P02775
• Protein name: Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affini
• Protein function: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen act
• PDB: 1F9P, 1NAP, 1TVX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	61 → 119	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAE
  LRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKK
  LAGDESAD

• Sequence length: 128

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway

Reactome:

Platelet degranulation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation