Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54620
Gene name Gene Name - the full gene name approved by the HGNC.
F-box and leucine rich repeat protein 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FBXL19
Synonyms (NCBI Gene) Gene synonyms aliases
CXXC11, Fbl19, JHDM1C
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049576 hsa-miR-92a-3p CLASH 23622248
MIRT042632 hsa-miR-423-3p CLASH 23622248
MIRT041349 hsa-miR-193b-3p CLASH 23622248
MIRT040201 hsa-miR-615-3p CLASH 23622248
MIRT037597 hsa-miR-744-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination TAS
GO:0003712 Function Transcription coregulator activity IBA 21873635
GO:0005515 Function Protein binding IPI 22660580
GO:0005829 Component Cytosol TAS
GO:0006357 Process Regulation of transcription by RNA polymerase II IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609085 25300 ENSG00000099364
Protein
UniProt ID Q6PCT2
Protein name F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19)
Protein function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:24684802, PubMed:2
PDB 6ASB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02008 zf-CXXC 31 77 CXXC zinc finger domain Domain
PF16866 PHD_4 82 149 PHD-finger Domain
PF00646 F-box 423 466 F-box domain Domain
Sequence
MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMK
KFGGPGRMKQSCLLRQC
TAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEI
VHPGCLKMGKAEGVINAEIPNCWECPRCT
QEGRTSKDSGEGPGRRRADNGEEGASLGSGW
KLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKK
VGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSP
SPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGS
SGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGS
DHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGV
VRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLR
WIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLS
ALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLR
SCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
Sequence length 694
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 20953189, 25574825
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Follicular Associate 31238008
Arthritis Psoriatic Associate 20953189, 22298274
Arthritis Rheumatoid Associate 35479077
Breast Neoplasms Associate 31696201
Carcinoma Hepatocellular Associate 34564989
Carcinoma Non Small Cell Lung Associate 31210311
Cardiovascular Diseases Associate 37207321
Colorectal Neoplasms Associate 30610161
Diffuse Neurofibrillary Tangles with Calcification Associate 35729600
Glioblastoma Associate 31674730