Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	54518
Gene name	Amyloid beta precursor protein binding family B member 1 interacting protein
Gene symbol	APBB1IP
Synonyms (NCBI Gene)	INAG1PREL1RARP1RIAM
Chromosome	10
Chromosome location	10p12.1

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miRTarBase ID	miRNA	Experiments	Reference
MIRT739743	hsa-miR-23b	HITS-CLIP	33718276
MIRT739744	hsa-miR-23a	HITS-CLIP	33718276
MIRT739745	hsa-miR-23c	HITS-CLIP	33718276
MIRT739746	hsa-miR-1253	HITS-CLIP	33718276
MIRT1932636	hsa-miR-181a	CLIP-seq
MIRT1932637	hsa-miR-181b	CLIP-seq
MIRT1932638	hsa-miR-181c	CLIP-seq
MIRT1932639	hsa-miR-181d	CLIP-seq
MIRT1932640	hsa-miR-2682	CLIP-seq
MIRT1932641	hsa-miR-3202	CLIP-seq
MIRT1932642	hsa-miR-4262	CLIP-seq
MIRT1932643	hsa-miR-4423-3p	CLIP-seq
MIRT1932644	hsa-miR-4453	CLIP-seq
MIRT1932645	hsa-miR-449c	CLIP-seq
MIRT1932646	hsa-miR-4533	CLIP-seq
MIRT1932647	hsa-miR-4538	CLIP-seq
MIRT1932648	hsa-miR-940	CLIP-seq
MIRT1932636	hsa-miR-181a	CLIP-seq
MIRT1932637	hsa-miR-181b	CLIP-seq
MIRT1932638	hsa-miR-181c	CLIP-seq
MIRT1932639	hsa-miR-181d	CLIP-seq
MIRT1932640	hsa-miR-2682	CLIP-seq
MIRT1932641	hsa-miR-3202	CLIP-seq
MIRT1932642	hsa-miR-4262	CLIP-seq
MIRT1932643	hsa-miR-4423-3p	CLIP-seq
MIRT1932644	hsa-miR-4453	CLIP-seq
MIRT1932645	hsa-miR-449c	CLIP-seq
MIRT1932646	hsa-miR-4533	CLIP-seq
MIRT1932647	hsa-miR-4538	CLIP-seq
MIRT1932648	hsa-miR-940	CLIP-seq
MIRT1932636	hsa-miR-181a	CLIP-seq
MIRT1932637	hsa-miR-181b	CLIP-seq
MIRT1932638	hsa-miR-181c	CLIP-seq
MIRT1932639	hsa-miR-181d	CLIP-seq
MIRT1932640	hsa-miR-2682	CLIP-seq
MIRT1932641	hsa-miR-3202	CLIP-seq
MIRT1932642	hsa-miR-4262	CLIP-seq
MIRT1932643	hsa-miR-4423-3p	CLIP-seq
MIRT1932644	hsa-miR-4453	CLIP-seq
MIRT1932645	hsa-miR-449c	CLIP-seq
MIRT1932646	hsa-miR-4533	CLIP-seq
MIRT1932647	hsa-miR-4538	CLIP-seq
MIRT1932648	hsa-miR-940	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002291	Process	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IEA
GO:0005515	Function	Protein binding	IPI	22084112, 24705354, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0030027	Component	Lamellipodium	IEA
GO:0042101	Component	T cell receptor complex	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045785	Process	Positive regulation of cell adhesion	IEA
GO:0070161	Component	Anchoring junction	IEA

MIM	HGNC	e!Ensembl
609036	17379	ENSG00000077420

Q7Z5R6

Protein name

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-

Protein function

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|Pu

PDB

2MWN , 3ZDL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00788	RA	176 → 263	Ras association (RalGDS/AF-6) domain	Domain
PF00169	PH	311 → 419	PH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.

Sequence

MGESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPRAEFNYSVGFKDLNESLNALE
DQDLDALMADLVADISEAEQRTIQAQKESLQNQHHSASLQASIFSGAASLGYGTNVAATG
ISQYEDDLPPPPADPVLDLPLPPPPPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVV
KVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENV
VEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLE
ESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFE
NVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYG
KTLYDNYQRAVAKAGLASRWTNLGTVNAAAPAQPSTGPKTGTTQPNGQIPQATHSVSAVL
QEAQRHAETSKDKKPALGNHHDPAVPRAPHAPKSSLPPPPPVRRSSDTSGSPATPLKAKG
TGGGGLPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSYAGIAGSELPP
PPPPPPAPAPAPVPDSARPPPAVAKRPPVPPKRQENPGHPGGAGGGEQDFMSDLMKALQK
KRGNVS

Sequence length

666

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway Platelet activation		Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants

APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein)