CPVL (carboxypeptidase vitellogenic like)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54504
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase vitellogenic like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPVL
Synonyms (NCBI Gene) Gene synonyms aliases
HVLP
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptid
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT907803 hsa-miR-3908 CLIP-seq
MIRT907804 hsa-miR-4291 CLIP-seq
MIRT907805 hsa-miR-545 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
GO ID Ontology Definition Evidence Reference
GO:0004185 Function Serine-type carboxypeptidase activity IBA 21873635
GO:0006508 Process Proteolysis IEA
GO:0070062 Component Extracellular exosome HDA 19056867, 23533145
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
609780 14399 ENSG00000106066
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9H3G5
Protein name Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)
Protein function May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00450 Peptidase_S10 64 → 468 Serine carboxypeptidase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in macrophages but not in other leukocytes. Abundantly expressed in heart and kidney. Also expressed in spleen, leukocytes, and placenta.
Sequence
Sequence length 476
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Basal cell neoplasm Basal Cell Neoplasm, Basal Cell Cancer rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813 31174203
Carcinoma Basal cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 31174203
Endometrial carcinoma Endometrial Carcinoma rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077
View all (247 more)		 30093612
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Vitiligo Vitiligo GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Psoriasis Psoriasis GWAS
Show/Hide Text Mining Associations (7)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 37925455
Behcet Syndrome Associate 19442274
Glioma Stimulate 34784299
Glycogen Storage Disease Type II Associate 30025106
Influenza Human Associate 33393450
Severe Acute Respiratory Syndrome Associate 33393450
Triple Negative Breast Neoplasms Associate 39776914