Gene Gene information from NCBI Gene database.
Entrez ID 54434
Gene name Slingshot protein phosphatase 1
Gene symbol SSH1
Synonyms (NCBI Gene)
SSH1L
Chromosome 12
Chromosome location 12q24.11
Summary The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds
miRNA miRNA information provided by mirtarbase database.
998
miRTarBase ID miRNA Experiments Reference
MIRT024217 hsa-miR-218-5p Sequencing 20371350
MIRT030159 hsa-miR-26b-5p Microarray 19088304
MIRT040382 hsa-miR-615-3p CLASH 23622248
MIRT036943 hsa-miR-877-3p CLASH 23622248
MIRT1391760 hsa-let-7a CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IMP 14645219
GO:0003779 Function Actin binding IBA
GO:0003779 Function Actin binding IDA 11832213
GO:0003779 Function Actin binding IEA
GO:0004721 Function Phosphoprotein phosphatase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606778 30579 ENSG00000084112
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WYL5
Protein name Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)
Protein function Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08766 DEK_C 250 303 DEK C terminal domain Domain
PF00782 DSPc 316 446 Dual specificity phosphatase, catalytic domain Domain
Sequence
MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQG
QRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTE
ENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWS
ALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPAL
FVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEML
LIL
GQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRV
YDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAY
NYVKQKRSITRPNAGFMRQLSEYEGI
LDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFL
PETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREAL
LEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGR
WGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGA
PEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGS
RRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPK
KDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPA
PPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPP
FFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIET
RLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQG
TPRDPAATSKPSGKPAPENLKSPSWMSKS
Sequence length 1049
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Axon guidance
Regulation of actin cytoskeleton
 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
7
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Ovarian serous cystadenocarcinoma Likely benign rs145198057 RCV005910661
Premature ovarian insufficiency Uncertain significance rs1566003171 RCV000766161
Sarcoma Likely benign rs145198057 RCV005910660
SSH1-related disorder Likely benign rs147936147, rs116903144, rs151176410, rs774022680 RCV003904215
RCV003924357
RCV003937004
RCV003964275
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Ovarian Epithelial Associate 34284854
Disseminated Intravascular Coagulation Associate 24039253
Lymphatic Metastasis Associate 29338701
Neoplasms Associate 29338701, 31965287
Stomach Neoplasms Associate 29338701
Urinary Bladder Neoplasms Associate 31965287