Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54434
Gene name Gene Name - the full gene name approved by the HGNC.
Slingshot protein phosphatase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SSH1
Synonyms (NCBI Gene) Gene synonyms aliases
SSH1L
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.11
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT024217 hsa-miR-218-5p Sequencing 20371350
MIRT030159 hsa-miR-26b-5p Microarray 19088304
MIRT040382 hsa-miR-615-3p CLASH 23622248
MIRT036943 hsa-miR-877-3p CLASH 23622248
MIRT1391760 hsa-let-7a CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IMP 14645219
GO:0003779 Function Actin binding IBA 21873635
GO:0003779 Function Actin binding IDA 11832213
GO:0004721 Function Phosphoprotein phosphatase activity IBA 21873635
GO:0004721 Function Phosphoprotein phosphatase activity IDA 11832213
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606778 30579 ENSG00000084112
Protein
UniProt ID Q8WYL5
Protein name Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)
Protein function Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08766 DEK_C 250 303 DEK C terminal domain Domain
PF00782 DSPc 316 446 Dual specificity phosphatase, catalytic domain Domain
Sequence
MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQG
QRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTE
ENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWS
ALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPAL
FVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEML
LIL
GQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRV
YDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAY
NYVKQKRSITRPNAGFMRQLSEYEGI
LDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFL
PETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREAL
LEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGR
WGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGA
PEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGS
RRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPK
KDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPA
PPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPP
FFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIET
RLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQG
TPRDPAATSKPSGKPAPENLKSPSWMSKS
Sequence length 1049
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Axon guidance
Regulation of actin cytoskeleton
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Porokeratosis Porokeratosis, Disseminated Superficial Actinic rs397514570, rs104895301, rs104895373, rs397514571, rs398122910, rs398122911, rs606231251, rs863225241, rs769193201, rs104895362, rs761991070, rs755948940 15459975
Unknown
Disease term Disease name Evidence References Source
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Ovarian Epithelial Associate 34284854
Disseminated Intravascular Coagulation Associate 24039253
Lymphatic Metastasis Associate 29338701
Neoplasms Associate 29338701, 31965287
Stomach Neoplasms Associate 29338701
Urinary Bladder Neoplasms Associate 31965287