Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
54431
Gene name Gene Name - the full gene name approved by the HGNC.
DnaJ heat shock protein family (Hsp40) member C10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DNAJC10
Synonyms (NCBI Gene) Gene synonyms aliases
ERdj5, JPDI, MTHr, PDIA19
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023948 hsa-miR-1-3p Proteomics 18668040
MIRT040460 hsa-miR-615-3p CLASH 23622248
MIRT696009 hsa-miR-3929 HITS-CLIP 23313552
MIRT696008 hsa-miR-4419b HITS-CLIP 23313552
MIRT696007 hsa-miR-4478 HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001671 Function ATPase activator activity ISS
GO:0001933 Process Negative regulation of protein phosphorylation IDA 19122239
GO:0005515 Function Protein binding IPI 19706418, 19815549
GO:0005783 Component Endoplasmic reticulum IDA 12411443
GO:0005788 Component Endoplasmic reticulum lumen IDA 23769672
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607987 24637 ENSG00000077232
Protein
UniProt ID Q8IXB1
Protein name DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)
Protein function Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native dis
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ 35 97 DnaJ domain Domain
PF00085 Thioredoxin 130 231 Thioredoxin Domain
PF00085 Thioredoxin 454 552 Thioredoxin Domain
PF00085 Thioredoxin 557 659 Thioredoxin Domain
PF00085 Thioredoxin 671 777 Thioredoxin Domain
Sequence
MGVWLNKDDYIRDLKRIILCFLIVYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLAL
KLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYD
KYGEKGLEDNQGGQYESWNYYRY
DFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLR
IGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQ
HVRSTVTEL
WTGNFVNSIQTAFAAGIGWLITFCSKGGDCLTSQTRLRLSGMLDGLVNVGWMDCATQDNL
CKSLDITTSTTAYFPPGATLNNKEKNSILFLNSLDAKEIYLEVIHNLPDFELLSANTLED
RLAHHRWLLFFHFGKNENSNDPELKKLKTLLKNDHIQVGRFDCSSAPDICSNLYVFQPSL
AVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANDKEPWLVDFFAPWC
PPCRALLPELRRASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGH
HSAEQILEFIED
LMNPSVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKR
MARTLTGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYS
L
RIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGK
VKAGKVDCQAYAQTCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISE
KLE
TLRNQGKRNKDEL
Sequence length 793
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Protein processing in endoplasmic reticulum  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease term Disease name Evidence References Source
Pulmonary arterial hypertension Pulmonary arterial hypertension GWAS
Retinitis Pigmentosa Retinitis Pigmentosa GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 29544444
Carcinogenesis Associate 17346424
Carcinoma Hepatocellular Associate 17346424
Glioma Associate 34988580
Graves Ophthalmopathy Associate 33613444
Neoplasms Stimulate 17346424
Neoplasms Associate 34988580
Neuroblastoma Associate 19122239