Gene Gene information from NCBI Gene database.
Entrez ID 54431
Gene name DnaJ heat shock protein family (Hsp40) member C10
Gene symbol DNAJC10
Synonyms (NCBI Gene)
ERdj5JPDIMTHrPDIA19
Chromosome 2
Chromosome location 2q32.1
Summary This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded
miRNA miRNA information provided by mirtarbase database.
1086
miRTarBase ID miRNA Experiments Reference
MIRT023948 hsa-miR-1-3p Proteomics 18668040
MIRT040460 hsa-miR-615-3p CLASH 23622248
MIRT696009 hsa-miR-3929 HITS-CLIP 23313552
MIRT696008 hsa-miR-4419b HITS-CLIP 23313552
MIRT696007 hsa-miR-4478 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0001671 Function ATPase activator activity IEA
GO:0001671 Function ATPase activator activity ISS
GO:0005515 Function Protein binding IPI 19706418, 19815549, 25416956
GO:0005783 Component Endoplasmic reticulum IDA 12411443
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607987 24637 ENSG00000077232
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IXB1
Protein name DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)
Protein function Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native dis
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ 35 97 DnaJ domain Domain
PF00085 Thioredoxin 130 231 Thioredoxin Domain
PF00085 Thioredoxin 454 552 Thioredoxin Domain
PF00085 Thioredoxin 557 659 Thioredoxin Domain
PF00085 Thioredoxin 671 777 Thioredoxin Domain
Sequence
MGVWLNKDDYIRDLKRIILCFLIVYMAILVGTDQDFYSLLGVSKTASSREIRQAFKKLAL
KLHPDKNPNNPNAHGDFLKINRAYEVLKDEDLRKKYD
KYGEKGLEDNQGGQYESWNYYRY
DFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLR
IGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQ
HVRSTVTEL
WTGNFVNSIQTAFAAGIGWLITFCSKGGDCLTSQTRLRLSGMLDGLVNVGWMDCATQDNL
CKSLDITTSTTAYFPPGATLNNKEKNSILFLNSLDAKEIYLEVIHNLPDFELLSANTLED
RLAHHRWLLFFHFGKNENSNDPELKKLKTLLKNDHIQVGRFDCSSAPDICSNLYVFQPSL
AVFKGQGTKEYEIHHGKKILYDILAFAKESVNSHVTTLGPQNFPANDKEPWLVDFFAPWC
PPCRALLPELRRASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGH
HSAEQILEFIED
LMNPSVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKR
MARTLTGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYS
L
RIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGK
VKAGKVDCQAYAQTCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISE
KLE
TLRNQGKRNKDEL
Sequence length 793
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Protein processing in endoplasmic reticulum