GNG2 (G protein subunit gamma 2)

Gene

• Entrez ID: 54331
• Gene name: G protein subunit gamma 2
• Gene symbol: GNG2
• Synonyms (NCBI Gene): HG3F1
• Chromosome: 14
• Chromosome location: 14q22.1
• Summary: This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provide

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028498	hsa-miR-30a-5p	Proteomics	18668040
MIRT715893	hsa-miR-16-1-3p	HITS-CLIP	19536157
MIRT715892	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT715891	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT715890	hsa-miR-222-5p	HITS-CLIP	19536157
MIRT715889	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT715888	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT715887	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT715886	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT715893	hsa-miR-16-1-3p	HITS-CLIP	19536157
MIRT715892	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT715891	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT715890	hsa-miR-222-5p	HITS-CLIP	19536157
MIRT715889	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT715888	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT715887	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT715886	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT1024413	hsa-miR-1252	CLIP-seq
MIRT1024414	hsa-miR-129-5p	CLIP-seq
MIRT1024415	hsa-miR-1305	CLIP-seq
MIRT1024416	hsa-miR-216a	CLIP-seq
MIRT1024417	hsa-miR-216b	CLIP-seq
MIRT1024418	hsa-miR-2278	CLIP-seq
MIRT1024419	hsa-miR-3125	CLIP-seq
MIRT1024420	hsa-miR-3132	CLIP-seq
MIRT1024421	hsa-miR-3140-5p	CLIP-seq
MIRT1024422	hsa-miR-3150a-3p	CLIP-seq
MIRT1024423	hsa-miR-3150b-3p	CLIP-seq
MIRT1024424	hsa-miR-3156-5p	CLIP-seq
MIRT1024425	hsa-miR-3173-3p	CLIP-seq
MIRT1024426	hsa-miR-3175	CLIP-seq
MIRT1024427	hsa-miR-3190	CLIP-seq
MIRT1024428	hsa-miR-3202	CLIP-seq
MIRT1024429	hsa-miR-331-3p	CLIP-seq
MIRT1024430	hsa-miR-335	CLIP-seq
MIRT1024431	hsa-miR-3679-3p	CLIP-seq
MIRT1024432	hsa-miR-3688-3p	CLIP-seq
MIRT1024433	hsa-miR-3916	CLIP-seq
MIRT1024434	hsa-miR-4317	CLIP-seq
MIRT1024435	hsa-miR-4427	CLIP-seq
MIRT1024436	hsa-miR-4434	CLIP-seq
MIRT1024437	hsa-miR-4446-5p	CLIP-seq
MIRT1024438	hsa-miR-4451	CLIP-seq
MIRT1024439	hsa-miR-4480	CLIP-seq
MIRT1024440	hsa-miR-4506	CLIP-seq
MIRT1024441	hsa-miR-4516	CLIP-seq
MIRT1024442	hsa-miR-4533	CLIP-seq
MIRT1024443	hsa-miR-4651	CLIP-seq
MIRT1024444	hsa-miR-4666-5p	CLIP-seq
MIRT1024445	hsa-miR-4698	CLIP-seq
MIRT1024446	hsa-miR-4728-5p	CLIP-seq
MIRT1024447	hsa-miR-4760-3p	CLIP-seq
MIRT1024448	hsa-miR-4777-5p	CLIP-seq
MIRT1024449	hsa-miR-4784	CLIP-seq
MIRT1024450	hsa-miR-4802-3p	CLIP-seq
MIRT1024451	hsa-miR-548u	CLIP-seq
MIRT1024452	hsa-miR-607	CLIP-seq
MIRT1024453	hsa-miR-608	CLIP-seq
MIRT1024454	hsa-miR-877	CLIP-seq
MIRT1024455	hsa-miR-939	CLIP-seq
MIRT1024413	hsa-miR-1252	CLIP-seq
MIRT1549324	hsa-miR-1915	CLIP-seq
MIRT1549325	hsa-miR-2467-5p	CLIP-seq
MIRT1024419	hsa-miR-3125	CLIP-seq
MIRT1024423	hsa-miR-3150b-3p	CLIP-seq
MIRT1024433	hsa-miR-3916	CLIP-seq
MIRT1549326	hsa-miR-3940-3p	CLIP-seq
MIRT1024436	hsa-miR-4434	CLIP-seq
MIRT1024441	hsa-miR-4516	CLIP-seq
MIRT1549327	hsa-miR-4726-3p	CLIP-seq
MIRT1024449	hsa-miR-4784	CLIP-seq
MIRT1549328	hsa-miR-665	CLIP-seq
MIRT1024454	hsa-miR-877	CLIP-seq
MIRT2003848	hsa-miR-1298	CLIP-seq
MIRT2003849	hsa-miR-2116	CLIP-seq
MIRT2003850	hsa-miR-3613-3p	CLIP-seq
MIRT2003851	hsa-miR-3647-3p	CLIP-seq
MIRT2003852	hsa-miR-3676	CLIP-seq
MIRT2003853	hsa-miR-4677-5p	CLIP-seq
MIRT2003854	hsa-miR-664	CLIP-seq
MIRT2003855	hsa-miR-888	CLIP-seq
MIRT2003850	hsa-miR-3613-3p	CLIP-seq
MIRT2236581	hsa-miR-371b-5p	CLIP-seq
MIRT2236582	hsa-miR-4719	CLIP-seq
MIRT2003855	hsa-miR-888	CLIP-seq
MIRT2450453	hsa-miR-29a	CLIP-seq
MIRT2450454	hsa-miR-29b	CLIP-seq
MIRT2450455	hsa-miR-29c	CLIP-seq
MIRT2450456	hsa-miR-4704-3p	CLIP-seq
MIRT2540449	hsa-miR-103b	CLIP-seq
MIRT2540450	hsa-miR-1264	CLIP-seq
MIRT2540451	hsa-miR-1265	CLIP-seq
MIRT2540452	hsa-miR-1284	CLIP-seq
MIRT2540453	hsa-miR-1303	CLIP-seq
MIRT2540454	hsa-miR-1323	CLIP-seq
MIRT2540455	hsa-miR-147	CLIP-seq
MIRT2540456	hsa-miR-153	CLIP-seq
MIRT2540457	hsa-miR-1537	CLIP-seq
MIRT2540458	hsa-miR-193a-5p	CLIP-seq
MIRT2540459	hsa-miR-194	CLIP-seq
MIRT2540460	hsa-miR-2053	CLIP-seq
MIRT2540461	hsa-miR-2113	CLIP-seq
MIRT2003849	hsa-miR-2116	CLIP-seq
MIRT2540462	hsa-miR-224	CLIP-seq
MIRT2540463	hsa-miR-23a	CLIP-seq
MIRT2540464	hsa-miR-23b	CLIP-seq
MIRT2540465	hsa-miR-23c	CLIP-seq
MIRT2540466	hsa-miR-2682	CLIP-seq
MIRT2540467	hsa-miR-2861	CLIP-seq
MIRT2540468	hsa-miR-2964a-3p	CLIP-seq
MIRT2540469	hsa-miR-3065-5p	CLIP-seq
MIRT2540470	hsa-miR-3126-3p	CLIP-seq
MIRT2540471	hsa-miR-3127-5p	CLIP-seq
MIRT2540472	hsa-miR-3144-5p	CLIP-seq
MIRT2540473	hsa-miR-3153	CLIP-seq
MIRT1024425	hsa-miR-3173-3p	CLIP-seq
MIRT2540474	hsa-miR-3180-5p	CLIP-seq
MIRT2540475	hsa-miR-338-3p	CLIP-seq
MIRT2540476	hsa-miR-33a	CLIP-seq
MIRT2540477	hsa-miR-33b	CLIP-seq
MIRT2003850	hsa-miR-3613-3p	CLIP-seq
MIRT2003851	hsa-miR-3647-3p	CLIP-seq
MIRT2540478	hsa-miR-3691-5p	CLIP-seq
MIRT2540479	hsa-miR-370	CLIP-seq
MIRT2540480	hsa-miR-3918	CLIP-seq
MIRT2540481	hsa-miR-3938	CLIP-seq
MIRT2540482	hsa-miR-409-5p	CLIP-seq
MIRT2540483	hsa-miR-4270	CLIP-seq
MIRT2540484	hsa-miR-4327	CLIP-seq
MIRT1024435	hsa-miR-4427	CLIP-seq
MIRT2540485	hsa-miR-4441	CLIP-seq
MIRT1024437	hsa-miR-4446-5p	CLIP-seq
MIRT2540486	hsa-miR-4491	CLIP-seq
MIRT2540487	hsa-miR-449c	CLIP-seq
MIRT2540488	hsa-miR-4512	CLIP-seq
MIRT2540489	hsa-miR-4514	CLIP-seq
MIRT2540490	hsa-miR-4645-5p	CLIP-seq
MIRT2540491	hsa-miR-4654	CLIP-seq
MIRT2540492	hsa-miR-4657	CLIP-seq
MIRT2540493	hsa-miR-4659a-3p	CLIP-seq
MIRT2540494	hsa-miR-4659b-3p	CLIP-seq
MIRT2540495	hsa-miR-4667-3p	CLIP-seq
MIRT2540496	hsa-miR-4673	CLIP-seq
MIRT2003853	hsa-miR-4677-5p	CLIP-seq
MIRT2540497	hsa-miR-4680-3p	CLIP-seq
MIRT2540498	hsa-miR-4685-5p	CLIP-seq
MIRT2540499	hsa-miR-4691-5p	CLIP-seq
MIRT2540500	hsa-miR-4692	CLIP-seq
MIRT2236582	hsa-miR-4719	CLIP-seq
MIRT2540501	hsa-miR-4752	CLIP-seq
MIRT2540502	hsa-miR-4755-5p	CLIP-seq
MIRT2540503	hsa-miR-4764-5p	CLIP-seq
MIRT2540504	hsa-miR-4769-5p	CLIP-seq
MIRT2540505	hsa-miR-4773	CLIP-seq
MIRT2540506	hsa-miR-4779	CLIP-seq
MIRT2540507	hsa-miR-4790-3p	CLIP-seq
MIRT2540508	hsa-miR-4803	CLIP-seq
MIRT2540509	hsa-miR-485-3p	CLIP-seq
MIRT2540510	hsa-miR-495	CLIP-seq
MIRT2540511	hsa-miR-499-3p	CLIP-seq
MIRT2540512	hsa-miR-499a-3p	CLIP-seq
MIRT2540513	hsa-miR-513b	CLIP-seq
MIRT2540514	hsa-miR-519a	CLIP-seq
MIRT2540515	hsa-miR-519b-3p	CLIP-seq
MIRT2540516	hsa-miR-519c-3p	CLIP-seq
MIRT2540517	hsa-miR-520a-5p	CLIP-seq
MIRT2540518	hsa-miR-525-5p	CLIP-seq
MIRT2540519	hsa-miR-548ac	CLIP-seq
MIRT2540520	hsa-miR-548d-3p	CLIP-seq
MIRT2540521	hsa-miR-548o	CLIP-seq
MIRT2540522	hsa-miR-548z	CLIP-seq
MIRT2540523	hsa-miR-556-5p	CLIP-seq
MIRT2540524	hsa-miR-578	CLIP-seq
MIRT2540525	hsa-miR-583	CLIP-seq
MIRT2540526	hsa-miR-590-3p	CLIP-seq
MIRT2540527	hsa-miR-599	CLIP-seq
MIRT2540528	hsa-miR-642a	CLIP-seq
MIRT2540529	hsa-miR-642b	CLIP-seq
MIRT2540530	hsa-miR-942	CLIP-seq
MIRT2540450	hsa-miR-1264	CLIP-seq
MIRT2540451	hsa-miR-1265	CLIP-seq
MIRT2540452	hsa-miR-1284	CLIP-seq
MIRT2540453	hsa-miR-1303	CLIP-seq
MIRT2540454	hsa-miR-1323	CLIP-seq
MIRT2540456	hsa-miR-153	CLIP-seq
MIRT2540457	hsa-miR-1537	CLIP-seq
MIRT2540458	hsa-miR-193a-5p	CLIP-seq
MIRT2540459	hsa-miR-194	CLIP-seq
MIRT2540460	hsa-miR-2053	CLIP-seq
MIRT2003849	hsa-miR-2116	CLIP-seq
MIRT2540462	hsa-miR-224	CLIP-seq
MIRT2540463	hsa-miR-23a	CLIP-seq
MIRT2540464	hsa-miR-23b	CLIP-seq
MIRT2540465	hsa-miR-23c	CLIP-seq
MIRT2540466	hsa-miR-2682	CLIP-seq
MIRT2540467	hsa-miR-2861	CLIP-seq
MIRT2540468	hsa-miR-2964a-3p	CLIP-seq
MIRT2540469	hsa-miR-3065-5p	CLIP-seq
MIRT2540470	hsa-miR-3126-3p	CLIP-seq
MIRT2681745	hsa-miR-3134	CLIP-seq
MIRT2540472	hsa-miR-3144-5p	CLIP-seq
MIRT1024425	hsa-miR-3173-3p	CLIP-seq
MIRT2540476	hsa-miR-33a	CLIP-seq
MIRT2540477	hsa-miR-33b	CLIP-seq
MIRT2003850	hsa-miR-3613-3p	CLIP-seq
MIRT2003851	hsa-miR-3647-3p	CLIP-seq
MIRT2540478	hsa-miR-3691-5p	CLIP-seq
MIRT2540479	hsa-miR-370	CLIP-seq
MIRT2540480	hsa-miR-3918	CLIP-seq
MIRT2540481	hsa-miR-3938	CLIP-seq
MIRT2540482	hsa-miR-409-5p	CLIP-seq
MIRT2540484	hsa-miR-4327	CLIP-seq
MIRT1024435	hsa-miR-4427	CLIP-seq
MIRT1024437	hsa-miR-4446-5p	CLIP-seq
MIRT2540486	hsa-miR-4491	CLIP-seq
MIRT2540487	hsa-miR-449c	CLIP-seq
MIRT2540488	hsa-miR-4512	CLIP-seq
MIRT2540489	hsa-miR-4514	CLIP-seq
MIRT2681746	hsa-miR-4534	CLIP-seq
MIRT2540490	hsa-miR-4645-5p	CLIP-seq
MIRT2540491	hsa-miR-4654	CLIP-seq
MIRT2540492	hsa-miR-4657	CLIP-seq
MIRT2540493	hsa-miR-4659a-3p	CLIP-seq
MIRT2540494	hsa-miR-4659b-3p	CLIP-seq
MIRT2540495	hsa-miR-4667-3p	CLIP-seq
MIRT2540496	hsa-miR-4673	CLIP-seq
MIRT2003853	hsa-miR-4677-5p	CLIP-seq
MIRT2540497	hsa-miR-4680-3p	CLIP-seq
MIRT2540498	hsa-miR-4685-5p	CLIP-seq
MIRT2540499	hsa-miR-4691-5p	CLIP-seq
MIRT2540500	hsa-miR-4692	CLIP-seq
MIRT2236582	hsa-miR-4719	CLIP-seq
MIRT2540501	hsa-miR-4752	CLIP-seq
MIRT2540502	hsa-miR-4755-5p	CLIP-seq
MIRT2540503	hsa-miR-4764-5p	CLIP-seq
MIRT2540504	hsa-miR-4769-5p	CLIP-seq
MIRT2540505	hsa-miR-4773	CLIP-seq
MIRT2540506	hsa-miR-4779	CLIP-seq
MIRT2540507	hsa-miR-4790-3p	CLIP-seq
MIRT2540508	hsa-miR-4803	CLIP-seq
MIRT2540509	hsa-miR-485-3p	CLIP-seq
MIRT2540510	hsa-miR-495	CLIP-seq
MIRT2540511	hsa-miR-499-3p	CLIP-seq
MIRT2540512	hsa-miR-499a-3p	CLIP-seq
MIRT2540513	hsa-miR-513b	CLIP-seq
MIRT2540514	hsa-miR-519a	CLIP-seq
MIRT2540515	hsa-miR-519b-3p	CLIP-seq
MIRT2540516	hsa-miR-519c-3p	CLIP-seq
MIRT2540519	hsa-miR-548ac	CLIP-seq
MIRT2540520	hsa-miR-548d-3p	CLIP-seq
MIRT2540521	hsa-miR-548o	CLIP-seq
MIRT2540522	hsa-miR-548z	CLIP-seq
MIRT2540524	hsa-miR-578	CLIP-seq
MIRT2540526	hsa-miR-590-3p	CLIP-seq
MIRT2681747	hsa-miR-602	CLIP-seq
MIRT2540528	hsa-miR-642a	CLIP-seq
MIRT2540529	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23739333, 28219978, 28437792, 32528175, 33961781, 35271311
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005834	Component	Heterotrimeric G-protein complex	IDA	29925951, 33762731, 34239069
GO:0005834	Component	Heterotrimeric G-protein complex	IEA
GO:0005834	Component	Heterotrimeric G-protein complex	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007191	Process	Adenylate cyclase-activating dopamine receptor signaling pathway	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0031681	Function	G-protein beta-subunit binding	IBA
GO:0031681	Function	G-protein beta-subunit binding	IEA
GO:0031681	Function	G-protein beta-subunit binding	IPI	12606627
GO:0045202	Component	Synapse	IEA
GO:0048144	Process	Fibroblast proliferation	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071380	Process	Cellular response to prostaglandin E stimulus	ISS
GO:0071870	Process	Cellular response to catecholamine stimulus	ISS

Other IDs

• MIM: 606981
• HGNC: 4404
• e!Ensembl: ENSG00000186469

Protein

• UniProt ID: P59768
• Protein name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
• Protein function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:3
• PDB: 4KFM, 5HE0, 5HE1, 5HE2, 5HE3, 5UKK, 5UKL, 5UKM, 5UZ7, 6B3J, 6CRK, 6D9H, 6DDE, 6DDF, 6E3Y, 6EG8, 6G79, 6GDG, 6K41, 6K42, 6KPF, 6KPG, 6LFM, 6LFO, 6LI3, 6LMK, 6LML, 6M1H, 6M1I, 6M8S, 6N4B, 6NI3, 6NIY, 6OIJ, 6OIK, 6OMM, 6ORV, 6OS9, 6OSA, 6OT0, 6P9X, 6P9Y, 6PB0, 6PB1, 6PT0, 6UUN, 6UUS, 6UVA, 6VCB, 6VMS, 6VN7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00631	G-gamma	5 → 71	GGL domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain. {ECO:0000269|PubMed:10833460}.
• Sequence:

  MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENP
  FREKKFFCAIL

• Sequence length: 71

Pathways

KEGG:

Ras signaling pathway
Chemokine signaling pathway
Hormone signaling
PI3K-Akt signaling pathway
Apelin signaling pathway
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Relaxin signaling pathway
Morphine addiction
Alcoholism
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer

Reactome:

Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits