Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	54206
Gene name Gene Name - the full gene name approved by the HGNC.	ERBB receptor feedback inhibitor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ERRFI1
Synonyms (NCBI Gene) Gene synonyms aliases	GENE-33, MIG-6, MIG6, RALT
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.23
Summary Summary of gene provided in NCBI Entrez Gene.	ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling

Show/Hide all(327)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006520	hsa-miR-200c-3p	Luciferase reporter assay	19671845
MIRT006520	hsa-miR-200c-3p	Luciferase reporter assay	19671845
MIRT006520	hsa-miR-200c-3p	Luciferase reporter assay	19671845
MIRT006520	hsa-miR-200c-3p	Luciferase reporter assay	19671845
MIRT006520	hsa-miR-200c-3p	Luciferase reporter assay	19671845
MIRT006520	hsa-miR-200c-3p	Luciferase reporter assay	19671845
MIRT016297	hsa-miR-193b-3p	Microarray	20304954
MIRT050678	hsa-miR-18a-5p	CLASH	23622248
MIRT043883	hsa-miR-378a-3p	CLASH	23622248
MIRT038059	hsa-miR-423-5p	CLASH	23622248
MIRT438088	hsa-miR-148a-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	24425048
MIRT438088	hsa-miR-148a-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	24425048
MIRT438088	hsa-miR-148a-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	24425048
MIRT438088	hsa-miR-148a-3p	Immunoblot, Luciferase reporter assay, qRT-PCR	24425048
MIRT544041	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT544040	hsa-miR-4678	PAR-CLIP	21572407
MIRT079652	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544039	hsa-miR-586	PAR-CLIP	21572407
MIRT544038	hsa-miR-4495	PAR-CLIP	21572407
MIRT544037	hsa-miR-379-3p	PAR-CLIP	21572407
MIRT544036	hsa-miR-411-3p	PAR-CLIP	21572407
MIRT544035	hsa-miR-380-3p	PAR-CLIP	21572407
MIRT544034	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT544033	hsa-miR-331-5p	PAR-CLIP	21572407
MIRT079650	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544032	hsa-miR-448	PAR-CLIP	21572407
MIRT544031	hsa-miR-675-3p	PAR-CLIP	21572407
MIRT544030	hsa-miR-6083	PAR-CLIP	21572407
MIRT024124	hsa-miR-200b-3p	PAR-CLIP	26701625
MIRT006520	hsa-miR-200c-3p	PAR-CLIP	26701625
MIRT016633	hsa-miR-429	PAR-CLIP	26701625
MIRT544041	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT544040	hsa-miR-4678	PAR-CLIP	21572407
MIRT079652	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT544039	hsa-miR-586	PAR-CLIP	21572407
MIRT544038	hsa-miR-4495	PAR-CLIP	21572407
MIRT544037	hsa-miR-379-3p	PAR-CLIP	21572407
MIRT544036	hsa-miR-411-3p	PAR-CLIP	21572407
MIRT544035	hsa-miR-380-3p	PAR-CLIP	21572407
MIRT544034	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT544033	hsa-miR-331-5p	PAR-CLIP	21572407
MIRT079650	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544032	hsa-miR-448	PAR-CLIP	21572407
MIRT544031	hsa-miR-675-3p	PAR-CLIP	21572407
MIRT544030	hsa-miR-6083	PAR-CLIP	21572407
MIRT969911	hsa-miR-1178	CLIP-seq
MIRT969912	hsa-miR-1183	CLIP-seq
MIRT969913	hsa-miR-1184	CLIP-seq
MIRT969914	hsa-miR-1236	CLIP-seq
MIRT969915	hsa-miR-125a-3p	CLIP-seq
MIRT969916	hsa-miR-1265	CLIP-seq
MIRT969917	hsa-miR-1290	CLIP-seq
MIRT969918	hsa-miR-1299	CLIP-seq
MIRT969919	hsa-miR-1301	CLIP-seq
MIRT969920	hsa-miR-1305	CLIP-seq
MIRT969921	hsa-miR-1324	CLIP-seq
MIRT969922	hsa-miR-141	CLIP-seq
MIRT969923	hsa-miR-148a	CLIP-seq
MIRT969924	hsa-miR-148b	CLIP-seq
MIRT969925	hsa-miR-152	CLIP-seq
MIRT969926	hsa-miR-200a	CLIP-seq
MIRT969927	hsa-miR-200b	CLIP-seq
MIRT969928	hsa-miR-200c	CLIP-seq
MIRT969929	hsa-miR-205	CLIP-seq
MIRT969930	hsa-miR-214	CLIP-seq
MIRT969931	hsa-miR-218	CLIP-seq
MIRT969932	hsa-miR-2355-3p	CLIP-seq
MIRT969933	hsa-miR-297	CLIP-seq
MIRT969934	hsa-miR-298	CLIP-seq
MIRT969935	hsa-miR-302f	CLIP-seq
MIRT969936	hsa-miR-30a	CLIP-seq
MIRT969937	hsa-miR-30b	CLIP-seq
MIRT969938	hsa-miR-30c	CLIP-seq
MIRT969939	hsa-miR-30d	CLIP-seq
MIRT969940	hsa-miR-30e	CLIP-seq
MIRT969941	hsa-miR-3115	CLIP-seq
MIRT969942	hsa-miR-3121-5p	CLIP-seq
MIRT969943	hsa-miR-3129-3p	CLIP-seq
MIRT969944	hsa-miR-3130-3p	CLIP-seq
MIRT969945	hsa-miR-3144-3p	CLIP-seq
MIRT969946	hsa-miR-3149	CLIP-seq
MIRT969947	hsa-miR-3163	CLIP-seq
MIRT969948	hsa-miR-3168	CLIP-seq
MIRT969949	hsa-miR-3174	CLIP-seq
MIRT969950	hsa-miR-3182	CLIP-seq
MIRT969951	hsa-miR-3200-5p	CLIP-seq
MIRT969952	hsa-miR-3202	CLIP-seq
MIRT969953	hsa-miR-323b-3p	CLIP-seq
MIRT969954	hsa-miR-330-3p	CLIP-seq
MIRT969955	hsa-miR-338-5p	CLIP-seq
MIRT969956	hsa-miR-3606	CLIP-seq
MIRT969957	hsa-miR-3607-3p	CLIP-seq
MIRT969958	hsa-miR-3613-5p	CLIP-seq
MIRT969959	hsa-miR-3619-5p	CLIP-seq
MIRT969960	hsa-miR-3646	CLIP-seq
MIRT969961	hsa-miR-3662	CLIP-seq
MIRT969962	hsa-miR-3663-3p	CLIP-seq
MIRT969963	hsa-miR-3671	CLIP-seq
MIRT969964	hsa-miR-3675-3p	CLIP-seq
MIRT969965	hsa-miR-3692	CLIP-seq
MIRT969966	hsa-miR-374c	CLIP-seq
MIRT969967	hsa-miR-3913-3p	CLIP-seq
MIRT969968	hsa-miR-3925-3p	CLIP-seq
MIRT969969	hsa-miR-3925-5p	CLIP-seq
MIRT969970	hsa-miR-3977	CLIP-seq
MIRT969971	hsa-miR-4267	CLIP-seq
MIRT969972	hsa-miR-4286	CLIP-seq
MIRT969973	hsa-miR-4291	CLIP-seq
MIRT969974	hsa-miR-4307	CLIP-seq
MIRT969975	hsa-miR-4325	CLIP-seq
MIRT969976	hsa-miR-4436a	CLIP-seq
MIRT969977	hsa-miR-4475	CLIP-seq
MIRT969978	hsa-miR-4477a	CLIP-seq
MIRT969979	hsa-miR-4501	CLIP-seq
MIRT969980	hsa-miR-4503	CLIP-seq
MIRT969981	hsa-miR-4504	CLIP-seq
MIRT969982	hsa-miR-450b-5p	CLIP-seq
MIRT969983	hsa-miR-4521	CLIP-seq
MIRT969984	hsa-miR-4528	CLIP-seq
MIRT969985	hsa-miR-4533	CLIP-seq
MIRT969986	hsa-miR-4643	CLIP-seq
MIRT969987	hsa-miR-4646-3p	CLIP-seq
MIRT969988	hsa-miR-466	CLIP-seq
MIRT969989	hsa-miR-4660	CLIP-seq
MIRT969990	hsa-miR-4668-3p	CLIP-seq
MIRT969991	hsa-miR-4677-3p	CLIP-seq
MIRT969992	hsa-miR-4680-3p	CLIP-seq
MIRT969993	hsa-miR-4682	CLIP-seq
MIRT969994	hsa-miR-4691-3p	CLIP-seq
MIRT969995	hsa-miR-4693-3p	CLIP-seq
MIRT969996	hsa-miR-4705	CLIP-seq
MIRT969997	hsa-miR-4728-3p	CLIP-seq
MIRT969998	hsa-miR-4729	CLIP-seq
MIRT969999	hsa-miR-4753-3p	CLIP-seq
MIRT970000	hsa-miR-4762-3p	CLIP-seq
MIRT970001	hsa-miR-4764-5p	CLIP-seq
MIRT970002	hsa-miR-4768-5p	CLIP-seq
MIRT970003	hsa-miR-4778-3p	CLIP-seq
MIRT970004	hsa-miR-4778-5p	CLIP-seq
MIRT970005	hsa-miR-4789-3p	CLIP-seq
MIRT970006	hsa-miR-4793-3p	CLIP-seq
MIRT970007	hsa-miR-4795-3p	CLIP-seq
MIRT970008	hsa-miR-4802-3p	CLIP-seq
MIRT970009	hsa-miR-485-3p	CLIP-seq
MIRT970010	hsa-miR-489	CLIP-seq
MIRT970011	hsa-miR-490-3p	CLIP-seq
MIRT970012	hsa-miR-498	CLIP-seq
MIRT970013	hsa-miR-500a	CLIP-seq
MIRT970014	hsa-miR-501-5p	CLIP-seq
MIRT970015	hsa-miR-5047	CLIP-seq
MIRT970016	hsa-miR-507	CLIP-seq
MIRT970017	hsa-miR-515-5p	CLIP-seq
MIRT970018	hsa-miR-542-3p	CLIP-seq
MIRT970019	hsa-miR-548a-3p	CLIP-seq
MIRT970020	hsa-miR-548e	CLIP-seq
MIRT970021	hsa-miR-548f	CLIP-seq
MIRT970022	hsa-miR-548g	CLIP-seq
MIRT970023	hsa-miR-552	CLIP-seq
MIRT970024	hsa-miR-557	CLIP-seq
MIRT970025	hsa-miR-567	CLIP-seq
MIRT970026	hsa-miR-576-3p	CLIP-seq
MIRT970027	hsa-miR-577	CLIP-seq
MIRT970028	hsa-miR-579	CLIP-seq
MIRT970029	hsa-miR-581	CLIP-seq
MIRT970030	hsa-miR-584	CLIP-seq
MIRT970031	hsa-miR-587	CLIP-seq
MIRT970032	hsa-miR-601	CLIP-seq
MIRT970033	hsa-miR-607	CLIP-seq
MIRT970034	hsa-miR-610	CLIP-seq
MIRT970035	hsa-miR-622	CLIP-seq
MIRT970036	hsa-miR-627	CLIP-seq
MIRT970037	hsa-miR-636	CLIP-seq
MIRT970038	hsa-miR-649	CLIP-seq
MIRT970039	hsa-miR-655	CLIP-seq
MIRT970040	hsa-miR-656	CLIP-seq
MIRT970041	hsa-miR-761	CLIP-seq
MIRT970042	hsa-miR-766	CLIP-seq
MIRT970043	hsa-miR-802	CLIP-seq
MIRT970044	hsa-miR-875-3p	CLIP-seq
MIRT970045	hsa-miR-921	CLIP-seq
MIRT970046	hsa-miR-922	CLIP-seq
MIRT970047	hsa-miR-924	CLIP-seq
MIRT970048	hsa-miR-942	CLIP-seq
MIRT969920	hsa-miR-1305	CLIP-seq
MIRT969934	hsa-miR-298	CLIP-seq
MIRT1548436	hsa-miR-3148	CLIP-seq
MIRT969986	hsa-miR-4643	CLIP-seq
MIRT969988	hsa-miR-466	CLIP-seq
MIRT970005	hsa-miR-4789-3p	CLIP-seq
MIRT969912	hsa-miR-1183	CLIP-seq
MIRT969914	hsa-miR-1236	CLIP-seq
MIRT1987501	hsa-miR-1293	CLIP-seq
MIRT969923	hsa-miR-148a	CLIP-seq
MIRT969924	hsa-miR-148b	CLIP-seq
MIRT969925	hsa-miR-152	CLIP-seq
MIRT969927	hsa-miR-200b	CLIP-seq
MIRT969928	hsa-miR-200c	CLIP-seq
MIRT969931	hsa-miR-218	CLIP-seq
MIRT969934	hsa-miR-298	CLIP-seq
MIRT969941	hsa-miR-3115	CLIP-seq
MIRT969945	hsa-miR-3144-3p	CLIP-seq
MIRT969948	hsa-miR-3168	CLIP-seq
MIRT969950	hsa-miR-3182	CLIP-seq
MIRT969951	hsa-miR-3200-5p	CLIP-seq
MIRT1987502	hsa-miR-3647-3p	CLIP-seq
MIRT1987503	hsa-miR-3649	CLIP-seq
MIRT969964	hsa-miR-3675-3p	CLIP-seq
MIRT969965	hsa-miR-3692	CLIP-seq
MIRT1987504	hsa-miR-4276	CLIP-seq
MIRT969972	hsa-miR-4286	CLIP-seq
MIRT969974	hsa-miR-4307	CLIP-seq
MIRT1987505	hsa-miR-4310	CLIP-seq
MIRT969977	hsa-miR-4475	CLIP-seq
MIRT1987506	hsa-miR-4483	CLIP-seq
MIRT969980	hsa-miR-4503	CLIP-seq
MIRT1987507	hsa-miR-4648	CLIP-seq
MIRT1987508	hsa-miR-4668-5p	CLIP-seq
MIRT969993	hsa-miR-4682	CLIP-seq
MIRT969999	hsa-miR-4753-3p	CLIP-seq
MIRT1987509	hsa-miR-495	CLIP-seq
MIRT1987510	hsa-miR-556-5p	CLIP-seq
MIRT970027	hsa-miR-577	CLIP-seq
MIRT970030	hsa-miR-584	CLIP-seq
MIRT970031	hsa-miR-587	CLIP-seq
MIRT970034	hsa-miR-610	CLIP-seq
MIRT970036	hsa-miR-627	CLIP-seq
MIRT970037	hsa-miR-636	CLIP-seq
MIRT1987511	hsa-miR-873	CLIP-seq
MIRT970047	hsa-miR-924	CLIP-seq
MIRT970048	hsa-miR-942	CLIP-seq
MIRT2221911	hsa-miR-10a	CLIP-seq
MIRT2221912	hsa-miR-10b	CLIP-seq
MIRT969911	hsa-miR-1178	CLIP-seq
MIRT969912	hsa-miR-1183	CLIP-seq
MIRT969923	hsa-miR-148a	CLIP-seq
MIRT969924	hsa-miR-148b	CLIP-seq
MIRT969925	hsa-miR-152	CLIP-seq
MIRT969927	hsa-miR-200b	CLIP-seq
MIRT969928	hsa-miR-200c	CLIP-seq
MIRT2221913	hsa-miR-217	CLIP-seq
MIRT969932	hsa-miR-2355-3p	CLIP-seq
MIRT969934	hsa-miR-298	CLIP-seq
MIRT969942	hsa-miR-3121-5p	CLIP-seq
MIRT969947	hsa-miR-3163	CLIP-seq
MIRT969951	hsa-miR-3200-5p	CLIP-seq
MIRT969953	hsa-miR-323b-3p	CLIP-seq
MIRT969960	hsa-miR-3646	CLIP-seq
MIRT969961	hsa-miR-3662	CLIP-seq
MIRT969965	hsa-miR-3692	CLIP-seq
MIRT969972	hsa-miR-4286	CLIP-seq
MIRT969974	hsa-miR-4307	CLIP-seq
MIRT1987505	hsa-miR-4310	CLIP-seq
MIRT969976	hsa-miR-4436a	CLIP-seq
MIRT969986	hsa-miR-4643	CLIP-seq
MIRT969987	hsa-miR-4646-3p	CLIP-seq
MIRT969988	hsa-miR-466	CLIP-seq
MIRT969990	hsa-miR-4668-3p	CLIP-seq
MIRT969991	hsa-miR-4677-3p	CLIP-seq
MIRT969993	hsa-miR-4682	CLIP-seq
MIRT969994	hsa-miR-4691-3p	CLIP-seq
MIRT969995	hsa-miR-4693-3p	CLIP-seq
MIRT2221914	hsa-miR-4698	CLIP-seq
MIRT2221915	hsa-miR-4711-3p	CLIP-seq
MIRT970003	hsa-miR-4778-3p	CLIP-seq
MIRT970005	hsa-miR-4789-3p	CLIP-seq
MIRT1987509	hsa-miR-495	CLIP-seq
MIRT970013	hsa-miR-500a	CLIP-seq
MIRT970014	hsa-miR-501-5p	CLIP-seq
MIRT970031	hsa-miR-587	CLIP-seq
MIRT970035	hsa-miR-622	CLIP-seq
MIRT970036	hsa-miR-627	CLIP-seq
MIRT970047	hsa-miR-924	CLIP-seq
MIRT969912	hsa-miR-1183	CLIP-seq
MIRT969914	hsa-miR-1236	CLIP-seq
MIRT1987501	hsa-miR-1293	CLIP-seq
MIRT969927	hsa-miR-200b	CLIP-seq
MIRT969928	hsa-miR-200c	CLIP-seq
MIRT969949	hsa-miR-3174	CLIP-seq
MIRT969951	hsa-miR-3200-5p	CLIP-seq
MIRT2387536	hsa-miR-3591-3p	CLIP-seq
MIRT969956	hsa-miR-3606	CLIP-seq
MIRT2387537	hsa-miR-3610	CLIP-seq
MIRT1987502	hsa-miR-3647-3p	CLIP-seq
MIRT1987503	hsa-miR-3649	CLIP-seq
MIRT969968	hsa-miR-3925-3p	CLIP-seq
MIRT969971	hsa-miR-4267	CLIP-seq
MIRT1987504	hsa-miR-4276	CLIP-seq
MIRT969972	hsa-miR-4286	CLIP-seq
MIRT969976	hsa-miR-4436a	CLIP-seq
MIRT1987506	hsa-miR-4483	CLIP-seq
MIRT1987507	hsa-miR-4648	CLIP-seq
MIRT969993	hsa-miR-4682	CLIP-seq
MIRT970007	hsa-miR-4795-3p	CLIP-seq
MIRT970017	hsa-miR-515-5p	CLIP-seq
MIRT970031	hsa-miR-587	CLIP-seq
MIRT970034	hsa-miR-610	CLIP-seq
MIRT970036	hsa-miR-627	CLIP-seq
MIRT970042	hsa-miR-766	CLIP-seq
MIRT1987511	hsa-miR-873	CLIP-seq
MIRT970045	hsa-miR-921	CLIP-seq
MIRT970047	hsa-miR-924	CLIP-seq
MIRT969951	hsa-miR-3200-5p	CLIP-seq
MIRT969972	hsa-miR-4286	CLIP-seq
MIRT969993	hsa-miR-4682	CLIP-seq
MIRT970031	hsa-miR-587	CLIP-seq
MIRT970036	hsa-miR-627	CLIP-seq
MIRT970047	hsa-miR-924	CLIP-seq
MIRT1987501	hsa-miR-1293	CLIP-seq
MIRT969951	hsa-miR-3200-5p	CLIP-seq
MIRT1987503	hsa-miR-3649	CLIP-seq
MIRT1987504	hsa-miR-4276	CLIP-seq
MIRT969972	hsa-miR-4286	CLIP-seq
MIRT1987506	hsa-miR-4483	CLIP-seq
MIRT1987507	hsa-miR-4648	CLIP-seq
MIRT969993	hsa-miR-4682	CLIP-seq
MIRT1987510	hsa-miR-556-5p	CLIP-seq
MIRT970031	hsa-miR-587	CLIP-seq
MIRT970034	hsa-miR-610	CLIP-seq
MIRT970036	hsa-miR-627	CLIP-seq
MIRT1987511	hsa-miR-873	CLIP-seq
MIRT970047	hsa-miR-924	CLIP-seq
MIRT969951	hsa-miR-3200-5p	CLIP-seq
MIRT969972	hsa-miR-4286	CLIP-seq
MIRT969993	hsa-miR-4682	CLIP-seq
MIRT970031	hsa-miR-587	CLIP-seq
MIRT970036	hsa-miR-627	CLIP-seq
MIRT970047	hsa-miR-924	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	TAS	10749885
GO:0005515	Function	Protein binding	IPI	15778465, 18046415, 18776048, 20936779, 21706016, 21988832, 22505024, 23273428, 24189400, 25640309, 28514442, 31980649, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0007175	Process	Negative regulation of epidermal growth factor-activated receptor activity	IDA	18046415
GO:0007175	Process	Negative regulation of epidermal growth factor-activated receptor activity	ISS
GO:0017124	Function	SH3 domain binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	18046415
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IBA	21873635
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	ISS
GO:0031267	Function	Small GTPase binding	IEA
GO:0031953	Process	Negative regulation of protein autophosphorylation	IDA	18046415
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0032966	Process	Negative regulation of collagen biosynthetic process	IEA
GO:0036120	Process	Cellular response to platelet-derived growth factor stimulus	IEA
GO:0042059	Process	Negative regulation of epidermal growth factor receptor signaling pathway	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0043589	Process	Skin morphogenesis	ISS
GO:0045616	Process	Regulation of keratinocyte differentiation	IBA	21873635
GO:0045616	Process	Regulation of keratinocyte differentiation	ISS
GO:0048286	Process	Lung alveolus development	ISS
GO:0060426	Process	Lung vasculature development	ISS
GO:0060428	Process	Lung epithelium development	ISS
GO:0061469	Process	Regulation of type B pancreatic cell proliferation	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IEA
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IEA
GO:0071474	Process	Cellular hyperosmotic response	IEA
GO:0071549	Process	Cellular response to dexamethasone stimulus	IEA
GO:1903243	Process	Negative regulation of cardiac muscle hypertrophy in response to stress	IEA

MIM	HGNC	e!Ensembl
608069	18185	ENSG00000116285

Protein

UniProt ID

Q9UJM3

Protein name

ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)

Protein function

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosp

PDB

2RF9 , 2RFD , 2RFE , 4I21 , 4R3P , 4R3R , 4ZJV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09027	GTPase_binding	6 → 68	GTPase binding	Domain
PF11555	Inhibitor_Mig-6	315 → 371	EGFR receptor inhibitor Mig-6	Family

Sequence

MSIAGVAAQEIRVPLKTGFLHNGRAMGNMRKTYWSSRSEFKNNFLNIDPITMAYSLNSSA
QERLIPLGHASKSAPMNGHCFAENGPSQKSSLPPLLIPPSENLGPHEEDQVVCGFKKLTV
NGVCASTPPLTPIKNSPSLFPCAPLCERGSRPLPPLPISEALSLDDTDCEVEFLTSSDTD
FLLEDSTLSDFKYDVPGRRSFRGCGQINYAYFDTPAVSAADLSYVSDQNGGVPDPNPPPP
QTHRRLRRSHSGPAGSFNKPAIRISNCCIHRASPNSDEDKPEVPPRVPIPPRPVKPDYRR
WSAEVTSSTYSDEDRPPKVPPREPLSPSNSRTPSPKSLPSYLNGVMPPTQSFAPDPKYVS
SKALQRQNSEGSASKVPCILPIIENGKKVSSTHYYLLPERPPYLDKYEKFFREAEETNGG
AQIQPLPADCGISSATEKPDSKTKMDLGGHVKRKHLSYVVSP

Sequence length

462

Interactions

View interactions

Show/Hide Unknown Diseases (10)

Disease term	Disease name	Evidence	References	Source
Unknown
Endometriosis	Endometriosis		20864642	ClinVar
Celiac disease	Celiac disease			GWAS
Ischemic Stroke	Ischemic Stroke			GWAS
Acne	Acne			GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Ulcerative colitis	Ulcerative colitis			GWAS
Psoriasis	Psoriasis			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Crohn Disease	Crohn Disease			GWAS

Show/Hide Text Mining Associations (38)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	30021798
Atherosclerosis	Associate	37699925
Breast Neoplasms	Inhibit	27341132, 33046784
Breast Neoplasms	Associate	32377505, 32432675, 35441810, 35859293
Carcinogenesis	Associate	12387890
Carcinogenesis	Inhibit	26760771, 27557663
Carcinoma Hepatocellular	Associate	17006932, 28734040, 35165519
Carcinoma Non Small Cell Lung	Associate	25400829, 37834326
Chemical and Drug Induced Liver Injury	Associate	35850069
Diabetes Mellitus	Associate	23324575, 35301888
Diabetes Mellitus Type 2	Associate	23324575, 35301888
Diabetic Nephropathies	Associate	23324575
DNA Virus Infections	Associate	30067982
Endometrial Hyperplasia	Stimulate	28516379
Endometrial Hyperplasia	Inhibit	36498921
Endometrial Neoplasms	Associate	28516379
Endometrial Neoplasms	Inhibit	36498921
Esophageal Squamous Cell Carcinoma	Inhibit	34845855
Fibrosis	Associate	35850069
Glioblastoma	Associate	21113414, 26280531
Glioma	Associate	26280531, 36231068
Hepatoblastoma	Associate	17006932
Hypercholesterolemia	Associate	35301888
Hypoxia	Stimulate	12387890
Hypoxia Brain	Stimulate	12387890
Lung Neoplasms	Associate	22701735, 28688920, 37834326, 38060494
Melanoma	Associate	22701735, 26967478
Nasopharyngeal Carcinoma	Associate	37070291
Neoplasm Metastasis	Associate	30679310
Neoplasms	Inhibit	18712736, 21113414, 22701735, 26239118, 27341132, 27557663, 28734040, 30067982, 32432675, 33046784, 35165519, 36108156
Neoplasms	Associate	24550739, 26280531, 33853673, 37748191
Neuroblastoma	Associate	36108156
Polycystic Ovary Syndrome	Associate	21411543
Prostatic Neoplasms	Associate	18712736, 22193779, 36008945
Rectal Neoplasms	Associate	29801473
Sleep Apnea Obstructive	Associate	37699925
Squamous Cell Carcinoma of Head and Neck	Associate	36007290
Triple Negative Breast Neoplasms	Associate	32377505, 32432675

ERRFI1 (ERBB receptor feedback inhibitor 1)