Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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54165
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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Defective in cullin neddylation 1 domain containing 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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DCUN1D1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3 |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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RP42 |
Chromosome
Chromosome number
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3 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q26.33 |
UniProt ID |
Q96GG9
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Protein name |
DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) |
Protein function |
Part of an E3 ubiquitin ligase complex for neddylation (PubMed:18826954). Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes (PubMed:19617556, PubMed:23201271, PubMed:23401859, PubMed:26906416). Acts by bindin |
PDB |
3TDU
,
3TDZ
,
4P5O
,
5UFI
,
5V83
,
5V86
,
5V88
,
6B5Q
,
6BG3
,
6BG5
,
6P5V
,
6P5W
,
6XOL
,
6XOM
,
6XON
,
6XOO
,
6XOP
,
6XOQ
,
7KWA
,
8OR2
,
8OR3
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF14555
|
UBA_4 |
9 → 50 |
|
Domain |
PF03556
|
Cullin_binding |
136 → 246 |
Cullin binding |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carci |
Sequence |
|
Sequence length |
259 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Parkinson disease |
Parkinson Disease |
rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121918104, rs1589451049, rs104893877, rs104893878, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106 View all (84 more) |
21738487 |
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