TRIM34 (tripartite motif containing 34)

Gene

• Entrez ID: 53840
• Gene name: Tripartite motif containing 34
• Gene symbol: TRIM34
• Synonyms (NCBI Gene): IFP1, RNF21
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by inte

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1454268	hsa-miR-1293	CLIP-seq
MIRT1454269	hsa-miR-337-3p	CLIP-seq
MIRT1454270	hsa-miR-4483	CLIP-seq
MIRT1454271	hsa-miR-4651	CLIP-seq
MIRT1454272	hsa-miR-608	CLIP-seq
MIRT1454273	hsa-miR-876-3p	CLIP-seq
MIRT2357121	hsa-miR-433	CLIP-seq
MIRT2357122	hsa-miR-548l	CLIP-seq
MIRT2357123	hsa-miR-664	CLIP-seq
MIRT2650735	hsa-miR-1193	CLIP-seq
MIRT2650736	hsa-miR-1265	CLIP-seq
MIRT1454268	hsa-miR-1293	CLIP-seq
MIRT2650737	hsa-miR-196a	CLIP-seq
MIRT2650738	hsa-miR-196b	CLIP-seq
MIRT2650739	hsa-miR-2861	CLIP-seq
MIRT2650740	hsa-miR-3074-3p	CLIP-seq
MIRT2650741	hsa-miR-3144-3p	CLIP-seq
MIRT2650742	hsa-miR-323-5p	CLIP-seq
MIRT1454269	hsa-miR-337-3p	CLIP-seq
MIRT2650743	hsa-miR-3927	CLIP-seq
MIRT2650744	hsa-miR-4438	CLIP-seq
MIRT1454270	hsa-miR-4483	CLIP-seq
MIRT1454271	hsa-miR-4651	CLIP-seq
MIRT2650745	hsa-miR-4757-5p	CLIP-seq
MIRT2650746	hsa-miR-4781-3p	CLIP-seq
MIRT2650747	hsa-miR-490-5p	CLIP-seq
MIRT2650748	hsa-miR-548b-3p	CLIP-seq
MIRT1454272	hsa-miR-608	CLIP-seq
MIRT2650749	hsa-miR-660	CLIP-seq
MIRT1454273	hsa-miR-876-3p	CLIP-seq
MIRT2650735	hsa-miR-1193	CLIP-seq
MIRT2650736	hsa-miR-1265	CLIP-seq
MIRT1454268	hsa-miR-1293	CLIP-seq
MIRT2650737	hsa-miR-196a	CLIP-seq
MIRT2650738	hsa-miR-196b	CLIP-seq
MIRT2650739	hsa-miR-2861	CLIP-seq
MIRT2650740	hsa-miR-3074-3p	CLIP-seq
MIRT2650741	hsa-miR-3144-3p	CLIP-seq
MIRT2650742	hsa-miR-323-5p	CLIP-seq
MIRT1454269	hsa-miR-337-3p	CLIP-seq
MIRT2650743	hsa-miR-3927	CLIP-seq
MIRT2694168	hsa-miR-4276	CLIP-seq
MIRT2650744	hsa-miR-4438	CLIP-seq
MIRT1454270	hsa-miR-4483	CLIP-seq
MIRT1454271	hsa-miR-4651	CLIP-seq
MIRT2650745	hsa-miR-4757-5p	CLIP-seq
MIRT2650746	hsa-miR-4781-3p	CLIP-seq
MIRT2650747	hsa-miR-490-5p	CLIP-seq
MIRT2650748	hsa-miR-548b-3p	CLIP-seq
MIRT1454272	hsa-miR-608	CLIP-seq
MIRT2650749	hsa-miR-660	CLIP-seq
MIRT1454273	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	17156811
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	17156811
GO:0045087	Process	Innate immune response	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0080090	Process	Regulation of primary metabolic process	IEA

Other IDs

• MIM: 605684
• HGNC: 10063
• e!Ensembl: ENSG00000258659

Protein

• UniProt ID: Q9BYJ4
• Protein name: E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21)
• Protein function: Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retr
• PDB: 2EGP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15227	zf-C3HC4_4	15 → 59		Domain
  PF00643	zf-B_box	92 → 133	B-box zinc finger	Domain
  PF00622	SPRY	348 → 483	SPRY domain	Family

• Tissue specificity: TISSUE SPECIFICITY: [Isoform 1]: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:11013086}.
• Sequence:

  MASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCG
  ISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCE
  RSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTER
  QRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECR
  SQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRCYW
  VDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYNYGVLGSQYFSSGKHYWEVDVSKKTA
  WILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPE
  VLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPWNCPAP
  MTLCPPSS

• Sequence length: 488

Pathways

Reactome:

Interferon gamma signaling