TRIM34 (tripartite motif containing 34)

Gene

• Entrez ID: 53840
• Gene name: Tripartite motif containing 34
• Gene symbol: TRIM34
• Synonyms (NCBI Gene): IFP1, RNF21
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by inte

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1454268	hsa-miR-1293	CLIP-seq
MIRT1454269	hsa-miR-337-3p	CLIP-seq
MIRT1454270	hsa-miR-4483	CLIP-seq
MIRT1454271	hsa-miR-4651	CLIP-seq
MIRT1454272	hsa-miR-608	CLIP-seq
MIRT1454273	hsa-miR-876-3p	CLIP-seq
MIRT2357121	hsa-miR-433	CLIP-seq
MIRT2357122	hsa-miR-548l	CLIP-seq
MIRT2357123	hsa-miR-664	CLIP-seq
MIRT2650735	hsa-miR-1193	CLIP-seq
MIRT2650736	hsa-miR-1265	CLIP-seq
MIRT1454268	hsa-miR-1293	CLIP-seq
MIRT2650737	hsa-miR-196a	CLIP-seq
MIRT2650738	hsa-miR-196b	CLIP-seq
MIRT2650739	hsa-miR-2861	CLIP-seq
MIRT2650740	hsa-miR-3074-3p	CLIP-seq
MIRT2650741	hsa-miR-3144-3p	CLIP-seq
MIRT2650742	hsa-miR-323-5p	CLIP-seq
MIRT1454269	hsa-miR-337-3p	CLIP-seq
MIRT2650743	hsa-miR-3927	CLIP-seq
MIRT2650744	hsa-miR-4438	CLIP-seq
MIRT1454270	hsa-miR-4483	CLIP-seq
MIRT1454271	hsa-miR-4651	CLIP-seq
MIRT2650745	hsa-miR-4757-5p	CLIP-seq
MIRT2650746	hsa-miR-4781-3p	CLIP-seq
MIRT2650747	hsa-miR-490-5p	CLIP-seq
MIRT2650748	hsa-miR-548b-3p	CLIP-seq
MIRT1454272	hsa-miR-608	CLIP-seq
MIRT2650749	hsa-miR-660	CLIP-seq
MIRT1454273	hsa-miR-876-3p	CLIP-seq
MIRT2650735	hsa-miR-1193	CLIP-seq
MIRT2650736	hsa-miR-1265	CLIP-seq
MIRT1454268	hsa-miR-1293	CLIP-seq
MIRT2650737	hsa-miR-196a	CLIP-seq
MIRT2650738	hsa-miR-196b	CLIP-seq
MIRT2650739	hsa-miR-2861	CLIP-seq
MIRT2650740	hsa-miR-3074-3p	CLIP-seq
MIRT2650741	hsa-miR-3144-3p	CLIP-seq
MIRT2650742	hsa-miR-323-5p	CLIP-seq
MIRT1454269	hsa-miR-337-3p	CLIP-seq
MIRT2650743	hsa-miR-3927	CLIP-seq
MIRT2694168	hsa-miR-4276	CLIP-seq
MIRT2650744	hsa-miR-4438	CLIP-seq
MIRT1454270	hsa-miR-4483	CLIP-seq
MIRT1454271	hsa-miR-4651	CLIP-seq
MIRT2650745	hsa-miR-4757-5p	CLIP-seq
MIRT2650746	hsa-miR-4781-3p	CLIP-seq
MIRT2650747	hsa-miR-490-5p	CLIP-seq
MIRT2650748	hsa-miR-548b-3p	CLIP-seq
MIRT1454272	hsa-miR-608	CLIP-seq
MIRT2650749	hsa-miR-660	CLIP-seq
MIRT1454273	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA	21873635
GO:0003674	Function	Molecular_function	ND
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	17156811
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA	21873635
GO:0010508	Process	Positive regulation of autophagy	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0032880	Process	Regulation of protein localization	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	17156811
GO:0042803	Function	Protein homodimerization activity	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0046596	Process	Regulation of viral entry into host cell	IBA	21873635
GO:0051091	Process	Positive regulation of DNA-binding transcription factor activity	IDA	23077300
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IBA	21873635
GO:0051607	Process	Defense response to virus	IEA
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635

Other IDs

• MIM: 605684
• HGNC: 10063
• e!Ensembl: ENSG00000258659

Protein

• UniProt ID: Q9BYJ4
• Protein name: E3 ubiquitin-protein ligase TRIM34 (EC 2.3.2.27) (Interferon-responsive finger protein 1) (RING finger protein 21)
• Protein function: Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retr
• PDB: 2EGP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15227	zf-C3HC4_4	15 → 59		Domain
  PF00643	zf-B_box	92 → 133	B-box zinc finger	Domain
  PF00622	SPRY	348 → 483	SPRY domain	Family

• Tissue specificity: TISSUE SPECIFICITY: [Isoform 1]: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:11013086}.
• Sequence:

  MASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCG
  ISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCE
  RSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTER
  QRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECR
  SQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRCYW
  VDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYNYGVLGSQYFSSGKHYWEVDVSKKTA
  WILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPE
  VLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPWNCPAP
  MTLCPPSS

• Sequence length: 488

Pathways

Reactome:

Interferon gamma signaling

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Unknown
Disease term	Disease name	Evidence	References	Source
Coronary artery disease	Coronary artery disease			GWAS