Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
53836
Gene name Gene Name - the full gene name approved by the HGNC.
G protein-coupled receptor 87
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GPR87
Synonyms (NCBI Gene) Gene synonyms aliases
FKSG78, GPR95, KPG_002
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMI
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018778 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane IEA
GO:0007186 Process G protein-coupled receptor signaling pathway IBA 21873635
GO:0007194 Process Negative regulation of adenylate cyclase activity IEA
GO:0008150 Process Biological_process ND
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606379 4538 ENSG00000138271
Protein
UniProt ID Q9BY21
Protein name G-protein coupled receptor 87 (G-protein coupled receptor 95)
Protein function Receptor for lysophosphatidic acid (LPA) (PubMed:17905198). Necessary for p53/TP53-dependent survival in response to DNA damage (PubMed:19602589). Promotes the Hippo-YAP signaling pathway and thereby modulates glycolysis and oxidative stress pro
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 59 314 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung. {ECO:0000269|PubMed:17905198}.
Sequence
Sequence length 358
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 23593389
Carcinoma Squamous Cell Associate 18057535
Idiopathic Pulmonary Fibrosis Associate 36622818
Lung Neoplasms Associate 27694942
Melanoma Associate 34659201
Neoplasm Metastasis Associate 23593389, 34290570
Neoplasms Associate 19602589, 23593389, 23752273, 29238192
Osteoporosis Associate 30569177
Pancreatic Neoplasms Associate 34290570
Squamous Cell Carcinoma of Head and Neck Associate 33628816