PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5366 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Phorbol-12-myristate-13-acetate-induced protein 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PMAIP1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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APR, NOXA |
Chromosome
Chromosome number
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18 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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18q21.32 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members i |
miRNA
miRNA information provided by mirtarbase database.
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Transcription factors | |||||||||||||||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q13794 | ||||||||||
Protein name | Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa) | ||||||||||
Protein function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradati | ||||||||||
PDB | 3MQP | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Highly expressed in adult T-cell leukemia cell line. | ||||||||||
Sequence |
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Sequence length | 54 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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