Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5366
Gene name Gene Name - the full gene name approved by the HGNC.
Phorbol-12-myristate-13-acetate-induced protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PMAIP1
Synonyms (NCBI Gene) Gene synonyms aliases
APR, NOXA
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members i
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007018 hsa-miR-200c-3p 5.0 22615771
MIRT021168 hsa-miR-186-5p Sequencing 20371350
MIRT027675 hsa-miR-98-5p Microarray 19088304
MIRT029656 hsa-miR-26b-5p Sequencing 20371350
MIRT045943 hsa-miR-125b-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
ATM Repression 20368352
ESR1 Activation 22216287
KLF6 Activation 22718761
KLF9 Repression 22144178
MYC Activation 22216287
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001836 Process Release of cytochrome c from mitochondria IEA
GO:0001844 Process Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
GO:0005515 Function Protein binding IPI 15705586, 15901672, 20085765, 21132008, 21145489, 21454712
GO:0005634 Component Nucleus IDA 12879012
GO:0005739 Component Mitochondrion IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604959 9108 ENSG00000141682
Protein
UniProt ID Q13794
Protein name Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
Protein function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradati
PDB 3MQP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15150 PMAIP1 1 54 Phorbol-12-myristate-13-acetate-induced Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in adult T-cell leukemia cell line.
Sequence
Sequence length 54
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Platinum drug resistance
p53 signaling pathway
Apoptosis
Apoptosis - multiple species
Pathways in cancer
Viral carcinogenesis
Colorectal cancer
  Activation of NOXA and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release