Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5360
Gene name	Phospholipid transfer protein
Gene symbol	PLTP
Synonyms (NCBI Gene)	BPIFEHDLCQ9
Chromosome	20
Chromosome location	20q13.12
Summary	The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017519	hsa-miR-335-5p	Microarray	18185580
MIRT2456715	hsa-miR-1225-5p	CLIP-seq
MIRT2456716	hsa-miR-1321	CLIP-seq
MIRT2456717	hsa-miR-184	CLIP-seq
MIRT2456718	hsa-miR-1915	CLIP-seq
MIRT2456719	hsa-miR-3165	CLIP-seq
MIRT2456720	hsa-miR-3664-3p	CLIP-seq
MIRT2456721	hsa-miR-3670	CLIP-seq
MIRT2456722	hsa-miR-3688-3p	CLIP-seq
MIRT2456723	hsa-miR-3689d	CLIP-seq
MIRT2456724	hsa-miR-3914	CLIP-seq
MIRT2456725	hsa-miR-4270	CLIP-seq
MIRT2456726	hsa-miR-4436a	CLIP-seq
MIRT2456727	hsa-miR-4441	CLIP-seq
MIRT2456728	hsa-miR-4690-3p	CLIP-seq
MIRT2456729	hsa-miR-4726-3p	CLIP-seq
MIRT2456730	hsa-miR-4739	CLIP-seq
MIRT2456731	hsa-miR-4756-5p	CLIP-seq
MIRT2456732	hsa-miR-4804-5p	CLIP-seq
MIRT2456733	hsa-miR-873	CLIP-seq
MIRT2456715	hsa-miR-1225-5p	CLIP-seq
MIRT2456716	hsa-miR-1321	CLIP-seq
MIRT2456717	hsa-miR-184	CLIP-seq
MIRT2456718	hsa-miR-1915	CLIP-seq
MIRT2456719	hsa-miR-3165	CLIP-seq
MIRT2456720	hsa-miR-3664-3p	CLIP-seq
MIRT2456721	hsa-miR-3670	CLIP-seq
MIRT2456722	hsa-miR-3688-3p	CLIP-seq
MIRT2456723	hsa-miR-3689d	CLIP-seq
MIRT2456724	hsa-miR-3914	CLIP-seq
MIRT2456725	hsa-miR-4270	CLIP-seq
MIRT2456726	hsa-miR-4436a	CLIP-seq
MIRT2456727	hsa-miR-4441	CLIP-seq
MIRT2456728	hsa-miR-4690-3p	CLIP-seq
MIRT2456729	hsa-miR-4726-3p	CLIP-seq
MIRT2456730	hsa-miR-4739	CLIP-seq
MIRT2456731	hsa-miR-4756-5p	CLIP-seq
MIRT2456732	hsa-miR-4804-5p	CLIP-seq
MIRT2456733	hsa-miR-873	CLIP-seq
MIRT2456715	hsa-miR-1225-5p	CLIP-seq
MIRT2456716	hsa-miR-1321	CLIP-seq
MIRT2456717	hsa-miR-184	CLIP-seq
MIRT2456718	hsa-miR-1915	CLIP-seq
MIRT2456719	hsa-miR-3165	CLIP-seq
MIRT2456720	hsa-miR-3664-3p	CLIP-seq
MIRT2456721	hsa-miR-3670	CLIP-seq
MIRT2595925	hsa-miR-3671	CLIP-seq
MIRT2456722	hsa-miR-3688-3p	CLIP-seq
MIRT2456723	hsa-miR-3689d	CLIP-seq
MIRT2456724	hsa-miR-3914	CLIP-seq
MIRT2456725	hsa-miR-4270	CLIP-seq
MIRT2456726	hsa-miR-4436a	CLIP-seq
MIRT2595926	hsa-miR-4438	CLIP-seq
MIRT2456727	hsa-miR-4441	CLIP-seq
MIRT2456728	hsa-miR-4690-3p	CLIP-seq
MIRT2456729	hsa-miR-4726-3p	CLIP-seq
MIRT2456730	hsa-miR-4739	CLIP-seq
MIRT2456731	hsa-miR-4756-5p	CLIP-seq
MIRT2595927	hsa-miR-4762-5p	CLIP-seq
MIRT2456732	hsa-miR-4804-5p	CLIP-seq
MIRT2595928	hsa-miR-5095	CLIP-seq
MIRT2595929	hsa-miR-605	CLIP-seq
MIRT2595930	hsa-miR-607	CLIP-seq
MIRT2595931	hsa-miR-637	CLIP-seq
MIRT2456733	hsa-miR-873	CLIP-seq
MIRT2595932	hsa-miR-877	CLIP-seq
MIRT2456715	hsa-miR-1225-5p	CLIP-seq
MIRT2688220	hsa-miR-1247	CLIP-seq
MIRT2456716	hsa-miR-1321	CLIP-seq
MIRT2456717	hsa-miR-184	CLIP-seq
MIRT2456718	hsa-miR-1915	CLIP-seq
MIRT2456719	hsa-miR-3165	CLIP-seq
MIRT2456720	hsa-miR-3664-3p	CLIP-seq
MIRT2456721	hsa-miR-3670	CLIP-seq
MIRT2595925	hsa-miR-3671	CLIP-seq
MIRT2456722	hsa-miR-3688-3p	CLIP-seq
MIRT2456723	hsa-miR-3689d	CLIP-seq
MIRT2456724	hsa-miR-3914	CLIP-seq
MIRT2456725	hsa-miR-4270	CLIP-seq
MIRT2456726	hsa-miR-4436a	CLIP-seq
MIRT2595926	hsa-miR-4438	CLIP-seq
MIRT2456727	hsa-miR-4441	CLIP-seq
MIRT2456728	hsa-miR-4690-3p	CLIP-seq
MIRT2456729	hsa-miR-4726-3p	CLIP-seq
MIRT2456730	hsa-miR-4739	CLIP-seq
MIRT2456731	hsa-miR-4756-5p	CLIP-seq
MIRT2595927	hsa-miR-4762-5p	CLIP-seq
MIRT2456732	hsa-miR-4804-5p	CLIP-seq
MIRT2595928	hsa-miR-5095	CLIP-seq
MIRT2595929	hsa-miR-605	CLIP-seq
MIRT2595930	hsa-miR-607	CLIP-seq
MIRT2595931	hsa-miR-637	CLIP-seq
MIRT2456733	hsa-miR-873	CLIP-seq
MIRT2595932	hsa-miR-877	CLIP-seq

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Transcription factor	Regulation	Reference
NR1H4	Unknown	10998425

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005576	Component	Extracellular region	IDA	19321130
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	7654777
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	19321130
GO:0005634	Component	Nucleus	IEA
GO:0006629	Process	Lipid metabolic process	TAS	7654777
GO:0006869	Process	Lipid transport	IDA	9132017
GO:0006869	Process	Lipid transport	IEA
GO:0008035	Function	High-density lipoprotein particle binding	IDA	29883800
GO:0008289	Function	Lipid binding	IEA
GO:0008429	Function	Phosphatidylethanolamine binding	IDA	9132017
GO:0008526	Function	Phosphatidylinositol transfer activity	IEA
GO:0008526	Function	Phosphatidylinositol transfer activity	ISS
GO:0010189	Process	Vitamin E biosynthetic process	IEA
GO:0010875	Process	Positive regulation of cholesterol efflux	IDA	24369175
GO:0015914	Process	Phospholipid transport	IBA
GO:0015914	Process	Phospholipid transport	IDA	9132017
GO:0015918	Process	Sterol transport	IEA
GO:0019992	Function	Diacylglycerol binding	IDA	9132017
GO:0030169	Function	Low-density lipoprotein particle binding	IDA	29883800
GO:0030317	Process	Flagellated sperm motility	IEA
GO:0031210	Function	Phosphatidylcholine binding	IDA	9132017
GO:0034189	Function	Very-low-density lipoprotein particle binding	IDA	29883800
GO:0034364	Component	High-density lipoprotein particle	IDA	9132017
GO:0034375	Process	High-density lipoprotein particle remodeling	IBA
GO:0034375	Process	High-density lipoprotein particle remodeling	IDA	9132017, 24369175, 29883800
GO:0035627	Process	Ceramide transport	IBA
GO:0035627	Process	Ceramide transport	IDA	9132017
GO:0046836	Process	Glycolipid transport	IDA	9132017
GO:0070300	Function	Phosphatidic acid binding	IDA	9132017
GO:0097001	Function	Ceramide binding	IDA	9132017
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0120014	Function	Phospholipid transfer activity	IDA	7654777, 11013307, 19321130, 29883800
GO:0120014	Function	Phospholipid transfer activity	IEA
GO:0120014	Function	Phospholipid transfer activity	IMP	21515415
GO:0120017	Function	Ceramide transfer activity	IBA
GO:0120019	Function	Phosphatidylcholine transfer activity	IDA	9132017
GO:0120019	Function	Phosphatidylcholine transfer activity	IEA
GO:0120020	Function	Cholesterol transfer activity	IEA
GO:0120020	Function	Cholesterol transfer activity	ISS
GO:0140337	Function	Diacylglyceride transfer activity	IDA	9132017
GO:0140338	Function	Sphingomyelin transfer activity	IDA	9132017
GO:0140338	Function	Sphingomyelin transfer activity	IEA
GO:0140339	Function	Phosphatidylglycerol transfer activity	IDA	9132017
GO:0140340	Function	Cerebroside transfer activity	IDA	9132017
GO:1901611	Function	Phosphatidylglycerol binding	IDA	9132017
GO:1904121	Function	Phosphatidylethanolamine transfer activity	IBA
GO:1904121	Function	Phosphatidylethanolamine transfer activity	IDA	9132017
GO:1904121	Function	Phosphatidylethanolamine transfer activity	IEA
GO:1990050	Function	Phosphatidic acid transfer activity	IBA
GO:1990050	Function	Phosphatidic acid transfer activity	IDA	9132017

MIM	HGNC	e!Ensembl
172425	9093	ENSG00000100979

P55058

Protein name

Phospholipid transfer protein (Lipid transfer protein II)

Protein function

Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholi

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01273	LBP_BPI_CETP	30 → 202	LBP / BPI / CETP family, N-terminal domain	Family
PF02886	LBP_BPI_CETP_C	228 → 464	LBP / BPI / CETP family, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highest level of expression in the ovary, thymus and placenta, with moderate levels found in the pancreas, small intestine, testis, lung and prostrate. Low level expression in the kidney, liver and spleen, with very l

Sequence

MALFGALFLALLAGAHAEFPGCKIRVTSKALELVKQEGLRFLEQELETITIPDLRGKEGH
FYYNISEVKVTELQLTSSELDFQPQQELMLQITNASLGLRFRRQLLYWFFYDGGYINASA
EGVSIRTGLELSRDPAGRMKVSNVSCQASVSRMHAAFGGTFKKVYDFLSTFITSGMRFLL
NQQICPVLYHAGTVLLNSLLDTVPVRSSVDELVGIDYSLMKDPVASTSNLDMDFRGAFFP
LTERNWSLPNRAVEPQLQEEERMVYVAFSEFFFDSAMESYFRAGALQLLLVGDKVPHDLD
MLLRATYFGSIVLLSPAVIDSPLKLELRVLAPPRCTIKPSGTTISVTASVTIALVPPDQP
EVQLSSMTMDARLSAKMALRGKALRTQLDLRRFRIYSNHSALESLALIPLQAPLKTMLQI
GVMPMLNERTWRGVQIPLPEGINFVHEVVTNHAGFLTIGADLHFAKGLREVIEKNRPADV
RASTAPTPSTAAV

Sequence length

493

Interactions

View interactions

	KEGG		Reactome
	PPAR signaling pathway Cholesterol metabolism		HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Likely benign	rs368148295	RCV005925554
Hepatocellular carcinoma	Uncertain significance	rs142277281	RCV005936615
Ovarian serous cystadenocarcinoma	Benign	rs200290139	RCV005928520
PLTP-related disorder	Likely benign	rs370035568, rs559294797, rs571253767, rs752967608, rs772838662, rs61731059	RCV003948772 RCV003946740 RCV003952133 RCV003951655 RCV003961488 RCV003956677
RECLASSIFIED - PLTP POLYMORPHISM	Benign	rs3843763	RCV000014604

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Inhibit	36544145
Adenocarcinoma of Lung	Associate	37880277
Aortic Valve Disease	Associate	27250500
Aortic Valve Stenosis	Associate	35341274
Arthritis Rheumatoid	Associate	29565987
Atherosclerosis	Associate	19446293, 19965587, 25710294, 29565987, 32641418
Atrial Fibrillation	Associate	32197906
Blindness	Associate	27605007
Cachexia	Associate	27879288
Carcinoma Hepatocellular	Associate	38022651
Cardiovascular Diseases	Associate	21973210
Carotid Artery Diseases	Associate	19965587, 26009633
Cholesterol pneumonia	Associate	30369316
Cognition Disorders	Associate	38502899
Coronary Artery Disease	Associate	25710294
Coronary Disease	Associate	16644710, 21347282, 25710294
Diabetes Mellitus	Stimulate	21973210
Diabetes Mellitus	Associate	25710294
Diabetes Mellitus Type 2	Associate	16644710, 21973210
Fibrosis	Associate	38027143
Glioma	Associate	27864281
Inflammation	Associate	19446293, 29565987
Kidney Diseases	Associate	38027143
Lead Poisoning Nervous System	Associate	27879288
Macular Degeneration	Stimulate	27605007
Mitral Valve Insufficiency	Associate	27250500
Multiple Sclerosis	Associate	37299978
Myocardial Infarction	Associate	19446293
Neoplasms	Inhibit	36309086
Neoplasms	Associate	36544145
Obesity	Associate	21973210
Stomach Neoplasms	Associate	32735728
Ventricular Dysfunction Left	Associate	19446293

PLTP (phospholipid transfer protein)