Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	53373
Gene name Gene Name - the full gene name approved by the HGNC.	Two pore segment channel 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TPCN1
Synonyms (NCBI Gene) Gene synonyms aliases	TPC1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.13
Summary Summary of gene provided in NCBI Entrez Gene.	Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018931	hsa-miR-335-5p	Microarray	18185580
MIRT046365	hsa-miR-23b-3p	CLASH	23622248
MIRT1448962	hsa-miR-1321	CLIP-seq
MIRT1448963	hsa-miR-137	CLIP-seq
MIRT1448964	hsa-miR-153	CLIP-seq
MIRT1448965	hsa-miR-200b	CLIP-seq
MIRT1448966	hsa-miR-200c	CLIP-seq
MIRT1448967	hsa-miR-25	CLIP-seq
MIRT1448968	hsa-miR-3152-3p	CLIP-seq
MIRT1448969	hsa-miR-3175	CLIP-seq
MIRT1448970	hsa-miR-3177-5p	CLIP-seq
MIRT1448971	hsa-miR-3179	CLIP-seq
MIRT1448972	hsa-miR-32	CLIP-seq
MIRT1448973	hsa-miR-3202	CLIP-seq
MIRT1448974	hsa-miR-329	CLIP-seq
MIRT1448975	hsa-miR-362-3p	CLIP-seq
MIRT1448976	hsa-miR-363	CLIP-seq
MIRT1448977	hsa-miR-3650	CLIP-seq
MIRT1448978	hsa-miR-367	CLIP-seq
MIRT1448979	hsa-miR-3678-5p	CLIP-seq
MIRT1448980	hsa-miR-3941	CLIP-seq
MIRT1448981	hsa-miR-4270	CLIP-seq
MIRT1448982	hsa-miR-4271	CLIP-seq
MIRT1448983	hsa-miR-429	CLIP-seq
MIRT1448984	hsa-miR-4299	CLIP-seq
MIRT1448985	hsa-miR-4441	CLIP-seq
MIRT1448986	hsa-miR-4456	CLIP-seq
MIRT1448987	hsa-miR-4468	CLIP-seq
MIRT1448988	hsa-miR-448	CLIP-seq
MIRT1448989	hsa-miR-4725-3p	CLIP-seq
MIRT1448990	hsa-miR-4728-5p	CLIP-seq
MIRT1448991	hsa-miR-4739	CLIP-seq
MIRT1448992	hsa-miR-4747-5p	CLIP-seq
MIRT1448993	hsa-miR-4756-5p	CLIP-seq
MIRT1448994	hsa-miR-496	CLIP-seq
MIRT1448995	hsa-miR-548q	CLIP-seq
MIRT1448996	hsa-miR-589	CLIP-seq
MIRT1448997	hsa-miR-603	CLIP-seq
MIRT1448998	hsa-miR-625	CLIP-seq
MIRT1448999	hsa-miR-92a	CLIP-seq
MIRT1449000	hsa-miR-92b	CLIP-seq
MIRT1449001	hsa-miR-936	CLIP-seq
MIRT1449002	hsa-miR-3173-3p	CLIP-seq
MIRT1449003	hsa-miR-3190	CLIP-seq
MIRT1449004	hsa-miR-4252	CLIP-seq
MIRT1449005	hsa-miR-4318	CLIP-seq
MIRT1449006	hsa-miR-4695-5p	CLIP-seq
MIRT1449007	hsa-miR-4717-5p	CLIP-seq
MIRT2134331	hsa-miR-3670	CLIP-seq
MIRT2134332	hsa-miR-4519	CLIP-seq
MIRT2134333	hsa-miR-516b	CLIP-seq
MIRT1448963	hsa-miR-137	CLIP-seq
MIRT1448964	hsa-miR-153	CLIP-seq
MIRT2355538	hsa-miR-1976	CLIP-seq
MIRT1448965	hsa-miR-200b	CLIP-seq
MIRT1448966	hsa-miR-200c	CLIP-seq
MIRT1448967	hsa-miR-25	CLIP-seq
MIRT2355539	hsa-miR-3130-3p	CLIP-seq
MIRT1448968	hsa-miR-3152-3p	CLIP-seq
MIRT1448972	hsa-miR-32	CLIP-seq
MIRT2355540	hsa-miR-3611	CLIP-seq
MIRT1448976	hsa-miR-363	CLIP-seq
MIRT2355541	hsa-miR-3652	CLIP-seq
MIRT1448978	hsa-miR-367	CLIP-seq
MIRT1448979	hsa-miR-3678-5p	CLIP-seq
MIRT2355542	hsa-miR-3682-5p	CLIP-seq
MIRT2355543	hsa-miR-3688-3p	CLIP-seq
MIRT2355544	hsa-miR-370	CLIP-seq
MIRT1448983	hsa-miR-429	CLIP-seq
MIRT2355545	hsa-miR-4430	CLIP-seq
MIRT2355546	hsa-miR-4474-3p	CLIP-seq
MIRT1448988	hsa-miR-448	CLIP-seq
MIRT2355547	hsa-miR-4505	CLIP-seq
MIRT2355548	hsa-miR-4525	CLIP-seq
MIRT2355549	hsa-miR-455-5p	CLIP-seq
MIRT2355550	hsa-miR-4646-5p	CLIP-seq
MIRT1448992	hsa-miR-4747-5p	CLIP-seq
MIRT2355551	hsa-miR-4793-3p	CLIP-seq
MIRT1448994	hsa-miR-496	CLIP-seq
MIRT2355552	hsa-miR-520a-5p	CLIP-seq
MIRT2355553	hsa-miR-525-5p	CLIP-seq
MIRT2355554	hsa-miR-544	CLIP-seq
MIRT1448998	hsa-miR-625	CLIP-seq
MIRT2355555	hsa-miR-767-5p	CLIP-seq
MIRT1448999	hsa-miR-92a	CLIP-seq
MIRT1449000	hsa-miR-92b	CLIP-seq
MIRT1449001	hsa-miR-936	CLIP-seq
MIRT2396237	hsa-miR-3689a-3p	CLIP-seq
MIRT2396238	hsa-miR-3689c	CLIP-seq
MIRT1448982	hsa-miR-4271	CLIP-seq
MIRT2355547	hsa-miR-4505	CLIP-seq
MIRT2396239	hsa-miR-4648	CLIP-seq
MIRT2396240	hsa-miR-4654	CLIP-seq
MIRT1448989	hsa-miR-4725-3p	CLIP-seq
MIRT1448990	hsa-miR-4728-5p	CLIP-seq
MIRT2396241	hsa-miR-4769-5p	CLIP-seq
MIRT2462201	hsa-miR-331-3p	CLIP-seq
MIRT2462202	hsa-miR-3692	CLIP-seq
MIRT2462203	hsa-miR-4749-3p	CLIP-seq
MIRT2462201	hsa-miR-331-3p	CLIP-seq
MIRT2462202	hsa-miR-3692	CLIP-seq
MIRT2462203	hsa-miR-4749-3p	CLIP-seq
MIRT2649144	hsa-miR-1225-5p	CLIP-seq
MIRT2649145	hsa-miR-1255a	CLIP-seq
MIRT2649146	hsa-miR-1255b	CLIP-seq
MIRT2649147	hsa-miR-1262	CLIP-seq
MIRT2649148	hsa-miR-1305	CLIP-seq
MIRT2649149	hsa-miR-1915	CLIP-seq
MIRT2649150	hsa-miR-2115	CLIP-seq
MIRT2649151	hsa-miR-3117-5p	CLIP-seq
MIRT2649152	hsa-miR-3136-3p	CLIP-seq
MIRT2649153	hsa-miR-3614-5p	CLIP-seq
MIRT2649154	hsa-miR-3913-3p	CLIP-seq
MIRT2649155	hsa-miR-3926	CLIP-seq
MIRT2649156	hsa-miR-3977	CLIP-seq
MIRT2649157	hsa-miR-421	CLIP-seq
MIRT2649158	hsa-miR-425	CLIP-seq
MIRT1449004	hsa-miR-4252	CLIP-seq
MIRT2649159	hsa-miR-4701-3p	CLIP-seq
MIRT2649160	hsa-miR-4712-3p	CLIP-seq
MIRT2649161	hsa-miR-4725-5p	CLIP-seq
MIRT2649162	hsa-miR-4769-3p	CLIP-seq
MIRT2649163	hsa-miR-489	CLIP-seq
MIRT2649164	hsa-miR-504	CLIP-seq
MIRT2649165	hsa-miR-516a-3p	CLIP-seq
MIRT2649166	hsa-miR-548aa	CLIP-seq
MIRT2649167	hsa-miR-548s	CLIP-seq
MIRT2649168	hsa-miR-663b	CLIP-seq
MIRT2649144	hsa-miR-1225-5p	CLIP-seq
MIRT2649145	hsa-miR-1255a	CLIP-seq
MIRT2649146	hsa-miR-1255b	CLIP-seq
MIRT2649147	hsa-miR-1262	CLIP-seq
MIRT2649149	hsa-miR-1915	CLIP-seq
MIRT2649151	hsa-miR-3117-5p	CLIP-seq
MIRT2649152	hsa-miR-3136-3p	CLIP-seq
MIRT2693942	hsa-miR-3200-5p	CLIP-seq
MIRT2649153	hsa-miR-3614-5p	CLIP-seq
MIRT2693943	hsa-miR-3616-3p	CLIP-seq
MIRT2355544	hsa-miR-370	CLIP-seq
MIRT2649154	hsa-miR-3913-3p	CLIP-seq
MIRT2649155	hsa-miR-3926	CLIP-seq
MIRT2649158	hsa-miR-425	CLIP-seq
MIRT1449004	hsa-miR-4252	CLIP-seq
MIRT2693944	hsa-miR-4303	CLIP-seq
MIRT2649159	hsa-miR-4701-3p	CLIP-seq
MIRT2649160	hsa-miR-4712-3p	CLIP-seq
MIRT2693945	hsa-miR-4761-3p	CLIP-seq
MIRT2649162	hsa-miR-4769-3p	CLIP-seq
MIRT2649163	hsa-miR-489	CLIP-seq
MIRT2649166	hsa-miR-548aa	CLIP-seq
MIRT2649167	hsa-miR-548s	CLIP-seq
MIRT2649168	hsa-miR-663b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005248	Function	Voltage-gated sodium channel activity	IDA	24776928
GO:0005248	Function	Voltage-gated sodium channel activity	IEA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	15094197, 21903581, 24188827
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	TAS	22012985
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	19620632, 23063126
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005768	Component	Endosome	TAS	22012985
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0010008	Component	Endosome membrane	IBA
GO:0010008	Component	Endosome membrane	IDA	19620632, 23063126
GO:0010008	Component	Endosome membrane	IEA
GO:0010508	Process	Positive regulation of autophagy	IDA	22012985
GO:0015280	Function	Ligand-gated sodium channel activity	IDA	23063126, 24776928
GO:0015280	Function	Ligand-gated sodium channel activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0019905	Function	Syntaxin binding	IEA
GO:0022832	Function	Voltage-gated channel activity	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0031901	Component	Early endosome membrane	ISS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0036019	Component	Endolysosome	IDA	24776928
GO:0036019	Component	Endolysosome	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	21903581
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0055038	Component	Recycling endosome membrane	ISS
GO:0055085	Process	Transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0072345	Function	NAADP-sensitive calcium-release channel activity	IDA	24776928
GO:0072345	Function	NAADP-sensitive calcium-release channel activity	IDA	19620632
GO:0072345	Function	NAADP-sensitive calcium-release channel activity	TAS
GO:0075509	Process	Endocytosis involved in viral entry into host cell	IEA
GO:0075509	Process	Endocytosis involved in viral entry into host cell	IMP	25722412
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IEA
GO:0097682	Function	Intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity	IDA	23063126, 24776928
GO:0097682	Function	Intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity	IEA

MIM	HGNC	e!Ensembl
609666	18182	ENSG00000186815

Protein

UniProt ID

Q9ULQ1

Protein name

Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1)

Protein function

Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00520	Ion_trans	105 → 331	Ion transport protein	Family
PF00520	Ion_trans	440 → 694	Ion transport protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highest expression found in the heart and kidney, and lowest expression found in the spleen. {ECO:0000269|PubMed:10574461}.

Sequence

MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP
SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL
LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL
VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL
FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF
IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY
RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF
DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL
VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP
LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT
STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT
SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL
VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW
YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT

Sequence length

816

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway		Stimuli-sensing channels

TPCN1 (two pore segment channel 1)