Gene Gene information from NCBI Gene database.
Entrez ID 5305
Gene name Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Gene symbol PIP4K2A
Synonyms (NCBI Gene)
PI5P4KAPIP5K2APIP5KII-alphaPIP5KIIAPIPK
Chromosome 10
Chromosome location 10p12.2
Summary Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encode
miRNA miRNA information provided by mirtarbase database.
956
miRTarBase ID miRNA Experiments Reference
MIRT016666 hsa-miR-425-5p Sequencing 20371350
MIRT023329 hsa-miR-122-5p Microarray 17612493
MIRT023462 hsa-miR-30b-5p Sequencing 20371350
MIRT027258 hsa-miR-101-3p Sequencing 20371350
MIRT041530 hsa-miR-193b-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001750 Component Photoreceptor outer segment IEA
GO:0001917 Component Photoreceptor inner segment IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603140 8997 ENSG00000150867
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P48426
Protein name Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-ph
Protein function Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-
PDB 2YBX , 6OSP , 6UX9 , 6YM3 , 6YM4 , 6YM5 , 7N6Z , 7N71 , 7N7J , 7N7K , 7N7L , 7N7M , 7N7N , 7N7O , 8C8C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01504 PIP5K 118 404 Phosphatidylinositol-4-phosphate 5-Kinase Family
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269|PubMed:7639683, ECO:0000269|PubMed:7852364}.
Sequence
Sequence length 406
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Regulation of actin cytoskeleton
  Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus