Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5305
Gene name Gene Name - the full gene name approved by the HGNC.
Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PIP4K2A
Synonyms (NCBI Gene) Gene synonyms aliases
PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p12.2
Summary Summary of gene provided in NCBI Entrez Gene.
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encode
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016666 hsa-miR-425-5p Sequencing 20371350
MIRT023329 hsa-miR-122-5p Microarray 17612493
MIRT023462 hsa-miR-30b-5p Sequencing 20371350
MIRT027258 hsa-miR-101-3p Sequencing 20371350
MIRT041530 hsa-miR-193b-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001750 Component Photoreceptor outer segment IEA
GO:0001917 Component Photoreceptor inner segment IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603140 8997 ENSG00000150867
Protein
UniProt ID P48426
Protein name Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-ph
Protein function Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP-
PDB 2YBX , 6OSP , 6UX9 , 6YM3 , 6YM4 , 6YM5 , 7N6Z , 7N71 , 7N7J , 7N7K , 7N7L , 7N7M , 7N7N , 7N7O , 8C8C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01504 PIP5K 118 404 Phosphatidylinositol-4-phosphate 5-Kinase Family
Tissue specificity TISSUE SPECIFICITY: Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269|PubMed:7639683, ECO:0000269|PubMed:7852364}.
Sequence
Sequence length 406
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Regulation of actin cytoskeleton
  Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer N/A N/A GWAS
Ischemic Stroke Ischemic stroke N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Bipolar Disorder Associate 17410640
Breast Neoplasms Associate 20074374, 28560454
Carcinoma Non Small Cell Lung Associate 23006423
Carcinoma Ovarian Epithelial Associate 28560454
Cardiovascular Diseases Associate 40026415
Cell Transformation Neoplastic Associate 21303971
Cerebral Hemorrhage Associate 30836997
Colorectal Neoplasms Associate 28560454, 31781676
Diabetes Mellitus Type 1 Associate 34006268
Diabetes Mellitus Type 2 Associate 40026415