PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha)
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
5305 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
PIP4K2A |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
PI5P4KA, PIP5K2A, PIP5KII-alpha, PIP5KIIA, PIPK |
|
Chromosome
Chromosome number
|
10 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
10p12.2 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encode |
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | |||||||||||
| UniProt ID | P48426 | ||||||||||
| Protein name | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-ph | ||||||||||
| Protein function | Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:23326584, PubMed:9367159). Has both ATP- and GTP- | ||||||||||
| PDB | 2YBX , 6OSP , 6UX9 , 6YM3 , 6YM4 , 6YM5 , 7N6Z , 7N71 , 7N7J , 7N7K , 7N7L , 7N7M , 7N7N , 7N7O , 8C8C | ||||||||||
| Family and domains |
Pfam
|
||||||||||
| Tissue specificity | TISSUE SPECIFICITY: Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269|PubMed:7639683, ECO:0000269|PubMed:7852364}. | ||||||||||
| Sequence |
|
||||||||||
| Sequence length | 406 | ||||||||||
| Interactions | View interactions | ||||||||||
|
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||