Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5291
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIK3CB
Synonyms (NCBI Gene) Gene synonyms aliases	P110BETA, PI3K, PI3KBETA, PIK3C1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encod

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1577033077	C>A	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025952	hsa-miR-7-5p	Microarray	19073608

Show/Hide all(65)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	TAS	10570282
GO:0001952	Process	Regulation of cell-matrix adhesion	IMP	25139353
GO:0002931	Process	Response to ischemia	ISS	30496354
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IMP	18558630
GO:0005515	Function	Protein binding	IPI	19380743, 20713702, 22402981, 23397142, 25241761, 25556234, 25814554, 26496610, 27107012, 28514442, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	30496354
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0006897	Process	Endocytosis	IEA
GO:0006914	Process	Autophagy	IEA
GO:0006935	Process	Chemotaxis	TAS	10570282
GO:0007165	Process	Signal transduction	NAS	10570282
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	TAS	21035500
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	21321382
GO:0007411	Process	Axon guidance	TAS
GO:0010508	Process	Positive regulation of autophagy	TAS	21321382
GO:0010595	Process	Positive regulation of endothelial cell migration	IGI	18558630
GO:0010628	Process	Positive regulation of gene expression	IMP	25139353
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IBA	21873635
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IGI	30496354
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IMP	18558630, 25339672
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	ISS	30496354
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	TAS	21321382
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0016020	Component	Membrane	IBA	21873635
GO:0016301	Function	Kinase activity	IDA	25327288
GO:0016303	Function	1-phosphatidylinositol-3-kinase activity	IBA	21873635
GO:0016310	Process	Phosphorylation	IDA	25327288
GO:0016477	Process	Cell migration	IBA	21873635
GO:0016477	Process	Cell migration	TAS	21035500, 21321382
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030168	Process	Platelet activation	TAS	21035500
GO:0030496	Component	Midbody	IDA
GO:0033031	Process	Positive regulation of neutrophil apoptotic process	IMP	25339672
GO:0035004	Function	Phosphatidylinositol 3-kinase activity	TAS	21035500
GO:0035005	Function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	21873635
GO:0035022	Process	Positive regulation of Rac protein signal transduction	IGI	18558630
GO:0036092	Process	Phosphatidylinositol-3-phosphate biosynthetic process	IBA	21873635
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043407	Process	Negative regulation of MAP kinase activity	ISS	30496354
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046934	Function	Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0048015	Process	Phosphatidylinositol-mediated signaling	TAS
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0050900	Process	Leukocyte migration	TAS
GO:0051000	Process	Positive regulation of nitric-oxide synthase activity	IMP	18558630
GO:0051897	Process	Positive regulation of protein kinase B signaling	IMP	18558630
GO:0051897	Process	Positive regulation of protein kinase B signaling	TAS
GO:0051898	Process	Negative regulation of protein kinase B signaling	IGI	30496354
GO:0052742	Function	Phosphatidylinositol kinase activity	IBA	21873635
GO:0052812	Function	Phosphatidylinositol-3,4-bisphosphate 5-kinase activity	IEA
GO:0070527	Process	Platelet aggregation	TAS	21035500
GO:1900747	Process	Negative regulation of vascular endothelial growth factor signaling pathway	IGI	30496354
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IMP	30496354
GO:2000369	Process	Regulation of clathrin-dependent endocytosis	TAS	21321382

MIM	HGNC	e!Ensembl
602925	8976	ENSG00000051382

Protein

UniProt ID

P42338

Protein name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (P

Protein function

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02192	PI3K_p85B	42 → 117	PI3-kinase family, p85-binding domain	Family
PF00794	PI3K_rbd	180 → 288	PI3-kinase family, ras-binding domain	Domain
PF00792	PI3K_C2	347 → 490	Phosphoinositide 3-kinase C2	Domain
PF00613	PI3Ka	527 → 711	Phosphoinositide 3-kinase family, accessory domain (PIK domain)	Family
PF00454	PI3_PI4_kinase	799 → 1017	Phosphatidylinositol 3- and 4-kinase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed ubiquitously.

Sequence

MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS

Sequence length

1070

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Axon guidance VEGF signaling pathway Osteoclast differentiation Focal adhesion Signaling pathways regulating pluripotency of stem cells Platelet activation Neutrophil extracellular trap formation Toll-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Leukocyte transendothelial migration Neurotrophin signaling pathway Cholinergic synapse Inflammatory mediator regulation of TRP channels Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Regulation of lipolysis in adipocytes Relaxin signaling pathway GnRH secretion Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Carbohydrate digestion and absorption Alzheimer disease Spinocerebellar ataxia Prion disease Bacterial invasion of epithelial cells Shigellosis Salmonella infection Yersinia infection Chagas disease Amoebiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Breast adenocarcinoma	Breast adenocarcinoma	rs28934874, rs112445441, rs121913279, rs121913286, rs104886003, rs121434592
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	21173233
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21743468

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Head and neck cancer	Malignant Head and Neck Neoplasm		ClinVar
Oligodendroglioma	Oligodendroglioma		GWAS
Lung adenocarcinoma	Lung adenocarcinoma	Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors	GWAS, CBGDA

Show/Hide Text Mining Associations (74)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	25473181, 26884879, 37249797, 40243539
Adenocarcinoma of Lung	Stimulate	35780638
Adenocarcinoma of Lung	Associate	40243539
Adenoma	Associate	26884879
Adenoma Villous	Stimulate	26884879
Alzheimer Disease	Associate	30611996, 40141059, 40273555, 40332288
Alzheimer Disease	Inhibit	35096262
Arthritis Rheumatoid	Associate	40190499
Autoimmune Diseases	Associate	40141059
Bacteremia	Inhibit	36351402
Bacterial Infections	Inhibit	36351402
Brain Neoplasms	Associate	40243539
Breast Neoplasms	Associate	19366795, 25195596, 28196852, 28569218, 29566768, 30659094, 31781306, 34990021, 40327992, 40481104, 40555003, 40696656, 40726220
Carcinogenesis	Associate	28002804, 28196852, 31642198, 36351402
Carcinoma Hepatocellular	Associate	40158165, 40424306
Carcinoma Non Small Cell Lung	Associate	24284056, 31952518, 36634615
Carcinoma Renal Cell	Associate	25528216, 25853938, 26537074
Carcinoma Renal Cell	Inhibit	35665729
Carcinoma Squamous Cell	Associate	24284056, 31952518, 37249797
Cognition Disorders	Associate	28050343
Colorectal Neoplasms	Associate	25473181, 25550888
Diabetes Mellitus Type 2	Associate	20107106
Diabetic Nephropathies	Associate	40312440
Diabetic Retinopathy	Associate	32993645
Drug Related Side Effects and Adverse Reactions	Associate	40147444
Endometrial Neoplasms	Associate	23674493, 28002804
Epilepsies Partial	Associate	40674414
Focal Cortical Dysplasia	Associate	40674414
Focal cortical dysplasia of Taylor	Associate	40674414
Focal Infection	Associate	25528892
Glioblastoma	Associate	26956052, 30542720, 40133683
Glioma	Associate	40656950
Graves Ophthalmopathy	Associate	30733969
Hereditary Breast and Ovarian Cancer Syndrome	Associate	40437613
Hypomagnesemia primary	Associate	37960754
Infections	Associate	36351402
Inflammation	Associate	36351402, 39683581, 40133701, 40191870
Insulin Resistance	Associate	20107106
Leukemia	Associate	40147444
Leukemia Myeloid Acute	Associate	15840695, 39273530
Leukemia Promyelocytic Acute	Associate	19176369
Lung Neoplasms	Associate	40135405
Lupus Erythematosus Systemic	Associate	32576231
Lymphatic Metastasis	Associate	25550888, 35780638
Lymphoma Large B Cell Diffuse	Associate	24418330
Lymphoma Mantle Cell	Associate	23341541
Melanoma	Associate	27391157
Melanosis	Associate	30559147
Mouth Neoplasms	Associate	36849997
Neoplasm Metastasis	Associate	23211529, 25473181
Neoplasms	Associate	18372911, 18498248, 21563232, 23211529, 25473181, 25550888, 26884879, 27310202, 28002804, 28196852, 28569218, 28723560, 29307797, 31292159, 31952518 View all (7 more)
Neoplasms	Stimulate	26956052
Neoplasms	Inhibit	32672423, 34479548, 40312292
Nephrolithiasis Calcium Oxalate	Associate	40191870
Neurodegenerative Diseases	Associate	40141059
Neuroendocrine Tumors	Associate	40390063
Obesity	Associate	20107106
Osteoarthritis	Associate	31886215
Osteosarcoma	Associate	40481236
Ovarian Neoplasms	Associate	21563232
Pancreatic Intraductal Neoplasms	Associate	28776573
Parkinson Disease	Associate	40141059
Peritonitis	Associate	36351402
Pneumonia Pneumococcal	Associate	36351402
Prostatic Neoplasms	Associate	18372911, 20231295, 35328346, 40188042
Respiratory Distress Syndrome	Associate	31531373
Respiratory Tract Infections	Associate	36351402
Stomach Neoplasms	Associate	27156070
Thyroid Cancer Papillary	Associate	31642198
Triple Negative Breast Neoplasms	Associate	32672423
Tuberculosis Multidrug Resistant	Associate	25550888, 31952518, 40332431
Urinary Bladder Neoplasms	Associate	40586548
Uterine Cervical Neoplasms	Associate	40238841
Vitiligo	Stimulate	31885781

PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)