Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5279
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphatidylinositol glycan anchor biosynthesis class C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIGC
Synonyms (NCBI Gene) Gene synonyms aliases	GPI2, GPIBD16, MRT62
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surfac

Show/Hide all(106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027669	hsa-miR-98-5p	Microarray	19088304
MIRT037438	hsa-miR-744-5p	CLASH	23622248
MIRT1233207	hsa-miR-1258	CLIP-seq
MIRT1233208	hsa-miR-1284	CLIP-seq
MIRT1233209	hsa-miR-129-5p	CLIP-seq
MIRT1233210	hsa-miR-140-3p	CLIP-seq
MIRT1233211	hsa-miR-2052	CLIP-seq
MIRT1233212	hsa-miR-2115	CLIP-seq
MIRT1233213	hsa-miR-2355-5p	CLIP-seq
MIRT1233214	hsa-miR-3120-3p	CLIP-seq
MIRT1233215	hsa-miR-3120-5p	CLIP-seq
MIRT1233216	hsa-miR-3168	CLIP-seq
MIRT1233217	hsa-miR-3180-5p	CLIP-seq
MIRT1233218	hsa-miR-335	CLIP-seq
MIRT1233219	hsa-miR-3664-5p	CLIP-seq
MIRT1233220	hsa-miR-3675-3p	CLIP-seq
MIRT1233221	hsa-miR-380	CLIP-seq
MIRT1233222	hsa-miR-3923	CLIP-seq
MIRT1233223	hsa-miR-3975	CLIP-seq
MIRT1233224	hsa-miR-4266	CLIP-seq
MIRT1233225	hsa-miR-4680-5p	CLIP-seq
MIRT1233226	hsa-miR-4695-3p	CLIP-seq
MIRT1233227	hsa-miR-4695-5p	CLIP-seq
MIRT1233228	hsa-miR-4753-3p	CLIP-seq
MIRT1233229	hsa-miR-4760-3p	CLIP-seq
MIRT1233230	hsa-miR-4779	CLIP-seq
MIRT1233231	hsa-miR-499-3p	CLIP-seq
MIRT1233232	hsa-miR-499a-3p	CLIP-seq
MIRT1233233	hsa-miR-511	CLIP-seq
MIRT1233234	hsa-miR-516a-3p	CLIP-seq
MIRT1233235	hsa-miR-520a-5p	CLIP-seq
MIRT1233236	hsa-miR-525-5p	CLIP-seq
MIRT1233237	hsa-miR-561	CLIP-seq
MIRT1233238	hsa-miR-579	CLIP-seq
MIRT1233239	hsa-miR-633	CLIP-seq
MIRT1233240	hsa-miR-659	CLIP-seq
MIRT1233241	hsa-miR-9	CLIP-seq
MIRT2068609	hsa-miR-1283	CLIP-seq
MIRT1233213	hsa-miR-2355-5p	CLIP-seq
MIRT1233214	hsa-miR-3120-3p	CLIP-seq
MIRT1233218	hsa-miR-335	CLIP-seq
MIRT1233221	hsa-miR-380	CLIP-seq
MIRT1233229	hsa-miR-4760-3p	CLIP-seq
MIRT1233231	hsa-miR-499-3p	CLIP-seq
MIRT1233232	hsa-miR-499a-3p	CLIP-seq
MIRT1233237	hsa-miR-561	CLIP-seq
MIRT1233238	hsa-miR-579	CLIP-seq
MIRT1233239	hsa-miR-633	CLIP-seq
MIRT1233240	hsa-miR-659	CLIP-seq
MIRT1233212	hsa-miR-2115	CLIP-seq
MIRT1233213	hsa-miR-2355-5p	CLIP-seq
MIRT2295733	hsa-miR-2964a-5p	CLIP-seq
MIRT1233214	hsa-miR-3120-3p	CLIP-seq
MIRT1233215	hsa-miR-3120-5p	CLIP-seq
MIRT1233216	hsa-miR-3168	CLIP-seq
MIRT1233217	hsa-miR-3180-5p	CLIP-seq
MIRT1233218	hsa-miR-335	CLIP-seq
MIRT1233219	hsa-miR-3664-5p	CLIP-seq
MIRT1233221	hsa-miR-380	CLIP-seq
MIRT1233223	hsa-miR-3975	CLIP-seq
MIRT1233225	hsa-miR-4680-5p	CLIP-seq
MIRT1233229	hsa-miR-4760-3p	CLIP-seq
MIRT2295734	hsa-miR-4764-5p	CLIP-seq
MIRT1233231	hsa-miR-499-3p	CLIP-seq
MIRT1233232	hsa-miR-499a-3p	CLIP-seq
MIRT1233233	hsa-miR-511	CLIP-seq
MIRT1233234	hsa-miR-516a-3p	CLIP-seq
MIRT1233235	hsa-miR-520a-5p	CLIP-seq
MIRT1233236	hsa-miR-525-5p	CLIP-seq
MIRT1233237	hsa-miR-561	CLIP-seq
MIRT1233240	hsa-miR-659	CLIP-seq
MIRT2295735	hsa-miR-676	CLIP-seq
MIRT1233207	hsa-miR-1258	CLIP-seq
MIRT1233208	hsa-miR-1284	CLIP-seq
MIRT1233212	hsa-miR-2115	CLIP-seq
MIRT1233215	hsa-miR-3120-5p	CLIP-seq
MIRT1233216	hsa-miR-3168	CLIP-seq
MIRT1233217	hsa-miR-3180-5p	CLIP-seq
MIRT1233219	hsa-miR-3664-5p	CLIP-seq
MIRT1233222	hsa-miR-3923	CLIP-seq
MIRT1233223	hsa-miR-3975	CLIP-seq
MIRT1233224	hsa-miR-4266	CLIP-seq
MIRT1233225	hsa-miR-4680-5p	CLIP-seq
MIRT1233227	hsa-miR-4695-5p	CLIP-seq
MIRT1233230	hsa-miR-4779	CLIP-seq
MIRT1233233	hsa-miR-511	CLIP-seq
MIRT1233234	hsa-miR-516a-3p	CLIP-seq
MIRT1233235	hsa-miR-520a-5p	CLIP-seq
MIRT1233236	hsa-miR-525-5p	CLIP-seq
MIRT1233207	hsa-miR-1258	CLIP-seq
MIRT1233208	hsa-miR-1284	CLIP-seq
MIRT1233212	hsa-miR-2115	CLIP-seq
MIRT1233215	hsa-miR-3120-5p	CLIP-seq
MIRT1233216	hsa-miR-3168	CLIP-seq
MIRT1233217	hsa-miR-3180-5p	CLIP-seq
MIRT1233219	hsa-miR-3664-5p	CLIP-seq
MIRT1233222	hsa-miR-3923	CLIP-seq
MIRT1233223	hsa-miR-3975	CLIP-seq
MIRT1233224	hsa-miR-4266	CLIP-seq
MIRT1233225	hsa-miR-4680-5p	CLIP-seq
MIRT1233227	hsa-miR-4695-5p	CLIP-seq
MIRT1233230	hsa-miR-4779	CLIP-seq
MIRT1233233	hsa-miR-511	CLIP-seq
MIRT1233234	hsa-miR-516a-3p	CLIP-seq
MIRT1233235	hsa-miR-520a-5p	CLIP-seq
MIRT1233236	hsa-miR-525-5p	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IBA
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	10944123, 16162815
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IPI	16162815
GO:0003824	Function	Catalytic activity	TAS	8806613
GO:0005515	Function	Protein binding	IPI	9463366, 10944123
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	16162815
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS	8806613
GO:0006506	Process	GPI anchor biosynthetic process	IDA	16162815
GO:0006506	Process	GPI anchor biosynthetic process	IEA
GO:0006506	Process	GPI anchor biosynthetic process	IMP	27694521
GO:0006506	Process	GPI anchor biosynthetic process	TAS	8806613
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
601730	8960	ENSG00000135845

Protein

UniProt ID

Q92535

Protein name

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C)

Protein function

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynth

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06432	GPI2	14 → 284	Phosphatidylinositol N-acetylglucosaminyltransferase	Family

Sequence

MYAQPVTNTKEVKWQKVLYERQPFPDNYVDRRFLEELRKNIHARKYQYWAVVFESSVVIQ
QLCSVCVFVVIWWYMDEGLLAPHWLLGTGLASSLIGYVLFDLIDGGEGRKKSGQTRWADL
KSALVFITFTYGFSPVLKTLTESVSTDTIYAMSVFMLLGHLIFFDYGANAAIVSSTLSLN
MAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTLLFAFSAV
GGLLSISAVGAVLFALLLMSISCLCPFYLIRLQLFKENIHGPWDEAEIKEDLSRFLS

Sequence length

297

Interactions

View interactions

	KEGG		Reactome
	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways		Synthesis of glycosylphosphatidylinositol (GPI)

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Glycosylphosphatidylinositol deficiency	glycosylphosphatidylinositol biosynthesis defect 16	rs1553259614, rs1553259602	N/A

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Non-Syndromic Intellectual Disability	autosomal recessive non-syndromic intellectual disability	N/A	N/A	GenCC
Nonimmune Hydrops Fetalis	non-immune hydrops fetalis	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	28901494

PIGC (phosphatidylinositol glycan anchor biosynthesis class C)