SERPINB10 (serpin family B member 10)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5273
Gene name Gene Name - the full gene name approved by the HGNC.
Serpin family B member 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SERPINB10
Synonyms (NCBI Gene) Gene synonyms aliases
PI-10, PI10
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis.
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT017019 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IBA 21873635
GO:0005615 Component Extracellular space IBA 21873635
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602058 8942 ENSG00000242550
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P48595
Protein name Serpin B10 (Bomapin) (Peptidase inhibitor 10) (PI-10)
Protein function Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10871600, ECO:0000269|P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00079 Serpin 6 → 397 Serpin (serine protease inhibitor) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed specifically in myeloid cells and the bone marrow. {ECO:0000269|PubMed:20433722, ECO:0000269|PubMed:7592909}.
Sequence
Sequence length 397
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Amoebiasis   Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 16172807
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Dermatitis Dermatitis GWAS
Show/Hide Text Mining Associations (15)
Associations from Text Mining
Disease Name Relationship Type References
Airway Remodeling Stimulate 35526531
Asthma Associate 35526531, 35550122
Coronary Artery Disease Associate 26573152
Drug Resistant Epilepsy Associate 26573152
Glioma Associate 36295489
Inflammation Associate 35526531, 36398030
Leukemia Monocytic Acute Associate 9454755
Leukemia Myeloid Acute Associate 10871600
Leukemia Myelomonocytic Chronic Associate 10871600
Leukemia T Cell Associate 20433722