PGGT1B (protein geranylgeranyltransferase type I subunit beta)

Gene

• Entrez ID: 5229
• Gene name: Protein geranylgeranyltransferase type I subunit beta
• Gene symbol: PGGT1B
• Synonyms (NCBI Gene): BGGI, GGTI
• Chromosome: 5
• Chromosome location: 5q22.3
• Summary: Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which `A` is an aliphatic amino acid and `X` is leucine (summarized by Zhang et al., 1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022675	hsa-miR-124-3p	Microarray	18668037
MIRT053412	hsa-miR-591	Microarray	23807165
MIRT438832	hsa-miR-582-5p	qRT-PCR	23295946
MIRT438821	hsa-miR-582-3p	qRT-PCR	23295946
MIRT438832	hsa-miR-582-5p	qRT-PCR	23295946
MIRT438821	hsa-miR-582-3p	qRT-PCR	23295946
MIRT566468	hsa-miR-1276	PAR-CLIP	20371350
MIRT566467	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT566466	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT566465	hsa-miR-3614-5p	PAR-CLIP	20371350
MIRT566464	hsa-let-7a-3p	PAR-CLIP	20371350
MIRT566463	hsa-let-7b-3p	PAR-CLIP	20371350
MIRT566462	hsa-let-7f-1-3p	PAR-CLIP	20371350
MIRT566461	hsa-miR-98-3p	PAR-CLIP	20371350
MIRT566460	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT566459	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT566458	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT566457	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT566456	hsa-miR-487a-5p	PAR-CLIP	20371350
MIRT566455	hsa-miR-487b-5p	PAR-CLIP	20371350
MIRT450764	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT450763	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT450762	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT450761	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT450760	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT450759	hsa-miR-4282	PAR-CLIP	22100165
MIRT450758	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT450757	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT450756	hsa-miR-573	PAR-CLIP	22100165
MIRT566468	hsa-miR-1276	PAR-CLIP	20371350
MIRT566467	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT566466	hsa-miR-942-3p	PAR-CLIP	20371350
MIRT566465	hsa-miR-3614-5p	PAR-CLIP	20371350
MIRT566464	hsa-let-7a-3p	PAR-CLIP	20371350
MIRT566463	hsa-let-7b-3p	PAR-CLIP	20371350
MIRT566462	hsa-let-7f-1-3p	PAR-CLIP	20371350
MIRT566461	hsa-miR-98-3p	PAR-CLIP	20371350
MIRT566460	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT566459	hsa-let-7f-2-3p	PAR-CLIP	20371350
MIRT566458	hsa-miR-1185-1-3p	PAR-CLIP	20371350
MIRT566457	hsa-miR-1185-2-3p	PAR-CLIP	20371350
MIRT566456	hsa-miR-487a-5p	PAR-CLIP	20371350
MIRT566455	hsa-miR-487b-5p	PAR-CLIP	20371350
MIRT450764	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT450763	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT450762	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT450761	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT450760	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT450759	hsa-miR-4282	PAR-CLIP	22100165
MIRT450758	hsa-miR-4795-5p	PAR-CLIP	22100165
MIRT450757	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT450756	hsa-miR-573	PAR-CLIP	22100165
MIRT1227385	hsa-miR-105	CLIP-seq
MIRT1227386	hsa-miR-1271	CLIP-seq
MIRT1227387	hsa-miR-139-5p	CLIP-seq
MIRT1227388	hsa-miR-214	CLIP-seq
MIRT1227389	hsa-miR-3124-3p	CLIP-seq
MIRT1227390	hsa-miR-3129-3p	CLIP-seq
MIRT1227391	hsa-miR-3146	CLIP-seq
MIRT1227392	hsa-miR-3152-5p	CLIP-seq
MIRT1227393	hsa-miR-3163	CLIP-seq
MIRT1227394	hsa-miR-329	CLIP-seq
MIRT1227395	hsa-miR-3609	CLIP-seq
MIRT1227396	hsa-miR-3613-3p	CLIP-seq
MIRT1227397	hsa-miR-3619-5p	CLIP-seq
MIRT1227398	hsa-miR-3622a-3p	CLIP-seq
MIRT1227399	hsa-miR-3622b-3p	CLIP-seq
MIRT1227400	hsa-miR-362-3p	CLIP-seq
MIRT1227401	hsa-miR-3646	CLIP-seq
MIRT1227402	hsa-miR-3662	CLIP-seq
MIRT1227403	hsa-miR-3671	CLIP-seq
MIRT1227404	hsa-miR-384	CLIP-seq
MIRT1227405	hsa-miR-3941	CLIP-seq
MIRT1227406	hsa-miR-3973	CLIP-seq
MIRT1227407	hsa-miR-4255	CLIP-seq
MIRT1227408	hsa-miR-4291	CLIP-seq
MIRT1227409	hsa-miR-4488	CLIP-seq
MIRT1227410	hsa-miR-4659a-3p	CLIP-seq
MIRT1227411	hsa-miR-4659b-3p	CLIP-seq
MIRT1227412	hsa-miR-4668-3p	CLIP-seq
MIRT1227413	hsa-miR-4697-5p	CLIP-seq
MIRT1227414	hsa-miR-4699-5p	CLIP-seq
MIRT1227415	hsa-miR-4717-5p	CLIP-seq
MIRT1227416	hsa-miR-4722-5p	CLIP-seq
MIRT1227417	hsa-miR-4733-5p	CLIP-seq
MIRT1227418	hsa-miR-4768-3p	CLIP-seq
MIRT1227419	hsa-miR-4774-3p	CLIP-seq
MIRT1227420	hsa-miR-4775	CLIP-seq
MIRT1227421	hsa-miR-4789-3p	CLIP-seq
MIRT1227422	hsa-miR-520g	CLIP-seq
MIRT1227423	hsa-miR-520h	CLIP-seq
MIRT1227424	hsa-miR-548ac	CLIP-seq
MIRT1227425	hsa-miR-548ae	CLIP-seq
MIRT1227426	hsa-miR-548ah	CLIP-seq
MIRT1227427	hsa-miR-548aj	CLIP-seq
MIRT1227428	hsa-miR-548am	CLIP-seq
MIRT1227429	hsa-miR-548c-3p	CLIP-seq
MIRT1227430	hsa-miR-548d-3p	CLIP-seq
MIRT1227431	hsa-miR-548l	CLIP-seq
MIRT1227432	hsa-miR-548p	CLIP-seq
MIRT1227433	hsa-miR-548v	CLIP-seq
MIRT1227434	hsa-miR-548x	CLIP-seq
MIRT1227435	hsa-miR-548z	CLIP-seq
MIRT1227436	hsa-miR-570	CLIP-seq
MIRT1227437	hsa-miR-580	CLIP-seq
MIRT1227438	hsa-miR-595	CLIP-seq
MIRT1227439	hsa-miR-603	CLIP-seq
MIRT1227440	hsa-miR-607	CLIP-seq
MIRT1227441	hsa-miR-610	CLIP-seq
MIRT1227442	hsa-miR-637	CLIP-seq
MIRT1227443	hsa-miR-761	CLIP-seq
MIRT1227444	hsa-miR-922	CLIP-seq
MIRT1227445	hsa-miR-96	CLIP-seq
MIRT1227386	hsa-miR-1271	CLIP-seq
MIRT1227390	hsa-miR-3129-3p	CLIP-seq
MIRT2066611	hsa-miR-3647-3p	CLIP-seq
MIRT2066612	hsa-miR-548a-3p	CLIP-seq
MIRT2066613	hsa-miR-548an	CLIP-seq
MIRT2066614	hsa-miR-548e	CLIP-seq
MIRT2066615	hsa-miR-548f	CLIP-seq
MIRT1227437	hsa-miR-580	CLIP-seq
MIRT1227445	hsa-miR-96	CLIP-seq
MIRT1227386	hsa-miR-1271	CLIP-seq
MIRT2294142	hsa-miR-1323	CLIP-seq
MIRT2294143	hsa-miR-140-3p	CLIP-seq
MIRT2294144	hsa-miR-191	CLIP-seq
MIRT2294145	hsa-miR-197	CLIP-seq
MIRT1227388	hsa-miR-214	CLIP-seq
MIRT2294146	hsa-miR-3120-3p	CLIP-seq
MIRT2294147	hsa-miR-3201	CLIP-seq
MIRT2294148	hsa-miR-3591-5p	CLIP-seq
MIRT2294149	hsa-miR-3606	CLIP-seq
MIRT1227397	hsa-miR-3619-5p	CLIP-seq
MIRT2294150	hsa-miR-3908	CLIP-seq
MIRT1227408	hsa-miR-4291	CLIP-seq
MIRT2294151	hsa-miR-4420	CLIP-seq
MIRT2294152	hsa-miR-4446-5p	CLIP-seq
MIRT2294153	hsa-miR-4709-3p	CLIP-seq
MIRT2294154	hsa-miR-4755-5p	CLIP-seq
MIRT2294155	hsa-miR-4774-5p	CLIP-seq
MIRT2294156	hsa-miR-4791	CLIP-seq
MIRT2294157	hsa-miR-548o	CLIP-seq
MIRT2294158	hsa-miR-642a	CLIP-seq
MIRT2294159	hsa-miR-668	CLIP-seq
MIRT1227443	hsa-miR-761	CLIP-seq
MIRT2294160	hsa-miR-921	CLIP-seq
MIRT1227444	hsa-miR-922	CLIP-seq
MIRT1227445	hsa-miR-96	CLIP-seq
MIRT1227385	hsa-miR-105	CLIP-seq
MIRT2592110	hsa-miR-1237	CLIP-seq
MIRT2592111	hsa-miR-1248	CLIP-seq
MIRT2592112	hsa-miR-1305	CLIP-seq
MIRT2294144	hsa-miR-191	CLIP-seq
MIRT2592113	hsa-miR-203	CLIP-seq
MIRT2592114	hsa-miR-2278	CLIP-seq
MIRT2592115	hsa-miR-2355-5p	CLIP-seq
MIRT2592116	hsa-miR-28-3p	CLIP-seq
MIRT1227389	hsa-miR-3124-3p	CLIP-seq
MIRT2592117	hsa-miR-3149	CLIP-seq
MIRT2592118	hsa-miR-3161	CLIP-seq
MIRT2592119	hsa-miR-3168	CLIP-seq
MIRT2294147	hsa-miR-3201	CLIP-seq
MIRT2294148	hsa-miR-3591-5p	CLIP-seq
MIRT2294149	hsa-miR-3606	CLIP-seq
MIRT1227401	hsa-miR-3646	CLIP-seq
MIRT1227402	hsa-miR-3662	CLIP-seq
MIRT1227403	hsa-miR-3671	CLIP-seq
MIRT2592120	hsa-miR-3679-3p	CLIP-seq
MIRT2592121	hsa-miR-374a	CLIP-seq
MIRT2592122	hsa-miR-374b	CLIP-seq
MIRT2592123	hsa-miR-376a	CLIP-seq
MIRT2592124	hsa-miR-376b	CLIP-seq
MIRT1227404	hsa-miR-384	CLIP-seq
MIRT1227406	hsa-miR-3973	CLIP-seq
MIRT2592125	hsa-miR-421	CLIP-seq
MIRT2294151	hsa-miR-4420	CLIP-seq
MIRT2592126	hsa-miR-4424	CLIP-seq
MIRT2592127	hsa-miR-4427	CLIP-seq
MIRT2592128	hsa-miR-4445	CLIP-seq
MIRT1227409	hsa-miR-4488	CLIP-seq
MIRT2592129	hsa-miR-4637	CLIP-seq
MIRT2592130	hsa-miR-4652-3p	CLIP-seq
MIRT1227410	hsa-miR-4659a-3p	CLIP-seq
MIRT1227411	hsa-miR-4659b-3p	CLIP-seq
MIRT2592131	hsa-miR-4680-3p	CLIP-seq
MIRT1227413	hsa-miR-4697-5p	CLIP-seq
MIRT2294153	hsa-miR-4709-3p	CLIP-seq
MIRT2592132	hsa-miR-4729	CLIP-seq
MIRT1227420	hsa-miR-4775	CLIP-seq
MIRT2592133	hsa-miR-4777-5p	CLIP-seq
MIRT2592134	hsa-miR-4790-3p	CLIP-seq
MIRT2294156	hsa-miR-4791	CLIP-seq
MIRT2592135	hsa-miR-4795-3p	CLIP-seq
MIRT2592136	hsa-miR-518d-5p	CLIP-seq
MIRT2592137	hsa-miR-519b-5p	CLIP-seq
MIRT2592138	hsa-miR-519c-5p	CLIP-seq
MIRT2592139	hsa-miR-520c-5p	CLIP-seq
MIRT2592140	hsa-miR-526a	CLIP-seq
MIRT1227424	hsa-miR-548ac	CLIP-seq
MIRT1227425	hsa-miR-548ae	CLIP-seq
MIRT1227427	hsa-miR-548aj	CLIP-seq
MIRT1227428	hsa-miR-548am	CLIP-seq
MIRT1227429	hsa-miR-548c-3p	CLIP-seq
MIRT1227430	hsa-miR-548d-3p	CLIP-seq
MIRT1227431	hsa-miR-548l	CLIP-seq
MIRT2592141	hsa-miR-548n	CLIP-seq
MIRT1227434	hsa-miR-548x	CLIP-seq
MIRT1227435	hsa-miR-548z	CLIP-seq
MIRT1227436	hsa-miR-570	CLIP-seq
MIRT2592142	hsa-miR-577	CLIP-seq
MIRT1227439	hsa-miR-603	CLIP-seq
MIRT1227440	hsa-miR-607	CLIP-seq
MIRT1227442	hsa-miR-637	CLIP-seq
MIRT2592143	hsa-miR-643	CLIP-seq
MIRT2592144	hsa-miR-646	CLIP-seq
MIRT2294159	hsa-miR-668	CLIP-seq
MIRT2294160	hsa-miR-921	CLIP-seq
MIRT1227385	hsa-miR-105	CLIP-seq
MIRT2592110	hsa-miR-1237	CLIP-seq
MIRT2592111	hsa-miR-1248	CLIP-seq
MIRT2592112	hsa-miR-1305	CLIP-seq
MIRT2294144	hsa-miR-191	CLIP-seq
MIRT2592113	hsa-miR-203	CLIP-seq
MIRT1227388	hsa-miR-214	CLIP-seq
MIRT2687735	hsa-miR-219-5p	CLIP-seq
MIRT2592115	hsa-miR-2355-5p	CLIP-seq
MIRT2687736	hsa-miR-24	CLIP-seq
MIRT2592116	hsa-miR-28-3p	CLIP-seq
MIRT1227389	hsa-miR-3124-3p	CLIP-seq
MIRT2592117	hsa-miR-3149	CLIP-seq
MIRT2592118	hsa-miR-3161	CLIP-seq
MIRT2592119	hsa-miR-3168	CLIP-seq
MIRT2294147	hsa-miR-3201	CLIP-seq
MIRT2294148	hsa-miR-3591-5p	CLIP-seq
MIRT2294149	hsa-miR-3606	CLIP-seq
MIRT1227395	hsa-miR-3609	CLIP-seq
MIRT1227397	hsa-miR-3619-5p	CLIP-seq
MIRT1227401	hsa-miR-3646	CLIP-seq
MIRT1227402	hsa-miR-3662	CLIP-seq
MIRT1227403	hsa-miR-3671	CLIP-seq
MIRT2592120	hsa-miR-3679-3p	CLIP-seq
MIRT2592121	hsa-miR-374a	CLIP-seq
MIRT2592122	hsa-miR-374b	CLIP-seq
MIRT2592123	hsa-miR-376a	CLIP-seq
MIRT2592124	hsa-miR-376b	CLIP-seq
MIRT1227406	hsa-miR-3973	CLIP-seq
MIRT2592125	hsa-miR-421	CLIP-seq
MIRT2687737	hsa-miR-4284	CLIP-seq
MIRT1227408	hsa-miR-4291	CLIP-seq
MIRT2294151	hsa-miR-4420	CLIP-seq
MIRT2592126	hsa-miR-4424	CLIP-seq
MIRT2687738	hsa-miR-4432	CLIP-seq
MIRT2592128	hsa-miR-4445	CLIP-seq
MIRT1227409	hsa-miR-4488	CLIP-seq
MIRT2592129	hsa-miR-4637	CLIP-seq
MIRT2592130	hsa-miR-4652-3p	CLIP-seq
MIRT1227413	hsa-miR-4697-5p	CLIP-seq
MIRT2294153	hsa-miR-4709-3p	CLIP-seq
MIRT1227416	hsa-miR-4722-5p	CLIP-seq
MIRT2592132	hsa-miR-4729	CLIP-seq
MIRT1227417	hsa-miR-4733-5p	CLIP-seq
MIRT1227418	hsa-miR-4768-3p	CLIP-seq
MIRT1227420	hsa-miR-4775	CLIP-seq
MIRT2592133	hsa-miR-4777-5p	CLIP-seq
MIRT2687739	hsa-miR-4782-3p	CLIP-seq
MIRT2592134	hsa-miR-4790-3p	CLIP-seq
MIRT2294156	hsa-miR-4791	CLIP-seq
MIRT2592135	hsa-miR-4795-3p	CLIP-seq
MIRT2687740	hsa-miR-499-5p	CLIP-seq
MIRT2687741	hsa-miR-508-3p	CLIP-seq
MIRT2592136	hsa-miR-518d-5p	CLIP-seq
MIRT2592137	hsa-miR-519b-5p	CLIP-seq
MIRT2592138	hsa-miR-519c-5p	CLIP-seq
MIRT2592139	hsa-miR-520c-5p	CLIP-seq
MIRT1227422	hsa-miR-520g	CLIP-seq
MIRT1227423	hsa-miR-520h	CLIP-seq
MIRT2592140	hsa-miR-526a	CLIP-seq
MIRT1227424	hsa-miR-548ac	CLIP-seq
MIRT1227425	hsa-miR-548ae	CLIP-seq
MIRT1227426	hsa-miR-548ah	CLIP-seq
MIRT1227427	hsa-miR-548aj	CLIP-seq
MIRT1227428	hsa-miR-548am	CLIP-seq
MIRT1227429	hsa-miR-548c-3p	CLIP-seq
MIRT1227430	hsa-miR-548d-3p	CLIP-seq
MIRT1227431	hsa-miR-548l	CLIP-seq
MIRT2592141	hsa-miR-548n	CLIP-seq
MIRT1227434	hsa-miR-548x	CLIP-seq
MIRT1227435	hsa-miR-548z	CLIP-seq
MIRT1227436	hsa-miR-570	CLIP-seq
MIRT2592142	hsa-miR-577	CLIP-seq
MIRT1227439	hsa-miR-603	CLIP-seq
MIRT1227440	hsa-miR-607	CLIP-seq
MIRT1227442	hsa-miR-637	CLIP-seq
MIRT2592143	hsa-miR-643	CLIP-seq
MIRT2294159	hsa-miR-668	CLIP-seq
MIRT1227443	hsa-miR-761	CLIP-seq
MIRT2294160	hsa-miR-921	CLIP-seq
MIRT1227444	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004659	Function	Prenyltransferase activity	IEA
GO:0004661	Function	Protein geranylgeranyltransferase activity	IDA	16893176
GO:0004661	Function	Protein geranylgeranyltransferase activity	IEA
GO:0004662	Function	CAAX-protein geranylgeranyltransferase activity	IBA
GO:0004662	Function	CAAX-protein geranylgeranyltransferase activity	IEA
GO:0004662	Function	CAAX-protein geranylgeranyltransferase activity	ISS
GO:0004662	Function	CAAX-protein geranylgeranyltransferase activity	TAS	8106351
GO:0005515	Function	Protein binding	IPI	24981860, 32296183, 33961781
GO:0005953	Component	CAAX-protein geranylgeranyltransferase complex	IBA
GO:0005953	Component	CAAX-protein geranylgeranyltransferase complex	IDA	16893176
GO:0005953	Component	CAAX-protein geranylgeranyltransferase complex	IEA
GO:0005953	Component	CAAX-protein geranylgeranyltransferase complex	IPI	8106351
GO:0005953	Component	CAAX-protein geranylgeranyltransferase complex	TAS	8106351
GO:0008270	Function	Zinc ion binding	ISS
GO:0008318	Function	Protein prenyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018344	Process	Protein geranylgeranylation	IDA	16893176
GO:0018344	Process	Protein geranylgeranylation	TAS	8106351
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 602031
• HGNC: 8895
• e!Ensembl: ENSG00000164219

Protein

• UniProt ID: P53609
• Protein name: Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)
• Protein function: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00432	Prenyltrans	142 → 186	Prenyltransferase and squalene oxidase repeat	Repeat
  PF00432	Prenyltrans	191 → 234	Prenyltransferase and squalene oxidase repeat	Repeat
  PF00432	Prenyltrans	240 → 284	Prenyltransferase and squalene oxidase repeat	Repeat
  PF00432	Prenyltrans	289 → 333	Prenyltransferase and squalene oxidase repeat	Repeat

• Sequence:

  MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
  LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
  HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
  ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
  SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
  TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
  WKTKDSKQCSENVHIST

• Sequence length: 377