PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3)

Gene

• Entrez ID: 5209
• Gene name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
• Gene symbol: PFKFB3
• Synonyms (NCBI Gene): IPFK2, PFK2, iPFK-2
• Chromosome: 10
• Chromosome location: 10p15.1
• Summary: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028775	hsa-miR-26b-5p	Microarray	19088304
MIRT043840	hsa-miR-330-3p	CLASH	23622248
MIRT527976	hsa-miR-6865-3p	PAR-CLIP	22012620
MIRT527975	hsa-miR-6840-5p	PAR-CLIP	22012620
MIRT527974	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT527973	hsa-miR-3185	PAR-CLIP	22012620
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT454761	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT454760	hsa-miR-765	PAR-CLIP	23592263
MIRT454759	hsa-miR-1291	PAR-CLIP	23592263
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	23592263
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT454749	hsa-miR-3689c	PAR-CLIP	23592263
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	26701625
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	26701625
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	26701625
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT454759	hsa-miR-1291	PAR-CLIP	26701625
MIRT454759	hsa-miR-1291	PAR-CLIP	26701625
MIRT454759	hsa-miR-1291	PAR-CLIP	26701625
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT454749	hsa-miR-3689c	PAR-CLIP	26701625
MIRT454749	hsa-miR-3689c	PAR-CLIP	26701625
MIRT454749	hsa-miR-3689c	PAR-CLIP	26701625
MIRT454761	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT454761	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT454761	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	26701625
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	26701625
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	26701625
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	26701625
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	26701625
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	26701625
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT454760	hsa-miR-765	PAR-CLIP	26701625
MIRT454760	hsa-miR-765	PAR-CLIP	26701625
MIRT454760	hsa-miR-765	PAR-CLIP	26701625
MIRT732446	hsa-miR-675-5p	Immunofluorescence, Immunohistochemistry (IHC), qRT-PCR, Western blotting	33762576
MIRT733774	hsa-miR-488-5p	Luciferase reporter assay, qRT-PCR	32990355
MIRT737237	hsa-miR-3666	Luciferase reporter assay, Western blotting, qRT-PCR	32982293
MIRT527976	hsa-miR-6865-3p	PAR-CLIP	22012620
MIRT527975	hsa-miR-6840-5p	PAR-CLIP	22012620
MIRT527974	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT527973	hsa-miR-3185	PAR-CLIP	22012620
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT454761	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT454760	hsa-miR-765	PAR-CLIP	23592263
MIRT454759	hsa-miR-1291	PAR-CLIP	23592263
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	23592263
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT454749	hsa-miR-3689c	PAR-CLIP	23592263
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT756385	hsa-miR-1915-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC)	34599680
MIRT1226254	hsa-miR-106a	CLIP-seq
MIRT1226255	hsa-miR-106b	CLIP-seq
MIRT1226256	hsa-miR-1197	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT1226258	hsa-miR-1254	CLIP-seq
MIRT1226259	hsa-miR-1266	CLIP-seq
MIRT1226260	hsa-miR-1286	CLIP-seq
MIRT1226261	hsa-miR-130a	CLIP-seq
MIRT1226262	hsa-miR-130b	CLIP-seq
MIRT1226263	hsa-miR-139-5p	CLIP-seq
MIRT1226264	hsa-miR-17	CLIP-seq
MIRT1226265	hsa-miR-1827	CLIP-seq
MIRT1226266	hsa-miR-1972	CLIP-seq
MIRT1226267	hsa-miR-19a	CLIP-seq
MIRT1226268	hsa-miR-19b	CLIP-seq
MIRT1226269	hsa-miR-20a	CLIP-seq
MIRT1226270	hsa-miR-20b	CLIP-seq
MIRT1226271	hsa-miR-216b	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226273	hsa-miR-2467-5p	CLIP-seq
MIRT1226274	hsa-miR-298	CLIP-seq
MIRT1226275	hsa-miR-301a	CLIP-seq
MIRT1226276	hsa-miR-301b	CLIP-seq
MIRT1226277	hsa-miR-3116	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT1226279	hsa-miR-3179	CLIP-seq
MIRT1226280	hsa-miR-3199	CLIP-seq
MIRT1226281	hsa-miR-3612	CLIP-seq
MIRT1226282	hsa-miR-3613-3p	CLIP-seq
MIRT1226283	hsa-miR-3616-3p	CLIP-seq
MIRT1226284	hsa-miR-3664-3p	CLIP-seq
MIRT1226285	hsa-miR-3675-3p	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT1226288	hsa-miR-3944-5p	CLIP-seq
MIRT1226289	hsa-miR-4266	CLIP-seq
MIRT1226290	hsa-miR-4269	CLIP-seq
MIRT1226291	hsa-miR-4295	CLIP-seq
MIRT1226292	hsa-miR-4302	CLIP-seq
MIRT1226293	hsa-miR-4436a	CLIP-seq
MIRT1226294	hsa-miR-4436b-3p	CLIP-seq
MIRT1226295	hsa-miR-4443	CLIP-seq
MIRT1226296	hsa-miR-4448	CLIP-seq
MIRT1226297	hsa-miR-4457	CLIP-seq
MIRT1226298	hsa-miR-4493	CLIP-seq
MIRT1226299	hsa-miR-4514	CLIP-seq
MIRT1226300	hsa-miR-4518	CLIP-seq
MIRT1226301	hsa-miR-4530	CLIP-seq
MIRT1226302	hsa-miR-454	CLIP-seq
MIRT1226303	hsa-miR-4635	CLIP-seq
MIRT1226304	hsa-miR-4645-5p	CLIP-seq
MIRT1226305	hsa-miR-4648	CLIP-seq
MIRT1226306	hsa-miR-4650-5p	CLIP-seq
MIRT1226307	hsa-miR-4660	CLIP-seq
MIRT1226308	hsa-miR-4673	CLIP-seq
MIRT1226309	hsa-miR-4684-5p	CLIP-seq
MIRT1226310	hsa-miR-4692	CLIP-seq
MIRT1226311	hsa-miR-4695-5p	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226313	hsa-miR-4709-3p	CLIP-seq
MIRT1226314	hsa-miR-4717-5p	CLIP-seq
MIRT1226315	hsa-miR-4727-5p	CLIP-seq
MIRT1226316	hsa-miR-4731-3p	CLIP-seq
MIRT1226317	hsa-miR-4747-5p	CLIP-seq
MIRT1226318	hsa-miR-4750	CLIP-seq
MIRT1226319	hsa-miR-4753-5p	CLIP-seq
MIRT1226320	hsa-miR-4755-3p	CLIP-seq
MIRT1226321	hsa-miR-4769-3p	CLIP-seq
MIRT1226322	hsa-miR-4779	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT1226324	hsa-miR-4789-5p	CLIP-seq
MIRT1226325	hsa-miR-4795-5p	CLIP-seq
MIRT1226326	hsa-miR-4801	CLIP-seq
MIRT1226327	hsa-miR-519a	CLIP-seq
MIRT1226328	hsa-miR-519b-3p	CLIP-seq
MIRT1226329	hsa-miR-519c-3p	CLIP-seq
MIRT1226330	hsa-miR-519d	CLIP-seq
MIRT1226331	hsa-miR-548t	CLIP-seq
MIRT1226332	hsa-miR-646	CLIP-seq
MIRT1226333	hsa-miR-648	CLIP-seq
MIRT1226334	hsa-miR-650	CLIP-seq
MIRT1226335	hsa-miR-658	CLIP-seq
MIRT1226336	hsa-miR-9	CLIP-seq
MIRT1226337	hsa-miR-922	CLIP-seq
MIRT1226338	hsa-miR-93	CLIP-seq
MIRT1226339	hsa-miR-940	CLIP-seq
MIRT1226340	hsa-miR-1	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT1226259	hsa-miR-1266	CLIP-seq
MIRT1226341	hsa-miR-1324	CLIP-seq
MIRT1226263	hsa-miR-139-5p	CLIP-seq
MIRT1226342	hsa-miR-150	CLIP-seq
MIRT1226343	hsa-miR-206	CLIP-seq
MIRT1226344	hsa-miR-2110	CLIP-seq
MIRT1226271	hsa-miR-216b	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226273	hsa-miR-2467-5p	CLIP-seq
MIRT1226274	hsa-miR-298	CLIP-seq
MIRT1226345	hsa-miR-302a	CLIP-seq
MIRT1226346	hsa-miR-302b	CLIP-seq
MIRT1226347	hsa-miR-302c	CLIP-seq
MIRT1226348	hsa-miR-302d	CLIP-seq
MIRT1226349	hsa-miR-302e	CLIP-seq
MIRT1226350	hsa-miR-3127-5p	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT1226284	hsa-miR-3664-3p	CLIP-seq
MIRT1226351	hsa-miR-3673	CLIP-seq
MIRT1226285	hsa-miR-3675-3p	CLIP-seq
MIRT1226352	hsa-miR-3688-3p	CLIP-seq
MIRT1226353	hsa-miR-372	CLIP-seq
MIRT1226354	hsa-miR-373	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT1226355	hsa-miR-3918	CLIP-seq
MIRT1226356	hsa-miR-3919	CLIP-seq
MIRT1226289	hsa-miR-4266	CLIP-seq
MIRT1226357	hsa-miR-4271	CLIP-seq
MIRT1226358	hsa-miR-4284	CLIP-seq
MIRT1226359	hsa-miR-4437	CLIP-seq
MIRT1226296	hsa-miR-4448	CLIP-seq
MIRT1226300	hsa-miR-4518	CLIP-seq
MIRT1226360	hsa-miR-4533	CLIP-seq
MIRT1226361	hsa-miR-4667-5p	CLIP-seq
MIRT1226362	hsa-miR-4672	CLIP-seq
MIRT1226309	hsa-miR-4684-5p	CLIP-seq
MIRT1226363	hsa-miR-4694-3p	CLIP-seq
MIRT1226364	hsa-miR-4695-3p	CLIP-seq
MIRT1226311	hsa-miR-4695-5p	CLIP-seq
MIRT1226365	hsa-miR-4700-5p	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226366	hsa-miR-4725-3p	CLIP-seq
MIRT1226367	hsa-miR-4731-5p	CLIP-seq
MIRT1226317	hsa-miR-4747-5p	CLIP-seq
MIRT1226320	hsa-miR-4755-3p	CLIP-seq
MIRT1226368	hsa-miR-4760-3p	CLIP-seq
MIRT1226322	hsa-miR-4779	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT1226324	hsa-miR-4789-5p	CLIP-seq
MIRT1226369	hsa-miR-512-3p	CLIP-seq
MIRT1226370	hsa-miR-520a-3p	CLIP-seq
MIRT1226371	hsa-miR-520b	CLIP-seq
MIRT1226372	hsa-miR-520c-3p	CLIP-seq
MIRT1226373	hsa-miR-520d-3p	CLIP-seq
MIRT1226374	hsa-miR-520e	CLIP-seq
MIRT1226375	hsa-miR-613	CLIP-seq
MIRT1226337	hsa-miR-922	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT2066222	hsa-miR-1183	CLIP-seq
MIRT2066223	hsa-miR-1206	CLIP-seq
MIRT2066224	hsa-miR-1245b-5p	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT1226259	hsa-miR-1266	CLIP-seq
MIRT2066225	hsa-miR-128	CLIP-seq
MIRT2066226	hsa-miR-1285	CLIP-seq
MIRT1226341	hsa-miR-1324	CLIP-seq
MIRT2066227	hsa-miR-140-3p	CLIP-seq
MIRT2066228	hsa-miR-1470	CLIP-seq
MIRT1226342	hsa-miR-150	CLIP-seq
MIRT2066229	hsa-miR-1915	CLIP-seq
MIRT2066230	hsa-miR-196a	CLIP-seq
MIRT2066231	hsa-miR-196b	CLIP-seq
MIRT2066232	hsa-miR-1976	CLIP-seq
MIRT2066233	hsa-miR-198	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226273	hsa-miR-2467-5p	CLIP-seq
MIRT2066234	hsa-miR-300	CLIP-seq
MIRT2066235	hsa-miR-3128	CLIP-seq
MIRT2066236	hsa-miR-3137	CLIP-seq
MIRT2066237	hsa-miR-3140-5p	CLIP-seq
MIRT2066238	hsa-miR-3142	CLIP-seq
MIRT2066239	hsa-miR-3144-5p	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT2066240	hsa-miR-3175	CLIP-seq
MIRT2066241	hsa-miR-3183	CLIP-seq
MIRT2066242	hsa-miR-3187-5p	CLIP-seq
MIRT2066243	hsa-miR-331-5p	CLIP-seq
MIRT2066244	hsa-miR-339-5p	CLIP-seq
MIRT2066245	hsa-miR-3611	CLIP-seq
MIRT2066246	hsa-miR-3620	CLIP-seq
MIRT2066247	hsa-miR-3685	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT2066248	hsa-miR-378g	CLIP-seq
MIRT2066249	hsa-miR-381	CLIP-seq
MIRT2066250	hsa-miR-384	CLIP-seq
MIRT2066251	hsa-miR-3910	CLIP-seq
MIRT1226356	hsa-miR-3919	CLIP-seq
MIRT2066252	hsa-miR-3927	CLIP-seq
MIRT1226288	hsa-miR-3944-5p	CLIP-seq
MIRT2066253	hsa-miR-4257	CLIP-seq
MIRT1226289	hsa-miR-4266	CLIP-seq
MIRT2066254	hsa-miR-4267	CLIP-seq
MIRT1226290	hsa-miR-4269	CLIP-seq
MIRT2066255	hsa-miR-4277	CLIP-seq
MIRT2066256	hsa-miR-4287	CLIP-seq
MIRT2066257	hsa-miR-4297	CLIP-seq
MIRT1226292	hsa-miR-4302	CLIP-seq
MIRT2066258	hsa-miR-433	CLIP-seq
MIRT2066259	hsa-miR-4421	CLIP-seq
MIRT1226293	hsa-miR-4436a	CLIP-seq
MIRT1226297	hsa-miR-4457	CLIP-seq
MIRT2066260	hsa-miR-4469	CLIP-seq
MIRT2066261	hsa-miR-4486	CLIP-seq
MIRT1226299	hsa-miR-4514	CLIP-seq
MIRT1226300	hsa-miR-4518	CLIP-seq
MIRT2066262	hsa-miR-4520a-3p	CLIP-seq
MIRT2066263	hsa-miR-4520b-3p	CLIP-seq
MIRT2066264	hsa-miR-4527	CLIP-seq
MIRT2066265	hsa-miR-4529-3p	CLIP-seq
MIRT1226303	hsa-miR-4635	CLIP-seq
MIRT1226304	hsa-miR-4645-5p	CLIP-seq
MIRT1226306	hsa-miR-4650-5p	CLIP-seq
MIRT1226307	hsa-miR-4660	CLIP-seq
MIRT2066266	hsa-miR-4666-3p	CLIP-seq
MIRT2066267	hsa-miR-4667-3p	CLIP-seq
MIRT1226362	hsa-miR-4672	CLIP-seq
MIRT1226308	hsa-miR-4673	CLIP-seq
MIRT2066268	hsa-miR-4678	CLIP-seq
MIRT2066269	hsa-miR-4683	CLIP-seq
MIRT2066270	hsa-miR-4685-3p	CLIP-seq
MIRT1226310	hsa-miR-4692	CLIP-seq
MIRT1226311	hsa-miR-4695-5p	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226313	hsa-miR-4709-3p	CLIP-seq
MIRT2066271	hsa-miR-4716-5p	CLIP-seq
MIRT2066272	hsa-miR-4720-5p	CLIP-seq
MIRT2066273	hsa-miR-4723-3p	CLIP-seq
MIRT2066274	hsa-miR-4726-3p	CLIP-seq
MIRT2066275	hsa-miR-4742-3p	CLIP-seq
MIRT1226317	hsa-miR-4747-5p	CLIP-seq
MIRT1226320	hsa-miR-4755-3p	CLIP-seq
MIRT1226368	hsa-miR-4760-3p	CLIP-seq
MIRT2066276	hsa-miR-4762-3p	CLIP-seq
MIRT2066277	hsa-miR-4762-5p	CLIP-seq
MIRT2066278	hsa-miR-4766-5p	CLIP-seq
MIRT1226322	hsa-miR-4779	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT2066279	hsa-miR-4799-3p	CLIP-seq
MIRT2066280	hsa-miR-485-5p	CLIP-seq
MIRT2066281	hsa-miR-488	CLIP-seq
MIRT2066282	hsa-miR-493	CLIP-seq
MIRT2066283	hsa-miR-513a-3p	CLIP-seq
MIRT2066284	hsa-miR-522	CLIP-seq
MIRT2066285	hsa-miR-548an	CLIP-seq
MIRT2066286	hsa-miR-579	CLIP-seq
MIRT2066287	hsa-miR-612	CLIP-seq
MIRT2066288	hsa-miR-621	CLIP-seq
MIRT2066289	hsa-miR-634	CLIP-seq
MIRT1226333	hsa-miR-648	CLIP-seq
MIRT2066290	hsa-miR-758	CLIP-seq
MIRT2066291	hsa-miR-759	CLIP-seq
MIRT2066292	hsa-miR-943	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT2066251	hsa-miR-3910	CLIP-seq
MIRT2066285	hsa-miR-548an	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT2066229	hsa-miR-1915	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226331	hsa-miR-548t	CLIP-seq
MIRT2066291	hsa-miR-759	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT2456278	hsa-miR-337-5p	CLIP-seq
MIRT2456279	hsa-miR-4768-5p	CLIP-seq
MIRT2456280	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HIF1A	Unknown	16025159

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003873	Function	6-phosphofructo-2-kinase activity	IBA
GO:0003873	Function	6-phosphofructo-2-kinase activity	IDA	10077634, 17499765
GO:0003873	Function	6-phosphofructo-2-kinase activity	IEA
GO:0003873	Function	6-phosphofructo-2-kinase activity	NAS	8830046
GO:0004331	Function	Fructose-2,6-bisphosphate 2-phosphatase activity	IBA
GO:0004331	Function	Fructose-2,6-bisphosphate 2-phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006000	Process	Fructose metabolic process	IEA
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IBA
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IDA	1749976
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IEA
GO:0006094	Process	Gluconeogenesis	NAS	15581487
GO:0006096	Process	Glycolytic process	IEA
GO:0006096	Process	Glycolytic process	NAS	15581487
GO:0006915	Process	Apoptotic process	IEA
GO:0010001	Process	Glial cell differentiation	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0043540	Component	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	IPI	1749976
GO:0046835	Process	Carbohydrate phosphorylation	IEA
GO:0061744	Process	Motor behavior	IEA

Other IDs

• MIM: 605319
• HGNC: 8874
• e!Ensembl: ENSG00000170525

Protein

• UniProt ID: Q16875
• Protein name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2
• Protein function: Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
• PDB: 2AXN, 2DWO, 2DWP, 2I1V, 3QPU, 3QPV, 3QPW, 4D4J, 4D4K, 4D4L, 4D4M, 4MA4, 5AJV, 5AJW, 5AJX, 5AJY, 5AJZ, 5AK0, 6ETJ, 6HVH, 6HVI, 6HVJ, 6IBX, 6IBY, 6IBZ, 6IC0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01591	6PF2K	24 → 246	6-phosphofructo-2-kinase	Domain
  PF00300	His_Phos_1	249 → 435	Histidine phosphatase superfamily (branch 1)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
  WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
  IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
  AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
  NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
  LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
  ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
  TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
  EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH

• Sequence length: 520

Pathways

KEGG:

Fructose and mannose metabolism
Metabolic pathways
HIF-1 signaling pathway
AMPK signaling pathway

Reactome:

Regulation of glycolysis by fructose 2,6-bisphosphate metabolism