Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5209
Gene name Gene Name - the full gene name approved by the HGNC.	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PFKFB3
Synonyms (NCBI Gene) Gene synonyms aliases	IPFK2, PFK2, iPFK-2
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p15.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-p

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028775	hsa-miR-26b-5p	Microarray	19088304
MIRT043840	hsa-miR-330-3p	CLASH	23622248
MIRT527976	hsa-miR-6865-3p	PAR-CLIP	22012620
MIRT527975	hsa-miR-6840-5p	PAR-CLIP	22012620
MIRT527974	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT527973	hsa-miR-3185	PAR-CLIP	22012620
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT454761	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT454760	hsa-miR-765	PAR-CLIP	23592263
MIRT454759	hsa-miR-1291	PAR-CLIP	23592263
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	23592263
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT454749	hsa-miR-3689c	PAR-CLIP	23592263
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	26701625
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	26701625
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	26701625
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT454759	hsa-miR-1291	PAR-CLIP	26701625
MIRT454759	hsa-miR-1291	PAR-CLIP	26701625
MIRT454759	hsa-miR-1291	PAR-CLIP	26701625
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT454749	hsa-miR-3689c	PAR-CLIP	26701625
MIRT454749	hsa-miR-3689c	PAR-CLIP	26701625
MIRT454749	hsa-miR-3689c	PAR-CLIP	26701625
MIRT454761	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT454761	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT454761	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	26701625
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	26701625
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	26701625
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	26701625
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	26701625
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	26701625
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT454760	hsa-miR-765	PAR-CLIP	26701625
MIRT454760	hsa-miR-765	PAR-CLIP	26701625
MIRT454760	hsa-miR-765	PAR-CLIP	26701625
MIRT732446	hsa-miR-675-5p	Immunofluorescence, Immunohistochemistry (IHC), qRT-PCR, Western blotting	33762576
MIRT733774	hsa-miR-488-5p	Luciferase reporter assay, qRT-PCR	32990355
MIRT737237	hsa-miR-3666	Luciferase reporter assay, Western blotting, qRT-PCR	32982293
MIRT527976	hsa-miR-6865-3p	PAR-CLIP	22012620
MIRT527975	hsa-miR-6840-5p	PAR-CLIP	22012620
MIRT527974	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT527973	hsa-miR-3185	PAR-CLIP	22012620
MIRT454764	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT454763	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT454762	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT454761	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT454760	hsa-miR-765	PAR-CLIP	23592263
MIRT454759	hsa-miR-1291	PAR-CLIP	23592263
MIRT454758	hsa-miR-6775-3p	PAR-CLIP	23592263
MIRT454757	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT454756	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT454755	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT454754	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT454753	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT454752	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT454751	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT454750	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT454749	hsa-miR-3689c	PAR-CLIP	23592263
MIRT454747	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT454748	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT756385	hsa-miR-1915-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC)	34599680
MIRT1226254	hsa-miR-106a	CLIP-seq
MIRT1226255	hsa-miR-106b	CLIP-seq
MIRT1226256	hsa-miR-1197	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT1226258	hsa-miR-1254	CLIP-seq
MIRT1226259	hsa-miR-1266	CLIP-seq
MIRT1226260	hsa-miR-1286	CLIP-seq
MIRT1226261	hsa-miR-130a	CLIP-seq
MIRT1226262	hsa-miR-130b	CLIP-seq
MIRT1226263	hsa-miR-139-5p	CLIP-seq
MIRT1226264	hsa-miR-17	CLIP-seq
MIRT1226265	hsa-miR-1827	CLIP-seq
MIRT1226266	hsa-miR-1972	CLIP-seq
MIRT1226267	hsa-miR-19a	CLIP-seq
MIRT1226268	hsa-miR-19b	CLIP-seq
MIRT1226269	hsa-miR-20a	CLIP-seq
MIRT1226270	hsa-miR-20b	CLIP-seq
MIRT1226271	hsa-miR-216b	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226273	hsa-miR-2467-5p	CLIP-seq
MIRT1226274	hsa-miR-298	CLIP-seq
MIRT1226275	hsa-miR-301a	CLIP-seq
MIRT1226276	hsa-miR-301b	CLIP-seq
MIRT1226277	hsa-miR-3116	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT1226279	hsa-miR-3179	CLIP-seq
MIRT1226280	hsa-miR-3199	CLIP-seq
MIRT1226281	hsa-miR-3612	CLIP-seq
MIRT1226282	hsa-miR-3613-3p	CLIP-seq
MIRT1226283	hsa-miR-3616-3p	CLIP-seq
MIRT1226284	hsa-miR-3664-3p	CLIP-seq
MIRT1226285	hsa-miR-3675-3p	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT1226288	hsa-miR-3944-5p	CLIP-seq
MIRT1226289	hsa-miR-4266	CLIP-seq
MIRT1226290	hsa-miR-4269	CLIP-seq
MIRT1226291	hsa-miR-4295	CLIP-seq
MIRT1226292	hsa-miR-4302	CLIP-seq
MIRT1226293	hsa-miR-4436a	CLIP-seq
MIRT1226294	hsa-miR-4436b-3p	CLIP-seq
MIRT1226295	hsa-miR-4443	CLIP-seq
MIRT1226296	hsa-miR-4448	CLIP-seq
MIRT1226297	hsa-miR-4457	CLIP-seq
MIRT1226298	hsa-miR-4493	CLIP-seq
MIRT1226299	hsa-miR-4514	CLIP-seq
MIRT1226300	hsa-miR-4518	CLIP-seq
MIRT1226301	hsa-miR-4530	CLIP-seq
MIRT1226302	hsa-miR-454	CLIP-seq
MIRT1226303	hsa-miR-4635	CLIP-seq
MIRT1226304	hsa-miR-4645-5p	CLIP-seq
MIRT1226305	hsa-miR-4648	CLIP-seq
MIRT1226306	hsa-miR-4650-5p	CLIP-seq
MIRT1226307	hsa-miR-4660	CLIP-seq
MIRT1226308	hsa-miR-4673	CLIP-seq
MIRT1226309	hsa-miR-4684-5p	CLIP-seq
MIRT1226310	hsa-miR-4692	CLIP-seq
MIRT1226311	hsa-miR-4695-5p	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226313	hsa-miR-4709-3p	CLIP-seq
MIRT1226314	hsa-miR-4717-5p	CLIP-seq
MIRT1226315	hsa-miR-4727-5p	CLIP-seq
MIRT1226316	hsa-miR-4731-3p	CLIP-seq
MIRT1226317	hsa-miR-4747-5p	CLIP-seq
MIRT1226318	hsa-miR-4750	CLIP-seq
MIRT1226319	hsa-miR-4753-5p	CLIP-seq
MIRT1226320	hsa-miR-4755-3p	CLIP-seq
MIRT1226321	hsa-miR-4769-3p	CLIP-seq
MIRT1226322	hsa-miR-4779	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT1226324	hsa-miR-4789-5p	CLIP-seq
MIRT1226325	hsa-miR-4795-5p	CLIP-seq
MIRT1226326	hsa-miR-4801	CLIP-seq
MIRT1226327	hsa-miR-519a	CLIP-seq
MIRT1226328	hsa-miR-519b-3p	CLIP-seq
MIRT1226329	hsa-miR-519c-3p	CLIP-seq
MIRT1226330	hsa-miR-519d	CLIP-seq
MIRT1226331	hsa-miR-548t	CLIP-seq
MIRT1226332	hsa-miR-646	CLIP-seq
MIRT1226333	hsa-miR-648	CLIP-seq
MIRT1226334	hsa-miR-650	CLIP-seq
MIRT1226335	hsa-miR-658	CLIP-seq
MIRT1226336	hsa-miR-9	CLIP-seq
MIRT1226337	hsa-miR-922	CLIP-seq
MIRT1226338	hsa-miR-93	CLIP-seq
MIRT1226339	hsa-miR-940	CLIP-seq
MIRT1226340	hsa-miR-1	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT1226259	hsa-miR-1266	CLIP-seq
MIRT1226341	hsa-miR-1324	CLIP-seq
MIRT1226263	hsa-miR-139-5p	CLIP-seq
MIRT1226342	hsa-miR-150	CLIP-seq
MIRT1226343	hsa-miR-206	CLIP-seq
MIRT1226344	hsa-miR-2110	CLIP-seq
MIRT1226271	hsa-miR-216b	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226273	hsa-miR-2467-5p	CLIP-seq
MIRT1226274	hsa-miR-298	CLIP-seq
MIRT1226345	hsa-miR-302a	CLIP-seq
MIRT1226346	hsa-miR-302b	CLIP-seq
MIRT1226347	hsa-miR-302c	CLIP-seq
MIRT1226348	hsa-miR-302d	CLIP-seq
MIRT1226349	hsa-miR-302e	CLIP-seq
MIRT1226350	hsa-miR-3127-5p	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT1226284	hsa-miR-3664-3p	CLIP-seq
MIRT1226351	hsa-miR-3673	CLIP-seq
MIRT1226285	hsa-miR-3675-3p	CLIP-seq
MIRT1226352	hsa-miR-3688-3p	CLIP-seq
MIRT1226353	hsa-miR-372	CLIP-seq
MIRT1226354	hsa-miR-373	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT1226355	hsa-miR-3918	CLIP-seq
MIRT1226356	hsa-miR-3919	CLIP-seq
MIRT1226289	hsa-miR-4266	CLIP-seq
MIRT1226357	hsa-miR-4271	CLIP-seq
MIRT1226358	hsa-miR-4284	CLIP-seq
MIRT1226359	hsa-miR-4437	CLIP-seq
MIRT1226296	hsa-miR-4448	CLIP-seq
MIRT1226300	hsa-miR-4518	CLIP-seq
MIRT1226360	hsa-miR-4533	CLIP-seq
MIRT1226361	hsa-miR-4667-5p	CLIP-seq
MIRT1226362	hsa-miR-4672	CLIP-seq
MIRT1226309	hsa-miR-4684-5p	CLIP-seq
MIRT1226363	hsa-miR-4694-3p	CLIP-seq
MIRT1226364	hsa-miR-4695-3p	CLIP-seq
MIRT1226311	hsa-miR-4695-5p	CLIP-seq
MIRT1226365	hsa-miR-4700-5p	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226366	hsa-miR-4725-3p	CLIP-seq
MIRT1226367	hsa-miR-4731-5p	CLIP-seq
MIRT1226317	hsa-miR-4747-5p	CLIP-seq
MIRT1226320	hsa-miR-4755-3p	CLIP-seq
MIRT1226368	hsa-miR-4760-3p	CLIP-seq
MIRT1226322	hsa-miR-4779	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT1226324	hsa-miR-4789-5p	CLIP-seq
MIRT1226369	hsa-miR-512-3p	CLIP-seq
MIRT1226370	hsa-miR-520a-3p	CLIP-seq
MIRT1226371	hsa-miR-520b	CLIP-seq
MIRT1226372	hsa-miR-520c-3p	CLIP-seq
MIRT1226373	hsa-miR-520d-3p	CLIP-seq
MIRT1226374	hsa-miR-520e	CLIP-seq
MIRT1226375	hsa-miR-613	CLIP-seq
MIRT1226337	hsa-miR-922	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT2066222	hsa-miR-1183	CLIP-seq
MIRT2066223	hsa-miR-1206	CLIP-seq
MIRT2066224	hsa-miR-1245b-5p	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT1226259	hsa-miR-1266	CLIP-seq
MIRT2066225	hsa-miR-128	CLIP-seq
MIRT2066226	hsa-miR-1285	CLIP-seq
MIRT1226341	hsa-miR-1324	CLIP-seq
MIRT2066227	hsa-miR-140-3p	CLIP-seq
MIRT2066228	hsa-miR-1470	CLIP-seq
MIRT1226342	hsa-miR-150	CLIP-seq
MIRT2066229	hsa-miR-1915	CLIP-seq
MIRT2066230	hsa-miR-196a	CLIP-seq
MIRT2066231	hsa-miR-196b	CLIP-seq
MIRT2066232	hsa-miR-1976	CLIP-seq
MIRT2066233	hsa-miR-198	CLIP-seq
MIRT1226272	hsa-miR-224	CLIP-seq
MIRT1226273	hsa-miR-2467-5p	CLIP-seq
MIRT2066234	hsa-miR-300	CLIP-seq
MIRT2066235	hsa-miR-3128	CLIP-seq
MIRT2066236	hsa-miR-3137	CLIP-seq
MIRT2066237	hsa-miR-3140-5p	CLIP-seq
MIRT2066238	hsa-miR-3142	CLIP-seq
MIRT2066239	hsa-miR-3144-5p	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT2066240	hsa-miR-3175	CLIP-seq
MIRT2066241	hsa-miR-3183	CLIP-seq
MIRT2066242	hsa-miR-3187-5p	CLIP-seq
MIRT2066243	hsa-miR-331-5p	CLIP-seq
MIRT2066244	hsa-miR-339-5p	CLIP-seq
MIRT2066245	hsa-miR-3611	CLIP-seq
MIRT2066246	hsa-miR-3620	CLIP-seq
MIRT2066247	hsa-miR-3685	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT1226287	hsa-miR-377	CLIP-seq
MIRT2066248	hsa-miR-378g	CLIP-seq
MIRT2066249	hsa-miR-381	CLIP-seq
MIRT2066250	hsa-miR-384	CLIP-seq
MIRT2066251	hsa-miR-3910	CLIP-seq
MIRT1226356	hsa-miR-3919	CLIP-seq
MIRT2066252	hsa-miR-3927	CLIP-seq
MIRT1226288	hsa-miR-3944-5p	CLIP-seq
MIRT2066253	hsa-miR-4257	CLIP-seq
MIRT1226289	hsa-miR-4266	CLIP-seq
MIRT2066254	hsa-miR-4267	CLIP-seq
MIRT1226290	hsa-miR-4269	CLIP-seq
MIRT2066255	hsa-miR-4277	CLIP-seq
MIRT2066256	hsa-miR-4287	CLIP-seq
MIRT2066257	hsa-miR-4297	CLIP-seq
MIRT1226292	hsa-miR-4302	CLIP-seq
MIRT2066258	hsa-miR-433	CLIP-seq
MIRT2066259	hsa-miR-4421	CLIP-seq
MIRT1226293	hsa-miR-4436a	CLIP-seq
MIRT1226297	hsa-miR-4457	CLIP-seq
MIRT2066260	hsa-miR-4469	CLIP-seq
MIRT2066261	hsa-miR-4486	CLIP-seq
MIRT1226299	hsa-miR-4514	CLIP-seq
MIRT1226300	hsa-miR-4518	CLIP-seq
MIRT2066262	hsa-miR-4520a-3p	CLIP-seq
MIRT2066263	hsa-miR-4520b-3p	CLIP-seq
MIRT2066264	hsa-miR-4527	CLIP-seq
MIRT2066265	hsa-miR-4529-3p	CLIP-seq
MIRT1226303	hsa-miR-4635	CLIP-seq
MIRT1226304	hsa-miR-4645-5p	CLIP-seq
MIRT1226306	hsa-miR-4650-5p	CLIP-seq
MIRT1226307	hsa-miR-4660	CLIP-seq
MIRT2066266	hsa-miR-4666-3p	CLIP-seq
MIRT2066267	hsa-miR-4667-3p	CLIP-seq
MIRT1226362	hsa-miR-4672	CLIP-seq
MIRT1226308	hsa-miR-4673	CLIP-seq
MIRT2066268	hsa-miR-4678	CLIP-seq
MIRT2066269	hsa-miR-4683	CLIP-seq
MIRT2066270	hsa-miR-4685-3p	CLIP-seq
MIRT1226310	hsa-miR-4692	CLIP-seq
MIRT1226311	hsa-miR-4695-5p	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226313	hsa-miR-4709-3p	CLIP-seq
MIRT2066271	hsa-miR-4716-5p	CLIP-seq
MIRT2066272	hsa-miR-4720-5p	CLIP-seq
MIRT2066273	hsa-miR-4723-3p	CLIP-seq
MIRT2066274	hsa-miR-4726-3p	CLIP-seq
MIRT2066275	hsa-miR-4742-3p	CLIP-seq
MIRT1226317	hsa-miR-4747-5p	CLIP-seq
MIRT1226320	hsa-miR-4755-3p	CLIP-seq
MIRT1226368	hsa-miR-4760-3p	CLIP-seq
MIRT2066276	hsa-miR-4762-3p	CLIP-seq
MIRT2066277	hsa-miR-4762-5p	CLIP-seq
MIRT2066278	hsa-miR-4766-5p	CLIP-seq
MIRT1226322	hsa-miR-4779	CLIP-seq
MIRT1226323	hsa-miR-4789-3p	CLIP-seq
MIRT2066279	hsa-miR-4799-3p	CLIP-seq
MIRT2066280	hsa-miR-485-5p	CLIP-seq
MIRT2066281	hsa-miR-488	CLIP-seq
MIRT2066282	hsa-miR-493	CLIP-seq
MIRT2066283	hsa-miR-513a-3p	CLIP-seq
MIRT2066284	hsa-miR-522	CLIP-seq
MIRT2066285	hsa-miR-548an	CLIP-seq
MIRT2066286	hsa-miR-579	CLIP-seq
MIRT2066287	hsa-miR-612	CLIP-seq
MIRT2066288	hsa-miR-621	CLIP-seq
MIRT2066289	hsa-miR-634	CLIP-seq
MIRT1226333	hsa-miR-648	CLIP-seq
MIRT2066290	hsa-miR-758	CLIP-seq
MIRT2066291	hsa-miR-759	CLIP-seq
MIRT2066292	hsa-miR-943	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT2066251	hsa-miR-3910	CLIP-seq
MIRT2066285	hsa-miR-548an	CLIP-seq
MIRT1226257	hsa-miR-1247	CLIP-seq
MIRT2066229	hsa-miR-1915	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT1226286	hsa-miR-3714	CLIP-seq
MIRT1226312	hsa-miR-4707-5p	CLIP-seq
MIRT1226331	hsa-miR-548t	CLIP-seq
MIRT2066291	hsa-miR-759	CLIP-seq
MIRT1226278	hsa-miR-3160-5p	CLIP-seq
MIRT2456278	hsa-miR-337-5p	CLIP-seq
MIRT2456279	hsa-miR-4768-5p	CLIP-seq
MIRT2456280	hsa-miR-942	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
HIF1A	Unknown	16025159

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003873	Function	6-phosphofructo-2-kinase activity	IBA
GO:0003873	Function	6-phosphofructo-2-kinase activity	IDA	10077634, 17499765
GO:0003873	Function	6-phosphofructo-2-kinase activity	IEA
GO:0003873	Function	6-phosphofructo-2-kinase activity	NAS	8830046
GO:0004331	Function	Fructose-2,6-bisphosphate 2-phosphatase activity	IBA
GO:0004331	Function	Fructose-2,6-bisphosphate 2-phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006000	Process	Fructose metabolic process	IEA
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IBA
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IDA	1749976
GO:0006003	Process	Fructose 2,6-bisphosphate metabolic process	IEA
GO:0006094	Process	Gluconeogenesis	NAS	15581487
GO:0006096	Process	Glycolytic process	IEA
GO:0006096	Process	Glycolytic process	NAS	15581487
GO:0006915	Process	Apoptotic process	IEA
GO:0010001	Process	Glial cell differentiation	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0043540	Component	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex	IPI	1749976
GO:0046835	Process	Carbohydrate phosphorylation	IEA
GO:0061744	Process	Motor behavior	IEA

MIM	HGNC	e!Ensembl
605319	8874	ENSG00000170525

Protein

UniProt ID

Q16875

Protein name

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2

Protein function

Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.

PDB

2AXN , 2DWO , 2DWP , 2I1V , 3QPU , 3QPV , 3QPW , 4D4J , 4D4K , 4D4L , 4D4M , 4MA4 , 5AJV , 5AJW , 5AJX , 5AJY , 5AJZ , 5AK0 , 6ETJ , 6HVH , 6HVI , 6HVJ , 6IBX , 6IBY , 6IBZ , 6IC0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01591	6PF2K	24 → 246	6-phosphofructo-2-kinase	Domain
PF00300	His_Phos_1	249 → 435	Histidine phosphatase superfamily (branch 1)	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH

Sequence length

520

Interactions

View interactions

	KEGG		Reactome
	Fructose and mannose metabolism Metabolic pathways HIF-1 signaling pathway AMPK signaling pathway		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alopecia Areata	Alopecia areata	N/A	N/A	GWAS
Breast Cancer	Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab)	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Stress Disorder	Post-traumatic stress disorder	N/A	N/A	GWAS

Show/Hide Text Mining Associations (70)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Psoriatic	Associate	31864394
Arthritis Rheumatoid	Associate	24043759, 35886000
Arthritis Rheumatoid	Inhibit	27777982
Autoimmune Diseases	Associate	30254083
Brain Ischemia	Associate	39969331
Breast Neoplasms	Associate	24515104, 36973739
Carcinogenesis	Associate	27079271
Carcinoma Hepatocellular	Associate	24568531
Carcinoma Non Small Cell Lung	Associate	31126985, 34359849
Carcinoma Renal Cell	Associate	37253634
Cerebral Infarction	Associate	38320734
Cholangiocarcinoma	Associate	34871464
Chronobiology Disorders	Stimulate	39256343
Colorectal Neoplasms	Associate	24829520, 31671668, 32990355
Colorectal Neoplasms	Stimulate	36733385
COVID 19	Associate	33228475
Dementia Vascular	Associate	38320734
Diabetes Mellitus	Associate	36973739
Diabetes Mellitus Type 1	Associate	30254083
Diabetes Mellitus Type 2	Associate	30254083
Diabetic Nephropathies	Associate	37986381
Disease	Associate	25052311
DNA Virus Infections	Associate	27901115
Drug Related Side Effects and Adverse Reactions	Associate	29866066, 31671668
Endometrial Neoplasms	Associate	33420377
Esophageal Squamous Cell Carcinoma	Associate	32282711
Glioblastoma	Associate	28834297, 34234350
Hemorrhage	Stimulate	39969331
Hemorrhagic Stroke	Stimulate	39969331
Hyperglycemia	Stimulate	35094634, 36973739
Hyperglycemia	Associate	36577299
Hyperplasia	Associate	37047426
Hypoxia	Stimulate	11744734, 16698023, 23840896
Hypoxia	Associate	15598882
Hypoxia Brain	Associate	11536182, 26337471
Idiopathic Pulmonary Fibrosis	Associate	34280322
Immunologic Deficiency Syndromes	Associate	35131382
Inflammation	Associate	35367413, 36405760
Inflammatory Bowel Diseases	Associate	36405760
Insulin Resistance	Associate	27535281
Invasive Pulmonary Aspergillosis	Associate	34044589
Latent Autoimmune Diabetes in Adults	Associate	30254083
Leydig Cell Tumor	Associate	35367413
Lung Neoplasms	Associate	31126985
Lymphatic Metastasis	Stimulate	27983531
Mesothelioma Malignant	Associate	35794237
Mouth Neoplasms	Associate	33762576
Multiple Myeloma	Associate	35371618
Muscular Dystrophy Duchenne	Associate	39595988
Nasopharyngeal Carcinoma	Associate	35131382
Neoplasm Metastasis	Associate	32282711
Neoplasms	Associate	10077634, 15598882, 15640157, 24633012, 24829520, 26337471, 27079271, 27803158, 28049552, 28945981, 29967256, 30250201, 31671668, 32282711, 33420377 View all (11 more)
Neoplasms	Stimulate	19473963, 35094634
Neoplasms	Inhibit	27491040
Non Muscle Invasive Bladder Neoplasms	Associate	26980488
Obesity	Stimulate	35787188
Ovarian Neoplasms	Associate	29866066
Pneumonia	Associate	32778874
Pre Eclampsia	Associate	30819197
Prostatic Neoplasms	Associate	31410981
Pulmonary Fibrosis	Associate	34775492
Rhabdomyosarcoma	Associate	29620138
Sepsis	Associate	31093495
Severe Acute Respiratory Syndrome	Stimulate	32778874
Stomach Neoplasms	Associate	27983531, 33390824, 35637411
Stomach Neoplasms	Stimulate	35094634
Stroke	Stimulate	39969331
Thyroid Neoplasms	Associate	36990998
Tongue Neoplasms	Associate	27079271
Urinary Bladder Neoplasms	Associate	26980488

PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3)