Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5178
Gene name Gene Name - the full gene name approved by the HGNC.	Paternally expressed 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PEG3
Synonyms (NCBI Gene) Gene synonyms aliases	PW1, ZKSCAN22, ZNF904, ZSCAN24
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.43
Summary Summary of gene provided in NCBI Entrez Gene.	In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5` exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5` exons either with the remainin

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018787	hsa-miR-335-5p	Microarray	18185580
MIRT440005	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT440005	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT1224680	hsa-miR-1236	CLIP-seq
MIRT1224681	hsa-miR-1262	CLIP-seq
MIRT1224682	hsa-miR-130a	CLIP-seq
MIRT1224683	hsa-miR-130b	CLIP-seq
MIRT1224684	hsa-miR-301a	CLIP-seq
MIRT1224685	hsa-miR-301b	CLIP-seq
MIRT1224686	hsa-miR-34b	CLIP-seq
MIRT1224687	hsa-miR-3545-3p	CLIP-seq
MIRT1224688	hsa-miR-3646	CLIP-seq
MIRT1224689	hsa-miR-3666	CLIP-seq
MIRT1224690	hsa-miR-4275	CLIP-seq
MIRT1224691	hsa-miR-4295	CLIP-seq
MIRT1224692	hsa-miR-454	CLIP-seq
MIRT1224693	hsa-miR-4671-3p	CLIP-seq
MIRT1224694	hsa-miR-4701-3p	CLIP-seq
MIRT1224695	hsa-miR-4753-3p	CLIP-seq
MIRT1224696	hsa-miR-4768-5p	CLIP-seq
MIRT1224697	hsa-miR-555	CLIP-seq
MIRT1224698	hsa-miR-1248	CLIP-seq
MIRT1224681	hsa-miR-1262	CLIP-seq
MIRT1224699	hsa-miR-3117-3p	CLIP-seq
MIRT1224700	hsa-miR-3147	CLIP-seq
MIRT1224701	hsa-miR-3169	CLIP-seq
MIRT1224702	hsa-miR-3680	CLIP-seq
MIRT1224690	hsa-miR-4275	CLIP-seq
MIRT1224703	hsa-miR-4287	CLIP-seq
MIRT1224704	hsa-miR-4425	CLIP-seq
MIRT1224705	hsa-miR-4455	CLIP-seq
MIRT1224706	hsa-miR-4685-3p	CLIP-seq
MIRT1224707	hsa-miR-4699-3p	CLIP-seq
MIRT1224694	hsa-miR-4701-3p	CLIP-seq
MIRT1224708	hsa-miR-4729	CLIP-seq
MIRT1224709	hsa-miR-4759	CLIP-seq
MIRT1224697	hsa-miR-555	CLIP-seq
MIRT1224710	hsa-miR-582-5p	CLIP-seq
MIRT1224711	hsa-miR-609	CLIP-seq
MIRT1224712	hsa-miR-616	CLIP-seq
MIRT1922908	hsa-miR-3120-5p	CLIP-seq
MIRT1922909	hsa-miR-3182	CLIP-seq
MIRT1922910	hsa-miR-3183	CLIP-seq
MIRT1922911	hsa-miR-4279	CLIP-seq
MIRT1922912	hsa-miR-4659a-3p	CLIP-seq
MIRT1922913	hsa-miR-4659b-3p	CLIP-seq
MIRT1922914	hsa-miR-4723-3p	CLIP-seq
MIRT1922908	hsa-miR-3120-5p	CLIP-seq
MIRT2293422	hsa-miR-2681	CLIP-seq
MIRT2439391	hsa-miR-3613-3p	CLIP-seq
MIRT2439392	hsa-miR-548ae	CLIP-seq
MIRT2439393	hsa-miR-548aj	CLIP-seq
MIRT2439394	hsa-miR-548am	CLIP-seq
MIRT2439395	hsa-miR-548x	CLIP-seq
MIRT2456236	hsa-miR-297	CLIP-seq
MIRT2456237	hsa-miR-3149	CLIP-seq
MIRT2456238	hsa-miR-4680-3p	CLIP-seq
MIRT2456239	hsa-miR-4724-5p	CLIP-seq
MIRT2456240	hsa-miR-561	CLIP-seq
MIRT2456237	hsa-miR-3149	CLIP-seq
MIRT2456238	hsa-miR-4680-3p	CLIP-seq
MIRT2456239	hsa-miR-4724-5p	CLIP-seq
MIRT2456240	hsa-miR-561	CLIP-seq
MIRT2591411	hsa-miR-154	CLIP-seq
MIRT2591412	hsa-miR-1914	CLIP-seq
MIRT2591413	hsa-miR-3120-3p	CLIP-seq
MIRT2591414	hsa-miR-374a	CLIP-seq
MIRT2591415	hsa-miR-374b	CLIP-seq
MIRT2591416	hsa-miR-4293	CLIP-seq
MIRT1224707	hsa-miR-4699-3p	CLIP-seq
MIRT2591417	hsa-miR-4712-3p	CLIP-seq
MIRT2591418	hsa-miR-4772-3p	CLIP-seq
MIRT2591419	hsa-miR-488	CLIP-seq
MIRT2591420	hsa-miR-596	CLIP-seq
MIRT2591421	hsa-miR-642b	CLIP-seq
MIRT2591422	hsa-miR-649	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
YY1	Unknown	18458536

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	21873635
GO:0003674	Function	Molecular_function	ND
GO:0005634	Component	Nucleus	ISS
GO:0005776	Component	Autophagosome	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006915	Process	Apoptotic process	IEA
GO:0010468	Process	Regulation of gene expression	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
601483	8826	ENSG00000198300

Protein

UniProt ID

Q9GZU2

Protein name

Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24)

Protein function

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-ka

PDB

4BHX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02023	SCAN	42 → 131	SCAN domain	Domain
PF00096	zf-C2H2	452 → 474	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	505 → 527	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	627 → 649	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	969 → 991	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	1107 → 1129	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	1163 → 1185	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	1225 → 1247	Zinc finger, C2H2 type	Domain
PF13913	zf-C2HC_2	1280 → 1303		Domain
PF00096	zf-C2H2	1332 → 1354	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	1564 → 1586	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the theca

Sequence

MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRFRNLIYVEFVGP
RKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRAKKPENCEKLVTL
LENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSDRDWDRRGRSRDMEPRDRW
SHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAESYQNVVDLAEDRKP
HNTIQDNMENYRKLLSLVQLAEDDGHSHMTQGHSSRSKRSAYPSTSRGLKTMPEAKKSTH
RRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRSQRFPRMSDDNWKDISLNKRESV
IQQRVYEGNAFRGGFRFNSTLVSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGS
EMRKAMSVSSLSSLSSPSFTESQPIDFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLY
EYGESFIHSVAVSEVQKSQVGGKRFECKDCGETFNKSAALAEHRKIHARGYLVECKNQEC
EEAFMPSPTFSELQKIYGKDKFYECRVCKETFLHSSALIEHQKIHFGDDKDNEREHERER
ERERGETFRPSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGK
VCEETFIPGQSLKRRQKTYNKEKLCDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEK
SVIHSGPFTESQKSHTITRPLESDEDEKAFTISSNPYENQKIPTKENVYEAKSYERSVIH
SLASVEAQKSHSVAGPSKPKVMAESTIQSFDAINHQRVRAGGNTSEGREYSRSVIHSLVA
SKPPRSHNGNELVESNEKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVF
RAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHRSNETSVIHSLPFGEQ
TFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIRSLAPTDPQTSYA
QEQYAKEQARNKCKDFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHG
QETIEDPVIQGSDMEDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKVHSRKCLVDSREY
THSVIHTHSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYSMKGCDDGF
IALLPMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMAE
EAIIPGLALTEFQRSQTEERLFECAVCGESFVNPAELADHVTVHKNEPYEYGSSYTHTSF
LTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEDEAAAAAAAAAQEVEANVHV
PQVVLRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEAGQPN
GEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEEPEGDADEPDGVGIEDPEEGEDQEIQV
EEPYYDCHECTETFTSSTAFSEHLKTHASMIIFEPANAFGECSGYIERASTSTGGANQAD
EKYFKCDVCGQLFNDRLSLARHQNTHTG

Sequence length

1588

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Cholangiocarcinoma	Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma		22561520	ClinVar

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text Mining
Abortion Habitual	Associate	37699152
Breast Neoplasms	Associate	25560175, 32729618
Carcinogenesis	Associate	19367087
Cell Transformation Neoplastic	Inhibit	32209654
Diabetes Gestational	Associate	40147358
Diabetes Mellitus Type 2	Associate	25201977
Endometrial Neoplasms	Associate	32555395
Glioblastoma	Inhibit	19367087
Glioma	Associate	19367087
Hemangioma Cavernous Central Nervous System	Associate	40238631
Hereditary Breast and Ovarian Cancer Syndrome	Associate	26338779
Melanoma	Associate	36139377
Metabolic Syndrome	Associate	28727822
Neoplasms	Associate	16646087, 19202553, 25560175, 26338779, 28427185, 28587194, 32729618
Neoplasms	Inhibit	18286529, 24737315, 28174297
Neuroblastoma	Associate	19202553
Obesity	Associate	24058506, 40147358
Obesity	Inhibit	24158121, 24819376
Oligodendroglioma	Stimulate	19367087
Ovarian Neoplasms	Associate	16646087
Ovarian Neoplasms	Inhibit	18286529
Overweight	Inhibit	24819376
Parkinson Disease	Associate	33319795
Pregnancy in Obesity	Associate	40147358
Prostatic Neoplasms	Associate	28035996
Testicular Germ Cell Tumor	Associate	28471449
Uterine Cervical Dysplasia	Associate	23418553
Uterine Cervical Neoplasms	Associate	23418553

PEG3 (paternally expressed 3)