FBXO40 (F-box protein 40)

Gene

• Entrez ID: 51725
• Gene name: F-box protein 40
• Gene symbol: FBXO40
• Synonyms (NCBI Gene): FBX40
• Chromosome: 3
• Chromosome location: 3q13.33
• Summary: Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT489012	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT489011	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT489010	hsa-miR-4693-3p	PAR-CLIP	23592263
MIRT489009	hsa-miR-5192	PAR-CLIP	23592263
MIRT489008	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489007	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489005	hsa-miR-3652	PAR-CLIP	23592263
MIRT489006	hsa-miR-4430	PAR-CLIP	23592263
MIRT489004	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489003	hsa-miR-8085	PAR-CLIP	23592263
MIRT489002	hsa-miR-3175	PAR-CLIP	23592263
MIRT489001	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT489000	hsa-miR-5698	PAR-CLIP	23592263
MIRT488999	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT488998	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT488996	hsa-miR-6515-5p	PAR-CLIP	23592263
MIRT446592	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT446590	hsa-miR-4725-5p	PAR-CLIP	22100165
MIRT446589	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT446588	hsa-miR-30a-3p	PAR-CLIP	22100165
MIRT446587	hsa-miR-30d-3p	PAR-CLIP	22100165
MIRT446586	hsa-miR-30e-3p	PAR-CLIP	22100165
MIRT446592	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT446590	hsa-miR-4725-5p	PAR-CLIP	22100165
MIRT446589	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT446588	hsa-miR-30a-3p	PAR-CLIP	22100165
MIRT446587	hsa-miR-30d-3p	PAR-CLIP	22100165
MIRT446586	hsa-miR-30e-3p	PAR-CLIP	22100165
MIRT489012	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT489011	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT489010	hsa-miR-4693-3p	PAR-CLIP	23592263
MIRT489009	hsa-miR-5192	PAR-CLIP	23592263
MIRT489008	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489007	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489005	hsa-miR-3652	PAR-CLIP	23592263
MIRT489006	hsa-miR-4430	PAR-CLIP	23592263
MIRT489004	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489003	hsa-miR-8085	PAR-CLIP	23592263
MIRT489002	hsa-miR-3175	PAR-CLIP	23592263
MIRT489001	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT489000	hsa-miR-5698	PAR-CLIP	23592263
MIRT488999	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT488998	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT488996	hsa-miR-6515-5p	PAR-CLIP	23592263
MIRT446592	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT446590	hsa-miR-4725-5p	PAR-CLIP	22100165
MIRT446589	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT446588	hsa-miR-30a-3p	PAR-CLIP	22100165
MIRT446587	hsa-miR-30d-3p	PAR-CLIP	22100165
MIRT446586	hsa-miR-30e-3p	PAR-CLIP	22100165
MIRT446592	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT446590	hsa-miR-4725-5p	PAR-CLIP	22100165
MIRT446589	hsa-miR-3942-3p	PAR-CLIP	22100165
MIRT446588	hsa-miR-30a-3p	PAR-CLIP	22100165
MIRT446587	hsa-miR-30d-3p	PAR-CLIP	22100165
MIRT446586	hsa-miR-30e-3p	PAR-CLIP	22100165
MIRT992311	hsa-miR-1256	CLIP-seq
MIRT992312	hsa-miR-1285	CLIP-seq
MIRT992313	hsa-miR-1827	CLIP-seq
MIRT992314	hsa-miR-1915	CLIP-seq
MIRT992315	hsa-miR-204	CLIP-seq
MIRT992316	hsa-miR-211	CLIP-seq
MIRT992317	hsa-miR-23a	CLIP-seq
MIRT992318	hsa-miR-23b	CLIP-seq
MIRT992319	hsa-miR-23c	CLIP-seq
MIRT992320	hsa-miR-30a	CLIP-seq
MIRT992321	hsa-miR-30b	CLIP-seq
MIRT992322	hsa-miR-30c	CLIP-seq
MIRT992323	hsa-miR-30d	CLIP-seq
MIRT992324	hsa-miR-30e	CLIP-seq
MIRT992325	hsa-miR-3155	CLIP-seq
MIRT992326	hsa-miR-3155b	CLIP-seq
MIRT992327	hsa-miR-3157-5p	CLIP-seq
MIRT992328	hsa-miR-3183	CLIP-seq
MIRT992329	hsa-miR-3187-5p	CLIP-seq
MIRT992330	hsa-miR-3202	CLIP-seq
MIRT992331	hsa-miR-3591-5p	CLIP-seq
MIRT992332	hsa-miR-3607-3p	CLIP-seq
MIRT992333	hsa-miR-3667-5p	CLIP-seq
MIRT992334	hsa-miR-3672	CLIP-seq
MIRT992335	hsa-miR-3918	CLIP-seq
MIRT992336	hsa-miR-3922-5p	CLIP-seq
MIRT992337	hsa-miR-3929	CLIP-seq
MIRT992338	hsa-miR-4280	CLIP-seq
MIRT992339	hsa-miR-4283	CLIP-seq
MIRT992340	hsa-miR-4293	CLIP-seq
MIRT992341	hsa-miR-4317	CLIP-seq
MIRT992342	hsa-miR-4330	CLIP-seq
MIRT992343	hsa-miR-4419b	CLIP-seq
MIRT992344	hsa-miR-4446-5p	CLIP-seq
MIRT992345	hsa-miR-4459	CLIP-seq
MIRT992346	hsa-miR-4461	CLIP-seq
MIRT992347	hsa-miR-4478	CLIP-seq
MIRT992348	hsa-miR-4493	CLIP-seq
MIRT992349	hsa-miR-4533	CLIP-seq
MIRT992350	hsa-miR-4537	CLIP-seq
MIRT992351	hsa-miR-4642	CLIP-seq
MIRT992352	hsa-miR-4649-3p	CLIP-seq
MIRT992353	hsa-miR-4659a-3p	CLIP-seq
MIRT992354	hsa-miR-4659a-5p	CLIP-seq
MIRT992355	hsa-miR-4659b-3p	CLIP-seq
MIRT992356	hsa-miR-4659b-5p	CLIP-seq
MIRT992357	hsa-miR-4685-5p	CLIP-seq
MIRT992358	hsa-miR-4691-3p	CLIP-seq
MIRT992359	hsa-miR-4695-5p	CLIP-seq
MIRT992360	hsa-miR-4717-3p	CLIP-seq
MIRT992361	hsa-miR-4722-5p	CLIP-seq
MIRT992362	hsa-miR-4723-3p	CLIP-seq
MIRT992363	hsa-miR-4727-5p	CLIP-seq
MIRT992364	hsa-miR-4746-3p	CLIP-seq
MIRT992365	hsa-miR-4753-5p	CLIP-seq
MIRT992366	hsa-miR-4755-5p	CLIP-seq
MIRT992367	hsa-miR-4768-3p	CLIP-seq
MIRT992368	hsa-miR-4769-3p	CLIP-seq
MIRT992369	hsa-miR-4786-5p	CLIP-seq
MIRT992370	hsa-miR-4796-5p	CLIP-seq
MIRT992371	hsa-miR-484	CLIP-seq
MIRT992372	hsa-miR-485-5p	CLIP-seq
MIRT992373	hsa-miR-515-5p	CLIP-seq
MIRT992374	hsa-miR-519a	CLIP-seq
MIRT992375	hsa-miR-519b-3p	CLIP-seq
MIRT992376	hsa-miR-519c-3p	CLIP-seq
MIRT992377	hsa-miR-612	CLIP-seq
MIRT992378	hsa-miR-616	CLIP-seq
MIRT992379	hsa-miR-623	CLIP-seq
MIRT992380	hsa-miR-658	CLIP-seq
MIRT992381	hsa-miR-661	CLIP-seq
MIRT992382	hsa-miR-665	CLIP-seq
MIRT992383	hsa-miR-766	CLIP-seq
MIRT992384	hsa-miR-769-5p	CLIP-seq
MIRT992385	hsa-miR-940	CLIP-seq
MIRT992386	hsa-miR-942	CLIP-seq
MIRT1994290	hsa-miR-1228	CLIP-seq
MIRT992312	hsa-miR-1285	CLIP-seq
MIRT1994291	hsa-miR-136	CLIP-seq
MIRT992313	hsa-miR-1827	CLIP-seq
MIRT992329	hsa-miR-3187-5p	CLIP-seq
MIRT992330	hsa-miR-3202	CLIP-seq
MIRT1994292	hsa-miR-3622a-3p	CLIP-seq
MIRT1994293	hsa-miR-3622b-3p	CLIP-seq
MIRT992334	hsa-miR-3672	CLIP-seq
MIRT992337	hsa-miR-3929	CLIP-seq
MIRT1994294	hsa-miR-4292	CLIP-seq
MIRT992340	hsa-miR-4293	CLIP-seq
MIRT1994295	hsa-miR-4308	CLIP-seq
MIRT992341	hsa-miR-4317	CLIP-seq
MIRT992343	hsa-miR-4419b	CLIP-seq
MIRT1994296	hsa-miR-4434	CLIP-seq
MIRT992345	hsa-miR-4459	CLIP-seq
MIRT1994297	hsa-miR-4469	CLIP-seq
MIRT992347	hsa-miR-4478	CLIP-seq
MIRT992348	hsa-miR-4493	CLIP-seq
MIRT1994298	hsa-miR-4516	CLIP-seq
MIRT1994299	hsa-miR-4531	CLIP-seq
MIRT992349	hsa-miR-4533	CLIP-seq
MIRT992352	hsa-miR-4649-3p	CLIP-seq
MIRT992359	hsa-miR-4695-5p	CLIP-seq
MIRT992361	hsa-miR-4722-5p	CLIP-seq
MIRT992364	hsa-miR-4746-3p	CLIP-seq
MIRT992365	hsa-miR-4753-5p	CLIP-seq
MIRT992367	hsa-miR-4768-3p	CLIP-seq
MIRT992369	hsa-miR-4786-5p	CLIP-seq
MIRT1994300	hsa-miR-4802-3p	CLIP-seq
MIRT992372	hsa-miR-485-5p	CLIP-seq
MIRT992377	hsa-miR-612	CLIP-seq
MIRT992378	hsa-miR-616	CLIP-seq
MIRT992380	hsa-miR-658	CLIP-seq
MIRT992381	hsa-miR-661	CLIP-seq
MIRT992382	hsa-miR-665	CLIP-seq
MIRT992383	hsa-miR-766	CLIP-seq
MIRT992384	hsa-miR-769-5p	CLIP-seq
MIRT992385	hsa-miR-940	CLIP-seq
MIRT992312	hsa-miR-1285	CLIP-seq
MIRT992313	hsa-miR-1827	CLIP-seq
MIRT992329	hsa-miR-3187-5p	CLIP-seq
MIRT1994292	hsa-miR-3622a-3p	CLIP-seq
MIRT1994293	hsa-miR-3622b-3p	CLIP-seq
MIRT992334	hsa-miR-3672	CLIP-seq
MIRT992337	hsa-miR-3929	CLIP-seq
MIRT992340	hsa-miR-4293	CLIP-seq
MIRT992341	hsa-miR-4317	CLIP-seq
MIRT992343	hsa-miR-4419b	CLIP-seq
MIRT992345	hsa-miR-4459	CLIP-seq
MIRT992347	hsa-miR-4478	CLIP-seq
MIRT992348	hsa-miR-4493	CLIP-seq
MIRT992350	hsa-miR-4537	CLIP-seq
MIRT992352	hsa-miR-4649-3p	CLIP-seq
MIRT2228329	hsa-miR-4649-5p	CLIP-seq
MIRT992359	hsa-miR-4695-5p	CLIP-seq
MIRT992361	hsa-miR-4722-5p	CLIP-seq
MIRT992364	hsa-miR-4746-3p	CLIP-seq
MIRT992365	hsa-miR-4753-5p	CLIP-seq
MIRT2228330	hsa-miR-4767	CLIP-seq
MIRT992367	hsa-miR-4768-3p	CLIP-seq
MIRT992369	hsa-miR-4786-5p	CLIP-seq
MIRT2228331	hsa-miR-4792	CLIP-seq
MIRT992372	hsa-miR-485-5p	CLIP-seq
MIRT992374	hsa-miR-519a	CLIP-seq
MIRT992375	hsa-miR-519b-3p	CLIP-seq
MIRT992376	hsa-miR-519c-3p	CLIP-seq
MIRT992377	hsa-miR-612	CLIP-seq
MIRT992378	hsa-miR-616	CLIP-seq
MIRT992380	hsa-miR-658	CLIP-seq
MIRT992381	hsa-miR-661	CLIP-seq
MIRT992382	hsa-miR-665	CLIP-seq
MIRT992383	hsa-miR-766	CLIP-seq
MIRT992384	hsa-miR-769-5p	CLIP-seq
MIRT992385	hsa-miR-940	CLIP-seq
MIRT992374	hsa-miR-519a	CLIP-seq
MIRT992375	hsa-miR-519b-3p	CLIP-seq
MIRT992376	hsa-miR-519c-3p	CLIP-seq
MIRT992312	hsa-miR-1285	CLIP-seq
MIRT992313	hsa-miR-1827	CLIP-seq
MIRT992329	hsa-miR-3187-5p	CLIP-seq
MIRT992341	hsa-miR-4317	CLIP-seq
MIRT992345	hsa-miR-4459	CLIP-seq
MIRT2449519	hsa-miR-4662a-5p	CLIP-seq
MIRT2449520	hsa-miR-4676-5p	CLIP-seq
MIRT2449521	hsa-miR-4684-5p	CLIP-seq
MIRT992359	hsa-miR-4695-5p	CLIP-seq
MIRT992361	hsa-miR-4722-5p	CLIP-seq
MIRT992364	hsa-miR-4746-3p	CLIP-seq
MIRT2449522	hsa-miR-4755-3p	CLIP-seq
MIRT992367	hsa-miR-4768-3p	CLIP-seq
MIRT2449523	hsa-miR-575	CLIP-seq
MIRT992377	hsa-miR-612	CLIP-seq
MIRT992378	hsa-miR-616	CLIP-seq
MIRT992380	hsa-miR-658	CLIP-seq
MIRT992381	hsa-miR-661	CLIP-seq
MIRT992382	hsa-miR-665	CLIP-seq
MIRT992383	hsa-miR-766	CLIP-seq
MIRT992385	hsa-miR-940	CLIP-seq
MIRT992312	hsa-miR-1285	CLIP-seq
MIRT992313	hsa-miR-1827	CLIP-seq
MIRT992329	hsa-miR-3187-5p	CLIP-seq
MIRT992341	hsa-miR-4317	CLIP-seq
MIRT1994296	hsa-miR-4434	CLIP-seq
MIRT992345	hsa-miR-4459	CLIP-seq
MIRT1994298	hsa-miR-4516	CLIP-seq
MIRT1994299	hsa-miR-4531	CLIP-seq
MIRT992350	hsa-miR-4537	CLIP-seq
MIRT2449519	hsa-miR-4662a-5p	CLIP-seq
MIRT2449520	hsa-miR-4676-5p	CLIP-seq
MIRT2449521	hsa-miR-4684-5p	CLIP-seq
MIRT992359	hsa-miR-4695-5p	CLIP-seq
MIRT992361	hsa-miR-4722-5p	CLIP-seq
MIRT992364	hsa-miR-4746-3p	CLIP-seq
MIRT2449522	hsa-miR-4755-3p	CLIP-seq
MIRT992367	hsa-miR-4768-3p	CLIP-seq
MIRT2228331	hsa-miR-4792	CLIP-seq
MIRT1994300	hsa-miR-4802-3p	CLIP-seq
MIRT2449523	hsa-miR-575	CLIP-seq
MIRT992377	hsa-miR-612	CLIP-seq
MIRT992378	hsa-miR-616	CLIP-seq
MIRT992380	hsa-miR-658	CLIP-seq
MIRT992381	hsa-miR-661	CLIP-seq
MIRT992382	hsa-miR-665	CLIP-seq
MIRT992383	hsa-miR-766	CLIP-seq
MIRT992385	hsa-miR-940	CLIP-seq
MIRT992312	hsa-miR-1285	CLIP-seq
MIRT992313	hsa-miR-1827	CLIP-seq
MIRT992329	hsa-miR-3187-5p	CLIP-seq
MIRT992341	hsa-miR-4317	CLIP-seq
MIRT992345	hsa-miR-4459	CLIP-seq
MIRT2449519	hsa-miR-4662a-5p	CLIP-seq
MIRT2449520	hsa-miR-4676-5p	CLIP-seq
MIRT2449521	hsa-miR-4684-5p	CLIP-seq
MIRT992359	hsa-miR-4695-5p	CLIP-seq
MIRT992361	hsa-miR-4722-5p	CLIP-seq
MIRT992364	hsa-miR-4746-3p	CLIP-seq
MIRT2449522	hsa-miR-4755-3p	CLIP-seq
MIRT992367	hsa-miR-4768-3p	CLIP-seq
MIRT2228331	hsa-miR-4792	CLIP-seq
MIRT2449523	hsa-miR-575	CLIP-seq
MIRT992377	hsa-miR-612	CLIP-seq
MIRT992378	hsa-miR-616	CLIP-seq
MIRT992380	hsa-miR-658	CLIP-seq
MIRT992381	hsa-miR-661	CLIP-seq
MIRT992382	hsa-miR-665	CLIP-seq
MIRT992383	hsa-miR-766	CLIP-seq
MIRT992385	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0042692	Process	Muscle cell differentiation	IEA
GO:0042692	Process	Muscle cell differentiation	ISS	17928169
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 609107
• HGNC: 29816
• e!Ensembl: ENSG00000163833

Protein

• UniProt ID: Q9UH90
• Protein name: F-box only protein 40 (Muscle disease-related protein)
• Protein function: Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15965	zf-TRAF_2	12 → 104	TRAF-like zinc-finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed only in heart and skeletal muscle. {ECO:0000269|PubMed:17928169}.
• Sequence:

  MGKARRSPPGHHRHCEGCFNRHCHIPVEPNTSCLVISCHLLCGATFHMCKEAEHQLLCPL
  EQVPCLNSEYGCPLSMSRHKLAKHLQVCPASVVCCSMEWNRWPNVDSETTLHENIMKETP
  SEECLDTALALQDQKVLFRSLKMVELFPETREATEEEPTMNGETSVEEMGGAVGGVDIGL
  VPHGLSATNGEMAELSQEEREVLAKTKEGMDLVKFGQWENIFSKEHAASALTNSSASCES
  KNKNDSEKEQISSGHNMVEGEGAPKKKEPQENQKQQDVRTAMETTGLAPWQDGVLERLKT
  AVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDFVYGKLEAQEVKTVYTFKVPVSYCGKR
  ARLGDAMLSCKPSEHKAVDTSDLGITVEDLPKSDLIKTTLQCALERELKGHVISESRSID
  GLFMDFATQTYNFEPEQFSSGTVLADLTAATPGGLHVELHSECVTRRHNKSSSAFTFTCN
  KFFRRDEFPLHFKNVHTDIQSCLNGWFQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQEL
  KTFAIKPEVAPELSEGRKNNHLLGHGGKSQNSLTSLPLEILKYIAGFLDSVSLAQLSQVS
  VLMRNICATLLQERGMVLLQWKKKRYSHGGTSWRVHREIWQFSSLFSKIKSWEFNEVTSM
  SEHLKSCPFNIVEHKTDPILLTSMCQPREQARESLVSTFRIRPRGRYVS

• Sequence length: 709

Pathways

Reactome:

Neddylation
Antigen processing: Ubiquitination & Proteasome degradation