Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51701
Gene name Gene Name - the full gene name approved by the HGNC.
Nemo like kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NLK
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q11.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000243 hsa-miR-181a-5p Luciferase reporter assay 19585654
MIRT000238 hsa-miR-181b-5p Luciferase reporter assay 19585654
MIRT000233 hsa-miR-181c-5p Luciferase reporter assay 19585654
MIRT024563 hsa-miR-215-5p Microarray 19074876
MIRT026531 hsa-miR-192-5p Microarray 19074876
Transcription factors
Transcription factor Regulation Reference
FOXO1 Unknown 23144700
STAT3 Unknown 15764709
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEA
GO:0000287 Function Magnesium ion binding ISS
GO:0004672 Function Protein kinase activity TAS 10863097
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609476 29858 ENSG00000087095
Protein
UniProt ID Q9UBE8
Protein name Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)
Protein function Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination (PubMed:12482967, PubMed:14960582, PubMed:15004007, PubMed:15764709, PubMed:20061393, PubMed:20874444, PubMed:21454679). P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 138 427 Protein kinase domain Domain
Sequence
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
ALAHPYL
DEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Sequence length 527
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
FoxO signaling pathway
Wnt signaling pathway
Adherens junction
  Ca2+ pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioblastoma Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 27622933 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 40471493
Anodontia Associate 31828582
Breast Neoplasms Inhibit 23935942
Breast Neoplasms Associate 24816797
Carcinogenesis Associate 26252054, 29132323
Carcinoma Hepatocellular Stimulate 26022162
Carcinoma Non Small Cell Lung Inhibit 31322229, 32236580
Carcinoma Non Small Cell Lung Associate 35692887
Carcinoma Ovarian Epithelial Associate 22253297
Cerebral Infarction Inhibit 27776139