Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51554
Gene name Gene Name - the full gene name approved by the HGNC.	Atypical chemokine receptor 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ACKR4
Synonyms (NCBI Gene) Gene synonyms aliases	CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL2

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004950	Function	Chemokine receptor activity	IDA	23341447
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	23341447
GO:0005769	Component	Early endosome	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	10767544
GO:0006897	Process	Endocytosis	IEA
GO:0006935	Process	Chemotaxis	TAS	10706668
GO:0006955	Process	Immune response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0016493	Function	C-C chemokine receptor activity	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IBA	21873635
GO:0019957	Function	C-C chemokine binding	IBA	21873635
GO:0055037	Component	Recycling endosome	IEA
GO:0060326	Process	Cell chemotaxis	IBA	21873635
GO:0070098	Process	Chemokine-mediated signaling pathway	IEA

MIM	HGNC	e!Ensembl
606065	1611	ENSG00000129048

Protein

UniProt ID

Q9NPB9

Protein name

Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)

Protein function

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation,

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	58 → 303	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine. {ECO:0000269|PubMed:10734104, ECO:0000269|PubMed:10767544, ECO:0000269|PubMed:11981810}.

Sequence

MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNS
MVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYT
LNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVND
NARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLK
VLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNP
ILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI

Sequence length

350

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor		Chemokine receptors bind chemokines

ACKR4 (atypical chemokine receptor 4)