Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51533
Gene name	PHD finger protein 7
Gene symbol	PHF7
Synonyms (NCBI Gene)	HSPC045HSPC226NYD-SP6
Chromosome	3
Chromosome location	3p21.1
Summary	Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023162	hsa-miR-124-3p	Microarray	18668037
MIRT710787	hsa-miR-4797-5p	HITS-CLIP	19536157
MIRT710786	hsa-miR-5586-3p	HITS-CLIP	19536157
MIRT710785	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT710784	hsa-miR-759	HITS-CLIP	19536157
MIRT714177	hsa-miR-4258	HITS-CLIP	19536157
MIRT714176	hsa-miR-7108-3p	HITS-CLIP	19536157
MIRT710783	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT710782	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT714175	hsa-miR-4485-5p	HITS-CLIP	19536157
MIRT714174	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT710781	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT710780	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT710779	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT710778	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT710777	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT710776	hsa-miR-4469	HITS-CLIP	19536157
MIRT710775	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT710774	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT710773	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT710772	hsa-miR-612	HITS-CLIP	19536157
MIRT710771	hsa-miR-6860	HITS-CLIP	19536157
MIRT710770	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT714173	hsa-miR-661	HITS-CLIP	19536157
MIRT710769	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT710768	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT710767	hsa-miR-3672	HITS-CLIP	19536157
MIRT710766	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT710787	hsa-miR-4797-5p	HITS-CLIP	19536157
MIRT710786	hsa-miR-5586-3p	HITS-CLIP	19536157
MIRT710785	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT710784	hsa-miR-759	HITS-CLIP	19536157
MIRT710783	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT710782	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT710781	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT710780	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT710779	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT710778	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT710777	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT710776	hsa-miR-4469	HITS-CLIP	19536157
MIRT710775	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT710774	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT710773	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT710772	hsa-miR-612	HITS-CLIP	19536157
MIRT710771	hsa-miR-6860	HITS-CLIP	19536157
MIRT710770	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT710769	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT710768	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT710767	hsa-miR-3672	HITS-CLIP	19536157
MIRT710766	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT655132	hsa-miR-4310	HITS-CLIP	23824327
MIRT655131	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT655130	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT655129	hsa-miR-4284	HITS-CLIP	23824327
MIRT655128	hsa-miR-6795-5p	HITS-CLIP	23824327
MIRT655127	hsa-miR-6887-5p	HITS-CLIP	23824327
MIRT655126	hsa-miR-328-5p	HITS-CLIP	23824327
MIRT655125	hsa-miR-6885-5p	HITS-CLIP	23824327
MIRT655124	hsa-miR-7977	HITS-CLIP	23824327
MIRT655123	hsa-miR-5011-3p	HITS-CLIP	23824327
MIRT655122	hsa-miR-1275	HITS-CLIP	23824327
MIRT655121	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT655120	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT655119	hsa-miR-6751-5p	HITS-CLIP	23824327
MIRT655118	hsa-miR-6803-5p	HITS-CLIP	23824327
MIRT655117	hsa-miR-450a-2-3p	HITS-CLIP	23824327
MIRT655116	hsa-miR-4260	HITS-CLIP	23824327
MIRT655115	hsa-miR-5572	HITS-CLIP	23824327
MIRT504441	hsa-miR-586	PAR-CLIP	22012620
MIRT504440	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT529966	hsa-miR-4440	PAR-CLIP	22012620
MIRT504439	hsa-miR-223-5p	PAR-CLIP	22012620
MIRT504438	hsa-miR-6867-5p	PAR-CLIP	22012620
MIRT529965	hsa-miR-3152-3p	PAR-CLIP	22012620
MIRT504437	hsa-miR-675-3p	PAR-CLIP	22012620
MIRT504436	hsa-miR-574-5p	PAR-CLIP	22012620
MIRT504441	hsa-miR-586	PAR-CLIP	23446348
MIRT504440	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT504439	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT504438	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT504437	hsa-miR-675-3p	PAR-CLIP	23446348
MIRT504436	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT504439	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT504436	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT504441	hsa-miR-586	HITS-CLIP	27418678
MIRT504437	hsa-miR-675-3p	HITS-CLIP	27418678
MIRT504438	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT710787	hsa-miR-4797-5p	HITS-CLIP	19536157
MIRT710786	hsa-miR-5586-3p	HITS-CLIP	19536157
MIRT710785	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT710784	hsa-miR-759	HITS-CLIP	19536157
MIRT714177	hsa-miR-4258	HITS-CLIP	19536157
MIRT714176	hsa-miR-7108-3p	HITS-CLIP	19536157
MIRT710783	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT710782	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT714175	hsa-miR-4485-5p	HITS-CLIP	19536157
MIRT714174	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT710781	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT710780	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT710779	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT710778	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT710777	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT710776	hsa-miR-4469	HITS-CLIP	19536157
MIRT710775	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT710774	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT710773	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT710772	hsa-miR-612	HITS-CLIP	19536157
MIRT710771	hsa-miR-6860	HITS-CLIP	19536157
MIRT710770	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT714173	hsa-miR-661	HITS-CLIP	19536157
MIRT710769	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT710768	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT710767	hsa-miR-3672	HITS-CLIP	19536157
MIRT710766	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT710787	hsa-miR-4797-5p	HITS-CLIP	19536157
MIRT710786	hsa-miR-5586-3p	HITS-CLIP	19536157
MIRT710785	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT710784	hsa-miR-759	HITS-CLIP	19536157
MIRT710783	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT710782	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT710781	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT710780	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT710779	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT710778	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT710777	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT710776	hsa-miR-4469	HITS-CLIP	19536157
MIRT710775	hsa-miR-1285-3p	HITS-CLIP	19536157
MIRT710774	hsa-miR-3187-5p	HITS-CLIP	19536157
MIRT710773	hsa-miR-5189-5p	HITS-CLIP	19536157
MIRT710772	hsa-miR-612	HITS-CLIP	19536157
MIRT710771	hsa-miR-6860	HITS-CLIP	19536157
MIRT710770	hsa-miR-873-3p	HITS-CLIP	19536157
MIRT710769	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT710768	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT710767	hsa-miR-3672	HITS-CLIP	19536157
MIRT710766	hsa-miR-6864-3p	HITS-CLIP	19536157
MIRT655132	hsa-miR-4310	HITS-CLIP	23824327
MIRT655131	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT655130	hsa-miR-338-3p	HITS-CLIP	23824327
MIRT655129	hsa-miR-4284	HITS-CLIP	23824327
MIRT655128	hsa-miR-6795-5p	HITS-CLIP	23824327
MIRT655127	hsa-miR-6887-5p	HITS-CLIP	23824327
MIRT655126	hsa-miR-328-5p	HITS-CLIP	23824327
MIRT655125	hsa-miR-6885-5p	HITS-CLIP	23824327
MIRT655124	hsa-miR-7977	HITS-CLIP	23824327
MIRT655123	hsa-miR-5011-3p	HITS-CLIP	23824327
MIRT655122	hsa-miR-1275	HITS-CLIP	23824327
MIRT655121	hsa-miR-4665-5p	HITS-CLIP	23824327
MIRT655120	hsa-miR-7109-5p	HITS-CLIP	23824327
MIRT655119	hsa-miR-6751-5p	HITS-CLIP	23824327
MIRT655118	hsa-miR-6803-5p	HITS-CLIP	23824327
MIRT655117	hsa-miR-450a-2-3p	HITS-CLIP	23824327
MIRT655116	hsa-miR-4260	HITS-CLIP	23824327
MIRT655115	hsa-miR-5572	HITS-CLIP	23824327
MIRT504441	hsa-miR-586	PAR-CLIP	22012620
MIRT504440	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT529966	hsa-miR-4440	PAR-CLIP	22012620
MIRT504439	hsa-miR-223-5p	PAR-CLIP	22012620
MIRT504438	hsa-miR-6867-5p	PAR-CLIP	22012620
MIRT529965	hsa-miR-3152-3p	PAR-CLIP	22012620
MIRT504437	hsa-miR-675-3p	PAR-CLIP	22012620
MIRT504436	hsa-miR-574-5p	PAR-CLIP	22012620
MIRT504441	hsa-miR-586	PAR-CLIP	23446348
MIRT504440	hsa-miR-6760-3p	PAR-CLIP	23446348
MIRT504439	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT504438	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT504437	hsa-miR-675-3p	PAR-CLIP	23446348
MIRT504436	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT2295324	hsa-miR-128	CLIP-seq
MIRT2295325	hsa-miR-27a	CLIP-seq
MIRT2295326	hsa-miR-27b	CLIP-seq
MIRT2295327	hsa-miR-342-3p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0090291	Process	Negative regulation of osteoclast proliferation	IEA
GO:0090291	Process	Negative regulation of osteoclast proliferation	ISS

MIM	HGNC	e!Ensembl
620057	18458	ENSG00000010318

Q9BWX1

Protein name

E3 ubiquitin-protein ligase PHF7 (EC 2.3.2.27) (PHD finger protein 7) (Testis development protein NYD-SP6)

Protein function

E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (By similarity). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13771	zf-HC5HC2H	58 → 145		Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in Sertoli cells, but not in germ cells in adult testis. Expression in embryonic testis is 30-times lower. Highly expressed in colon, spleen, white blood cells, pancreas, lung, liver, placenta and brain. Detected at lo

Sequence

MKTVKEKKECQRLRKSAKTRRVTQRKPSSGPVCWLCLREPGDPEKLGEFLQKDNISVHYF
CLILSSKLPQRGQSNRGFHGFLPEDIKKEAARASRKICFVCKKKGAAINCQKDQCLRNFH
LPCGQERGCLSQFFGEYKSFCDKHRPTQNIQHGHVGEESCILCCEDLSQQSVENIQSPCC
SQAIYHRKCIQKYAHTSAKHFFKCPQCNNRKEFPQEMLRMGIHIPDRDAAWELEPGAFSD
LYQRYQHCDAPICLYEQGRDSFEDEGRWCLILCATCGSHGTHRDCSSLRSNSKKWECEEC
SPAAATDYIPENSGDIPCCSSTFHPEEHFCRDNTLEENPGLSWTDWPEPSLLEKPESSRG
RRSYSWRSKGVRITNSCKKSK

Sequence length

381

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PHF7-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Progressive sensorineural hearing impairment	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PHF7 (PHD finger protein 7)