Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	51510
Gene name	Charged multivesicular body protein 5
Gene symbol	CHMP5
Synonyms (NCBI Gene)	C9orf83CGI-34HSPC177PNAS-2SNF7DC2SpikeVps60
Chromosome	9
Chromosome location	9p13.3
Summary	CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor pr

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miRTarBase ID	miRNA	Experiments
MIRT890828	hsa-miR-1273d	CLIP-seq
MIRT890829	hsa-miR-1278	CLIP-seq
MIRT890830	hsa-miR-140-3p	CLIP-seq
MIRT890831	hsa-miR-186	CLIP-seq
MIRT890832	hsa-miR-200b	CLIP-seq
MIRT890833	hsa-miR-200c	CLIP-seq
MIRT890834	hsa-miR-2054	CLIP-seq
MIRT890835	hsa-miR-2114	CLIP-seq
MIRT890836	hsa-miR-3065-5p	CLIP-seq
MIRT890837	hsa-miR-3126-5p	CLIP-seq
MIRT890838	hsa-miR-3545-3p	CLIP-seq
MIRT890839	hsa-miR-3662	CLIP-seq
MIRT890840	hsa-miR-369-3p	CLIP-seq
MIRT890841	hsa-miR-374a	CLIP-seq
MIRT890842	hsa-miR-374b	CLIP-seq
MIRT890843	hsa-miR-380	CLIP-seq
MIRT890844	hsa-miR-429	CLIP-seq
MIRT890845	hsa-miR-4419a	CLIP-seq
MIRT890846	hsa-miR-4424	CLIP-seq
MIRT890847	hsa-miR-4457	CLIP-seq
MIRT890848	hsa-miR-4503	CLIP-seq
MIRT890849	hsa-miR-4510	CLIP-seq
MIRT890850	hsa-miR-4517	CLIP-seq
MIRT890851	hsa-miR-4529-5p	CLIP-seq
MIRT890852	hsa-miR-4698	CLIP-seq
MIRT890853	hsa-miR-4714-3p	CLIP-seq
MIRT890854	hsa-miR-4718	CLIP-seq
MIRT890855	hsa-miR-4753-5p	CLIP-seq
MIRT890856	hsa-miR-513b	CLIP-seq
MIRT890857	hsa-miR-554	CLIP-seq
MIRT1964039	hsa-miR-1284	CLIP-seq
MIRT1964040	hsa-miR-323-3p	CLIP-seq
MIRT1964041	hsa-miR-337-3p	CLIP-seq
MIRT1964042	hsa-miR-4422	CLIP-seq
MIRT1964043	hsa-miR-676	CLIP-seq
MIRT2200225	hsa-miR-101	CLIP-seq
MIRT2200226	hsa-miR-1245	CLIP-seq
MIRT2200227	hsa-miR-125a-3p	CLIP-seq
MIRT2200228	hsa-miR-144	CLIP-seq
MIRT2200229	hsa-miR-199a-3p	CLIP-seq
MIRT2200230	hsa-miR-199b-3p	CLIP-seq
MIRT890832	hsa-miR-200b	CLIP-seq
MIRT890833	hsa-miR-200c	CLIP-seq
MIRT890834	hsa-miR-2054	CLIP-seq
MIRT890837	hsa-miR-3126-5p	CLIP-seq
MIRT2200231	hsa-miR-3129-5p	CLIP-seq
MIRT890843	hsa-miR-380	CLIP-seq
MIRT2200232	hsa-miR-3908	CLIP-seq
MIRT2200233	hsa-miR-3934	CLIP-seq
MIRT890844	hsa-miR-429	CLIP-seq
MIRT2200234	hsa-miR-433	CLIP-seq
MIRT890845	hsa-miR-4419a	CLIP-seq
MIRT890849	hsa-miR-4510	CLIP-seq
MIRT2200235	hsa-miR-4643	CLIP-seq
MIRT2200236	hsa-miR-4693-3p	CLIP-seq
MIRT2200237	hsa-miR-4712-3p	CLIP-seq
MIRT2200238	hsa-miR-548c-3p	CLIP-seq
MIRT2200239	hsa-miR-548g	CLIP-seq
MIRT2200240	hsa-miR-610	CLIP-seq
MIRT2200241	hsa-miR-627	CLIP-seq
MIRT2200242	hsa-miR-642b	CLIP-seq
MIRT2200243	hsa-miR-764	CLIP-seq
MIRT2200244	hsa-miR-924	CLIP-seq
MIRT2200225	hsa-miR-101	CLIP-seq
MIRT2200226	hsa-miR-1245	CLIP-seq
MIRT2200228	hsa-miR-144	CLIP-seq
MIRT2200229	hsa-miR-199a-3p	CLIP-seq
MIRT2200230	hsa-miR-199b-3p	CLIP-seq
MIRT2200231	hsa-miR-3129-5p	CLIP-seq
MIRT2503065	hsa-miR-323b-3p	CLIP-seq
MIRT2503066	hsa-miR-361-5p	CLIP-seq
MIRT2503067	hsa-miR-3658	CLIP-seq
MIRT2503068	hsa-miR-3671	CLIP-seq
MIRT2503069	hsa-miR-3672	CLIP-seq
MIRT2503070	hsa-miR-376a	CLIP-seq
MIRT2503071	hsa-miR-376b	CLIP-seq
MIRT2503072	hsa-miR-4477a	CLIP-seq
MIRT2503073	hsa-miR-4682	CLIP-seq
MIRT2503074	hsa-miR-4795-3p	CLIP-seq
MIRT2200238	hsa-miR-548c-3p	CLIP-seq
MIRT2200239	hsa-miR-548g	CLIP-seq
MIRT2503075	hsa-miR-570	CLIP-seq
MIRT2503076	hsa-miR-590-3p	CLIP-seq
MIRT2503077	hsa-miR-607	CLIP-seq
MIRT2200240	hsa-miR-610	CLIP-seq
MIRT2503078	hsa-miR-944	CLIP-seq
MIRT2503066	hsa-miR-361-5p	CLIP-seq
MIRT2503067	hsa-miR-3658	CLIP-seq
MIRT2503068	hsa-miR-3671	CLIP-seq
MIRT2503069	hsa-miR-3672	CLIP-seq
MIRT2503070	hsa-miR-376a	CLIP-seq
MIRT2503071	hsa-miR-376b	CLIP-seq
MIRT2503072	hsa-miR-4477a	CLIP-seq
MIRT2503073	hsa-miR-4682	CLIP-seq
MIRT2503074	hsa-miR-4795-3p	CLIP-seq
MIRT2200238	hsa-miR-548c-3p	CLIP-seq
MIRT2200239	hsa-miR-548g	CLIP-seq
MIRT2503075	hsa-miR-570	CLIP-seq
MIRT2503076	hsa-miR-590-3p	CLIP-seq
MIRT2503077	hsa-miR-607	CLIP-seq
MIRT2200240	hsa-miR-610	CLIP-seq
MIRT2503078	hsa-miR-944	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000421	Component	Autophagosome membrane	IDA	17984323
GO:0000776	Component	Kinetochore	IDA	26040712
GO:0000776	Component	Kinetochore	IEA
GO:0000815	Component	ESCRT III complex	NAS	36107470
GO:0001778	Process	Plasma membrane repair	IDA	24482116
GO:0001778	Process	Plasma membrane repair	IEA
GO:0001919	Process	Regulation of receptor recycling	IEA
GO:0005515	Function	Protein binding	IPI	15644320, 16730941, 17711858, 18385515, 21543490, 21988832, 22484091, 23105106, 25416956, 26496610, 27812135, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005643	Component	Nuclear pore	IDA	26040713
GO:0005643	Component	Nuclear pore	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005765	Component	Lysosomal membrane	IDA	17984323
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005771	Component	Multivesicular body	IBA
GO:0005828	Component	Kinetochore microtubule	IDA	26040712
GO:0005828	Component	Kinetochore microtubule	IEA
GO:0005829	Component	Cytosol	IDA	15644320
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	24878737
GO:0006900	Process	Vesicle budding from membrane	IBA
GO:0006914	Process	Autophagy	IMP	17984323
GO:0006997	Process	Nucleus organization	IMP	20616062
GO:0007034	Process	Vacuolar transport	IEA
GO:0007040	Process	Lysosome organization	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	20616062
GO:0008333	Process	Endosome to lysosome transport	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0010824	Process	Regulation of centrosome duplication	IMP	20616062
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0030218	Process	Erythrocyte differentiation	IEA
GO:0030496	Component	Midbody	IDA	26040712
GO:0030496	Component	Midbody	IEA
GO:0031468	Process	Nuclear membrane reassembly	IEA
GO:0031468	Process	Nuclear membrane reassembly	IMP	26040713
GO:0032511	Process	Late endosome to vacuole transport via multivesicular body sorting pathway	IBA
GO:0032585	Component	Multivesicular body membrane	IDA	16554368
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0036258	Process	Multivesicular body assembly	NAS	16505166, 20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IDA	24878737
GO:0039702	Process	Viral budding via host ESCRT complex	IEA
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA	17984323
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046755	Process	Viral budding	IMP	15644320
GO:0046761	Process	Viral budding from plasma membrane	IDA	24878737
GO:0046761	Process	Viral budding from plasma membrane	IEA
GO:0051469	Process	Vesicle fusion with vacuole	NAS	16505166
GO:0061763	Process	Multivesicular body-lysosome fusion	NAS	16505166
GO:0061952	Process	Midbody abscission	IEA
GO:0061952	Process	Midbody abscission	IMP	20616062
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0071222	Process	Cellular response to lipopolysaccharide	IMP	27812135
GO:0071225	Process	Cellular response to muramyl dipeptide	IMP	27812135
GO:0071985	Process	Multivesicular body sorting pathway	IDA	16554368
GO:0071985	Process	Multivesicular body sorting pathway	IEA
GO:0071985	Process	Multivesicular body sorting pathway	IMP	15644320
GO:0090148	Process	Membrane fission	NAS	19234443
GO:0097352	Process	Autophagosome maturation	IEA
GO:0097352	Process	Autophagosome maturation	IMP	17984323
GO:1901673	Process	Regulation of mitotic spindle assembly	IEA
GO:1901673	Process	Regulation of mitotic spindle assembly	IMP	20616062
GO:1902774	Process	Late endosome to lysosome transport	IEA
GO:1902774	Process	Late endosome to lysosome transport	IMP	17984323
GO:1904903	Process	ESCRT III complex disassembly	NAS	20588296
GO:1904930	Component	Amphisome membrane	IDA	17984323
GO:1904930	Component	Amphisome membrane	IEA

MIM	HGNC	e!Ensembl
610900	26942	ENSG00000086065

Q9NZZ3

Protein name

Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)

Protein function

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intral

PDB

2LXM , 3ULY , 3UM0 , 3UM1 , 3UM2 , 4TXR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03357	Snf7	12 → 197	Snf7	Family

Sequence

MNRLFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNM
VKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAY
KQVKIDQIEDLQDQLEDMMEDANEIQEALSRSYGTPELDEDDLEAELDALGDELLADEDS
SYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPAS

Sequence length

219

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Necroptosis		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)

CHMP5 (charged multivesicular body protein 5)