Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51510
Gene name Gene Name - the full gene name approved by the HGNC.	Charged multivesicular body protein 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CHMP5
Synonyms (NCBI Gene) Gene synonyms aliases	C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2, Spike, Vps60
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor pr

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miRTarBase ID	miRNA	Experiments
MIRT890828	hsa-miR-1273d	CLIP-seq
MIRT890829	hsa-miR-1278	CLIP-seq
MIRT890830	hsa-miR-140-3p	CLIP-seq
MIRT890831	hsa-miR-186	CLIP-seq
MIRT890832	hsa-miR-200b	CLIP-seq
MIRT890833	hsa-miR-200c	CLIP-seq
MIRT890834	hsa-miR-2054	CLIP-seq
MIRT890835	hsa-miR-2114	CLIP-seq
MIRT890836	hsa-miR-3065-5p	CLIP-seq
MIRT890837	hsa-miR-3126-5p	CLIP-seq
MIRT890838	hsa-miR-3545-3p	CLIP-seq
MIRT890839	hsa-miR-3662	CLIP-seq
MIRT890840	hsa-miR-369-3p	CLIP-seq
MIRT890841	hsa-miR-374a	CLIP-seq
MIRT890842	hsa-miR-374b	CLIP-seq
MIRT890843	hsa-miR-380	CLIP-seq
MIRT890844	hsa-miR-429	CLIP-seq
MIRT890845	hsa-miR-4419a	CLIP-seq
MIRT890846	hsa-miR-4424	CLIP-seq
MIRT890847	hsa-miR-4457	CLIP-seq
MIRT890848	hsa-miR-4503	CLIP-seq
MIRT890849	hsa-miR-4510	CLIP-seq
MIRT890850	hsa-miR-4517	CLIP-seq
MIRT890851	hsa-miR-4529-5p	CLIP-seq
MIRT890852	hsa-miR-4698	CLIP-seq
MIRT890853	hsa-miR-4714-3p	CLIP-seq
MIRT890854	hsa-miR-4718	CLIP-seq
MIRT890855	hsa-miR-4753-5p	CLIP-seq
MIRT890856	hsa-miR-513b	CLIP-seq
MIRT890857	hsa-miR-554	CLIP-seq
MIRT1964039	hsa-miR-1284	CLIP-seq
MIRT1964040	hsa-miR-323-3p	CLIP-seq
MIRT1964041	hsa-miR-337-3p	CLIP-seq
MIRT1964042	hsa-miR-4422	CLIP-seq
MIRT1964043	hsa-miR-676	CLIP-seq
MIRT2200225	hsa-miR-101	CLIP-seq
MIRT2200226	hsa-miR-1245	CLIP-seq
MIRT2200227	hsa-miR-125a-3p	CLIP-seq
MIRT2200228	hsa-miR-144	CLIP-seq
MIRT2200229	hsa-miR-199a-3p	CLIP-seq
MIRT2200230	hsa-miR-199b-3p	CLIP-seq
MIRT890832	hsa-miR-200b	CLIP-seq
MIRT890833	hsa-miR-200c	CLIP-seq
MIRT890834	hsa-miR-2054	CLIP-seq
MIRT890837	hsa-miR-3126-5p	CLIP-seq
MIRT2200231	hsa-miR-3129-5p	CLIP-seq
MIRT890843	hsa-miR-380	CLIP-seq
MIRT2200232	hsa-miR-3908	CLIP-seq
MIRT2200233	hsa-miR-3934	CLIP-seq
MIRT890844	hsa-miR-429	CLIP-seq
MIRT2200234	hsa-miR-433	CLIP-seq
MIRT890845	hsa-miR-4419a	CLIP-seq
MIRT890849	hsa-miR-4510	CLIP-seq
MIRT2200235	hsa-miR-4643	CLIP-seq
MIRT2200236	hsa-miR-4693-3p	CLIP-seq
MIRT2200237	hsa-miR-4712-3p	CLIP-seq
MIRT2200238	hsa-miR-548c-3p	CLIP-seq
MIRT2200239	hsa-miR-548g	CLIP-seq
MIRT2200240	hsa-miR-610	CLIP-seq
MIRT2200241	hsa-miR-627	CLIP-seq
MIRT2200242	hsa-miR-642b	CLIP-seq
MIRT2200243	hsa-miR-764	CLIP-seq
MIRT2200244	hsa-miR-924	CLIP-seq
MIRT2200225	hsa-miR-101	CLIP-seq
MIRT2200226	hsa-miR-1245	CLIP-seq
MIRT2200228	hsa-miR-144	CLIP-seq
MIRT2200229	hsa-miR-199a-3p	CLIP-seq
MIRT2200230	hsa-miR-199b-3p	CLIP-seq
MIRT2200231	hsa-miR-3129-5p	CLIP-seq
MIRT2503065	hsa-miR-323b-3p	CLIP-seq
MIRT2503066	hsa-miR-361-5p	CLIP-seq
MIRT2503067	hsa-miR-3658	CLIP-seq
MIRT2503068	hsa-miR-3671	CLIP-seq
MIRT2503069	hsa-miR-3672	CLIP-seq
MIRT2503070	hsa-miR-376a	CLIP-seq
MIRT2503071	hsa-miR-376b	CLIP-seq
MIRT2503072	hsa-miR-4477a	CLIP-seq
MIRT2503073	hsa-miR-4682	CLIP-seq
MIRT2503074	hsa-miR-4795-3p	CLIP-seq
MIRT2200238	hsa-miR-548c-3p	CLIP-seq
MIRT2200239	hsa-miR-548g	CLIP-seq
MIRT2503075	hsa-miR-570	CLIP-seq
MIRT2503076	hsa-miR-590-3p	CLIP-seq
MIRT2503077	hsa-miR-607	CLIP-seq
MIRT2200240	hsa-miR-610	CLIP-seq
MIRT2503078	hsa-miR-944	CLIP-seq
MIRT2503066	hsa-miR-361-5p	CLIP-seq
MIRT2503067	hsa-miR-3658	CLIP-seq
MIRT2503068	hsa-miR-3671	CLIP-seq
MIRT2503069	hsa-miR-3672	CLIP-seq
MIRT2503070	hsa-miR-376a	CLIP-seq
MIRT2503071	hsa-miR-376b	CLIP-seq
MIRT2503072	hsa-miR-4477a	CLIP-seq
MIRT2503073	hsa-miR-4682	CLIP-seq
MIRT2503074	hsa-miR-4795-3p	CLIP-seq
MIRT2200238	hsa-miR-548c-3p	CLIP-seq
MIRT2200239	hsa-miR-548g	CLIP-seq
MIRT2503075	hsa-miR-570	CLIP-seq
MIRT2503076	hsa-miR-590-3p	CLIP-seq
MIRT2503077	hsa-miR-607	CLIP-seq
MIRT2200240	hsa-miR-610	CLIP-seq
MIRT2503078	hsa-miR-944	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001919	Process	Regulation of receptor recycling	IEA
GO:0005515	Function	Protein binding	IPI	15644320, 16730941, 17711858, 18385515, 21543490, 21988832, 23105106, 25416956, 26496610, 27812135, 28514442, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005771	Component	Multivesicular body	IBA	21873635
GO:0005829	Component	Cytosol	IDA	15644320
GO:0005829	Component	Cytosol	TAS
GO:0006900	Process	Vesicle budding from membrane	IBA	21873635
GO:0006997	Process	Nucleus organization	IMP	20616062
GO:0007040	Process	Lysosome organization	IEA
GO:0007080	Process	Mitotic metaphase plate congression	IMP	20616062
GO:0008333	Process	Endosome to lysosome transport	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0010824	Process	Regulation of centrosome duplication	IMP	20616062
GO:0015031	Process	Protein transport	IEA
GO:0016197	Process	Endosomal transport	TAS
GO:0019058	Process	Viral life cycle	TAS
GO:0032511	Process	Late endosome to vacuole transport via multivesicular body sorting pathway	IBA	21873635
GO:0036258	Process	Multivesicular body assembly	NAS	20588296
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046755	Process	Viral budding	IMP	15644320
GO:0061952	Process	Midbody abscission	IMP	20616062
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0071222	Process	Cellular response to lipopolysaccharide	IMP	27812135
GO:0071225	Process	Cellular response to muramyl dipeptide	IMP	27812135
GO:0071985	Process	Multivesicular body sorting pathway	IMP	15644320
GO:1901673	Process	Regulation of mitotic spindle assembly	IMP	20616062
GO:1904903	Process	ESCRT III complex disassembly	NAS	20588296

MIM	HGNC	e!Ensembl
610900	26942	ENSG00000086065

Protein

UniProt ID

Q9NZZ3

Protein name

Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)

Protein function

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intral

PDB

2LXM , 3ULY , 3UM0 , 3UM1 , 3UM2 , 4TXR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03357	Snf7	12 → 197	Snf7	Family

Sequence

MNRLFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNM
VKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAY
KQVKIDQIEDLQDQLEDMMEDANEIQEALSRSYGTPELDEDDLEAELDALGDELLADEDS
SYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPAS

Sequence length

219

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Necroptosis		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	17708794, 27903959

CHMP5 (charged multivesicular body protein 5)