ISYNA1 (inositol-3-phosphate synthase 1)

Gene

• Entrez ID: 51477
• Gene name: Inositol-3-phosphate synthase 1
• Gene symbol: ISYNA1
• Synonyms (NCBI Gene): INO1, INOS, IPS, IPS 1, IPS-1
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively splic

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004188	hsa-miR-197-3p	Microarray	16822819
MIRT044693	hsa-miR-320a	CLASH	23622248
MIRT1073181	hsa-miR-4726-3p	CLIP-seq
MIRT1073182	hsa-miR-513a-5p	CLIP-seq
MIRT1073183	hsa-miR-548b-3p	CLIP-seq
MIRT2018006	hsa-miR-3151	CLIP-seq
MIRT2018007	hsa-miR-4265	CLIP-seq
MIRT2018008	hsa-miR-4296	CLIP-seq
MIRT2018009	hsa-miR-4322	CLIP-seq
MIRT2018010	hsa-miR-4447	CLIP-seq
MIRT2018011	hsa-miR-4472	CLIP-seq
MIRT2018012	hsa-miR-4481	CLIP-seq
MIRT2018013	hsa-miR-4745-5p	CLIP-seq
MIRT2018014	hsa-miR-4758-5p	CLIP-seq
MIRT2018015	hsa-miR-491-5p	CLIP-seq
MIRT2018016	hsa-miR-885-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Activation	15464731

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004512	Function	Inositol-3-phosphate synthase activity	IBA
GO:0004512	Function	Inositol-3-phosphate synthase activity	IEA
GO:0004512	Function	Inositol-3-phosphate synthase activity	IGI	23902760
GO:0004512	Function	Inositol-3-phosphate synthase activity	IMP	23902760
GO:0005515	Function	Protein binding	IPI	21044950, 25416956, 25910212, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006021	Process	Inositol biosynthetic process	IBA
GO:0006021	Process	Inositol biosynthetic process	IEA
GO:0006021	Process	Inositol biosynthetic process	IGI	23902760
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0016853	Function	Isomerase activity	IEA

Other IDs

• MIM: 611670
• HGNC: 29821
• e!Ensembl: ENSG00000105655

Protein

• UniProt ID: Q9NPH2
• Protein name: Inositol-3-phosphate synthase 1 (IPS 1) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1)
• Protein function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all inosito
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07994	NAD_binding_5	59 → 491	Myo-inositol-1-phosphate synthase	Family
  PF01658	Inos-1-P_synth	307 → 420	Myo-inositol-1-phosphate synthase	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon. {ECO:0000269|PubMed:12941308}.
• Sequence:

  MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLG
  VMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVF
  VPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYI
  PEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPG
  LNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVG
  GDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVV
  DDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDS
  LLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALF
  RQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNG
  CTGDANGHLQEEPPMPTT

• Sequence length: 558

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways

Reactome:

Synthesis of IP2, IP, and Ins in the cytosol

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