ISYNA1 (inositol-3-phosphate synthase 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51477
Gene name Gene Name - the full gene name approved by the HGNC.
Inositol-3-phosphate synthase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ISYNA1
Synonyms (NCBI Gene) Gene synonyms aliases
INO1, INOS, IPS, IPS 1, IPS-1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IPS
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively splic
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
miRTarBase ID miRNA Experiments Reference
MIRT004188 hsa-miR-197-3p Microarray 16822819
MIRT044693 hsa-miR-320a CLASH 23622248
MIRT1073181 hsa-miR-4726-3p CLIP-seq
MIRT1073182 hsa-miR-513a-5p CLIP-seq
MIRT1073183 hsa-miR-548b-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
E2F1 Activation 15464731
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0004512 Function Inositol-3-phosphate synthase activity IBA 21873635
GO:0004512 Function Inositol-3-phosphate synthase activity IMP 23902760
GO:0005515 Function Protein binding IPI 21044950, 25416956, 25910212, 32296183
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
611670 29821 ENSG00000105655
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9NPH2
Protein name Inositol-3-phosphate synthase 1 (IPS 1) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1)
Protein function Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:15024000, PubMed:23902760). Rate-limiting enzyme in the synthesis of all inosito
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07994 NAD_binding_5 59 → 491 Myo-inositol-1-phosphate synthase Family
PF01658 Inos-1-P_synth 307 → 420 Myo-inositol-1-phosphate synthase Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon. {ECO:0000269|PubMed:12941308}.
Sequence
Sequence length 558
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Inositol phosphate metabolism
Metabolic pathways 		  Synthesis of IP2, IP, and Ins in the cytosol
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenoid Cystic Carcinoma rs121913530, rs886039394, rs121913474 16762588
Show/Hide Text Mining Associations (65)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 16534838
Adenoma Associate 21249124
Alzheimer Disease Associate 30478411
Angina Stable Stimulate 12775581
Angina Unstable Associate 12189017
Angina Unstable Stimulate 12775581
Aortic Aneurysm Abdominal Associate 23506637, 31473210
Arthritis Psoriatic Inhibit 27706699
Brain Ischemia Associate 30539420
Brain Neoplasms Associate 33420630