Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51454
Gene name Gene Name - the full gene name approved by the HGNC.	GULP PTB domain containing engulfment adaptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GULP1
Synonyms (NCBI Gene) Gene synonyms aliases	CED-6, CED6, GULP
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q32.1-q32.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by R

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016998	hsa-miR-335-5p	Microarray	18185580
MIRT024316	hsa-miR-215-5p	Microarray	19074876
MIRT026204	hsa-miR-192-5p	Microarray	19074876
MIRT527139	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT527138	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT527137	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT527136	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT527135	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT527134	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT527133	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT527132	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	22012620
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT527131	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	22012620
MIRT512655	hsa-miR-7975	PAR-CLIP	22012620
MIRT527130	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT527129	hsa-miR-448	PAR-CLIP	22012620
MIRT512654	hsa-miR-3685	PAR-CLIP	22012620
MIRT512653	hsa-miR-384	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	23446348
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	23446348
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	23446348
MIRT512655	hsa-miR-7975	PAR-CLIP	23446348
MIRT512654	hsa-miR-3685	PAR-CLIP	23446348
MIRT512653	hsa-miR-384	PAR-CLIP	23446348
MIRT527139	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT527138	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT527137	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT527136	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT527135	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT527134	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT527133	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT527132	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	22012620
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT527131	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	22012620
MIRT512655	hsa-miR-7975	PAR-CLIP	22012620
MIRT527130	hsa-miR-153-3p	PAR-CLIP	22012620
MIRT527129	hsa-miR-448	PAR-CLIP	22012620
MIRT512654	hsa-miR-3685	PAR-CLIP	22012620
MIRT512653	hsa-miR-384	PAR-CLIP	22012620
MIRT512658	hsa-miR-627-3p	PAR-CLIP	23446348
MIRT512656	hsa-miR-3606-5p	PAR-CLIP	23446348
MIRT512657	hsa-miR-5571-3p	PAR-CLIP	23446348
MIRT512655	hsa-miR-7975	PAR-CLIP	23446348
MIRT512654	hsa-miR-3685	PAR-CLIP	23446348
MIRT512653	hsa-miR-384	PAR-CLIP	23446348
MIRT1038516	hsa-miR-1305	CLIP-seq
MIRT1038517	hsa-miR-299-5p	CLIP-seq
MIRT1038518	hsa-miR-300	CLIP-seq
MIRT1038519	hsa-miR-3065-3p	CLIP-seq
MIRT1038520	hsa-miR-3129-3p	CLIP-seq
MIRT1038521	hsa-miR-3200-3p	CLIP-seq
MIRT1038522	hsa-miR-33a	CLIP-seq
MIRT1038523	hsa-miR-33b	CLIP-seq
MIRT1038524	hsa-miR-3646	CLIP-seq
MIRT1038525	hsa-miR-381	CLIP-seq
MIRT1038526	hsa-miR-4666-3p	CLIP-seq
MIRT1038527	hsa-miR-499-3p	CLIP-seq
MIRT1038528	hsa-miR-499a-3p	CLIP-seq
MIRT1038529	hsa-miR-548ac	CLIP-seq
MIRT1038530	hsa-miR-548ae	CLIP-seq
MIRT1038531	hsa-miR-548aj	CLIP-seq
MIRT1038532	hsa-miR-548am	CLIP-seq
MIRT1038533	hsa-miR-548d-3p	CLIP-seq
MIRT1038534	hsa-miR-548n	CLIP-seq
MIRT1038535	hsa-miR-548t	CLIP-seq
MIRT1038536	hsa-miR-548x	CLIP-seq
MIRT1038537	hsa-miR-548z	CLIP-seq
MIRT2007921	hsa-miR-1324	CLIP-seq
MIRT2007922	hsa-miR-142-5p	CLIP-seq
MIRT2007923	hsa-miR-219-1-3p	CLIP-seq
MIRT1038517	hsa-miR-299-5p	CLIP-seq
MIRT2007924	hsa-miR-340	CLIP-seq
MIRT2007925	hsa-miR-369-3p	CLIP-seq
MIRT2007926	hsa-miR-3714	CLIP-seq
MIRT2007927	hsa-miR-4457	CLIP-seq
MIRT2007928	hsa-miR-4643	CLIP-seq
MIRT2007929	hsa-miR-4678	CLIP-seq
MIRT2007930	hsa-miR-4731-3p	CLIP-seq
MIRT2007931	hsa-miR-4736	CLIP-seq
MIRT2007932	hsa-miR-4801	CLIP-seq
MIRT2007933	hsa-miR-514	CLIP-seq
MIRT2007934	hsa-miR-514b-3p	CLIP-seq
MIRT2007935	hsa-miR-548c-3p	CLIP-seq
MIRT2007936	hsa-miR-548l	CLIP-seq
MIRT2007937	hsa-miR-548u	CLIP-seq
MIRT2007938	hsa-miR-642b	CLIP-seq
MIRT2007939	hsa-miR-940	CLIP-seq
MIRT2240619	hsa-miR-1236	CLIP-seq
MIRT2240620	hsa-miR-144	CLIP-seq
MIRT2240621	hsa-miR-224	CLIP-seq
MIRT2240622	hsa-miR-23a	CLIP-seq
MIRT2240623	hsa-miR-23b	CLIP-seq
MIRT2240624	hsa-miR-23c	CLIP-seq
MIRT2240625	hsa-miR-3163	CLIP-seq
MIRT2240626	hsa-miR-3622b-5p	CLIP-seq
MIRT2240627	hsa-miR-4642	CLIP-seq
MIRT2240628	hsa-miR-4789-5p	CLIP-seq
MIRT2240629	hsa-miR-593	CLIP-seq
MIRT2388882	hsa-miR-101	CLIP-seq
MIRT2240620	hsa-miR-144	CLIP-seq
MIRT2544067	hsa-miR-1	CLIP-seq
MIRT2240619	hsa-miR-1236	CLIP-seq
MIRT2544068	hsa-miR-1245b-3p	CLIP-seq
MIRT2544069	hsa-miR-1253	CLIP-seq
MIRT2544070	hsa-miR-1299	CLIP-seq
MIRT2544071	hsa-miR-1322	CLIP-seq
MIRT2544072	hsa-miR-1323	CLIP-seq
MIRT2544073	hsa-miR-135a	CLIP-seq
MIRT2544074	hsa-miR-135b	CLIP-seq
MIRT2007922	hsa-miR-142-5p	CLIP-seq
MIRT2544075	hsa-miR-206	CLIP-seq
MIRT2544076	hsa-miR-2909	CLIP-seq
MIRT2544077	hsa-miR-3064-3p	CLIP-seq
MIRT2544078	hsa-miR-3119	CLIP-seq
MIRT2544079	hsa-miR-3122	CLIP-seq
MIRT2544080	hsa-miR-3140-3p	CLIP-seq
MIRT2544081	hsa-miR-3143	CLIP-seq
MIRT2544082	hsa-miR-3148	CLIP-seq
MIRT2544083	hsa-miR-3150b-3p	CLIP-seq
MIRT2544084	hsa-miR-3153	CLIP-seq
MIRT2544085	hsa-miR-3157-3p	CLIP-seq
MIRT2544086	hsa-miR-3162-5p	CLIP-seq
MIRT2007924	hsa-miR-340	CLIP-seq
MIRT2544087	hsa-miR-34c-3p	CLIP-seq
MIRT2544088	hsa-miR-3616-3p	CLIP-seq
MIRT2240626	hsa-miR-3622b-5p	CLIP-seq
MIRT1038524	hsa-miR-3646	CLIP-seq
MIRT2544089	hsa-miR-3662	CLIP-seq
MIRT2544090	hsa-miR-3673	CLIP-seq
MIRT2544091	hsa-miR-3913-5p	CLIP-seq
MIRT2544092	hsa-miR-409-3p	CLIP-seq
MIRT2544093	hsa-miR-410	CLIP-seq
MIRT2544094	hsa-miR-4290	CLIP-seq
MIRT2544095	hsa-miR-4307	CLIP-seq
MIRT2544096	hsa-miR-4432	CLIP-seq
MIRT2544097	hsa-miR-4477b	CLIP-seq
MIRT2544098	hsa-miR-4517	CLIP-seq
MIRT2544099	hsa-miR-4524	CLIP-seq
MIRT2544100	hsa-miR-4540	CLIP-seq
MIRT2240627	hsa-miR-4642	CLIP-seq
MIRT2544101	hsa-miR-4668-5p	CLIP-seq
MIRT2544102	hsa-miR-4689	CLIP-seq
MIRT2544103	hsa-miR-4712-3p	CLIP-seq
MIRT2544104	hsa-miR-4719	CLIP-seq
MIRT2544105	hsa-miR-4735-5p	CLIP-seq
MIRT2544106	hsa-miR-4761-3p	CLIP-seq
MIRT2544107	hsa-miR-4762-5p	CLIP-seq
MIRT2544108	hsa-miR-4778-3p	CLIP-seq
MIRT2544109	hsa-miR-4784	CLIP-seq
MIRT2544110	hsa-miR-491-3p	CLIP-seq
MIRT2544111	hsa-miR-494	CLIP-seq
MIRT2544112	hsa-miR-498	CLIP-seq
MIRT2544113	hsa-miR-513a-3p	CLIP-seq
MIRT2544114	hsa-miR-539	CLIP-seq
MIRT2544115	hsa-miR-543	CLIP-seq
MIRT2544116	hsa-miR-548a-5p	CLIP-seq
MIRT2544117	hsa-miR-548aa	CLIP-seq
MIRT2544118	hsa-miR-548ab	CLIP-seq
MIRT2544119	hsa-miR-548ag	CLIP-seq
MIRT2544120	hsa-miR-548ai	CLIP-seq
MIRT2544121	hsa-miR-548ak	CLIP-seq
MIRT2544122	hsa-miR-548b-5p	CLIP-seq
MIRT2544123	hsa-miR-548c-5p	CLIP-seq
MIRT2544124	hsa-miR-548d-5p	CLIP-seq
MIRT2544125	hsa-miR-548h	CLIP-seq
MIRT2544126	hsa-miR-548i	CLIP-seq
MIRT2544127	hsa-miR-548j	CLIP-seq
MIRT2544128	hsa-miR-548k	CLIP-seq
MIRT2007936	hsa-miR-548l	CLIP-seq
MIRT2544129	hsa-miR-548o	CLIP-seq
MIRT2007937	hsa-miR-548u	CLIP-seq
MIRT2544130	hsa-miR-548w	CLIP-seq
MIRT2544131	hsa-miR-548y	CLIP-seq
MIRT2544132	hsa-miR-559	CLIP-seq
MIRT2544133	hsa-miR-576-3p	CLIP-seq
MIRT2544134	hsa-miR-577	CLIP-seq
MIRT2544135	hsa-miR-579	CLIP-seq
MIRT2240629	hsa-miR-593	CLIP-seq
MIRT2544136	hsa-miR-613	CLIP-seq
MIRT2544137	hsa-miR-874	CLIP-seq
MIRT2544138	hsa-miR-875-3p	CLIP-seq
MIRT2544139	hsa-miR-889	CLIP-seq
MIRT2544140	hsa-miR-9	CLIP-seq
MIRT2544067	hsa-miR-1	CLIP-seq
MIRT2240619	hsa-miR-1236	CLIP-seq
MIRT2544068	hsa-miR-1245b-3p	CLIP-seq
MIRT2544069	hsa-miR-1253	CLIP-seq
MIRT2544070	hsa-miR-1299	CLIP-seq
MIRT2544071	hsa-miR-1322	CLIP-seq
MIRT2544072	hsa-miR-1323	CLIP-seq
MIRT2544073	hsa-miR-135a	CLIP-seq
MIRT2544074	hsa-miR-135b	CLIP-seq
MIRT2007922	hsa-miR-142-5p	CLIP-seq
MIRT2544075	hsa-miR-206	CLIP-seq
MIRT2544076	hsa-miR-2909	CLIP-seq
MIRT2544077	hsa-miR-3064-3p	CLIP-seq
MIRT2544078	hsa-miR-3119	CLIP-seq
MIRT2544079	hsa-miR-3122	CLIP-seq
MIRT2544080	hsa-miR-3140-3p	CLIP-seq
MIRT2544082	hsa-miR-3148	CLIP-seq
MIRT2544083	hsa-miR-3150b-3p	CLIP-seq
MIRT2544084	hsa-miR-3153	CLIP-seq
MIRT2544085	hsa-miR-3157-3p	CLIP-seq
MIRT2544086	hsa-miR-3162-5p	CLIP-seq
MIRT2007924	hsa-miR-340	CLIP-seq
MIRT2544087	hsa-miR-34c-3p	CLIP-seq
MIRT2544088	hsa-miR-3616-3p	CLIP-seq
MIRT2240626	hsa-miR-3622b-5p	CLIP-seq
MIRT1038524	hsa-miR-3646	CLIP-seq
MIRT2544089	hsa-miR-3662	CLIP-seq
MIRT2544090	hsa-miR-3673	CLIP-seq
MIRT2544091	hsa-miR-3913-5p	CLIP-seq
MIRT2544094	hsa-miR-4290	CLIP-seq
MIRT2544095	hsa-miR-4307	CLIP-seq
MIRT2544096	hsa-miR-4432	CLIP-seq
MIRT2544097	hsa-miR-4477b	CLIP-seq
MIRT2544098	hsa-miR-4517	CLIP-seq
MIRT2544099	hsa-miR-4524	CLIP-seq
MIRT2544100	hsa-miR-4540	CLIP-seq
MIRT2240627	hsa-miR-4642	CLIP-seq
MIRT2544101	hsa-miR-4668-5p	CLIP-seq
MIRT2544102	hsa-miR-4689	CLIP-seq
MIRT2544103	hsa-miR-4712-3p	CLIP-seq
MIRT2544104	hsa-miR-4719	CLIP-seq
MIRT2544105	hsa-miR-4735-5p	CLIP-seq
MIRT2544106	hsa-miR-4761-3p	CLIP-seq
MIRT2544107	hsa-miR-4762-5p	CLIP-seq
MIRT2544108	hsa-miR-4778-3p	CLIP-seq
MIRT2544109	hsa-miR-4784	CLIP-seq
MIRT2544110	hsa-miR-491-3p	CLIP-seq
MIRT2544111	hsa-miR-494	CLIP-seq
MIRT2544112	hsa-miR-498	CLIP-seq
MIRT2544113	hsa-miR-513a-3p	CLIP-seq
MIRT2544114	hsa-miR-539	CLIP-seq
MIRT2544116	hsa-miR-548a-5p	CLIP-seq
MIRT2544117	hsa-miR-548aa	CLIP-seq
MIRT2544118	hsa-miR-548ab	CLIP-seq
MIRT2544119	hsa-miR-548ag	CLIP-seq
MIRT2544120	hsa-miR-548ai	CLIP-seq
MIRT2544121	hsa-miR-548ak	CLIP-seq
MIRT2544122	hsa-miR-548b-5p	CLIP-seq
MIRT2544123	hsa-miR-548c-5p	CLIP-seq
MIRT2544124	hsa-miR-548d-5p	CLIP-seq
MIRT2544125	hsa-miR-548h	CLIP-seq
MIRT2544126	hsa-miR-548i	CLIP-seq
MIRT2544127	hsa-miR-548j	CLIP-seq
MIRT2544128	hsa-miR-548k	CLIP-seq
MIRT2007936	hsa-miR-548l	CLIP-seq
MIRT2544129	hsa-miR-548o	CLIP-seq
MIRT2007937	hsa-miR-548u	CLIP-seq
MIRT2544130	hsa-miR-548w	CLIP-seq
MIRT2544131	hsa-miR-548y	CLIP-seq
MIRT2544132	hsa-miR-559	CLIP-seq
MIRT2544133	hsa-miR-576-3p	CLIP-seq
MIRT2544134	hsa-miR-577	CLIP-seq
MIRT2544135	hsa-miR-579	CLIP-seq
MIRT2240629	hsa-miR-593	CLIP-seq
MIRT2544136	hsa-miR-613	CLIP-seq
MIRT2544137	hsa-miR-874	CLIP-seq
MIRT2544138	hsa-miR-875-3p	CLIP-seq
MIRT2544139	hsa-miR-889	CLIP-seq
MIRT2544140	hsa-miR-9	CLIP-seq

Show/Hide all(4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0006911	Process	Phagocytosis, engulfment	IDA	11729193
GO:0006915	Process	Apoptotic process	IEA

MIM	HGNC	e!Ensembl
608165	18649	ENSG00000144366

Protein

UniProt ID

Q9UBP9

Protein name

PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP)

Protein function

May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands,

PDB

6ITU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00640	PID	27 → 155	Phosphotyrosine interaction domain (PTB/PID)	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. {ECO:0000269|PubMed:10574763}.

Sequence

MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIK
KSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSES
NKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETEN
MELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPP
PVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPL
DSRC

Sequence length

304

Interactions

View interactions

	KEGG
	Efferocytosis

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Uterine Fibroids	Uterine Fibroids	GWAS
Schizophrenia	Schizophrenia	GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Emphysema	Associate	28284325
Neoplasm Invasiveness	Associate	34576193
Neoplasms	Associate	40447753
Pancreatic Neoplasms	Associate	40447753
Pulmonary Disease Chronic Obstructive	Associate	22829758, 28284325
Urinary Bladder Neoplasms	Associate	34576193

GULP1 (GULP PTB domain containing engulfment adaptor 1)