Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51447
Gene name Gene Name - the full gene name approved by the HGNC.	Inositol hexakisphosphate kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IP6K2
Synonyms (NCBI Gene) Gene synonyms aliases	IHPK2, InsP6K2, PIUS
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,

Show/Hide all(151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003850	hsa-miR-1-3p	Microarray	15685193
MIRT003850	hsa-miR-1-3p	Microarray;Other	15685193
MIRT003850	hsa-miR-1-3p	Microarray	18668037
MIRT027801	hsa-miR-98-5p	Microarray	19088304
MIRT040826	hsa-miR-18a-3p	CLASH	23622248
MIRT040826	hsa-miR-18a-3p	CLASH	23622248
MIRT038635	hsa-miR-125a-3p	CLASH	23622248
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT640456	hsa-miR-1264	HITS-CLIP	23824327
MIRT640455	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT640454	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT640453	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT640456	hsa-miR-1264	HITS-CLIP	19536157
MIRT640455	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT640454	hsa-miR-361-3p	HITS-CLIP	19536157
MIRT640453	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT640457	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT640456	hsa-miR-1264	HITS-CLIP	23824327
MIRT640455	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT640454	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT640453	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT640451	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT640452	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT1068391	hsa-miR-2110	CLIP-seq
MIRT1068392	hsa-miR-2467-3p	CLIP-seq
MIRT1068393	hsa-miR-3117-5p	CLIP-seq
MIRT1068394	hsa-miR-3150a-3p	CLIP-seq
MIRT1068395	hsa-miR-3175	CLIP-seq
MIRT1068396	hsa-miR-326	CLIP-seq
MIRT1068397	hsa-miR-330-5p	CLIP-seq
MIRT1068398	hsa-miR-3678-3p	CLIP-seq
MIRT1068399	hsa-miR-380	CLIP-seq
MIRT1068400	hsa-miR-3924	CLIP-seq
MIRT1068401	hsa-miR-4267	CLIP-seq
MIRT1068402	hsa-miR-4303	CLIP-seq
MIRT1068403	hsa-miR-4495	CLIP-seq
MIRT1068404	hsa-miR-4649-3p	CLIP-seq
MIRT1068405	hsa-miR-4651	CLIP-seq
MIRT1068406	hsa-miR-4659a-3p	CLIP-seq
MIRT1068407	hsa-miR-4659b-3p	CLIP-seq
MIRT1068408	hsa-miR-4775	CLIP-seq
MIRT1068409	hsa-miR-576-5p	CLIP-seq
MIRT1068410	hsa-miR-590-3p	CLIP-seq
MIRT1068411	hsa-miR-608	CLIP-seq
MIRT1068412	hsa-miR-663b	CLIP-seq
MIRT1068413	hsa-miR-939	CLIP-seq
MIRT1068414	hsa-miR-214	CLIP-seq
MIRT1068415	hsa-miR-2392	CLIP-seq
MIRT1068416	hsa-miR-3605-5p	CLIP-seq
MIRT1068417	hsa-miR-3619-5p	CLIP-seq
MIRT1068418	hsa-miR-3665	CLIP-seq
MIRT1068419	hsa-miR-3675-5p	CLIP-seq
MIRT1068420	hsa-miR-3934	CLIP-seq
MIRT1068421	hsa-miR-4283	CLIP-seq
MIRT1068422	hsa-miR-4291	CLIP-seq
MIRT1068423	hsa-miR-4447	CLIP-seq
MIRT1068424	hsa-miR-4472	CLIP-seq
MIRT1068425	hsa-miR-4488	CLIP-seq
MIRT1068426	hsa-miR-4489	CLIP-seq
MIRT1068427	hsa-miR-4675	CLIP-seq
MIRT1068428	hsa-miR-4697-5p	CLIP-seq
MIRT1068429	hsa-miR-4719	CLIP-seq
MIRT1068430	hsa-miR-4741	CLIP-seq
MIRT1068431	hsa-miR-761	CLIP-seq
MIRT1068432	hsa-miR-764	CLIP-seq
MIRT1068433	hsa-miR-922	CLIP-seq
MIRT1068434	hsa-miR-124	CLIP-seq
MIRT1068435	hsa-miR-3130-5p	CLIP-seq
MIRT1068436	hsa-miR-3919	CLIP-seq
MIRT1068437	hsa-miR-4482	CLIP-seq
MIRT1068438	hsa-miR-4712-5p	CLIP-seq
MIRT1068439	hsa-miR-4797-5p	CLIP-seq
MIRT1068440	hsa-miR-506	CLIP-seq
MIRT1068441	hsa-miR-548an	CLIP-seq
MIRT1068442	hsa-miR-770-5p	CLIP-seq
MIRT2016658	hsa-miR-4446-5p	CLIP-seq
MIRT2016659	hsa-miR-488	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT2552514	hsa-miR-1913	CLIP-seq
MIRT2552515	hsa-miR-1915	CLIP-seq
MIRT1068392	hsa-miR-2467-3p	CLIP-seq
MIRT1068393	hsa-miR-3117-5p	CLIP-seq
MIRT2552516	hsa-miR-3127-3p	CLIP-seq
MIRT2552517	hsa-miR-3183	CLIP-seq
MIRT2552518	hsa-miR-3189-5p	CLIP-seq
MIRT2552519	hsa-miR-324-3p	CLIP-seq
MIRT1068396	hsa-miR-326	CLIP-seq
MIRT1068397	hsa-miR-330-5p	CLIP-seq
MIRT1068398	hsa-miR-3678-3p	CLIP-seq
MIRT1068401	hsa-miR-4267	CLIP-seq
MIRT1068402	hsa-miR-4303	CLIP-seq
MIRT2016658	hsa-miR-4446-5p	CLIP-seq
MIRT1068404	hsa-miR-4649-3p	CLIP-seq
MIRT2552520	hsa-miR-4650-5p	CLIP-seq
MIRT2552521	hsa-miR-4691-5p	CLIP-seq
MIRT2552522	hsa-miR-4723-3p	CLIP-seq
MIRT2552523	hsa-miR-4726-3p	CLIP-seq
MIRT2552524	hsa-miR-4757-5p	CLIP-seq
MIRT2552525	hsa-miR-4758-3p	CLIP-seq
MIRT2016659	hsa-miR-488	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT1068412	hsa-miR-663b	CLIP-seq
MIRT2552514	hsa-miR-1913	CLIP-seq
MIRT2552515	hsa-miR-1915	CLIP-seq
MIRT1068392	hsa-miR-2467-3p	CLIP-seq
MIRT1068393	hsa-miR-3117-5p	CLIP-seq
MIRT2552517	hsa-miR-3183	CLIP-seq
MIRT2552518	hsa-miR-3189-5p	CLIP-seq
MIRT2552519	hsa-miR-324-3p	CLIP-seq
MIRT1068396	hsa-miR-326	CLIP-seq
MIRT1068397	hsa-miR-330-5p	CLIP-seq
MIRT1068398	hsa-miR-3678-3p	CLIP-seq
MIRT1068401	hsa-miR-4267	CLIP-seq
MIRT1068402	hsa-miR-4303	CLIP-seq
MIRT1068404	hsa-miR-4649-3p	CLIP-seq
MIRT2552520	hsa-miR-4650-5p	CLIP-seq
MIRT2552521	hsa-miR-4691-5p	CLIP-seq
MIRT2552522	hsa-miR-4723-3p	CLIP-seq
MIRT2552523	hsa-miR-4726-3p	CLIP-seq
MIRT2552524	hsa-miR-4757-5p	CLIP-seq
MIRT2552525	hsa-miR-4758-3p	CLIP-seq
MIRT2016659	hsa-miR-488	CLIP-seq
MIRT2016660	hsa-miR-646	CLIP-seq
MIRT1068412	hsa-miR-663b	CLIP-seq

Show/Hide all(42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000827	Function	Inositol-1,3,4,5,6-pentakisphosphate kinase activity	IEA
GO:0000827	Function	Inositol-1,3,4,5,6-pentakisphosphate kinase activity	TAS
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IBA
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IDA	10574768
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IEA
GO:0000828	Function	Inositol hexakisphosphate kinase activity	TAS
GO:0000829	Function	Diphosphoinositol pentakisphosphate kinase activity	IEA
GO:0000829	Function	Diphosphoinositol pentakisphosphate kinase activity	TAS
GO:0000832	Function	Inositol hexakisphosphate 5-kinase activity	IDA	30624931
GO:0000832	Function	Inositol hexakisphosphate 5-kinase activity	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	18195352, 21078964, 21516116, 25416956, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11502751
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030308	Process	Negative regulation of cell growth	IMP	11337497
GO:0032958	Process	Inositol phosphate biosynthetic process	IBA
GO:0032958	Process	Inositol phosphate biosynthetic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	11337497
GO:0043647	Process	Inositol phosphate metabolic process	IDA	30624931
GO:0043647	Process	Inositol phosphate metabolic process	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IBA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IDA	10574768
GO:0050821	Process	Protein stabilization	IEA
GO:0052836	Function	Inositol 5-diphosphate pentakisphosphate 5-kinase activity	IEA
GO:0052836	Function	Inositol 5-diphosphate pentakisphosphate 5-kinase activity	TAS
GO:0052839	Function	Diphosphoinositol tetrakisphosphate kinase activity	IEA
GO:0052839	Function	Diphosphoinositol tetrakisphosphate kinase activity	TAS
GO:0090407	Process	Organophosphate biosynthetic process	IEA
GO:0097243	Function	Flavonoid binding	IDA	30624931
GO:1905396	Process	Cellular response to flavonoid	IMP	30624931

MIM	HGNC	e!Ensembl
606992	17313	ENSG00000068745

Protein

UniProt ID

Q9UHH9

Protein name

Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (InsP6K2) (EC 2.7.4.-) (P(i)-uptake stimulator) (PiUS)

Protein function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03770	IPK	203 → 418	Inositol polyphosphate kinase	Family

Sequence

MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMR
KFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNSDCEPKSKLLRWTTNKKHH
VLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISSQLKHYNPWS
MKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQ
IRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLR
RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAEDLEDLSEESA
DESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHEGQDAGYIFGLQSLIDIVTEI
SEESGE

Sequence length

426

Interactions

View interactions

	KEGG		Reactome
	Phosphatidylinositol signaling system		Synthesis of IPs in the nucleus Interferon alpha/beta signaling

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma (childhood onset)	N/A	N/A	GWAS
Hypertension	Hypertension (confirmatory factor analysis Factor 12)	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease (MTAG)	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Parkinson Disease	Parkinson's disease	N/A	N/A	GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Anorexia Nervosa	Associate	39741260
Autoimmune Diseases	Associate	22446964
Autonomic Nervous System Diseases	Associate	34994165
Axial osteomalacia	Associate	34602499
Carcinoma Hepatocellular	Associate	31856847
Colorectal Neoplasms	Associate	21078964
Glioblastoma	Associate	32176627
Glioma	Associate	35156508
Neoplasms	Associate	11896621
Ovarian Neoplasms	Associate	11337497, 11896621, 15634191
Parkinson Disease	Associate	34994165
Prostatic Neoplasms Castration Resistant	Associate	37270558

IP6K2 (inositol hexakisphosphate kinase 2)