GMPR2 (guanosine monophosphate reductase 2)

Gene

• Entrez ID: 51292
• Gene name: Guanosine monophosphate reductase 2
• Gene symbol: GMPR2
• Synonyms (NCBI Gene): GMPR 2, hGMPR-II
• Chromosome: 14
• Chromosome location: 14q12
• Summary: This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022133	hsa-miR-124-3p	Microarray	18668037
MIRT027420	hsa-miR-98-5p	Microarray	19088304
MIRT041522	hsa-miR-193b-3p	CLASH	23622248
MIRT1022761	hsa-let-7a	CLIP-seq
MIRT1022762	hsa-let-7b	CLIP-seq
MIRT1022763	hsa-let-7c	CLIP-seq
MIRT1022764	hsa-let-7d	CLIP-seq
MIRT1022765	hsa-let-7e	CLIP-seq
MIRT1022766	hsa-let-7f	CLIP-seq
MIRT1022767	hsa-let-7g	CLIP-seq
MIRT1022768	hsa-let-7i	CLIP-seq
MIRT1022769	hsa-miR-147	CLIP-seq
MIRT1022770	hsa-miR-202	CLIP-seq
MIRT1022771	hsa-miR-2113	CLIP-seq
MIRT1022772	hsa-miR-2115	CLIP-seq
MIRT1022773	hsa-miR-2355-5p	CLIP-seq
MIRT1022774	hsa-miR-300	CLIP-seq
MIRT1022775	hsa-miR-3174	CLIP-seq
MIRT1022776	hsa-miR-3189-3p	CLIP-seq
MIRT1022777	hsa-miR-3670	CLIP-seq
MIRT1022778	hsa-miR-3671	CLIP-seq
MIRT1022779	hsa-miR-381	CLIP-seq
MIRT1022780	hsa-miR-3944-5p	CLIP-seq
MIRT1022781	hsa-miR-3945	CLIP-seq
MIRT1022782	hsa-miR-3977	CLIP-seq
MIRT1022783	hsa-miR-4253	CLIP-seq
MIRT1022784	hsa-miR-4312	CLIP-seq
MIRT1022785	hsa-miR-4458	CLIP-seq
MIRT1022786	hsa-miR-4461	CLIP-seq
MIRT1022787	hsa-miR-4494	CLIP-seq
MIRT1022788	hsa-miR-4500	CLIP-seq
MIRT1022789	hsa-miR-452	CLIP-seq
MIRT1022790	hsa-miR-4666-3p	CLIP-seq
MIRT1022791	hsa-miR-4676-3p	CLIP-seq
MIRT1022792	hsa-miR-4678	CLIP-seq
MIRT1022793	hsa-miR-4691-5p	CLIP-seq
MIRT1022794	hsa-miR-4753-3p	CLIP-seq
MIRT1022795	hsa-miR-499a-5p	CLIP-seq
MIRT1022796	hsa-miR-502-5p	CLIP-seq
MIRT1022797	hsa-miR-515-3p	CLIP-seq
MIRT1022798	hsa-miR-516a-3p	CLIP-seq
MIRT1022799	hsa-miR-519e	CLIP-seq
MIRT1022800	hsa-miR-556-5p	CLIP-seq
MIRT1022801	hsa-miR-582-5p	CLIP-seq
MIRT1022802	hsa-miR-599	CLIP-seq
MIRT1022803	hsa-miR-607	CLIP-seq
MIRT1022804	hsa-miR-635	CLIP-seq
MIRT1022805	hsa-miR-98	CLIP-seq
MIRT2539954	hsa-miR-1224-5p	CLIP-seq
MIRT2539955	hsa-miR-1262	CLIP-seq
MIRT2539956	hsa-miR-1278	CLIP-seq
MIRT2539957	hsa-miR-3132	CLIP-seq
MIRT1022776	hsa-miR-3189-3p	CLIP-seq
MIRT2539958	hsa-miR-3189-5p	CLIP-seq
MIRT2539959	hsa-miR-3529	CLIP-seq
MIRT2539960	hsa-miR-3614-5p	CLIP-seq
MIRT2539961	hsa-miR-3689a-3p	CLIP-seq
MIRT2539962	hsa-miR-3689c	CLIP-seq
MIRT2539963	hsa-miR-374c	CLIP-seq
MIRT2539964	hsa-miR-379	CLIP-seq
MIRT2539965	hsa-miR-3973	CLIP-seq
MIRT2539966	hsa-miR-4286	CLIP-seq
MIRT1022784	hsa-miR-4312	CLIP-seq
MIRT2539967	hsa-miR-4451	CLIP-seq
MIRT2539968	hsa-miR-450b-3p	CLIP-seq
MIRT2539969	hsa-miR-4650-3p	CLIP-seq
MIRT2539970	hsa-miR-4701-3p	CLIP-seq
MIRT2539971	hsa-miR-4710	CLIP-seq
MIRT2539972	hsa-miR-4728-5p	CLIP-seq
MIRT2539973	hsa-miR-4751	CLIP-seq
MIRT2539974	hsa-miR-4758-3p	CLIP-seq
MIRT2539975	hsa-miR-4797-5p	CLIP-seq
MIRT2539976	hsa-miR-548a-5p	CLIP-seq
MIRT2539977	hsa-miR-548ab	CLIP-seq
MIRT2539978	hsa-miR-548ak	CLIP-seq
MIRT2539979	hsa-miR-548b-5p	CLIP-seq
MIRT2539980	hsa-miR-548c-5p	CLIP-seq
MIRT2539981	hsa-miR-548d-5p	CLIP-seq
MIRT2539982	hsa-miR-548h	CLIP-seq
MIRT2539983	hsa-miR-548i	CLIP-seq
MIRT2539984	hsa-miR-548j	CLIP-seq
MIRT2539985	hsa-miR-548q	CLIP-seq
MIRT2539986	hsa-miR-548w	CLIP-seq
MIRT2539987	hsa-miR-548y	CLIP-seq
MIRT2539988	hsa-miR-558	CLIP-seq
MIRT2539989	hsa-miR-559	CLIP-seq
MIRT2539990	hsa-miR-655	CLIP-seq
MIRT2539991	hsa-miR-767-3p	CLIP-seq
MIRT2539992	hsa-miR-769-3p	CLIP-seq
MIRT2539954	hsa-miR-1224-5p	CLIP-seq
MIRT2539955	hsa-miR-1262	CLIP-seq
MIRT2539956	hsa-miR-1278	CLIP-seq
MIRT1022776	hsa-miR-3189-3p	CLIP-seq
MIRT2539958	hsa-miR-3189-5p	CLIP-seq
MIRT2539959	hsa-miR-3529	CLIP-seq
MIRT2539960	hsa-miR-3614-5p	CLIP-seq
MIRT2539961	hsa-miR-3689a-3p	CLIP-seq
MIRT2539962	hsa-miR-3689c	CLIP-seq
MIRT2539963	hsa-miR-374c	CLIP-seq
MIRT2539964	hsa-miR-379	CLIP-seq
MIRT2539965	hsa-miR-3973	CLIP-seq
MIRT2539966	hsa-miR-4286	CLIP-seq
MIRT1022784	hsa-miR-4312	CLIP-seq
MIRT2539967	hsa-miR-4451	CLIP-seq
MIRT2539968	hsa-miR-450b-3p	CLIP-seq
MIRT2539969	hsa-miR-4650-3p	CLIP-seq
MIRT2539970	hsa-miR-4701-3p	CLIP-seq
MIRT2539971	hsa-miR-4710	CLIP-seq
MIRT2539972	hsa-miR-4728-5p	CLIP-seq
MIRT2539973	hsa-miR-4751	CLIP-seq
MIRT2539974	hsa-miR-4758-3p	CLIP-seq
MIRT2539975	hsa-miR-4797-5p	CLIP-seq
MIRT2539976	hsa-miR-548a-5p	CLIP-seq
MIRT2539977	hsa-miR-548ab	CLIP-seq
MIRT2539978	hsa-miR-548ak	CLIP-seq
MIRT2539979	hsa-miR-548b-5p	CLIP-seq
MIRT2539980	hsa-miR-548c-5p	CLIP-seq
MIRT2539981	hsa-miR-548d-5p	CLIP-seq
MIRT2539982	hsa-miR-548h	CLIP-seq
MIRT2539983	hsa-miR-548i	CLIP-seq
MIRT2539984	hsa-miR-548j	CLIP-seq
MIRT2539985	hsa-miR-548q	CLIP-seq
MIRT2539986	hsa-miR-548w	CLIP-seq
MIRT2539987	hsa-miR-548y	CLIP-seq
MIRT2539988	hsa-miR-558	CLIP-seq
MIRT2539989	hsa-miR-559	CLIP-seq
MIRT2539990	hsa-miR-655	CLIP-seq
MIRT2539992	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003920	Function	GMP reductase activity	IDA	22037469
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005829	Component	Cytosol	TAS
GO:0006144	Process	Purine nucleobase metabolic process	IEA
GO:0043101	Process	Purine-containing compound salvage	TAS
GO:0046037	Process	GMP metabolic process	IDA	22037469
GO:0046872	Function	Metal ion binding	IEA
GO:1902560	Component	GMP reductase complex	IEA

Other IDs

• MIM: 610781
• HGNC: 4377
• e!Ensembl: ENSG00000100938

Protein

• UniProt ID: Q9P2T1
• Protein name: GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)
• Protein function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
• PDB: 2A7R, 2BZN, 2C6Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00478	IMPDH	9 → 341	IMP dehydrogenase / GMP reductase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231}
• Sequence:

  MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGT
  FEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAI
  PQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGI
  GPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVM
  LGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGD
  VEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSEAC

• Sequence length: 348

Pathways

KEGG:

Purine metabolism
Metabolic pathways
Nucleotide metabolism

Reactome:

Purine salvage

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	15378696
Carcinoma	Carcinoma, Cribriform, Carcinoma, Granular Cell	rs121912654, rs555607708, rs786202962, rs1564055259	15378696
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	15378696

Unknown
Disease term	Disease name	Evidence	References	Source
Uterine Fibroids	Uterine Fibroids			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Neoplasms	Associate	12669231