Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51247
Gene name Gene Name - the full gene name approved by the HGNC.
Poly(A) binding protein interacting protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PAIP2
Synonyms (NCBI Gene) Gene synonyms aliases
PAIP-2, PAIP2A
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049925 hsa-miR-30a-3p CLASH 23622248
MIRT046752 hsa-miR-222-3p CLASH 23622248
MIRT046752 hsa-miR-222-3p PAR-CLIP 20371350
MIRT256500 hsa-miR-221-3p PAR-CLIP 20371350
MIRT571835 hsa-miR-218-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000900 Function Translation repressor activity, mRNA regulatory element binding IEA
GO:0003729 Function MRNA binding IEA
GO:0005515 Function Protein binding IPI 11172725, 14685257, 16601676, 32296183, 32814053
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm IDA 11172725
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605604 17970 ENSG00000120727
Protein
UniProt ID Q9BPZ3
Protein name Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)
Protein function Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP
PDB 1JGN , 3KUS , 3KUT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07145 PAM2 106 123 Ataxin-2 C-terminal region Motif
Tissue specificity TISSUE SPECIFICITY: Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid. {ECO:0000269|PubMed:16804161}.
Sequence
MKDPSRSSTSPSIINEDVIINGHSHEDDNPFAEYMWMENEEEFNRQIEEELWEEEFIERC
FQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSLEDLVVKSNLNPNAKEFVP
GVK
YGNI
Sequence length 127
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
25944804
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
25944804
Associations from Text Mining
Disease Name Relationship Type References
Head and Neck Neoplasms Associate 16641910
Leukoplakia Associate 24403051
Squamous Cell Carcinoma of Head and Neck Associate 16641910, 24403051